RCCD1

Summary

RCCD1 (RCC1 domain containing 1, HGNC:30457) is a protein-coding gene on chromosome 15q26.1, encoding RCC1 domain-containing protein 1 (A6NED2). Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8.

Predicted to be involved in chromatin organization. Located in cytosol and plasma membrane.

Source: NCBI Gene 91433 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_001017919

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30457
Approved symbol	RCCD1
Name	RCC1 domain containing 1
Location	15q26.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC14386
Ensembl gene	ENSG00000166965
Ensembl biotype	protein_coding
OMIM	617997
Entrez	91433

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 18 protein_coding, 4 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000394258, ENST00000554302, ENST00000555155, ENST00000555737, ENST00000556333, ENST00000556618, ENST00000556774, ENST00000557266, ENST00000557750, ENST00000850874, ENST00000852981, ENST00000852982, ENST00000852983, ENST00000852984, ENST00000852985, ENST00000852986, ENST00000852987, ENST00000852988, ENST00000935355, ENST00000935356, ENST00000935357, ENST00000935358, ENST00000970828, ENST00000970829

RefSeq mRNA: 2 — MANE Select: NM_001017919 NM_001017919, NM_033544

CCDS: CCDS32333

Canonical transcript exons

ENST00000394258 — 8 exons

Exon	Start	End
ENSE00001310134	90961618	90963125
ENSE00001371811	90957113	90957503
ENSE00001744895	90956612	90956900
ENSE00002485508	90954884	90954948
ENSE00003612263	90961025	90961054
ENSE00003614091	90957604	90957725
ENSE00003634215	90959900	90959998
ENSE00003680038	90960328	90960498

Expression profiles

Bgee: expression breadth ubiquitous, 218 present calls, max score 93.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.9598 / max 188.3527, expressed in 1693 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148530	5.5272	1556
148531	0.9520	458
148537	0.7808	105
148535	0.6954	412
148532	0.6120	352
148533	0.3012	167
148536	0.0912	26

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	93.37	gold quality
oocyte	CL:0000023	92.76	gold quality
ileal mucosa	UBERON:0000331	92.35	silver quality
pancreatic ductal cell	CL:0002079	86.99	silver quality
mucosa of transverse colon	UBERON:0004991	86.69	gold quality
pigmented layer of retina	UBERON:0001782	85.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.02	gold quality
right adrenal gland cortex	UBERON:0035827	85.00	gold quality
right adrenal gland	UBERON:0001233	84.72	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.69	gold quality
left ventricle myocardium	UBERON:0006566	84.46	gold quality
cerebellar hemisphere	UBERON:0002245	84.30	gold quality
cerebellar cortex	UBERON:0002129	84.17	gold quality
lower esophagus mucosa	UBERON:0035834	83.82	gold quality
left adrenal gland cortex	UBERON:0035825	83.59	gold quality
left adrenal gland	UBERON:0001234	83.58	gold quality
cerebellum	UBERON:0002037	83.49	gold quality
adrenal cortex	UBERON:0001235	83.38	gold quality
ventricular zone	UBERON:0003053	83.37	gold quality
epithelial cell of pancreas	CL:0000083	83.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.85	gold quality
kidney epithelium	UBERON:0004819	82.57	gold quality
body of pancreas	UBERON:0001150	82.54	gold quality
parotid gland	UBERON:0001831	82.53	gold quality
adrenal gland	UBERON:0002369	82.34	gold quality
transverse colon	UBERON:0001157	82.04	gold quality
left ovary	UBERON:0002119	81.99	gold quality
stromal cell of endometrium	CL:0002255	81.96	gold quality
trabecular bone tissue	UBERON:0002483	81.91	gold quality
right ovary	UBERON:0002118	81.63	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.00
E-MTAB-4850	no	123.42

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

58 targeting RCCD1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-448	99.79	72.37	2103
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-2681-5P	99.75	67.64	1655
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-3934-5P	99.67	64.04	846
HSA-MIR-298	99.63	67.56	1916
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-5689	99.50	71.26	1154
HSA-MIR-2392	99.43	67.50	708
HSA-MIR-2115-3P	99.31	69.68	2026
HSA-MIR-5589-3P	99.29	68.30	1443
HSA-MIR-1273H-3P	99.29	67.55	980

Literature-anchored findings (GeneRIF, showing 5)

