RBMY1E

Summary

RBMY1E (RNA binding motif protein Y-linked family 1 member E, HGNC:23916) is a protein-coding gene on chromosome Yq11.223, encoding RNA-binding motif protein, Y chromosome, family 1 member E (A6NEQ0). RNA-binding protein which may be involved in spermatogenesis.

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked.

Source: NCBI Gene 378950 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total — 1 pathogenic
• MANE Select transcript: NM_001006118

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23916
Approved symbol	RBMY1E
Name	RNA binding motif protein Y-linked family 1 member E
Location	Yq11.223
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000242389
Ensembl biotype	protein_coding
Entrez	378950

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 nonsense_mediated_decay

ENST00000358944, ENST00000382658, ENST00000382659

RefSeq mRNA: 1 — MANE Select: NM_001006118 NM_001006118

CCDS: CCDS35481

Canonical transcript exons

ENST00000382659 — 12 exons

Exon	Start	End
ENSE00001619375	21912169	21912346
ENSE00001635505	21915946	21916058
ENSE00001802644	21915366	21915469
ENSE00003468556	21910101	21910253
ENSE00003480174	21906910	21907020
ENSE00003482521	21905813	21905923
ENSE00003528506	21907976	21908090
ENSE00003547647	21904606	21904694
ENSE00003559850	21904781	21904891
ENSE00003577506	21906358	21906468
ENSE00003613569	21903622	21904194
ENSE00003721712	21917920	21918032

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 83.65.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.09	gold quality
right testis	UBERON:0004534	62.28	gold quality
testis	UBERON:0000473	59.14	gold quality
left testis	UBERON:0004533	57.74	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.27	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.88	gold quality
blood	UBERON:0000178	26.62	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.21	silver quality
leukocyte	CL:0000738	24.80	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

23 targeting RBMY1E, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-7856-5P	99.75	69.99	2901
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-766-5P	99.47	67.91	2225
HSA-MIR-4777-3P	99.15	68.92	626
HSA-MIR-1843	98.97	66.07	838
HSA-MIR-4802-5P	98.97	66.26	833
HSA-MIR-6894-5P	98.70	63.78	809
HSA-MIR-6831-5P	98.26	67.20	990
HSA-MIR-509-3P	98.12	67.25	612
HSA-MIR-3927-3P	97.68	66.76	892
HSA-MIR-7154-3P	97.65	65.02	985
HSA-MIR-490-5P	96.75	65.81	661
HSA-MIR-875-5P	96.74	66.48	579

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rbmyf3	ENSMUSG00000091987
mus_musculus	Rbmyf5	ENSMUSG00000093918
mus_musculus	Rbmyf7	ENSMUSG00000093987
mus_musculus	Rbmyf6	ENSMUSG00000094511
mus_musculus	Rbmy	ENSMUSG00000094658
mus_musculus	Rbmyf2	ENSMUSG00000095852
mus_musculus	Rbmyf8	ENSMUSG00000095948
mus_musculus	Rbmyf9	ENSMUSG00000096520
mus_musculus	Rbmyf4	ENSMUSG00000101667
mus_musculus	Rbmyf1	ENSMUSG00000102053
rattus_norvegicus	Rbmy1j	ENSRNOG00000060963

Paralogs (36): DAZAP1 (ENSG00000071626), CIRBP (ENSG00000099622), RBM23 (ENSG00000100461), RBM3 (ENSG00000102317), NCL (ENSG00000115053), TIA1 (ENSG00000116001), HNRNPA2B1 (ENSG00000122566), RBM19 (ENSG00000122965), RBM39 (ENSG00000131051), MSI1 (ENSG00000135097), HNRNPA1 (ENSG00000135486), HNRNPD (ENSG00000138668), HNRNPA1L2 (ENSG00000139675), RBMX (ENSG00000147274), A1CF (ENSG00000148584), TIAL1 (ENSG00000151923), RBM46 (ENSG00000151962), HNRNPDL (ENSG00000152795), MSI2 (ENSG00000153944), RBM47 (ENSG00000163694), RBMY1F (ENSG00000169800), HNRNPA3 (ENSG00000170144), RBMXL2 (ENSG00000170748), RBM4B (ENSG00000173914), RBM4 (ENSG00000173933), RBMXL3 (ENSG00000175718), HNRNPA0 (ENSG00000177733), TRNAU1AP (ENSG00000180098), HNRNPAB (ENSG00000197451), RBMXL1 (ENSG00000213516), HNRNPA1L3 (ENSG00000224578), RBMY1J (ENSG00000226941), RBMY1A1 (ENSG00000234414), RBMY1B (ENSG00000242875), RBMY1D (ENSG00000244395), DND1 (ENSG00000256453)

Protein

Protein identifiers

RNA-binding motif protein, Y chromosome, family 1 member E — A6NEQ0 (reviewed: A6NEQ0)

All UniProt accessions (3): A6NEQ0, F2Z2U1, J3KPK3

UniProt curated annotations — full annotation on UniProt →

Function. RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Subunit / interactions. Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.

