RETREG2

Summary

RETREG2 (reticulophagy regulator family member 2, HGNC:28450) is a protein-coding gene on chromosome 2q35, encoding Reticulophagy regulator 2 (Q8NC44). Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress.

Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Predicted to be involved in autophagy. Predicted to act upstream of or within collagen catabolic process; endoplasmic reticulum organization; and reticulophagy. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane.

Source: NCBI Gene 79137 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 94 total — 1 pathogenic
• MANE Select transcript: NM_024293

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28450
Approved symbol	RETREG2
Name	reticulophagy regulator family member 2
Location	2q35
Locus type	gene with protein product
Status	Approved
Aliases	MGC3035, MAG-2
Ensembl gene	ENSG00000144567
Ensembl biotype	protein_coding
Entrez	79137

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 7 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron

ENST00000273048, ENST00000420189, ENST00000430297, ENST00000430747, ENST00000443757, ENST00000452022, ENST00000452293, ENST00000458520, ENST00000465672, ENST00000481925, ENST00000934281

RefSeq mRNA: 3 — MANE Select: NM_024293 NM_001321109, NM_001321110, NM_024293

CCDS: CCDS2434

Canonical transcript exons

ENST00000430297 — 9 exons

Exon	Start	End
ENSE00001654336	219182013	219185475
ENSE00001791238	219178275	219178633
ENSE00003460368	219180110	219180245
ENSE00003475059	219180670	219180754
ENSE00003512374	219179733	219179763
ENSE00003528364	219181369	219181463
ENSE00003612593	219178922	219179028
ENSE00003618199	219181062	219181205
ENSE00003634182	219181640	219181775

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 98.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.5383 / max 356.9954, expressed in 1821 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25426	21.5224	1814
25425	15.9045	1803
25427	0.1114	40

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	98.92	gold quality
left testis	UBERON:0004533	98.82	gold quality
right testis	UBERON:0004534	98.75	gold quality
endothelial cell	CL:0000115	98.59	gold quality
male germ cell	CL:0000015	98.57	gold quality
prefrontal cortex	UBERON:0000451	98.55	gold quality
cerebellar hemisphere	UBERON:0002245	98.33	gold quality
cerebellar cortex	UBERON:0002129	98.29	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.28	gold quality
Brodmann (1909) area 23	UBERON:0013554	98.23	gold quality
cerebellum	UBERON:0002037	98.15	gold quality
primary visual cortex	UBERON:0002436	98.15	gold quality
middle temporal gyrus	UBERON:0002771	98.02	gold quality
right frontal lobe	UBERON:0002810	97.96	gold quality
Brodmann (1909) area 9	UBERON:0013540	97.77	gold quality
testis	UBERON:0000473	97.75	gold quality
frontal cortex	UBERON:0001870	97.75	gold quality
adult organism	UBERON:0007023	97.70	gold quality
neocortex	UBERON:0001950	97.66	gold quality
occipital lobe	UBERON:0002021	97.54	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	97.48	gold quality
cingulate cortex	UBERON:0003027	97.39	gold quality
anterior cingulate cortex	UBERON:0009835	97.39	gold quality
cortical plate	UBERON:0005343	97.19	gold quality
medial globus pallidus	UBERON:0002477	97.15	gold quality
islet of Langerhans	UBERON:0000006	97.14	gold quality
amniotic fluid	UBERON:0000173	97.09	gold quality
pancreatic ductal cell	CL:0002079	97.08	gold quality
cerebral cortex	UBERON:0000956	97.05	gold quality
nucleus accumbens	UBERON:0001882	96.93	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.38
E-CURD-112	yes	4.33
E-GEOD-75367	no	383.06

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

109 targeting RETREG2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798

Literature-anchored findings (GeneRIF, showing 2)

• MAG-2 may be a novel causal gene for lung cancer invasion and metastasis. (PMID:19212629)
• Depleting the endoplasmic reticulum-localized protein FAM134A impairs mitotic progression by affecting metaphase plate alignment and pressure generation by delocalizing cortical myosin II. (PMID:29097687)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Retreg2	ENSMUSG00000049339
rattus_norvegicus	Retreg2	ENSRNOG00000018586

Protein

Protein identifiers

Reticulophagy regulator 2 — Q8NC44 (reviewed: Q8NC44)

All UniProt accessions (6): Q8NC44, C9J3K5, C9JIF3, F8WAL5, F8WE68, H7C3D5

UniProt curated annotations — full annotation on UniProt →

Function. Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress. When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins. Required for collagen quality control in a LIR motif-independent manner.