• RCCD1 and KDM8 form a histone demethylase complex. (PMID:24981860)
• Expression of RCCD1 in whole blood was also suggestively associated with disease risk (p-value: 1.2x10-05), as were expression of ACAP1 (p-value: 1.9x10-05) and LRRC25 (p-value: 5.2x10-05). While genome-wide association studies (GWAS) have implicated RCCD1 and ANKLE1 in breast cancer risk, they have not identified the remaining three genes (PMID:28362817)
• RCCD1 as a novel regulator of TGF-beta-induced epithelial mesenchymal transformation and cell migration in non-small lung carcinoma cells. (PMID:28455245)
• JMJD5 catalyzes stereoselective C-3 hydroxylation of arginine residues in sequences from human RCCD1 and ribosomal protein S6. (PMID:29563586)
• miR-519b-3p binds to LINC01419 and has a role in upregulating RCCD1 in lung adenocarcinoma cells (PMID:31582214)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	rccd1	ENSDARG00000071074
danio_rerio	herc7	ENSDARG00000098906
		ENSDARG00000104505
mus_musculus	Rccd1	ENSMUSG00000038930
rattus_norvegicus	Rccd1	ENSRNOG00000042059
drosophila_melanogaster	ca	FBGN0000247
drosophila_melanogaster	Rcc1	FBGN0002638
drosophila_melanogaster	CG7420	FBGN0031344
drosophila_melanogaster	CG6678	FBGN0038917
caenorhabditis_elegans		WBGENE00004304
caenorhabditis_elegans	K11D2.1	WBGENE00010768

Paralogs (9): ALS2 (ENSG00000003393), HERC1 (ENSG00000103657), SERGEF (ENSG00000129158), RCBTB1 (ENSG00000136144), RCBTB2 (ENSG00000136161), RPGR (ENSG00000156313), RCC2 (ENSG00000179051), RCC1 (ENSG00000180198), RCC1L (ENSG00000274523)

Protein

Protein identifiers

RCC1 domain-containing protein 1 — A6NED2 (reviewed: A6NED2)

All UniProt accessions (3): A6NED2, G3V2I3, G3V3Q4

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8.

Subunit / interactions. Found in a complex with KDM8. Interacts (via N-terminus) with KDM8 (via N-terminus).

Subcellular location. Chromosome.

Post-translational modifications. Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-141 by KDM8.

RefSeq proteins (2): NP_001017919, NP_291022 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000408	Reg_chr_condens	Repeat
IPR009091	RCC1/BLIP-II	Homologous_superfamily
IPR052830	RCC1_domain-containing	Family

Pfam: PF00415

UniProt features (10 total): repeat 4, chain 1, region of interest 1, modified residue 1, sequence variant 1, mutagenesis site 1, sequence conflict 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
6F4T	X-RAY DIFFRACTION	1.22
6F4R	X-RAY DIFFRACTION	1.3
6F4S	X-RAY DIFFRACTION	1.46

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NED2-F1	87.75	0.73

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 141

Mutagenesis-validated functional residues (1):

Position	Phenotype
141	abolishes hydroxylation by kdm8.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9629569	Protein hydroxylation

MSigDB gene sets: 90 (showing top): GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, CADWELL_ATG16L1_TARGETS_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, chr15q26, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WHITFIELD_CELL_CYCLE_G2, FOSTER_KDM1A_TARGETS_DN, REACTOME_GAMMA_CARBOXYLATION_HYPUSINYLATION_HYDROXYLATION_AND_ARYLSULFATASE_ACTIVATION, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_UP, CREB3L4_TARGET_GENES, E2F5_TARGET_GENES, ELF2_TARGET_GENES, HOXA13_TARGET_GENES

GO Biological Process (1): chromatin organization (GO:0006325)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): chromosome (GO:0005694), cytosol (GO:0005829), plasma membrane (GO:0005886)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular component organization	1
binding	1
intracellular membraneless organelle	1
cytoplasm	1
cellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

1084 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RCCD1	KDM8	Q8N371	668
RCCD1	WDFY4	Q6ZS81	469
RCCD1	LRRC25	Q8N386	465
RCCD1	CZIB	Q9NWV4	447
RCCD1	ANKLE1	Q8NAG6	441
RCCD1	TMEM220	Q6QAJ8	433
RCCD1	ZNF433	Q8N7K0	420
RCCD1	ACAP1	Q15027	401
RCCD1	TYW5	A2RUC4	397
RCCD1	FLACC1	Q96Q35	396
RCCD1	LRRC37A	A6NMS7	393
RCCD1	LRRC37A3	O60309	390
RCCD1	ZDHHC11B	P0C7U3	382
RCCD1	C11orf24	Q96F05	371
RCCD1	ZNF530	Q6P9A1	369

IntAct

34 interactions, top by confidence:

