REPIN1

Summary

REPIN1 (replication initiator 1, HGNC:17922) is a protein-coding gene on chromosome 7q36.1, encoding DNA-binding protein REPIN1 (Q9BWE0). Sequence-specific double-stranded DNA-binding protein.

Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of fatty acid transport and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of D-glucose import. Located in nucleoplasm.

Source: NCBI Gene 29803 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 112 total
• MANE Select transcript: NM_001099695

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17922
Approved symbol	REPIN1
Name	replication initiator 1
Location	7q36.1
Locus type	gene with protein product
Status	Approved
Aliases	RIP60, AP4, H_DJ0584D14.12, Zfp464
Ensembl gene	ENSG00000214022
Ensembl biotype	protein_coding
OMIM	619039
Entrez	29803

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 18 protein_coding, 4 retained_intron, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000397281, ENST00000425389, ENST00000444957, ENST00000466559, ENST00000467980, ENST00000469309, ENST00000473391, ENST00000475514, ENST00000479668, ENST00000482680, ENST00000486714, ENST00000487455, ENST00000488943, ENST00000489432, ENST00000495535, ENST00000518462, ENST00000518514, ENST00000519397, ENST00000522266, ENST00000892312, ENST00000892313, ENST00000892314, ENST00000892315, ENST00000892316, ENST00000932521, ENST00000932522

RefSeq mRNA: 35 — MANE Select: NM_001099695 NM_001099695, NM_001099696, NM_001362745, NM_001362746, NM_001362747, NM_001388037, NM_001388038, NM_001388039, NM_001388040, NM_001388041, NM_001388042, NM_001388043, NM_001388044, NM_001388045, NM_001388046, NM_001388047, NM_001388048, NM_001388049, NM_001388050, NM_001388051, NM_001388052, NM_001388053, NM_001388054, NM_001388055, NM_001388056, NM_001388057, NM_001388058, NM_001388059, NM_001388060, NM_001388061, NM_001388062, NM_001388063, NM_001388064, NM_001388065, NM_013400

CCDS: CCDS43677, CCDS47745

Canonical transcript exons

ENST00000489432 — 3 exons

Exon	Start	End
ENSE00001829992	150368822	150368941
ENSE00001910228	150371228	150374039
ENSE00003682831	150369671	150369868

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 97.80.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.4610 / max 250.9676, expressed in 1812 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
81931	29.4892	1811
81927	1.8050	554
81932	1.5213	607
81930	0.6655	370
81929	0.4947	199
81933	0.0756	29
81928	0.0752	31

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	97.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.63	gold quality
mucosa of transverse colon	UBERON:0004991	97.36	gold quality
pituitary gland	UBERON:0000007	97.17	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	97.08	gold quality
gastrocnemius	UBERON:0001388	97.06	gold quality
left adrenal gland cortex	UBERON:0035825	97.05	gold quality
right adrenal gland cortex	UBERON:0035827	97.04	gold quality
left adrenal gland	UBERON:0001234	97.02	gold quality
adrenal cortex	UBERON:0001235	97.01	gold quality
right adrenal gland	UBERON:0001233	96.98	gold quality
transverse colon	UBERON:0001157	96.86	gold quality
adenohypophysis	UBERON:0002196	96.82	gold quality
thymus	UBERON:0002370	96.81	gold quality
apex of heart	UBERON:0002098	96.77	gold quality
gluteal muscle	UBERON:0002000	96.60	gold quality
triceps brachii	UBERON:0001509	96.44	gold quality
muscle of leg	UBERON:0001383	96.31	gold quality
adrenal gland	UBERON:0002369	96.16	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.12	gold quality
biceps brachii	UBERON:0001507	96.10	gold quality
metanephros cortex	UBERON:0010533	96.10	gold quality
renal medulla	UBERON:0000362	96.07	gold quality
body of pancreas	UBERON:0001150	96.04	gold quality
body of tongue	UBERON:0011876	96.01	gold quality
mucosa of sigmoid colon	UBERON:0004993	95.96	gold quality
corpus epididymis	UBERON:0004359	95.95	gold quality
small intestine Peyer’s patch	UBERON:0003454	95.86	gold quality
colonic mucosa	UBERON:0000317	95.83	gold quality
body of stomach	UBERON:0001161	95.81	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-114	yes	10.78
E-ANND-3	yes	8.91