Subunit / interactions. Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Shows higher affinity for GABARAPL1 than for MAP1LC3B. Interacts with CANX.

Subcellular location. Endoplasmic reticulum membrane.

Domain organisation. The LIR motif interacts with ATG8 family proteins.

Similarity. Belongs to the RETREG family.

RefSeq proteins (3): NP_001308038, NP_001308039, NP_077269* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR052114	ER_autophagy_membrane_reg	Family
IPR055257	RETR2_RHD	Domain
IPR057282	RETREG1-3-like_RHD	Domain

Pfam: PF24456

UniProt features (27 total): modified residue 10, compositionally biased region 4, region of interest 4, transmembrane region 3, sequence variant 2, chain 1, mutagenesis site 1, sequence conflict 1, short sequence motif 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6EWC	X-RAY DIFFRACTION	3.2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NC44-F1	59.84	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 279, 281, 283, 291, 311, 334, 337, 344, 347, 385

Mutagenesis-validated functional residues (1):

Position	Phenotype
492–495	abolishes interaction with atg8 family proteins, induction of er fragmentation and er degradation.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 205 (showing top): GOBP_VACUOLE_ORGANIZATION, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, FOXO4_01, GOBP_MACROAUTOPHAGY, FREAC3_01, USF_01, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, HFH4_01, GOBP_ORGANELLE_ASSEMBLY, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, ACTTTAT_MIR1425P, NRF2_01, GCM_NF2, LIU_CMYB_TARGETS_UP, GOBP_ENDOPLASMIC_RETICULUM_ORGANIZATION

GO Biological Process (5): endoplasmic reticulum organization (GO:0007029), collagen catabolic process (GO:0030574), reticulophagy (GO:0061709), autophagy (GO:0006914), substrate localization to autophagosome (GO:0061753)

GO Molecular Function (2): endoplasmic reticulum-autophagosome adaptor activity (GO:0140506), protein binding (GO:0005515)

GO Cellular Component (3): endoplasmic reticulum membrane (GO:0005789), membrane (GO:0016020), endoplasmic reticulum (GO:0005783)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
catabolic process	2
organelle organization	1
endomembrane system organization	1
collagen metabolic process	1
macroautophagy	1
transmembrane transport	1
process utilizing autophagic mechanism	1
autophagosome assembly	1
establishment of localization in cell	1
autophagosome-membrane adaptor activity	1
endoplasmic reticulum-organelle membrane tether activity	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cellular anatomical structure	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1316 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RETREG2	GABARAP	O95166	781
RETREG2	ARHGAP1	Q07960	598
RETREG2	TEX264	Q9Y6I9	509
RETREG2	SEC62	Q99442	470
RETREG2	F5GZY7	F5GZY7	458
RETREG2	GABARAPL2	P60520	450
RETREG2	CCPG1	Q9ULG6	448
RETREG2	F5H6H0	F5H6H0	434
RETREG2	RTN3	O95197	395
RETREG2	DPY19L4	Q7Z388	368
RETREG2	ATL3	Q6DD88	359
RETREG2	SHISAL2A	Q6UWV7	359
RETREG2	VCF1	Q969W3	346
RETREG2	CD300C	Q08708	316
RETREG2	SLC33A1	O00400	308