Subcellular location. Nucleus.

Tissue specificity. Testis-specific.

Miscellaneous. The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

RefSeq proteins (1): NP_001006118* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000504	RRM_dom	Domain
IPR012604	RBM1CTR	Domain
IPR012677	Nucleotide-bd_a/b_plait_sf	Homologous_superfamily
IPR035979	RBD_domain_sf	Homologous_superfamily
IPR050441	RBM	Family

Pfam: PF00076, PF08081

UniProt features (13 total): compositionally biased region 9, region of interest 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NEQ0-F1	50.09	0.08

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 17 (showing top): GOBP_RNA_SPLICING, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOCC_SPLICEOSOMAL_COMPLEX, GOCC_RIBONUCLEOPROTEIN_COMPLEX, GOMF_MRNA_BINDING, chrYq11, GOBP_MRNA_PROCESSING, MIR7856_5P, MIR766_5P, MIR1843, MIR4802_5P, MIR509_3P, GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN, GOBP_MRNA_METABOLIC_PROCESS

GO Biological Process (3): mRNA processing (GO:0006397), RNA splicing (GO:0008380), positive regulation of mRNA splicing, via spliceosome (GO:0048026)

GO Molecular Function (3): RNA binding (GO:0003723), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (4): nucleoplasm (GO:0005654), spliceosomal complex (GO:0005681), nucleolus (GO:0005730), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
binding	2
nuclear lumen	2
mRNA metabolic process	1
mRNA splicing, via spliceosome	1
positive regulation of RNA splicing	1
regulation of mRNA splicing, via spliceosome	1
positive regulation of mRNA processing	1
nucleic acid binding	1
cellular anatomical structure	1
nuclear protein-containing complex	1
ribonucleoprotein complex	1
intracellular membraneless organelle	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1180 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RBMY1E	A6NGL4	A6NGL4	717
RBMY1E	A6NEC3	A6NEC3	584
RBMY1E	A6NGT6	A6NGT6	577
RBMY1E	RPS4Y2	Q8TD47	501
RBMY1E	AMELY	Q99218	447
RBMY1E	RC3H2	Q9HBD1	394
RBMY1E	EIF1AY	O14602	389
RBMY1E	RPS4Y1	P22090	371
RBMY1E	SPRY3	O43610	371
RBMY1E	TSPY1	P09002	350
RBMY1E	ZFY	P08048	347
RBMY1E	NLGN4Y	Q8NFZ3	315
RBMY1E	UTY	O14607	307
RBMY1E	RC3H1	Q5TC82	302
RBMY1E	ZFX	P17010	294

IntAct

7 interactions, top by confidence:

A	B	Type	Score
RBMY1E	RBMX	psi-mi:“MI:0915”(physical association)	0.560
RBMY1E	RBMY1F	psi-mi:“MI:0915”(physical association)	0.560
RBMY1E	RBMX	psi-mi:“MI:0915”(physical association)	0.000
RBMY1E	RBMY1F	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (3): RBMY1E (Two-hybrid), RBMY1E (Two-hybrid), RBMY1E (Two-hybrid)

ESM2 similar proteins: A0A1I8MUL8, A1YFA7, A2T806, A6NDE4, A6NEQ0, E9Q5K9, E9Q784, F4JCU0, O22703, O23372, O35698, O60828, O74418, O75526, P0C7P1, P0DJD3, P0DJD4, P11596, P78332, Q10B98, Q15415, Q1ECZ9, Q23935, Q24669, Q24761, Q2HJC9, Q3MHY8, Q3UC65, Q3URU2, Q3V0C1, Q4PB36, Q4R626, Q4R813, Q4R881, Q5R840, Q5T200, Q5U2S0, Q60990, Q62504, Q80Y39

