RBM15B

Summary

RBM15B (RNA binding motif protein 15B, HGNC:24303) is a protein-coding gene on chromosome 3p21.2, encoding Putative RNA-binding protein 15B (Q8NDT2). RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA.

Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).

Source: NCBI Gene 29890 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 99 total
• MANE Select transcript: NM_013286

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24303
Approved symbol	RBM15B
Name	RNA binding motif protein 15B
Location	3p21.2
Locus type	gene with protein product
Status	Approved
Aliases	HUMAGCGB, OTT3
Ensembl gene	ENSG00000259956
Ensembl biotype	protein_coding
OMIM	612602
Entrez	29890

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000563281

RefSeq mRNA: 1 — MANE Select: NM_013286 NM_013286

CCDS: CCDS33764

Canonical transcript exons

ENST00000563281 — 1 exons

Exon	Start	End
ENSE00002589139	51391285	51397908

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 91.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.7444 / max 280.4106, expressed in 1804 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36765	24.9612	1803
36767	0.6712	407
36766	0.0869	27
202763	0.0251	3

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	91.61	gold quality
cortical plate	UBERON:0005343	90.61	gold quality
embryo	UBERON:0000922	90.51	gold quality
ventricular zone	UBERON:0003053	89.65	gold quality
amniotic fluid	UBERON:0000173	87.71	gold quality
endometrium epithelium	UBERON:0004811	87.65	silver quality
stromal cell of endometrium	CL:0002255	86.69	gold quality
mammary duct	UBERON:0001765	86.47	gold quality
type B pancreatic cell	CL:0000169	85.92	gold quality
granulocyte	CL:0000094	85.56	gold quality
olfactory bulb	UBERON:0002264	85.52	gold quality
paraflocculus	UBERON:0005351	85.47	silver quality
frontal pole	UBERON:0002795	85.28	silver quality
epithelium of mammary gland	UBERON:0003244	85.26	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.08	gold quality
cartilage tissue	UBERON:0002418	84.95	gold quality
gingival epithelium	UBERON:0001949	84.80	gold quality
gingiva	UBERON:0001828	84.69	gold quality
islet of Langerhans	UBERON:0000006	84.64	gold quality
tongue squamous epithelium	UBERON:0006919	84.42	silver quality
middle frontal gyrus	UBERON:0002702	84.35	silver quality
leukocyte	CL:0000738	84.27	gold quality
tibialis anterior	UBERON:0001385	84.13	silver quality
mononuclear cell	CL:0000842	84.09	gold quality
monocyte	CL:0000576	84.01	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.01	gold quality
lower esophagus	UBERON:0013473	83.99	gold quality
esophagus mucosa	UBERON:0002469	83.79	gold quality
esophagus	UBERON:0001043	83.72	gold quality
tibial artery	UBERON:0007610	83.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.58

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

115 targeting RBM15B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-6755-5P	99.95	65.59	464
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-6739-5P	99.80	67.87	2806

Literature-anchored findings (GeneRIF, showing 4)

• The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. (PMID:19586903)
• HHV-8 ORF57 interacts with RBM15 and OTT3 to promote expression of viral intronless genes. (PMID:21106733)
• BAP1 is highly positively correlated with RBM15B and USP19 expression in invasive breast carcinoma, UM, and colon adenocarcinoma (PMID:30716094)
• N(6)-Methyladenosine regulator RBM15B acts as an independent prognostic biomarker and its clinical significance in uveal melanoma. (PMID:36003405)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	rbm15b	ENSDARG00000078966
mus_musculus	Rbm15b	ENSMUSG00000074102
rattus_norvegicus	Rbm15b	ENSRNOG00000014161
drosophila_melanogaster	nonA	FBGN0004227
drosophila_melanogaster	nonA-l	FBGN0015520
drosophila_melanogaster	nito	FBGN0027548

Paralogs (7): SPEN (ENSG00000065526), SFPQ (ENSG00000116560), PSPC1 (ENSG00000121390), NONO (ENSG00000147140), RAVER1 (ENSG00000161847), RAVER2 (ENSG00000162437), RBM15 (ENSG00000162775)

Protein

Protein identifiers

Putative RNA-binding protein 15B — Q8NDT2 (reviewed: Q8NDT2)

Alternative names: One-twenty two protein 3, RNA-binding motif protein 15B

All UniProt accessions (1): Q8NDT2

UniProt curated annotations — full annotation on UniProt →

Function. RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1.