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
DBH	Repression

miRNA regulators (miRDB)

53 targeting REPIN1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4663	99.62	65.33	957
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-4762-5P	99.57	68.54	1424
HSA-MIR-2392	99.43	67.50	708
HSA-MIR-5695	99.41	67.48	1047
HSA-MIR-520A-5P	99.35	66.72	1632
HSA-MIR-525-5P	99.35	66.85	1615
HSA-MIR-4685-5P	99.25	65.99	1563

Literature-anchored findings (GeneRIF, showing 11)

• AP4 and geminin act as a repressor complex distinct from REST/NRSF to negatively regulate the expression of target genes in nonneuronal cells. (PMID:16924111)
• a potential role for Repin1 as regulator of adipocyte size was shown.Repin1 seems to be involved in the regulation of genes involved in adipogenesis. (PMID:20727851)
• there is a p53-induced double-negative feedback loop involving miR-15a/16-1 and AP4 that stabilizes epithelial and mesenchymal states, respectively, which may determine metastatic prowess in colorectal cancer (PMID:24285725)
• AP4 is transcriptionally activated by TGFB1 to inhibit phosphorylation of SMAD2 as a negative regulator of an activated TGFB receptor signaling on cell growth inhibition in non-small cell lung cancer (PMID:25266805)
• Results show that breast cancer cells underwent epithelial-mesenchymal transition when AP4 was upregulated, and that AP4 regulated p53 expression level suggesting AP4 can regulate cell migration via the activity of p53. (PMID:26037074)
• AP4 and LAPTM4B are highly coexpressed in hepatocellular carcinoma tissues, and their coexpression may be a marker of poor prognosis. (PMID:29337428)
• data suggest that genetic variation in human REPIN1 plays a role in glucose and lipid metabolism by differentially affecting the expression of REPIN1 target genes including glucose and fatty acid transporters (PMID:29915365)
• Increased expression of hsa-mir-127 and decreased expression of REPIN1 were both associated with poor overall survival (PMID:29979259)
• A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease. (PMID:31922994)
• Overexpression of miR-127 Predicts Poor Prognosis and Contributes to the Progression of Papillary Thyroid Cancer by Targeting REPIN1. (PMID:33339069)
• REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis. (PMID:37749079)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Repin1	ENSMUSG00000052751
rattus_norvegicus	Repin1	ENSRNOG00000008239
drosophila_melanogaster	CG14667	FBGN0037317
caenorhabditis_elegans		WBGENE00016712

Protein

Protein identifiers

DNA-binding protein REPIN1 — Q9BWE0 (reviewed: Q9BWE0)

Alternative names: 60 kDa origin-specific DNA-binding protein, 60 kDa replication initiation region protein, ATT-binding protein, DHFR oribeta-binding protein RIP60, Zinc finger protein 464

All UniProt accessions (10): A0A090N8H1, C9J0L4, C9J590, C9J7D4, C9J7L2, C9JYJ8, C9JZE3, E5RK52, E7EVL6, Q9BWE0

UniProt curated annotations — full annotation on UniProt →

Function. Sequence-specific double-stranded DNA-binding protein. Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending. May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation. May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways. May regulate the expression of genes involved in glucose transport.

Subunit / interactions. Homodimers and homomultimers. Found in a complex with RIP60 and RIP100.

Subcellular location. Nucleus. Cytoplasm. Cytosol.

Tissue specificity. Expressed in adipose tissue and bone tissue.