Diamond homologs: A0A0A0LLY1, A2A5N3, A2VDB3, A5A6M3, A6NDE4, A6NEQ0, D4AE41, F1QB54, F4I3B3, O60176, O64380, O75526, O93235, P0C7P1, P0C8Z4, P0CB38, P0CP46, P0CP47, P0DJD3, P0DJD4, P10979, P11940, P20965, P21187, P29341, P31483, P32588, P38159, P38760, P39684, P49310, P49311, P52912, P60824, P60825, P60826, P61286, P70318, P84586, Q00539

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
870515	GRCh37/hg19 Yq11.223-11.23(chrY:23887108-28799937)x0	Pathogenic

SpliceAI

1458 predictions. Top by Δscore:

Variant	Effect	Δscore
Y:21904599:CCCTT:C	donor_loss	1.0000
Y:21904600:CCTTA:C	donor_loss	1.0000
Y:21904601:CTTA:C	donor_loss	1.0000
Y:21904602:TTA:T	donor_loss	1.0000
Y:21904603:T:TG	donor_loss	1.0000
Y:21904604:A:AC	donor_gain	1.0000
Y:21904604:A:AT	donor_loss	1.0000
Y:21904605:C:CC	donor_gain	1.0000
Y:21904690:GATAA:G	acceptor_gain	1.0000
Y:21904691:ATAA:A	acceptor_gain	1.0000
Y:21904692:TAA:T	acceptor_gain	1.0000
Y:21904693:AA:A	acceptor_gain	1.0000
Y:21904693:AACT:A	acceptor_loss	1.0000
Y:21904694:ACTA:A	acceptor_loss	1.0000
Y:21904695:C:CC	acceptor_gain	1.0000
Y:21904695:CT:C	acceptor_loss	1.0000
Y:21904700:T:C	acceptor_gain	1.0000
Y:21904700:T:TC	acceptor_gain	1.0000
Y:21904783:ATAT:A	donor_gain	1.0000
Y:21905809:GTACC:G	donor_loss	1.0000
Y:21905810:TACCT:T	donor_loss	1.0000
Y:21905815:ATAT:A	donor_gain	1.0000
Y:21905921:TTT:T	acceptor_gain	1.0000
Y:21905921:TTTC:T	acceptor_loss	1.0000
Y:21905922:TT:T	acceptor_gain	1.0000
Y:21905923:TCTG:T	acceptor_loss	1.0000
Y:21905924:C:CC	acceptor_gain	1.0000
Y:21905928:A:AC	acceptor_gain	1.0000
Y:21905928:A:C	acceptor_gain	1.0000
Y:21905931:C:CT	acceptor_gain	1.0000

AlphaMissense

3226 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
Y:21915423:A:C	F52L	1.000
Y:21915423:A:T	F52L	1.000
Y:21915425:A:G	F52L	1.000
Y:21915429:A:C	F50L	1.000
Y:21915429:A:T	F50L	1.000
Y:21915431:A:G	F50L	1.000
Y:21916022:G:C	F11L	1.000
Y:21916022:G:T	F11L	1.000
Y:21916024:A:G	F11L	1.000
Y:21915414:A:C	F55L	0.999
Y:21915414:A:T	F55L	0.999
Y:21915416:A:G	F55L	0.999
Y:21915424:A:G	F52S	0.999
Y:21915430:A:G	F50S	0.999
Y:21915435:T:A	R48S	0.999
Y:21915435:T:G	R48S	0.999
Y:21915971:A:C	F28L	0.999
Y:21915971:A:T	F28L	0.999
Y:21915973:A:G	F28L	0.999
Y:21916023:A:G	F11S	0.999
Y:21915436:C:G	R48T	0.998
Y:21915984:A:T	L24H	0.998
Y:21916020:A:T	I12N	0.998
Y:21916023:A:C	F11C	0.998
Y:21915415:A:G	F55S	0.997
Y:21915421:A:T	I53N	0.997
Y:21915427:G:T	A51E	0.997
Y:21915972:A:G	F28S	0.997
Y:21916026:A:G	L10P	0.997
Y:21915424:A:C	F52C	0.996

dbSNP variants (sampled 113 via entrez): RS1160419817 (Y:21904100 G>A), RS1164519279 (Y:21906357 C>T), RS1175616459 (Y:21906334 C>T), RS1180219298 (Y:21904702 GA>G), RS1189660077 (Y:21906342 G>C), RS1194098937 (Y:21904019 A>C), RS1197406025 (Y:21906451 C>T), RS1202321544 (Y:21906473 A>G), RS1214396324 (Y:21903975 C>T), RS1233316015 (Y:21906401 A>T), RS1233391775 (Y:21904737 A>G), RS1240013790 (Y:21903984 C>T), RS1272169212 (Y:21906416 G>A), RS1273430528 (Y:21906454 G>C), RS1280668224 (Y:21904188 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (1): male infertility (MONDO:0005372)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D007248	Infertility, Male	C12.100.500.430; C12.100.750.700; C12.200.294.430