A	B	Type	Score
KDM8	RCCD1	psi-mi:“MI:0915”(physical association)	0.710
ALDH3A1	RCCD1	psi-mi:“MI:0914”(association)	0.640
RCCD1	SPAG9	psi-mi:“MI:0914”(association)	0.640
POLR2L	RCCD1	psi-mi:“MI:0914”(association)	0.640
MAPK8IP3	RCCD1	psi-mi:“MI:0914”(association)	0.640
YJU2B	RCCD1	psi-mi:“MI:0914”(association)	0.530
INPP5A	RCCD1	psi-mi:“MI:0914”(association)	0.530
ZNF219	RCCD1	psi-mi:“MI:0914”(association)	0.530
SLC27A3	RCCD1	psi-mi:“MI:0914”(association)	0.350
RCCD1	ZNF609	psi-mi:“MI:0914”(association)	0.350
ZNF219		psi-mi:“MI:0914”(association)	0.350
CDC73	RCCD1	psi-mi:“MI:0914”(association)	0.350
CTR9	RCCD1	psi-mi:“MI:0914”(association)	0.350
DDX6	RCCD1	psi-mi:“MI:0914”(association)	0.350
EZH1	RCCD1	psi-mi:“MI:0914”(association)	0.350
CSTL1	DENND11	psi-mi:“MI:0914”(association)	0.350
UBL3	RCCD1	psi-mi:“MI:0914”(association)	0.350
RCCD1	IFT56	psi-mi:“MI:0914”(association)	0.350
MAPK8IP3	SHTN1	psi-mi:“MI:0914”(association)	0.350
MRPS17	RCCD1	psi-mi:“MI:0914”(association)	0.350
AFG2B	RCCD1	psi-mi:“MI:0914”(association)	0.350

BioGRID (89): RCCD1 (Affinity Capture-MS), KCTD9 (Affinity Capture-MS), KDM8 (Affinity Capture-MS), MAPK8IP3 (Affinity Capture-MS), RCCD1 (Affinity Capture-MS), SPAG9 (Affinity Capture-MS), TSC22D3 (Affinity Capture-MS), POLR2L (Affinity Capture-MS), DDHD2 (Affinity Capture-MS), C5orf34 (Affinity Capture-MS), RCCD1 (Affinity Capture-MS), TUBA1A (Affinity Capture-MS), RAB3GAP1 (Affinity Capture-MS), RCCD1 (Affinity Capture-MS), ZNF609 (Affinity Capture-MS)

ESM2 similar proteins: A1A4I4, A5PKD8, A6NED2, A8MQ27, O35465, O60294, O75808, O94819, O95382, P70268, Q0MW30, Q14318, Q16512, Q2T9J0, Q32NY4, Q32P44, Q3B7U9, Q3MHW0, Q3U5Q7, Q3USL1, Q4R828, Q561R2, Q5EBM0, Q5EBP3, Q5PQP9, Q60806, Q63433, Q6PAT0, Q7T0L4, Q8BNW9, Q8BTU7, Q8BYR1, Q8IYL2, Q8N5A5, Q8NEP7, Q8VC03, Q8VHS5, Q8WXI3, Q91ZT7, Q96C12

Diamond homologs: A6NED2, F1RD40, F2Z461, O74881, O75592, O95714, P18754, P23800, Q15034, Q4R828, Q4U2R1, Q52KW8, Q5GLZ8, Q5PQN1, Q6NRS1, Q6PAV2, Q7TPH6, Q80YD6, Q8BTU7, Q8IVU3, Q8VE37, Q9FN03, Q9NB71, Q9P2D0, Q9UII4, D3ZGQ5, O95199, P0C5Y8, P25171, P25183, P58544, Q15751, Q5BIW4, Q5DX34, Q5RCZ7, Q6NXM2, Q6NYE2, Q6ZPR6, Q7ZZC8, Q86SG6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	59
Likely benign	1
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1487 predictions. Top by Δscore:

Variant	Effect	Δscore
15:90959894:TTTCA:T	acceptor_loss	1.0000
15:90959896:TCAGA:T	acceptor_loss	1.0000
15:90959897:CA:C	acceptor_loss	1.0000
15:90959898:A:AG	acceptor_gain	1.0000
15:90959898:A:C	acceptor_loss	1.0000
15:90959899:G:GA	acceptor_gain	1.0000
15:90959899:G:GT	acceptor_loss	1.0000
15:90959899:GA:G	acceptor_gain	1.0000
15:90959899:GAGA:G	acceptor_gain	1.0000
15:90959995:G:T	donor_gain	1.0000
15:90955791:AAC:A	acceptor_gain	0.9900
15:90955793:C:CA	acceptor_gain	0.9900
15:90956896:GACCC:G	donor_gain	0.9900
15:90956901:G:GG	donor_gain	0.9900
15:90957723:GTG:G	donor_gain	0.9900
15:90959887:T:A	acceptor_gain	0.9900
15:90959899:GAGAC:G	acceptor_gain	0.9900
15:90959996:A:T	donor_gain	0.9900
15:90959996:AAGG:A	donor_loss	0.9900
15:90959997:AG:A	donor_loss	0.9900
15:90959998:GG:G	donor_loss	0.9900
15:90959999:GTGAG:G	donor_loss	0.9900
15:90960000:T:A	donor_loss	0.9900
15:90955220:G:T	donor_gain	0.9800
15:90955787:A:AG	acceptor_gain	0.9800
15:90955792:AC:A	acceptor_gain	0.9800
15:90956897:ACCC:A	donor_gain	0.9800
15:90957721:GAGTG:G	donor_gain	0.9800
15:90959995:G:GT	donor_gain	0.9800
15:90960001:G:GG	donor_loss	0.9800