Subunit / interactions. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of METTL3 and METTL14. The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B). May interact with NCOR2. Interacts with NXF1, the interaction is required to promote mRNA export. (Microbial infection) Interacts (via the SPOC domain) with Epstein-Barr virus BMLF1 (via the N-terminus); the interaction is direct.

Subcellular location. Nucleus. Nucleoplasm. Nucleus speckle. Nucleus envelope.

Tissue specificity. Ubiquitously expressed.

Similarity. Belongs to the RRM Spen family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8NDT2-1	1	yes
Q8NDT2-2	2

RefSeq proteins (1): NP_037418* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000504	RRM_dom	Domain
IPR010912	SPOC_met	Domain
IPR012677	Nucleotide-bd_a/b_plait_sf	Homologous_superfamily
IPR012921	SPOC_C	Domain
IPR016194	SPOC-like_C_dom_sf	Homologous_superfamily
IPR034475	RBM15B_RRM1	Domain
IPR034535	RBM15B_RRM2	Domain
IPR034536	RBM15B_RRM3	Domain
IPR035979	RBD_domain_sf	Homologous_superfamily

Pfam: PF00076, PF07744

UniProt features (33 total): compositionally biased region 11, modified residue 8, domain 4, region of interest 4, cross-link 2, chain 1, splice variant 1, sequence conflict 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NDT2-F1	62.05	0.26

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 109, 113, 265, 267, 532, 552, 556, 562, 213, 702

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 155 (showing top): YAGI_AML_WITH_INV_16_TRANSLOCATION, GCANCTGNY_MYOD_Q6, GOBP_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME, CAGCTG_AP4_Q5, YY1_Q6, GOBP_RNA_METHYLATION, GOBP_NUCLEAR_TRANSPORT, BROWNE_HCMV_INFECTION_48HR_DN, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, GOBP_RNA_MODIFICATION, YY1_02, TGCTGAY_UNKNOWN, USF_01, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, AAAGACA_MIR511

GO Biological Process (6): regulation of alternative mRNA splicing, via spliceosome (GO:0000381), RNA methylation (GO:0001510), mRNA processing (GO:0006397), mRNA export from nucleus (GO:0006406), RNA splicing (GO:0008380), dosage compensation by inactivation of X chromosome (GO:0009048)

GO Molecular Function (4): RNA binding (GO:0003723), mRNA binding (GO:0003729), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), nuclear envelope (GO:0005635), nucleoplasm (GO:0005654), nuclear speck (GO:0016607), RNA N6-methyladenosine methyltransferase complex (GO:0036396)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
binding	2
alternative mRNA splicing, via spliceosome	1
regulation of mRNA splicing, via spliceosome	1
RNA modification	1
macromolecule methylation	1
mRNA metabolic process	1
RNA export from nucleus	1
gene expression	1
mRNA transport	1
sex-chromosome dosage compensation	1
heterochromatin formation	1
nucleic acid binding	1
RNA binding	1
intracellular membrane-bounded organelle	1
nucleus	1
endomembrane system	1
organelle envelope	1
nuclear lumen	1
cellular anatomical structure	1
nuclear ribonucleoprotein granule	1
methyltransferase complex	1

Protein interactions and networks

STRING

804 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RBM15B	ZC3H13	Q5T200	998
RBM15B	VIRMA	Q69YN4	998
RBM15B	WTAP	Q15007	998
RBM15B	METTL14	Q9HCE5	998
RBM15B	METTL3	Q86U44	997
RBM15B	CBLL1	Q75N03	990
RBM15B	RBM15	Q96T37	983
RBM15B	METTL16	Q86W50	966
RBM15B	MAPRE2	Q15555	903
RBM15B	RAE1	P78406	891
RBM15B	YTHDC1	Q96MU7	842
RBM15B	YTHDC2	Q9H6S0	829
RBM15B	YTHDF3	Q7Z739	827
RBM15B	YTHDF1	Q9BYJ9	823
RBM15B	ALKBH5	Q6P6C2	823

IntAct

76 interactions, top by confidence:

A	B	Type	Score
ASH2L	KMT2D	psi-mi:“MI:0914”(association)	0.890
P4HA3	FAM171A2	psi-mi:“MI:0914”(association)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
RBM15B	NAV2	psi-mi:“MI:0915”(physical association)	0.560
NAV2	RBM15B	psi-mi:“MI:0915”(physical association)	0.560
METTL3	WTAP	psi-mi:“MI:0914”(association)	0.530
IL13RA2	METTL15	psi-mi:“MI:0914”(association)	0.530
TRIM23	POTEB3	psi-mi:“MI:0914”(association)	0.530
ZC3H18	AQR	psi-mi:“MI:0914”(association)	0.530
RBM15B	KLHL22	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
WDR83	SH2B2	psi-mi:“MI:0914”(association)	0.530
RBM15B	YWHAH	psi-mi:“MI:0914”(association)	0.530
EZH1	EPOP	psi-mi:“MI:0914”(association)	0.530
RPL13	RRP8	psi-mi:“MI:0914”(association)	0.530
ERBB2	RBM15B	psi-mi:“MI:0915”(physical association)	0.370
RBM15B	PA	psi-mi:“MI:0915”(physical association)	0.370
RBM15B	PB1	psi-mi:“MI:0915”(physical association)	0.370
RBM15B	PB2	psi-mi:“MI:0915”(physical association)	0.370
RBM15B	EGR2	psi-mi:“MI:0915”(physical association)	0.370
TNNC1	RBM15B	psi-mi:“MI:0915”(physical association)	0.370
ATP6V0D2	RBM15B	psi-mi:“MI:0915”(physical association)	0.370
NCAPH	SCAMP2	psi-mi:“MI:0914”(association)	0.350
CEP170P1	PCYT1A	psi-mi:“MI:0914”(association)	0.350
THOC1	TARS3	psi-mi:“MI:0914”(association)	0.350
MATR3	BCLAF3	psi-mi:“MI:0914”(association)	0.350

BioGRID (122): RBM15B (Two-hybrid), NAV2 (Two-hybrid), RBM15B (Affinity Capture-MS), RBM15B (Affinity Capture-MS), RBM15B (Affinity Capture-MS), DDX47 (Co-fractionation), RBM15B (Co-fractionation), RBM15B (Biochemical Activity), RBM15B (Affinity Capture-MS), RBM15B (Affinity Capture-MS), RBM15B (Affinity Capture-MS), RBM15B (Affinity Capture-MS), RBM15B (Affinity Capture-MS), RBM15B (Affinity Capture-MS), RBM15B (Affinity Capture-MS)

ESM2 similar proteins: D3YXK2, F4IS91, F4JCU0, O13845, O88453, P18615, P19426, P51116, Q05519, Q08CF3, Q08DZ2, Q0P5D2, Q0V898, Q0VBL3, Q14151, Q15424, Q16630, Q2QKB3, Q5NVH8, Q5R452, Q5RKH1, Q5TYQ8, Q5VUA4, Q5XI29, Q5ZL34, Q61136, Q62504, Q641G3, Q68UI8, Q6DDW4, Q6NVF9, Q6NWC6, Q6PHZ5, Q7KMJ6, Q803E1, Q86U06, Q8BTV2, Q8N684, Q8NDT2, Q91W39

Diamond homologs: F4I3B3, O15042, O64380, O93235, Q0VBL3, Q1LZD9, Q4KLH4, Q5R7X2, Q5ZK88, Q62504, Q6NV83, Q6PHZ5, Q7KMJ6, Q8NDT2, Q8R326, Q8SX83, Q8WXF1, Q96T37, Q96T58, Q9SX79, A2A5N3, A4F5G6, A6NFN3, B3LYP1, B4JUT1, B4KCD5, B4LZ88, B4NB54, C0H859, O74400, O75494, P19682, P19683, P23246, P28644, P30352, P60824, P60825, P60826, Q01130

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 88 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Processing of Capped Intron-Containing Pre-mRNA	8	12.6×	8e-05

GO biological processes:

GO term	Partners	Fold	FDR
RNA splicing	7	8.3×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

99 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	97
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

107 predictions. Top by Δscore:

Variant	Effect	Δscore
3:51393756:G:T	donor_gain	0.9800
3:51394046:A:AG	donor_gain	0.9600
3:51394045:GAT:G	donor_gain	0.9200
3:51393795:C:T	donor_gain	0.8500
3:51393908:A:AG	donor_gain	0.8300
3:51395912:CTTG:C	acceptor_gain	0.8200
3:51393756:G:GT	donor_gain	0.8000
3:51394098:T:G	donor_gain	0.7700
3:51394118:T:G	donor_gain	0.7700
3:51396193:T:TC	acceptor_gain	0.7400
3:51396207:C:CT	acceptor_gain	0.7300
3:51396193:T:C	acceptor_gain	0.7200
3:51396208:A:T	acceptor_gain	0.7100
3:51396864:T:TA	acceptor_gain	0.6800
3:51396225:C:T	acceptor_gain	0.6700
3:51395915:G:GC	acceptor_gain	0.6600
3:51393889:G:GT	donor_gain	0.6300
3:51396195:G:C	acceptor_gain	0.6300
3:51396185:TCCCA:T	acceptor_gain	0.5900
3:51396223:TGC:T	acceptor_gain	0.5800
3:51393768:GC:G	donor_gain	0.5700
3:51396191:CTT:C	acceptor_gain	0.5500
3:51396192:TTT:T	acceptor_gain	0.5500
3:51396193:T:G	acceptor_gain	0.5500
3:51393865:G:GT	donor_gain	0.5400
3:51393736:C:A	donor_gain	0.5300
3:51393735:TCAC:T	donor_gain	0.5200
3:51393536:GA:G	donor_gain	0.5100
3:51393866:A:T	donor_gain	0.5000
3:51396195:G:GC	acceptor_gain	0.4900

AlphaMissense

5733 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:51391821:T:C	L141S	1.000
3:51391887:T:C	F163S	1.000
3:51391899:G:T	G167V	1.000
3:51391947:C:A	A183D	1.000
3:51391958:T:C	F187L	1.000
3:51391959:T:C	F187S	1.000
3:51391960:C:A	F187L	1.000
3:51391960:C:G	F187L	1.000
3:51392403:C:A	A335D	1.000
3:51392415:T:A	L339H	1.000
3:51392415:T:C	L339P	1.000
3:51392415:T:G	L339R	1.000
3:51392417:T:A	F340I	1.000
3:51392417:T:C	F340L	1.000
3:51392417:T:G	F340V	1.000
3:51392418:T:C	F340S	1.000
3:51392418:T:G	F340C	1.000
3:51392419:C:A	F340L	1.000
3:51392419:C:G	F340L	1.000
3:51392421:T:A	I341N	1.000
3:51392423:G:C	G342R	1.000
3:51392423:G:T	G342C	1.000
3:51392424:G:A	G342D	1.000
3:51392424:G:T	G342V	1.000
3:51392428:C:A	N343K	1.000
3:51392428:C:G	N343K	1.000
3:51392430:T:A	L344Q	1.000
3:51392430:T:C	L344P	1.000
3:51392457:T:C	L353P	1.000
3:51392468:T:C	F357L	1.000

dbSNP variants (sampled 300 via entrez): RS1000436457 (3:51390648 C>A,T), RS1000542905 (3:51391111 C>T), RS1000624451 (3:51396109 A>C), RS1000678216 (3:51395841 C>T), RS1001145996 (3:51389899 G>A), RS1002349348 (3:51397445 C>G), RS1003381331 (3:51394238 A>G,T), RS1003905304 (3:51396955 C>T), RS1003931959 (3:51390569 C>T), RS1003957503 (3:51396565 T>C), RS1004282464 (3:51390277 G>A,T), RS1005340086 (3:51389284 C>A,T), RS1005550607 (3:51391944 T>C), RS1005630609 (3:51398161 T>A), RS1006017481 (3:51392263 G>A,T)

Disease associations

OMIM: gene MIM:612602 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST007732_15	Allergic disease (asthma, hay fever or eczema)	1.000000e-07
GCST012232_7	Lipoprotein (a) levels	3.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006925	lipoprotein A measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	increases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	decreases expression	1
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
quercitrin	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	increases expression	1
cobaltous chloride	decreases expression	1
butyraldehyde	decreases expression	1
potassium chromate(VI)	increases expression, affects cotreatment	1
coumarin	decreases phosphorylation	1
cyclic 3’,5’-uridine monophosphate	affects binding	1
epigallocatechin gallate	affects cotreatment, increases expression	1
pentanal	decreases expression	1
CGP 52608	affects binding, increases reaction	1
NSC 689534	affects binding, decreases expression	1
Temozolomide	decreases expression	1
Decitabine	affects expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	affects phosphorylation	1
Cisplatin	affects expression	1
Copper	affects binding, decreases expression	1
Diazinon	increases methylation	1
Dimethyl Sulfoxide	increases expression	1
Folic Acid	decreases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Ribonucleotides	affects binding	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D9QC	Ubigene HEK293 RBM15B KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.