RBM26

Summary

RBM26 (RNA binding motif protein 26, HGNC:20327) is a protein-coding gene on chromosome 13q31.1, encoding RNA-binding protein 26 (Q5T8P6). May be involved in the turnover of nuclear polyadenylated (pA+) RNA.

Enables RNA binding activity. Predicted to be active in nucleus.

Source: NCBI Gene 64062 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 127 total
• Druggable target: yes
• MANE Select transcript: NM_001366735

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20327
Approved symbol	RBM26
Name	RNA binding motif protein 26
Location	13q31.1
Locus type	gene with protein product
Status	Approved
Aliases	PRO1777, SE70-2, FLJ20957, ZC3H17, ARRS2, PPP1R132
Ensembl gene	ENSG00000139746
Ensembl biotype	protein_coding
OMIM	620081
Entrez	64062

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 26 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000267229, ENST00000438724, ENST00000438737, ENST00000449987, ENST00000461008, ENST00000472143, ENST00000622611, ENST00000862496, ENST00000862497, ENST00000862498, ENST00000862499, ENST00000862500, ENST00000862501, ENST00000862502, ENST00000862503, ENST00000862504, ENST00000862505, ENST00000862506, ENST00000862507, ENST00000862508, ENST00000862509, ENST00000862510, ENST00000862511, ENST00000915847, ENST00000915848, ENST00000915849, ENST00000969727, ENST00000969728

RefSeq mRNA: 4 — MANE Select: NM_001366735 NM_001286631, NM_001286632, NM_001366735, NM_022118

CCDS: CCDS66566, CCDS73591, CCDS91822, CCDS9462

Canonical transcript exons

ENST00000438737 — 22 exons

Exon	Start	End
ENSE00001231009	79353153	79353224
ENSE00001336737	79354439	79354570
ENSE00001601616	79365578	79365718
ENSE00001635156	79318868	79320710
ENSE00001639116	79366055	79366195
ENSE00001667197	79405704	79406255
ENSE00001672249	79370945	79371162
ENSE00001766507	79377379	79377515
ENSE00001789788	79368730	79368990
ENSE00001804108	79371842	79371930
ENSE00003462108	79355220	79355384
ENSE00003470309	79337102	79337302
ENSE00003474657	79359575	79359686
ENSE00003493487	79322349	79322462
ENSE00003519382	79344248	79344322
ENSE00003549970	79358274	79358433
ENSE00003570558	79378789	79378907
ENSE00003577445	79334344	79334430
ENSE00003586232	79342664	79342831
ENSE00003616321	79341123	79341227
ENSE00003660890	79366633	79366872
ENSE00003678261	79344669	79344794

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 96.56.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.7145 / max 516.7301, expressed in 1789 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137725	15.1654	1781
137723	1.7573	926
137722	1.2382	614
137724	0.5536	288

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pylorus	UBERON:0001166	96.56	gold quality
pigmented layer of retina	UBERON:0001782	96.54	gold quality
retina	UBERON:0000966	96.51	gold quality
cardia of stomach	UBERON:0001162	96.47	gold quality
blood vessel layer	UBERON:0004797	96.11	gold quality
tibia	UBERON:0000979	96.10	gold quality
choroid plexus epithelium	UBERON:0003911	96.10	gold quality
penis	UBERON:0000989	95.95	gold quality
cerebellar vermis	UBERON:0004720	95.84	gold quality
epithelium of nasopharynx	UBERON:0001951	95.56	gold quality
nasopharynx	UBERON:0001728	95.54	gold quality
visceral pleura	UBERON:0002401	95.52	gold quality
urethra	UBERON:0000057	95.37	gold quality
superior surface of tongue	UBERON:0007371	95.29	gold quality
oocyte	CL:0000023	95.08	gold quality
mucosa of sigmoid colon	UBERON:0004993	94.97	gold quality
pericardium	UBERON:0002407	94.94	gold quality
secondary oocyte	CL:0000655	94.89	gold quality
postcentral gyrus	UBERON:0002581	94.81	gold quality
parietal pleura	UBERON:0002400	94.80	gold quality
trigeminal ganglion	UBERON:0001675	94.72	gold quality
renal medulla	UBERON:0000362	94.68	gold quality
ventricular zone	UBERON:0003053	94.62	gold quality
buccal mucosa cell	CL:0002336	94.48	gold quality
parietal lobe	UBERON:0001872	94.46	gold quality
pleura	UBERON:0000977	94.39	gold quality
trabecular bone tissue	UBERON:0002483	94.39	gold quality
inferior vagus X ganglion	UBERON:0005363	94.29	gold quality
cartilage tissue	UBERON:0002418	94.08	gold quality
adrenal tissue	UBERON:0018303	94.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.85