Induction. Expression is increased in bone tissue of osteoporosis patients.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BWE0-3	1	yes
Q9BWE0-4	2

RefSeq proteins (35): NP_001093165, NP_001093166, NP_001349674, NP_001349675, NP_001349676, NP_001374966, NP_001374967, NP_001374968, NP_001374969, NP_001374970, NP_001374971, NP_001374972, NP_001374973, NP_001374974, NP_001374975, NP_001374976, NP_001374977, NP_001374978, NP_001374979, NP_001374980, NP_001374981, NP_001374982, NP_001374983, NP_001374984, NP_001374985, NP_001374986, NP_001374987, NP_001374988, NP_001374989, NP_001374990, NP_001374991, NP_001374992, NP_001374993, NP_001374994, NP_037532 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096

UniProt features (44 total): zinc finger region 15, sequence conflict 12, sequence variant 6, modified residue 4, compositionally biased region 3, region of interest 2, chain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BWE0-F1	70.86	0.04

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 27, 30, 33, 276

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 204 (showing top): AHRARNT_01, RNGTGGGC_UNKNOWN, TGCGCANK_UNKNOWN, GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT, MODULE_255, AREB6_03, MODULE_317, GOBP_ORGANIC_ACID_TRANSPORT, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_REGULATION_OF_FATTY_ACID_TRANSPORT, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN, GOBP_ORGANIC_ANION_TRANSPORT, ONDER_CDH1_TARGETS_2_UP

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of fatty acid transport (GO:2000191)

GO Molecular Function (7): RNA binding (GO:0003723), zinc ion binding (GO:0008270), chromatin insulator sequence binding (GO:0043035), sequence-specific DNA binding (GO:0043565), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (6): nucleoplasm (GO:0005654), chromosome (GO:0005694), cytosol (GO:0005829), nuclear membrane (GO:0031965), nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
nucleic acid binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
fatty acid transport	1
regulation of lipid transport	1
regulation of organic acid transport	1
transition metal ion binding	1
chromatin DNA binding	1
DNA binding	1
binding	1
cation binding	1
nuclear lumen	1
intracellular membraneless organelle	1
cytoplasm	1
nucleus	1
nuclear envelope	1
organelle membrane	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

960 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
REPIN1	NFYB	P25208	983
REPIN1	HAP1	P54257	934
REPIN1	NFYC	Q13952	924
REPIN1	SMARCB1	Q12824	627
REPIN1	NFYA	P23511	595
REPIN1	SRD5A2	P31213	519
REPIN1	F8A2	P23610	480
REPIN1	AP1S1	P61966	478
REPIN1	SMARCA2	P51531	469
REPIN1	RAD9A	Q99638	459
REPIN1	SWI5	Q1ZZU3	445
REPIN1	ELAC2	Q9BQ52	443
REPIN1	SMARCA4	P51532	442
REPIN1	ARHGEF17	Q96PE2	441
REPIN1	CYP3A4	P05184	439

IntAct

58 interactions, top by confidence:

