RBM5-AS1

Summary

RBM5-AS1 (RBM5 antisense RNA 1, HGNC:48871) is a long non-coding RNA gene on chromosome 3p21.31.

This gene produces a non-coding RNA in antisense to the RNA binding motif protein 5 (RBM5) gene. This transcript interacts with beta catenin and may regulate expression of WNT target genes.

Source: NCBI Gene 100775107 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48871
Approved symbol	RBM5-AS1
Name	RBM5 antisense RNA 1
Location	3p21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	LUST
Ensembl gene	ENSG00000281691
Ensembl biotype	lncRNA
Entrez	100775107
RNAcentral	URS000019B796 — lncRNA, 1386 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000630404

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000630404 — 1 exons

Exon	Start	End
ENSE00003773990	50099603	50100988

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 83.06.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	83.06	gold quality
skeletal muscle tissue	UBERON:0001134	81.13	gold quality
bone marrow cell	CL:0002092	80.64	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.55	gold quality
bone marrow	UBERON:0002371	76.89	gold quality
tonsil	UBERON:0002372	76.22	gold quality
apex of heart	UBERON:0002098	75.09	gold quality
ventricular zone	UBERON:0003053	74.85	gold quality
sural nerve	UBERON:0015488	74.67	gold quality
uterine cervix	UBERON:0000002	74.14	gold quality
muscle tissue	UBERON:0002385	74.12	gold quality
body of pancreas	UBERON:0001150	73.06	gold quality
tibial nerve	UBERON:0001323	73.00	gold quality
calcaneal tendon	UBERON:0003701	72.86	gold quality
body of uterus	UBERON:0009853	72.83	gold quality
right ovary	UBERON:0002118	72.78	gold quality
left ovary	UBERON:0002119	72.76	gold quality
myometrium	UBERON:0001296	72.62	gold quality
left lobe of thyroid gland	UBERON:0001120	72.55	gold quality
skin of leg	UBERON:0001511	72.52	gold quality
zone of skin	UBERON:0000014	72.51	gold quality
thoracic mammary gland	UBERON:0005200	72.38	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.35	gold quality
ovary	UBERON:0000992	72.34	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.34	gold quality
urinary bladder	UBERON:0001255	72.13	gold quality
skin of abdomen	UBERON:0001416	72.10	gold quality
thyroid gland	UBERON:0002046	72.00	gold quality
right lobe of thyroid gland	UBERON:0001119	71.84	gold quality
blood	UBERON:0000178	71.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Long non-coding RNA RBM5-AS1 promotes the aggressive behaviors of oral squamous cell carcinoma by regulation of miR-1285-3p/YAP1 axis. (PMID:31869662)
• LncRNA RBM5-AS1 Promotes Osteosarcoma Cell Proliferation, Migration, and Invasion. (PMID:33816613)
• lncRNA RBM5-AS1 promotes cell proliferation and invasion by epigenetically silencing miR-132/212 in hepatocellular carcinoma cells. (PMID:34019714)
• RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein. (PMID:34225779)
• Hypoxia-induced lncRNA RBM5-AS1 promotes tumorigenesis via activating Wnt/beta-catenin signaling in breast cancer. (PMID:35110544)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.