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

103 targeting RBM26, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-126-5P	100.00	72.71	3180
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-374A-5P	99.90	71.34	2923

Literature-anchored findings (GeneRIF, showing 1)

• three additional proteins required for Poly(A) Tail eXosome Targeting (PAXT) function: ZC3H3, RBM26 and RBM27 along with the known PAXT-associated protein, PABPN1, were identified. (PMID:31950173)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	rbm26	ENSDARG00000104130
mus_musculus	Rbm26	ENSMUSG00000022119
rattus_norvegicus	Rbm26	ENSRNOG00000009836
drosophila_melanogaster	swm	FBGN0002044
caenorhabditis_elegans		WBGENE00015143

Paralogs (1): RBM27 (ENSG00000091009)

Protein

Protein identifiers

RNA-binding protein 26 — Q5T8P6 (reviewed: Q5T8P6)

Alternative names: CTCL tumor antigen se70-2, RNA-binding motif protein 26

All UniProt accessions (3): Q5T8P6, A0A087X0H9, E2PSN0

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in the turnover of nuclear polyadenylated (pA+) RNA.

Isoforms (6)

UniProt ID	Names	Canonical?
Q5T8P6-1	1	yes
Q5T8P6-2	2
Q5T8P6-3	3
Q5T8P6-4	4
Q5T8P6-5	5
Q5T8P6-6	6

RefSeq proteins (4): NP_001273560, NP_001273561, NP_001353664, NP_071401 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000504	RRM_dom	Domain
IPR000571	Znf_CCCH	Domain
IPR002483	PWI_dom	Domain
IPR012677	Nucleotide-bd_a/b_plait_sf	Homologous_superfamily
IPR034859	RBM26_RRM1	Domain
IPR035979	RBD_domain_sf	Homologous_superfamily
IPR039511	RBM26-like_RRM2	Domain
IPR045137	RBM26/27	Family

Pfam: PF01480

UniProt features (41 total): compositionally biased region 10, sequence conflict 6, modified residue 5, splice variant 5, region of interest 5, cross-link 3, domain 2, coiled-coil region 2, chain 1, zinc finger region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T8P6-F1	58.09	0.13

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 127, 496, 510, 518, 616, 94, 106, 106

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9930044	Nuclear RNA decay

MSigDB gene sets: 158 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, RNGTGGGC_UNKNOWN, AAGCAAT_MIR137, ACTACCT_MIR196A_MIR196B, GCANCTGNY_MYOD_Q6, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, KENNY_CTNNB1_TARGETS_UP, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GGCNKCCATNK_UNKNOWN, WANG_LMO4_TARGETS_DN, YY1_02, ATTACAT_MIR3803P, AAAGACA_MIR511, ATTCTTT_MIR186, MYOD_Q6

GO Biological Process (0):

GO Molecular Function (5): RNA binding (GO:0003723), zinc ion binding (GO:0008270), nucleic acid binding (GO:0003676), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of RNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1252 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RBM26	ZFC3H1	O60293	667
RBM26	ZC3H3	Q8IXZ2	581
RBM26	PCED1A	Q9H1Q7	538
RBM26	MTREX	P42285	523
RBM26	RBM7	Q9Y580	513
RBM26	ZCCHC8	Q6NZY4	513
RBM26	PABPN1	Q86U42	459
RBM26	VPS50	Q96JG6	450
RBM26	KBTBD4	Q9NVX7	449
RBM26	RBM22	Q9NW64	440
RBM26	NOC3L	Q8WTT2	426
RBM26	ZC3HAV1L	Q96H79	404
RBM26	SRRT	Q9BXP5	383
RBM26	GDPD4	Q6W3E5	382
RBM26	TOE1	Q96GM8	382

IntAct

104 interactions, top by confidence:

A	B	Type	Score
IKBKG	IKBKB	psi-mi:“MI:0914”(association)	0.980
FOXK2	DVL2	psi-mi:“MI:0914”(association)	0.640
CHCHD10	CLPX	psi-mi:“MI:0914”(association)	0.640
NEUROG3	GXYLT2	psi-mi:“MI:0914”(association)	0.640
NCK2	RBM26	psi-mi:“MI:0915”(physical association)	0.560
RBM26	NCK2	psi-mi:“MI:0915”(physical association)	0.560
NCBP3	SAP18	psi-mi:“MI:0914”(association)	0.530
TNFRSF13B	TNFRSF10B	psi-mi:“MI:0914”(association)	0.530
SRPK2	RRP9	psi-mi:“MI:0914”(association)	0.530
CPSF6	DDX39A	psi-mi:“MI:0914”(association)	0.480
RBM26	PPP1CA	psi-mi:“MI:0407”(direct interaction)	0.440
RBM26	Dlg4	psi-mi:“MI:0407”(direct interaction)	0.440
ANKRD26	RBM26	psi-mi:“MI:0915”(physical association)	0.400
JUNB	RBM26	psi-mi:“MI:0915”(physical association)	0.400
RBM26	FXR1	psi-mi:“MI:0915”(physical association)	0.370
CDKN2A	RBM26	psi-mi:“MI:0915”(physical association)	0.370
RBM26	ATXN1	psi-mi:“MI:0915”(physical association)	0.370
CEP170P1	PCYT1A	psi-mi:“MI:0914”(association)	0.350
FZD1	ATP5F1B	psi-mi:“MI:0914”(association)	0.350
SETD1B	WBP4	psi-mi:“MI:0914”(association)	0.350
Rtf2	UBE2V2	psi-mi:“MI:0914”(association)	0.350
Pip4p2	ATP6V1B2	psi-mi:“MI:0914”(association)	0.350
Chmp2a	MEN1	psi-mi:“MI:0914”(association)	0.350
VPS26A	LCMT2	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
KBTBD7	POLRMT	psi-mi:“MI:0914”(association)	0.350

BioGRID (175): RBM26 (Two-hybrid), RBM26 (Affinity Capture-MS), RBM26 (Affinity Capture-MS), RBM26 (Affinity Capture-MS), RBM26 (Affinity Capture-MS), RBM26 (Affinity Capture-MS), RBM26 (Co-fractionation), RBM26 (Co-fractionation), RBM26 (Affinity Capture-MS), RBM26 (Proximity Label-MS), RBM26 (Affinity Capture-MS), RBM26 (Affinity Capture-MS), RBM26 (Affinity Capture-MS), RBM26 (Affinity Capture-MS), RBM26 (Affinity Capture-MS)

ESM2 similar proteins: A0A8M2, A0JMU8, A1L1K8, A5D7H5, B9DFV2, E1BUG7, F4JP52, G1SW77, G3X9Z4, O08719, O15234, O94913, Q0V898, Q1LVV0, Q2T9I5, Q32NW2, Q3MHF8, Q498K9, Q566L7, Q5CZI8, Q5JVS0, Q5R4R4, Q5T8P6, Q5TYQ8, Q659C4, Q68FI1, Q6AXS5, Q6NVR8, Q6NZN0, Q6PKG0, Q8AVJ2, Q8CGC4, Q8K2F8, Q8K3W3, Q8K3X0, Q8NC51, Q8ND56, Q91W18, Q91W39, Q96D71

Diamond homologs: Q2T9I5, Q5SFM8, Q5T8P6, Q6NZN0, Q9P2N5, Q9USP9, Q0JDM0, Q9LVX1, Q9VIV2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 145 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA 3’-end processing	7	13.2×	2e-04
mRNA Polyadenylation	11	9.3×	2e-05
mRNA Splicing	8	8.4×	5e-04
Processing of Capped Intron-Containing Pre-mRNA	9	7.1×	5e-04
mRNA Splicing - Major Pathway	13	6.8×	2e-05
Dengue Virus-Host Interactions	12	5.3×	5e-04
Metabolism of RNA	12	4.8×	7e-04

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal small subunit biogenesis	6	10.3×	4e-03
mRNA splicing, via spliceosome	10	6.9×	6e-04
RNA splicing	10	6.7×	6e-04
mRNA processing	11	6.6×	5e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

127 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	89
Likely benign	4
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

4105 predictions. Top by Δscore:

Variant	Effect	Δscore
13:79322344:CATA:C	donor_gain	1.0000
13:79322345:ATACT:A	donor_loss	1.0000
13:79322346:TACT:T	donor_loss	1.0000
13:79322347:A:AC	donor_gain	1.0000
13:79322347:ACTT:A	donor_gain	1.0000
13:79322347:ACTTC:A	donor_loss	1.0000
13:79322348:C:CC	donor_gain	1.0000
13:79322348:CT:C	donor_gain	1.0000
13:79322348:CTT:C	donor_gain	1.0000
13:79322348:CTTC:C	donor_gain	1.0000
13:79322348:CTTCT:C	donor_gain	1.0000
13:79322350:T:TA	donor_gain	1.0000
13:79322458:GCAGC:G	acceptor_gain	1.0000
13:79322459:CAGCC:C	acceptor_gain	1.0000
13:79322460:AGCC:A	acceptor_gain	1.0000
13:79322461:GC:G	acceptor_gain	1.0000
13:79322461:GCCTA:G	acceptor_gain	1.0000
13:79322462:CC:C	acceptor_gain	1.0000
13:79322462:CCTA:C	acceptor_gain	1.0000
13:79322463:C:T	acceptor_gain	1.0000
13:79322463:CT:C	acceptor_gain	1.0000
13:79322468:A:AC	acceptor_gain	1.0000
13:79322468:A:C	acceptor_gain	1.0000
13:79322471:A:C	acceptor_gain	1.0000
13:79322472:T:C	acceptor_gain	1.0000
13:79322472:T:TC	acceptor_gain	1.0000
13:79337013:ATGT:A	donor_gain	1.0000
13:79337124:T:TA	donor_gain	1.0000
13:79337136:T:A	donor_gain	1.0000
13:79337299:CAGC:C	acceptor_gain	1.0000