A	B	Type	Score
TUBGCP5	TUBG1	psi-mi:“MI:0914”(association)	0.840
GDI1	RAB4A	psi-mi:“MI:0914”(association)	0.820
PPP2R2C	PPP2R1A	psi-mi:“MI:0914”(association)	0.730
REPIN1	IPO8	psi-mi:“MI:0914”(association)	0.640
KCTD17	CBX4	psi-mi:“MI:0914”(association)	0.530
SET	REPIN1	psi-mi:“MI:0914”(association)	0.530
REPIN1	SET	psi-mi:“MI:0914”(association)	0.530
Dlg4	REPIN1	psi-mi:“MI:0407”(direct interaction)	0.440
Set	ZKSCAN1	psi-mi:“MI:0914”(association)	0.350
IPO8	BIN1	psi-mi:“MI:0914”(association)	0.350
Zbtb48	VWA8	psi-mi:“MI:0914”(association)	0.350
PDLIM7	TPM1	psi-mi:“MI:0914”(association)	0.350
CDC23	VWA8	psi-mi:“MI:0914”(association)	0.350
LDHD	METTL8	psi-mi:“MI:0914”(association)	0.350
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
KCTD17	CBX4	psi-mi:“MI:0914”(association)	0.350
REPIN1		psi-mi:“MI:0914”(association)	0.350
DGCR8	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
CNBP	NOP56	psi-mi:“MI:0914”(association)	0.350
CLK2	CASC3	psi-mi:“MI:0914”(association)	0.350
PPP2R2C	TCP1	psi-mi:“MI:0914”(association)	0.350
SET	HSPA14	psi-mi:“MI:0914”(association)	0.350
DOCK3	SEC16A	psi-mi:“MI:0914”(association)	0.350
SET	WDR46	psi-mi:“MI:0914”(association)	0.350
rl3_rl3l_human	NKRF	psi-mi:“MI:0914”(association)	0.350
REPIN1	POTEB	psi-mi:“MI:0914”(association)	0.350
TRIM23	POTEB	psi-mi:“MI:0914”(association)	0.350
LDLRAD1	GXYLT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (151): REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS), REPIN1 (Affinity Capture-MS)

ESM2 similar proteins: A3KN32, A6NM28, A8K8V0, E9PYI1, O75467, O95201, P10072, P10075, P10078, P10754, P28698, P30373, P52736, Q0VCC5, Q14929, Q16587, Q17QR7, Q29RZ4, Q3KNW1, Q3TDE8, Q3US17, Q58DK7, Q5RJR4, Q5T619, Q5TEC3, Q5U4E2, Q62396, Q68H95, Q6AW86, Q6PGE4, Q6ZMY9, Q7Z398, Q7Z7K2, Q8BI73, Q8BIF9, Q8BIQ3, Q8BKK5, Q8JZL0, Q8N393, Q8R0T2

Diamond homologs: Q0VCC5, Q5U4E2, Q68H95, Q966L8, Q96EG3, Q9BWE0, Q9UDV6, P30373, A0A9P4XV22, O75290, Q5R8X1, Q62255, Q9BXA9, Q9ER74, Q9H7R5, Q9NSC2, Q9NW07

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 77 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
rRNA modification in the nucleus and cytosol	5	19.1×	3e-03
Major pathway of rRNA processing in the nucleolus and cytosol	7	8.8×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal small subunit biogenesis	6	21.0×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	104
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

662 predictions. Top by Δscore:

Variant	Effect	Δscore
7:150368937:CAGAG:C	donor_loss	0.9900
7:150368938:AGAGG:A	donor_loss	0.9900
7:150368939:GAG:G	donor_gain	0.9900
7:150368940:AGGT:A	donor_loss	0.9900
7:150368941:GGTA:G	donor_loss	0.9900
7:150368942:GTAC:G	donor_loss	0.9900
7:150368943:T:A	donor_loss	0.9900
7:150369867:GG:G	donor_gain	0.9900
7:150369868:GG:G	donor_gain	0.9900
7:150369869:G:T	donor_gain	0.9900
7:150370349:G:GT	donor_gain	0.9900
7:150371226:A:AG	acceptor_gain	0.9900
7:150371227:G:GG	acceptor_gain	0.9900
7:150371227:GCA:G	acceptor_gain	0.9900
7:150369800:G:GT	donor_gain	0.9800
7:150369448:G:T	donor_gain	0.9700
7:150369800:G:T	donor_gain	0.9700
7:150371229:A:AG	acceptor_gain	0.9700
7:150371230:G:GG	acceptor_gain	0.9700
7:150368942:G:GG	donor_gain	0.9600
7:150369014:G:GG	donor_gain	0.9600
7:150369945:A:T	donor_gain	0.9600
7:150369190:G:GG	donor_gain	0.9500
7:150369297:G:T	donor_gain	0.9500
7:150369944:G:GT	donor_gain	0.9500
7:150371228:CAG:C	acceptor_gain	0.9500
7:150371229:AGA:A	acceptor_gain	0.9500
7:150371230:GAG:G	acceptor_gain	0.9500
7:150369241:G:GT	donor_gain	0.9400
7:150371227:GCAGA:G	acceptor_gain	0.9400

AlphaMissense

4033 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:150372058:T:C	F273L	1.000
7:150372059:T:C	F273S	1.000
7:150372060:T:A	F273L	1.000
7:150372060:T:G	F273L	1.000
7:150372142:T:C	F301L	1.000
7:150372143:T:C	F301S	1.000
7:150372144:C:A	F301L	1.000
7:150372144:C:G	F301L	1.000
7:150372622:T:C	C461R	1.000
7:150372643:T:C	F468L	1.000
7:150372645:C:A	F468L	1.000
7:150372645:C:G	F468L	1.000
7:150372706:T:C	C489R	1.000
7:150372727:T:A	F496I	1.000
7:150372727:T:C	F496L	1.000
7:150372728:T:C	F496S	1.000
7:150372729:C:A	F496L	1.000
7:150372729:C:G	F496L	1.000
7:150372754:C:G	H505D	1.000
7:150372811:T:C	F524L	1.000
7:150372813:C:A	F524L	1.000
7:150372813:C:G	F524L	1.000
7:150371974:T:C	F245L	0.999
7:150371975:T:C	F245S	0.999
7:150371976:C:A	F245L	0.999
7:150371976:C:G	F245L	0.999
7:150371993:T:C	L251S	0.999
7:150372037:T:C	C266R	0.999
7:150372046:T:A	C269S	0.999
7:150372046:T:C	C269R	0.999

dbSNP variants (sampled 300 via entrez): RS1000075065 (7:150372861 C>T), RS1000447807 (7:150370214 C>A), RS1000466308 (7:150371106 C>A,T), RS1001020169 (7:150368744 C>T), RS1001740394 (7:150369682 C>T), RS1002016701 (7:150368173 C>T), RS1003694166 (7:150366697 C>T), RS1003746664 (7:150366598 C>T), RS1003854813 (7:150371754 C>T), RS1004311794 (7:150371449 G>A,T), RS1004324071 (7:150367648 T>A,C), RS1004498391 (7:150373953 T>C), RS1004871180 (7:150374177 G>A), RS1005238709 (7:150372278 C>A,G,T), RS1005578291 (7:150370083 C>T)

Disease associations

OMIM: gene MIM:619039 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST004389_5	Circulating chemerin levels	2.000000e-10
GCST004389_6	Circulating chemerin levels	9.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004573	chemerin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	2
Arsenic Trioxide	increases expression, affects cotreatment	2
Valproic Acid	affects expression, increases methylation	2
Aflatoxin B1	decreases methylation, increases methylation	2
FR900359	affects phosphorylation	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
beta-lapachone	decreases expression, increases expression	1
butyraldehyde	decreases expression	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine	decreases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
monomethylarsonous acid	increases expression	1
K 7174	decreases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
mono-isobutyl phthalate	increases methylation	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Air Pollutants	affects cotreatment, decreases expression, increases abundance	1
Amiodarone	increases expression	1
Benzo(a)pyrene	decreases expression	1
Chromium	decreases expression	1
Cisplatin	decreases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Estradiol	decreases expression, affects cotreatment	1
Ozone	affects cotreatment, decreases expression, increases abundance	1
Plant Extracts	decreases expression, affects cotreatment	1

Cellosaurus cell lines

5 cell lines: 3 embryonic stem cell, 2 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A5U7	SEES3-1V human REPIN1, clone1	Embryonic stem cell	Male
CVCL_A5U8	SEES3-1V human REPIN1, clone2	Embryonic stem cell	Male
CVCL_A5U9	SEES3-1V human REPIN1, clone3	Embryonic stem cell	Male
CVCL_B3FX	Abcam HEK293T REPIN1 KO	Transformed cell line	Female
CVCL_XV77	HEK293 eGFP-REPIN1	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.