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Temozolomide	increases expression	1

Clinical trials (associated diseases)

125 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02202382	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Male Infertility
NCT02204826	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
NCT03802864	PHASE4	COMPLETED	Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine
NCT06100432	PHASE4	ACTIVE_NOT_RECRUITING	Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Males
NCT07523022	PHASE4	ENROLLING_BY_INVITATION	Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
NCT00975117	PHASE3	COMPLETED	Spermotrend in the Treatment of Male Infertility
NCT01407432	PHASE3	COMPLETED	Impact of Folates in the Care of the Male Infertility
NCT01895816	PHASE3	COMPLETED	Herbal Tonic Fertile Supplement(ZO2C5)
NCT02605070	PHASE3	TERMINATED	Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
NCT07402759	PHASE3	ACTIVE_NOT_RECRUITING	Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men
NCT01880086	PHASE2	COMPLETED	Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
NCT02061384	PHASE2	COMPLETED	RA-2 13-cis Retinoic Acid (Isotretinoin)
NCT02421887	PHASE2	COMPLETED	Males, Antioxidants, and Infertility Trial
NCT05200663	PHASE2	UNKNOWN	Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
NCT05290558	PHASE2	ACTIVE_NOT_RECRUITING	The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial
NCT06091969	PHASE2	NOT_YET_RECRUITING	Supplementation for Male Subfertility
NCT01595308	PHASE1	COMPLETED	A Pilot Study to Evaluate the Effect of Pomegranate Juice on Semen Parameters in Healthy Male Volunteers
NCT02122211	PHASE1	COMPLETED	Choline Dehydrogenase and Sperm Function: Effects of Betaine
NCT02575924	PHASE1	UNKNOWN	Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility
NCT01304927	PHASE2/PHASE3	COMPLETED	Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial
NCT02349945	PHASE2/PHASE3	COMPLETED	FSH Receptor Polymorphism p.N680S and Efficacy of FSH Therapy
NCT05222841	PHASE2/PHASE3	COMPLETED	The Effectiveness of Spermotrend Food Supplement in the Treatment of Male Infertility
NCT05616598	PHASE2/PHASE3	COMPLETED	Effect of New Oral Treatment for Hepatitis C Virus on Seminal Parameters
NCT02025270	PHASE1/PHASE2	COMPLETED	MSCs For Treatment of Azoospermic Patients
NCT04541459	EARLY_PHASE1	UNKNOWN	Validation of New Devices Against Ambient Electromagnetic Radiation
NCT05792813	EARLY_PHASE1	UNKNOWN	Efficacy and Safety of Linggui Yangyuan Paste in Patients With Male Infertility
NCT06188936	EARLY_PHASE1	COMPLETED	Home Semen Analysis Tests As a Screening Tool for Fertility Patients
NCT00012480	Not specified	COMPLETED	Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm
NCT00044369	Not specified	COMPLETED	Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
NCT00119925	Not specified	UNKNOWN	‘SPRING’-Study: Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists
NCT00178516	Not specified	COMPLETED	Vitamin E and Male Infertility
NCT00315029	Not specified	COMPLETED	Patient-Centered Implementation Trial for Single Embryo Transfer
NCT00341120	Not specified	COMPLETED	Genetic Causes of Male Infertility
NCT00481403	Not specified	COMPLETED	Study of Sperm Molecular Factors Implicated in Male Fertility
NCT00548977	Not specified	COMPLETED	Genetic Studies Spermatogenic Failure
NCT00596739	Not specified	COMPLETED	A Study of the Pre- and Post-operative Semen Analyses and Reproductive Hormone Levels of Men Undergoing Weight-reduction Surgery
NCT00756561	Not specified	COMPLETED	HOP-2A - Intratesticular Hormone Levels
NCT00961558	Not specified	TERMINATED	Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy
NCT01075334	Not specified	UNKNOWN	Is a Carnitine Based Food Supplement (PorimoreTM) for Infertile Men Superior to Folate and Zinc With Regard to Pregnancy Rates in Intrauterine Insemination Cycles?
NCT01178463	Not specified	UNKNOWN	Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia