RCN3

Summary

RCN3 (reticulocalbin 3, HGNC:21145) is a protein-coding gene on chromosome 19q13.33, encoding Reticulocalbin-3 (Q96D15). Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum.

Enables calcium ion binding activity. Involved in several processes, including collagen biosynthetic process; positive regulation of peptidase activity; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in endoplasmic reticulum.

Source: NCBI Gene 57333 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_020650

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21145
Approved symbol	RCN3
Name	reticulocalbin 3
Location	19q13.33
Locus type	gene with protein product
Status	Approved
Aliases	RLP49
Ensembl gene	ENSG00000142552
Ensembl biotype	protein_coding
OMIM	619032
Entrez	57333

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 13 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000270645, ENST00000593483, ENST00000593644, ENST00000597801, ENST00000598833, ENST00000892641, ENST00000892642, ENST00000892643, ENST00000933698, ENST00000933699, ENST00000956869, ENST00000956870, ENST00000956871, ENST00000956872

RefSeq mRNA: 1 — MANE Select: NM_020650 NM_020650

CCDS: CCDS12771

Canonical transcript exons

ENST00000270645 — 7 exons

Exon	Start	End
ENSE00000954871	49528467	49528714
ENSE00000954872	49534193	49534395
ENSE00000954873	49537033	49537205
ENSE00000954874	49539119	49539179
ENSE00000954875	49542553	49542752
ENSE00001289910	49528003	49528058
ENSE00003110008	49543106	49543633

Expression profiles

Bgee: expression breadth ubiquitous, 259 present calls, max score 99.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 44.6813 / max 1181.9112, expressed in 1165 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177019	43.2823	1161
177020	1.3990	491

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	99.20	gold quality
mucosa of transverse colon	UBERON:0004991	97.81	gold quality
ascending aorta	UBERON:0001496	97.36	gold quality
thoracic aorta	UBERON:0001515	97.30	gold quality
descending thoracic aorta	UBERON:0002345	96.71	gold quality
right coronary artery	UBERON:0001625	96.21	gold quality
left coronary artery	UBERON:0001626	95.83	gold quality
cartilage tissue	UBERON:0002418	95.79	gold quality
tendon of biceps brachii	UBERON:0008188	95.72	gold quality
endocervix	UBERON:0000458	95.71	gold quality
coronary artery	UBERON:0001621	95.02	gold quality
omental fat pad	UBERON:0010414	94.83	gold quality
peritoneum	UBERON:0002358	94.77	gold quality
right lobe of liver	UBERON:0001114	94.76	gold quality
right ovary	UBERON:0002118	94.22	gold quality
aorta	UBERON:0000947	94.21	gold quality
adipose tissue of abdominal region	UBERON:0007808	93.84	gold quality
calcaneal tendon	UBERON:0003701	93.76	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.62	gold quality
body of uterus	UBERON:0009853	93.49	gold quality
ectocervix	UBERON:0012249	93.29	gold quality
transverse colon	UBERON:0001157	93.15	gold quality
spleen	UBERON:0002106	93.12	gold quality
left ovary	UBERON:0002119	93.12	gold quality
tibial nerve	UBERON:0001323	92.77	gold quality
apex of heart	UBERON:0002098	92.62	gold quality
right atrium auricular region	UBERON:0006631	92.61	gold quality
tendon	UBERON:0000043	92.59	gold quality
subcutaneous adipose tissue	UBERON:0002190	92.10	gold quality
popliteal artery	UBERON:0002250	92.04	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	103.86
E-HCAD-1	yes	74.85
E-MTAB-8410	yes	38.75
E-HCAD-10	yes	29.19
E-ANND-3	yes	19.57
E-CURD-112	yes	18.09
E-MTAB-5061	yes	11.93

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting RCN3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-6884-5P	99.10	64.50	1987
HSA-MIR-485-5P	99.10	64.78	1889
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-5001-5P	99.05	66.76	1972
HSA-MIR-3196	98.96	63.91	326
HSA-MIR-4755-3P	98.77	65.59	1915
HSA-MIR-1227-5P	98.65	65.32	1549
HSA-MIR-9903	98.47	66.70	748
HSA-MIR-3180	98.46	64.68	348
HSA-MIR-3180-3P	98.46	64.68	348
HSA-MIR-6816-5P	98.46	64.35	364
HSA-MIR-6829-3P	97.45	64.31	1137
HSA-MIR-2467-5P	97.36	67.71	991
HSA-MIR-6836-3P	97.08	64.99	712
HSA-MIR-6762-5P	96.55	64.62	972

Literature-anchored findings (GeneRIF, showing 6)

• Autoactivation & secretion of rat PACE4 was increased upon co-expression with recombinant human RCN-3. Selective and transient association of RCN-3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4. (PMID:16433634)
• RCN3 expression in systemic sclerosis was not statistically significantly different to healthy controls. (PMID:27468573)
• Study identified reticulocalbin-3 (RCN-3) as a common molecule down-regulated by aldosterone (Aldo), galectin-3 and cardiotrophin-1 - key factors in the cardiac remodeling induced by Aldo associated with cardiac hypertrophy and fibrosis. Moreover, RCN-3 emerges as a new potential negative regulator of collagen production. (PMID:28939891)
• genome-wide association study in US: Data suggest, among white subjects, an SNP in RCN3 (rs34459162) and a missense mutation in GCKR (rs1260236) are associated with serum levels of glycated albumin; among black subjects, an intergenic SNP in PRKCA (rs2438321) is associated with fructosamine levels and intronic variant in PRKCA (rs59443763) is associated with glycated albumin levels. (GCKR = glucokinase regulatory protein) (PMID:29844224)
• Rcn3 Suppression Was Responsible for Partial Relief of Emphysema as Shown by Specific Type II Alveolar Epithelial Cell Rcn3 CKO Mouse Model. (PMID:33531801)
• An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript. (PMID:34753797)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	rcn3	ENSDARG00000037961
mus_musculus	Rcn3	ENSMUSG00000019539
rattus_norvegicus	Rcn3	ENSRNOG00000043007
drosophila_melanogaster	scf	FBGN0025682
caenorhabditis_elegans		WBGENE00019760

Paralogs (4): RCN1 (ENSG00000049449), SDF4 (ENSG00000078808), RCN2 (ENSG00000117906), CALU (ENSG00000128595)

Protein

Protein identifiers

Reticulocalbin-3 — Q96D15 (reviewed: Q96D15)

Alternative names: EF-hand calcium-binding protein RLP49

All UniProt accessions (4): Q96D15, M0QYB8, M0QZH0, M0QZU3

UniProt curated annotations — full annotation on UniProt →

Function. Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.

Subunit / interactions. Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.

Subcellular location. Endoplasmic reticulum lumen.

Tissue specificity. Widely expressed.

Post-translational modifications. Degraded by PCSK6 and other endoproteases including FURIN and PCSK5. N-glycosylated.

Induction. Down-regulated by aldosterone (at protein level). No effect at the transcript level.

Similarity. Belongs to the CREC family.

RefSeq proteins (1): NP_065701* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002048	EF_hand_dom	Domain
IPR011992	EF-hand-dom_pair	Homologous_superfamily
IPR018247	EF_Hand_1_Ca_BS	Binding_site

Pfam: PF13202, PF13499

UniProt features (46 total): binding site 29, domain 6, mutagenesis site 3, sequence conflict 2, signal peptide 1, chain 1, glycosylation site 1, sequence variant 1, region of interest 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96D15-F1	82.89	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (29): 92; 94; 96; 101; 126; 128; 130; 132; 137; 176; 178; 180 …

Glycosylation sites (1): 140

Mutagenesis-validated functional residues (3):

Position	Phenotype
86	decreased function in pcsk6 maturation and/or secretion.
112	decreased function in pcsk6 maturation and/or secretion.
325–328	decreased function in pcsk6 maturation and/or secretion.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 161 (showing top): RRAGTTGT_UNKNOWN, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_LUNG_EPITHELIUM_DEVELOPMENT, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GNF2_PTX3, AACWWCAANK_UNKNOWN, GOBP_LIPID_HOMEOSTASIS, GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY, GOBP_REGULATION_OF_HYDROLASE_ACTIVITY, GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION, GOBP_PHOSPHATIDYLINOSITOL_3_KINASE_PROTEIN_KINASE_B_SIGNAL_TRANSDUCTION, GOBP_REGULATION_OF_PEPTIDASE_ACTIVITY, GOBP_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY

GO Biological Process (9): protein secretion (GO:0009306), positive regulation of peptidase activity (GO:0010952), protein transport (GO:0015031), collagen biosynthetic process (GO:0032964), ERAD pathway (GO:0036503), surfactant homeostasis (GO:0043129), regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051896), phospholipid homeostasis (GO:0055091), lung epithelium development (GO:0060428)

GO Molecular Function (3): calcium ion binding (GO:0005509), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): endoplasmic reticulum (GO:0005783), endoplasmic reticulum lumen (GO:0005788)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein transport	1
secretion by cell	1
establishment of protein localization to extracellular region	1
protein localization to extracellular region	1
peptidase activity	1
positive regulation of proteolysis	1
positive regulation of hydrolase activity	1
regulation of peptidase activity	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
biosynthetic process	1
collagen metabolic process	1
proteasomal protein catabolic process	1
response to endoplasmic reticulum stress	1
response to chemical	1
multicellular organismal-level chemical homeostasis	1
phosphatidylinositol 3-kinase/protein kinase B signal transduction	1
regulation of intracellular signal transduction	1
lipid homeostasis	1
lung development	1
epithelium development	1
metal ion binding	1
binding	1
cation binding	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
endoplasmic reticulum	1
intracellular organelle lumen	1

Protein interactions and networks

STRING

582 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RCN3	PRRG2	O14669	495
RCN3	NOSIP	Q9Y314	452
RCN3	EIF3I	Q13347	423
RCN3	LURAP1	Q96LR2	405
RCN3	FKBP9	O95302	400
RCN3	RPL13A	P40429	376
RCN3	SRL	Q86TD4	376
RCN3	A0A087WVV2	A0A087WVV2	371
RCN3	SH3BGRL3	Q9H299	346
RCN3	FAM234B	A2RU67	339
RCN3	NARS2	Q96I59	335
RCN3	RNF181	Q9P0P0	327
RCN3	FKBP10	Q96AY3	323
RCN3	PSMB2	P31145	322
RCN3	CPN2	P22792	308

IntAct

41 interactions, top by confidence:

A	B	Type	Score
RCN3	SUFU	psi-mi:“MI:0915”(physical association)	0.700
SUFU	RCN3	psi-mi:“MI:0915”(physical association)	0.700
MBD3	RCN3	psi-mi:“MI:0915”(physical association)	0.560
RCN3	PACRGL	psi-mi:“MI:0915”(physical association)	0.560
PACRGL	RCN3	psi-mi:“MI:0915”(physical association)	0.560
ZNF417	RCN3	psi-mi:“MI:0915”(physical association)	0.560
DNAAF19	RCN3	psi-mi:“MI:0915”(physical association)	0.560
MYO15B	RCN3	psi-mi:“MI:0915”(physical association)	0.560
NAA10	RCN3	psi-mi:“MI:0915”(physical association)	0.560
PIP	TBKBP1	psi-mi:“MI:0914”(association)	0.530
RCN3	STAT6	psi-mi:“MI:0915”(physical association)	0.370
RCN3	MKNK1	psi-mi:“MI:0915”(physical association)	0.370
RCN3	PRUNE2	psi-mi:“MI:0915”(physical association)	0.370
RCN3	HID1	psi-mi:“MI:0915”(physical association)	0.370
RCN3	KLHL42	psi-mi:“MI:0915”(physical association)	0.370
	RCN3	psi-mi:“MI:0915”(physical association)	0.370
XRCC3	DERL1	psi-mi:“MI:0914”(association)	0.350
	SNAP23	psi-mi:“MI:0914”(association)	0.350
EMID1	NDUFS4	psi-mi:“MI:0914”(association)	0.350
POMGNT2	FAM83G	psi-mi:“MI:0914”(association)	0.350
RNASE3	RNASEH1	psi-mi:“MI:0914”(association)	0.350
SCCPDH	IPO5	psi-mi:“MI:0914”(association)	0.350
SUFU	RCN3	psi-mi:“MI:0915”(physical association)	0.000
MBD3	RCN3	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (31): RCN3 (Two-hybrid), PACRGL (Two-hybrid), PRUNE2 (Two-hybrid), RCN3 (Two-hybrid), HID1 (Two-hybrid), KLHL42 (Two-hybrid), RCN3 (Affinity Capture-Western), RCN3 (Affinity Capture-MS), RCN3 (Affinity Capture-MS), RCN3 (Co-fractionation), RCN3 (Two-hybrid), RCN3 (Two-hybrid), RCN3 (Two-hybrid), CCDC103 (Two-hybrid), ZNF417 (Two-hybrid)

ESM2 similar proteins: A0A6I8RMG7, A0AVX7, A2VEI2, A4IG32, A5D7A0, B5X186, B5X4E0, I6L9G5, J3S9D9, O35783, O35887, O93390, O93434, P07214, P09486, P13213, P16975, P20112, P22676, P36377, P36378, P41044, P49257, P61022, P61023, P79881, Q05186, Q14257, Q15293, Q28BT4, Q2KJ39, Q3T0K1, Q4U471, Q5R767, Q5R7F0, Q5ZM44, Q62703, Q62902, Q6IP82, Q6IQP3

Diamond homologs: B5X186, B5X4E0, I6L9G5, J3S9D9, O35783, O35887, O43852, O93434, P02597, P04464, Q05186, Q14257, Q15293, Q28BT4, Q2KJ39, Q3T0K1, Q4U471, Q5RDD8, Q62703, Q66JA6, Q6IP82, Q6IQP3, Q6XLQ7, Q7SXV9, Q8BH97, Q8BP92, Q96D15, Q9FKW4, P42529, Q5ZKE5, Q03975, Q9M7R0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1157 predictions. Top by Δscore:

Variant	Effect	Δscore
19:49528057:GG:G	donor_gain	1.0000
19:49528058:GG:G	donor_gain	1.0000
19:49528065:G:GT	donor_gain	1.0000
19:49528695:G:GT	donor_gain	1.0000
19:49528696:A:T	donor_gain	1.0000
19:49528712:GGG:G	donor_gain	1.0000
19:49528713:GG:G	donor_gain	1.0000
19:49528713:GGG:G	donor_gain	1.0000
19:49528714:GG:G	donor_gain	1.0000
19:49528715:G:GG	donor_gain	1.0000
19:49528715:G:T	donor_loss	1.0000
19:49528716:T:A	donor_loss	1.0000
19:49534191:AGGCG:A	acceptor_gain	1.0000
19:49534192:GGCGG:G	acceptor_gain	1.0000
19:49537028:CCCAG:C	acceptor_loss	1.0000
19:49537031:A:AG	acceptor_gain	1.0000
19:49537031:AG:A	acceptor_gain	1.0000
19:49537032:G:GA	acceptor_gain	1.0000
19:49537032:GG:G	acceptor_gain	1.0000
19:49537032:GGT:G	acceptor_gain	1.0000
19:49537032:GGTGA:G	acceptor_gain	1.0000
19:49537201:TTGCT:T	donor_gain	1.0000
19:49537202:TGCTG:T	donor_loss	1.0000
19:49537203:GCT:G	donor_gain	1.0000
19:49537204:CT:C	donor_gain	1.0000
19:49537204:CTGT:C	donor_loss	1.0000
19:49537205:TGTG:T	donor_loss	1.0000
19:49537206:G:GG	donor_gain	1.0000
19:49537206:GTG:G	donor_loss	1.0000
19:49537207:T:A	donor_loss	1.0000

AlphaMissense

2162 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:49542596:G:C	W241C	1.000
19:49542596:G:T	W241C	1.000
19:49542727:T:C	L285P	1.000
19:49543152:T:C	F309S	1.000
19:49543152:T:G	F309C	1.000
19:49534255:T:C	L102P	0.999
19:49537101:T:C	F172L	0.999
19:49537102:T:C	F172S	0.999
19:49537103:C:A	F172L	0.999
19:49537103:C:G	F172L	0.999
19:49537111:C:A	A175D	0.999
19:49537150:T:C	L188P	0.999
19:49539159:T:A	V220D	0.999
19:49542594:T:A	W241R	0.999
19:49542594:T:C	W241R	0.999
19:49542618:T:C	F249L	0.999
19:49542619:T:C	F249S	0.999
19:49542619:T:G	F249C	0.999
19:49542620:C:A	F249L	0.999
19:49542620:C:G	F249L	0.999
19:49542680:G:C	W269C	0.999
19:49542680:G:T	W269C	0.999
19:49542717:G:C	A282P	0.999
19:49542723:C:G	H284D	0.999
19:49543151:T:C	F309L	0.999
19:49543153:T:A	F309L	0.999
19:49543153:T:G	F309L	0.999
19:49543160:A:C	S312R	0.999
19:49543162:T:A	S312R	0.999
19:49543162:T:G	S312R	0.999

dbSNP variants (sampled 300 via entrez): RS1000196721 (19:49532378 T>G), RS1000248030 (19:49529403 A>G,T), RS1000356116 (19:49540893 G>A,T), RS1000376443 (19:49535002 C>T), RS1000930793 (19:49539382 A>C), RS1001179655 (19:49526866 C>T), RS1001584499 (19:49534640 A>G), RS1001660000 (19:49534392 C>A,G,T), RS1001804090 (19:49539878 A>C), RS1002056313 (19:49528301 C>A,T), RS1002122534 (19:49531229 G>A), RS1002168104 (19:49540201 G>T), RS1002188351 (19:49535229 A>G,T), RS1002463358 (19:49540392 G>A), RS1002665838 (19:49533231 C>G)

Disease associations

OMIM: gene MIM:619032 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST000583_10	Hematological and biochemical traits	3.000000e-08
GCST002539_91	Schizophrenia	5.000000e-08
GCST004615_127	Hemoglobin concentration	1.000000e-11
GCST006056_1	Fructosamine levels	5.000000e-09
GCST006058_1	Total glycated albumin levels	4.000000e-08
GCST008839_380	Height	4.000000e-10
GCST010241_67	Apolipoprotein A1 levels	5.000000e-14
GCST012619_1	Fructosamine levels	6.000000e-11
GCST90002383_292	Hematocrit	4.000000e-13
GCST90002384_461	Hemoglobin	1.000000e-10
GCST90002397_437	Mean spheric corpuscular volume	2.000000e-11
GCST90017143_1	Fructosamine levels	5.000000e-11

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004747	protein measurement
EFO:0004509	hemoglobin measurement
EFO:0009303	fructosamine measurement
EFO:0009305	total glycated albumin
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004348	hematocrit

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	6
Air Pollutants	increases abundance, decreases expression, increases expression, affects expression	3
tobacco tar	decreases expression, decreases reaction	2
Benzo(a)pyrene	decreases expression, increases methylation	2
Tobacco Smoke Pollution	decreases expression, affects expression	2
Aflatoxin B1	increases methylation, decreases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
bisphenol A	decreases expression	1
sodium arsenate	decreases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	increases expression	1
butyraldehyde	increases expression	1
benzo(e)pyrene	decreases methylation	1
diallyl disulfide	decreases expression, decreases reaction	1
pentanal	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	increases expression	1
bisphenol AF	increases expression	1
Arsenic Trioxide	increases expression	1
Acetaminophen	decreases expression	1
Aldehydes	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.