IntAct

46 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
RETREG2	MAP1LC3B	psi-mi:“MI:0915”(physical association)	0.570
MAP1LC3B	RETREG2	psi-mi:“MI:0915”(physical association)	0.570
HTR2C	KLRG2	psi-mi:“MI:0914”(association)	0.530
GPR52	SYNGR2	psi-mi:“MI:0914”(association)	0.530
ZDHHC11	APOB	psi-mi:“MI:0914”(association)	0.530
STS	GJA1	psi-mi:“MI:0914”(association)	0.530
YIPF3	TMEM120B	psi-mi:“MI:0914”(association)	0.530
MAP1LC3A	RETREG2	psi-mi:“MI:0915”(physical association)	0.400
RETREG2	GABARAPL1	psi-mi:“MI:0915”(physical association)	0.400
RETREG2	GABARAP	psi-mi:“MI:0915”(physical association)	0.400
Retreg2		psi-mi:“MI:0915”(physical association)	0.400
RETREG2	SLC27A2	psi-mi:“MI:0914”(association)	0.350
	ESYT2	psi-mi:“MI:0914”(association)	0.350
YIPF3	TMEM223	psi-mi:“MI:0914”(association)	0.350
GRPR	GPR89A	psi-mi:“MI:0914”(association)	0.350
PVR	QSOX1	psi-mi:“MI:0914”(association)	0.350
	NBAS	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
ARL6IP1	ESYT2	psi-mi:“MI:0914”(association)	0.350
CLTA	CLTB	psi-mi:“MI:0914”(association)	0.350
TSPAN15	TMEM223	psi-mi:“MI:0914”(association)	0.350
GPR17	TMEM120B	psi-mi:“MI:0914”(association)	0.350
HCST	TMEM120B	psi-mi:“MI:0914”(association)	0.350
TSPAN31	TMEM120B	psi-mi:“MI:0914”(association)	0.350
GPR52	GPR89A	psi-mi:“MI:0914”(association)	0.350

BioGRID (59): ATP5A1 (Affinity Capture-MS), ATP5F1 (Affinity Capture-MS), ATP5J (Affinity Capture-MS), ATP5O (Affinity Capture-MS), EIF5A (Affinity Capture-MS), GOLGA3 (Affinity Capture-MS), ABCD3 (Affinity Capture-MS), PRDX2 (Affinity Capture-MS), MRPL33 (Affinity Capture-MS), CHD1L (Affinity Capture-MS), ATP5H (Affinity Capture-MS), HPSE (Affinity Capture-MS), SLC27A2 (Affinity Capture-MS), SLC25A19 (Affinity Capture-MS), FAM134A (Affinity Capture-MS)

ESM2 similar proteins: A2A8U2, A4D2P6, A4IG66, A7MCY6, B5DF41, D4AE48, O15079, O75129, O97676, P12755, P36956, P53349, P56720, P85299, Q0QWG9, Q1JPG0, Q3B7M3, Q3MHU5, Q3TPJ7, Q3U0L2, Q504T8, Q50H33, Q5FVG6, Q5SNT2, Q60416, Q60698, Q66K64, Q6DVA0, Q6NS60, Q6NS82, Q6ZWB6, Q7L4E1, Q80U23, Q80U62, Q80Z10, Q812A5, Q86V42, Q86XL3, Q8C0R7, Q8CC12

Diamond homologs: Q0P4Z1, Q3MHU5, Q5E9K8, Q5FVM3, Q6NS82, Q86VR2, Q8NC44, Q8VE91, Q9CQV4, Q9H6L5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 45 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
mitophagy	5	37.0×	3e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

94 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	74
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
58844	GRCh38/hg38 2q35-36.3(chr2:219081620-225430308)x1	Pathogenic

SpliceAI

1497 predictions. Top by Δscore:

Variant	Effect	Δscore
2:219176756:TCA:T	donor_loss	1.0000
2:219176757:CACC:C	donor_loss	1.0000
2:219176758:A:AC	donor_gain	1.0000
2:219176758:AC:A	donor_gain	1.0000
2:219176758:ACCGT:A	donor_loss	1.0000
2:219176759:C:CC	donor_gain	1.0000
2:219176759:CC:C	donor_gain	1.0000
2:219176759:CCGTG:C	donor_gain	1.0000
2:219179029:GTGA:G	donor_loss	1.0000
2:219179731:A:AG	acceptor_gain	1.0000
2:219179732:G:GG	acceptor_gain	1.0000
2:219179732:GC:G	acceptor_gain	1.0000
2:219180755:G:GG	donor_gain	1.0000
2:219181060:A:AG	acceptor_gain	1.0000
2:219181061:G:GG	acceptor_gain	1.0000
2:219181086:T:TA	acceptor_gain	1.0000
2:219181201:GAGGA:G	donor_gain	1.0000
2:219181203:G:GT	donor_gain	1.0000
2:219181203:GGA:G	donor_gain	1.0000
2:219181204:GA:G	donor_gain	1.0000
2:219181204:GAG:G	donor_gain	1.0000
2:219181206:G:GG	donor_gain	1.0000
2:219181461:GTG:G	donor_gain	1.0000
2:219181609:C:G	acceptor_gain	1.0000
2:219181611:T:G	acceptor_gain	1.0000
2:219181621:ATCCT:A	acceptor_gain	1.0000
2:219181625:T:TA	acceptor_gain	1.0000
2:219181634:T:TA	acceptor_gain	1.0000
2:219181636:CCAGG:C	acceptor_loss	1.0000
2:219181637:CAG:C	acceptor_loss	1.0000

