RBPMS-AS1

Summary

RBPMS-AS1 (RBPMS antisense RNA 1, HGNC:48721) is a long non-coding RNA gene on chromosome 8p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48721
Approved symbol	RBPMS-AS1
Name	RBPMS antisense RNA 1
Location	8p12
Locus type	RNA, long non-coding
Status	Approved
Aliases	TP53LC06
Ensembl gene	ENSG00000254109
Ensembl biotype	lncRNA
Entrez	100128750
RNAcentral	URS000075B634 — lncRNA, 941 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000517521, ENST00000519753, ENST00000523643, ENST00000662163, ENST00000792122, ENST00000792123, ENST00000792124, ENST00000792125, ENST00000792126, ENST00000792127, ENST00000792128, ENST00000792129, ENST00000792130, ENST00000792131, ENST00000792132, ENST00000792133

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517521 — 3 exons

Exon	Start	End
ENSE00002113630	30383544	30383697
ENSE00002121920	30385144	30385401
ENSE00002125501	30382119	30382615

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 83.19.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4710 / max 25.0367, expressed in 253 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
92615	0.3987	199
92616	0.0723	20

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
popliteal artery	UBERON:0002250	83.19	gold quality
tibial artery	UBERON:0007610	83.14	gold quality
right lobe of thyroid gland	UBERON:0001119	81.87	gold quality
left coronary artery	UBERON:0001626	81.86	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.53	gold quality
left lobe of thyroid gland	UBERON:0001120	80.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.01	silver quality
mucosa of stomach	UBERON:0001199	79.68	gold quality
aorta	UBERON:0000947	79.66	gold quality
coronary artery	UBERON:0001621	79.60	gold quality
thyroid gland	UBERON:0002046	79.43	gold quality
right coronary artery	UBERON:0001625	78.19	gold quality
lower esophagus muscularis layer	UBERON:0035833	77.72	gold quality
lower esophagus	UBERON:0013473	77.71	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	77.33	gold quality
amniotic fluid	UBERON:0000173	77.02	gold quality
left ovary	UBERON:0002119	76.98	gold quality
omental fat pad	UBERON:0010414	76.28	gold quality
buccal mucosa cell	CL:0002336	76.23	gold quality
peritoneum	UBERON:0002358	76.18	gold quality
adipose tissue of abdominal region	UBERON:0007808	76.01	gold quality
sural nerve	UBERON:0015488	76.01	gold quality
right ovary	UBERON:0002118	75.75	gold quality
tibialis anterior	UBERON:0001385	75.73	silver quality
thoracic aorta	UBERON:0001515	75.50	gold quality
ascending aorta	UBERON:0001496	75.46	gold quality
minor salivary gland	UBERON:0001830	75.43	gold quality
right lung	UBERON:0002167	75.35	gold quality
lower esophagus mucosa	UBERON:0035834	75.29	gold quality
left adrenal gland cortex	UBERON:0035825	75.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.56

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Overexpressed RBPMS-AS1 increased cell radiosensitivity by sponging miR-19a-3p in lung cancer cell lines (A549 and SK-MES-1) via regulating PTEN/AKT axis. (PMID:36912590)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.