AlphaMissense

2378 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:90959920:T:A	W234R	0.994
15:90959920:T:C	W234R	0.994
15:90956768:T:C	F12L	0.993
15:90956770:C:A	F12L	0.993
15:90956770:C:G	F12L	0.993
15:90960487:C:A	A313D	0.992
15:90961045:T:A	W324R	0.992
15:90961045:T:C	W324R	0.992
15:90960486:G:C	A313P	0.991
15:90957711:C:T	S222F	0.990
15:90957710:T:C	S222P	0.989
15:90956774:T:C	F14L	0.988
15:90956776:C:A	F14L	0.988
15:90956776:C:G	F14L	0.988
15:90959931:T:A	N237K	0.988
15:90959931:T:G	N237K	0.988
15:90957490:T:A	W182R	0.987
15:90957490:T:C	W182R	0.987
15:90957618:G:A	G191D	0.987
15:90959930:A:T	N237I	0.987
15:90960472:G:A	G308E	0.987
15:90956772:G:A	G13D	0.986
15:90959923:G:C	G235R	0.986
15:90961048:G:C	G325R	0.986
15:90961728:T:A	W364R	0.986
15:90961728:T:C	W364R	0.986
15:90956783:T:C	F17L	0.984
15:90956785:C:A	F17L	0.984
15:90956785:C:G	F17L	0.984
15:90957711:C:A	S222Y	0.983

dbSNP variants (sampled 300 via entrez): RS1000110959 (15:90953864 G>A), RS1000139699 (15:90960562 GACGGAAAA>G), RS1000362431 (15:90962686 T>C), RS1000652566 (15:90955711 A>AC), RS1000797326 (15:90962483 T>C,G), RS1001061196 (15:90956997 G>T), RS1001283759 (15:90960635 A>C,G), RS1001393007 (15:90961262 C>G,T), RS1001419787 (15:90956121 G>T), RS1001492923 (15:90956293 A>AT), RS1001540351 (15:90956563 C>G), RS1002659509 (15:90955171 G>C), RS1002980751 (15:90961880 G>A), RS1003168491 (15:90957255 G>A), RS1003294040 (15:90962792 A>G)

Disease associations

OMIM: gene MIM:617997 | disease phenotypes: MIM:210900

GenCC curated gene-disease

Mondo (1): Bloom syndrome (MONDO:0008876)

Orphanet (1): Bloom syndrome (Orphanet:125)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST006804_14	Red cell distribution width	1.000000e-110
GCST006914_16	Sleep duration	3.000000e-08
GCST90013466_16	Height	3.000000e-09
GCST90013466_37	Height	2.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009188	Red cell distribution width

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D001816	Bloom Syndrome	C16.131.077.137; C16.320.798.313; C18.452.284.100; C20.673.795.313

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases expression	3
Resveratrol	affects cotreatment, increases expression	2
Benzo(a)pyrene	affects methylation, increases methylation	2
Cisplatin	affects expression, affects cotreatment, increases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	decreases expression	1
trichostatin A	affects expression	1
beta-lapachone	decreases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	decreases expression	1
potassium chromate(VI)	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
aflatoxin B2	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Decitabine	affects expression	1
Leflunomide	decreases expression	1
Acetaminophen	increases expression	1
Arsenic	affects methylation	1
Calcitriol	decreases expression, affects cotreatment	1
Coumestrol	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Sodium Dodecyl Sulfate	decreases expression	1
Testosterone	affects cotreatment, decreases expression	1
Thiram	decreases expression	1

Clinical trials (associated diseases)

3 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT00021437	Not specified	COMPLETED	Biological Significance of the Bloom’s Syndrome Protein
NCT04251325	Not specified	UNKNOWN	Socio-demographic Characteristics of Basic Life Support Course Participants
NCT04353089	Not specified	UNKNOWN	Geographical Association Between Basic Life Support Courses, Bystander Cardiopulmonary Resuscitation and Survival