AlphaMissense

3447 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:219181067:A:C	S216R	1.000
2:219181069:T:A	S216R	1.000
2:219181069:T:G	S216R	1.000
2:219178578:T:A	W76R	0.999
2:219178578:T:C	W76R	0.999
2:219180227:G:C	K179N	0.999
2:219180227:G:T	K179N	0.999
2:219180715:G:A	G201R	0.999
2:219180715:G:C	G201R	0.999
2:219180716:G:A	G201E	0.999
2:219180725:T:A	V204D	0.999
2:219181079:T:A	W220R	0.999
2:219181079:T:C	W220R	0.999
2:219181082:C:A	P221T	0.999
2:219181082:C:T	P221S	0.999
2:219181083:C:A	P221H	0.999
2:219181083:C:G	P221R	0.999
2:219181140:T:C	L240P	0.999
2:219181670:G:C	A304P	0.999
2:219181674:T:A	I305N	0.999
2:219181674:T:C	I305T	0.999
2:219181674:T:G	I305S	0.999
2:219181677:C:T	T306I	0.999
2:219181680:A:T	D307V	0.999
2:219178580:G:C	W76C	0.998
2:219178580:G:T	W76C	0.998
2:219178596:A:C	S82R	0.998
2:219178598:C:A	S82R	0.998
2:219178598:C:G	S82R	0.998
2:219180670:T:C	F186L	0.998

dbSNP variants (sampled 300 via entrez): RS1000345599 (2:219180999 G>A,C), RS1000748974 (2:219184784 A>C,G), RS1001202666 (2:219185105 G>A,T), RS1001287169 (2:219180975 T>G), RS1001401915 (2:219181945 A>T), RS1002407603 (2:219183333 ACT>A), RS1002962446 (2:219182259 G>T), RS1003268353 (2:219183067 C>A,G,T), RS1003270513 (2:219179255 T>A), RS1003309404 (2:219183352 T>C), RS1003447924 (2:219178090 C>A,G,T), RS1003821548 (2:219177824 C>A), RS1003824102 (2:219177779 A>G), RS1004064772 (2:219177978 A>C,G), RS1004336454 (2:219183319 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004625_58	Monocyte count	5.000000e-11
GCST012226_198	Waist circumference adjusted for body mass index	1.000000e-08
GCST90002389_4	Lymphocyte percentage of white cells	9.000000e-13
GCST90002398_116	Neutrophil count	1.000000e-11

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0005091	monocyte count
EFO:0007789	BMI-adjusted waist circumference
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0004833	neutrophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression	3
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
perfluorooctanoic acid	decreases expression	1
nickel sulfate	increases expression	1
coumarin	affects phosphorylation	1
2-palmitoylglycerol	increases expression	1
eprenetapopt	affects expression, affects reaction	1
jinfukang	increases expression, affects cotreatment	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Vehicle Emissions	increases abundance, decreases expression	1
Cadmium	increases abundance, increases expression	1
Caffeine	affects phosphorylation	1
Cisplatin	affects cotreatment, increases expression	1
Lead	affects expression	1
Phenylmercuric Acetate	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Selenium	increases expression	1
Valproic Acid	increases expression	1
Cadmium Chloride	increases abundance, increases expression	1
Vitamin K 3	affects expression	1
Particulate Matter	decreases expression, increases abundance	1

Cellosaurus cell lines

15 cell lines: 15 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D1IB	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/-	Embryonic stem cell	Female
CVCL_D1IC	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/-	Embryonic stem cell	Female
CVCL_D1ID	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/-	Embryonic stem cell	Female
CVCL_D1IE	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/- CCPG1-/-	Embryonic stem cell	Female
CVCL_D1IG	H9 AAVS1-TRE3G-NGN2 RETREG2-/-	Embryonic stem cell	Female
CVCL_D1IR	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IS	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- Keima-REEP5	Embryonic stem cell	Female
CVCL_D1IT	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IU	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- Keima-REEP5	Embryonic stem cell	Female
CVCL_D1IV	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/- Keima-RAMP4	Embryonic stem cell	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.