AlphaMissense

6592 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:79320630:C:A	W1005C	1.000
13:79320630:C:G	W1005C	1.000
13:79320632:A:G	W1005R	1.000
13:79320632:A:T	W1005R	1.000
13:79322412:C:A	W957C	1.000
13:79322412:C:G	W957C	1.000
13:79322414:A:G	W957R	1.000
13:79322414:A:T	W957R	1.000
13:79322449:C:T	G945E	1.000
13:79322461:G:T	A941D	1.000
13:79334351:G:T	A938D	1.000
13:79334352:C:G	A938P	1.000
13:79337106:A:G	F910S	1.000
13:79337302:C:G	A845P	1.000
13:79341199:A:G	L819P	1.000
13:79355265:C:A	W603C	1.000
13:79355265:C:G	W603C	1.000
13:79355267:A:G	W603R	1.000
13:79355267:A:T	W603R	1.000
13:79355272:A:T	V601D	1.000
13:79355278:A:C	I599S	1.000
13:79355278:A:T	I599N	1.000
13:79355280:A:C	F598L	1.000
13:79355280:A:T	F598L	1.000
13:79355281:A:C	F598C	1.000
13:79355281:A:G	F598S	1.000
13:79355282:A:C	F598V	1.000
13:79355282:A:G	F598L	1.000
13:79355282:A:T	F598I	1.000
13:79355284:C:A	R597L	1.000

dbSNP variants (sampled 300 via entrez): RS1000013073 (13:79407750 C>T), RS1000017803 (13:79386183 C>T), RS1000024243 (13:79347565 A>G), RS1000110420 (13:79337144 T>C,G), RS1000113467 (13:79380825 T>A,C), RS1000123372 (13:79381059 T>A), RS1000141816 (13:79323734 A>G,T), RS1000171756 (13:79330620 G>A), RS1000183001 (13:79335652 A>C), RS1000213099 (13:79329928 G>A,C), RS1000230041 (13:79372633 A>G), RS1000276280 (13:79359863 T>C), RS1000290106 (13:79367827 A>G), RS1000353505 (13:79379669 T>A,C), RS1000448354 (13:79375756 T>C)

Disease associations

OMIM: gene MIM:620081 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST000748_2	Response to anti-TNF alpha therapy in inflammatory bowel disease	5.000000e-07
GCST002928_6	Nickel levels	5.000000e-06
GCST004495_95	BMI (adjusted for smoking behaviour)	9.000000e-06
GCST004497_37	Body mass index (joint analysis main effects and smoking interaction)	3.000000e-06
GCST006624_88	Systolic blood pressure	3.000000e-09
GCST008162_101	Hip circumference	6.000000e-06
GCST009391_1070	Metabolite levels	6.000000e-06
GCST010988_472	Adult body size	2.000000e-15
GCST010989_60	Body size at age 10	4.000000e-16

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004653	response to TNF antagonist
EFO:0004318	smoking behavior
EFO:0004340	body mass index
EFO:0006335	systolic blood pressure
EFO:0010364	lysophosphatidylcholine 20:5 measurement
EFO:0009819	comparative body size at age 10, self-reported

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067233 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.04	Kd	921.6	nM	CHEMBL5653589
6.04	ED50	921.6	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149206: Binding affinity to human RBM26 incubated for 45 mins by Kinobead based pull down assay	kd	0.9216	uM

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, decreases methylation	6
sodium arsenite	decreases expression, increases abundance, increases expression, increases activity, affects binding (+1 more)	4
trichostatin A	affects cotreatment, decreases expression	3
Acetaminophen	decreases expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
TAK-243	decreases sumoylation	1
geldanamycin	increases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
aflatoxin B2	decreases methylation	1
coumarin	increases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
pentabromodiphenyl ether	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
clothianidin	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
Temozolomide	decreases expression	1
Vorinostat	decreases expression	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Cadmium	increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Cisplatin	decreases expression	1
Dinitrochlorobenzene	affects binding	1
Doxorubicin	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652248	Binding	Binding affinity to human RBM26 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.