RETREG3

Summary

RETREG3 (reticulophagy regulator family member 3, HGNC:27258) is a protein-coding gene on chromosome 17q21.2, encoding Reticulophagy regulator 3 (Q86VR2). Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress.

Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Involved in endoplasmic reticulum tubular network organization; positive regulation of neuron projection development; and reticulophagy. Located in endoplasmic reticulum tubular network. Part of protein-containing complex.

Source: NCBI Gene 162427 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 78 total — 1 likely-pathogenic
• MANE Select transcript: NM_178126

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27258
Approved symbol	RETREG3
Name	reticulophagy regulator family member 3
Location	17q21.2
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp686B1036, FLJ33806
Ensembl gene	ENSG00000141699
Ensembl biotype	protein_coding
OMIM	616498
Entrez	162427

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 8 protein_coding, 5 nonsense_mediated_decay, 3 retained_intron

ENST00000309428, ENST00000585726, ENST00000585894, ENST00000586796, ENST00000586870, ENST00000588423, ENST00000589007, ENST00000589797, ENST00000590035, ENST00000590541, ENST00000591547, ENST00000593251, ENST00000875457, ENST00000875458, ENST00000917259, ENST00000955309

RefSeq mRNA: 1 — MANE Select: NM_178126 NM_178126

CCDS: CCDS11432

Canonical transcript exons

ENST00000309428 — 9 exons

Exon	Start	End
ENSE00001320492	42587834	42587864
ENSE00002875077	42579515	42582270
ENSE00003469683	42582674	42582806
ENSE00003472314	42592056	42592162
ENSE00003519199	42586765	42586891
ENSE00003565339	42585125	42585262
ENSE00003565827	42583498	42583580
ENSE00003613741	42586053	42586137
ENSE00003850199	42609086	42609374

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 96.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.1876 / max 215.6569, expressed in 1817 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166172	22.1876	1817

Top tissues by expression

300 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	96.41	gold quality
epithelium of nasopharynx	UBERON:0001951	95.58	gold quality
nasopharynx	UBERON:0001728	95.56	gold quality
gingival epithelium	UBERON:0001949	95.43	gold quality
nipple	UBERON:0002030	95.20	gold quality
periodontal ligament	UBERON:0008266	94.88	gold quality
nasal cavity epithelium	UBERON:0005384	94.66	gold quality
gingiva	UBERON:0001828	94.37	gold quality
pylorus	UBERON:0001166	94.16	gold quality
body of pancreas	UBERON:0001150	94.15	gold quality
granulocyte	CL:0000094	93.95	gold quality
tendon of biceps brachii	UBERON:0008188	93.88	gold quality
ileal mucosa	UBERON:0000331	93.83	gold quality
thymus	UBERON:0002370	93.71	gold quality
right testis	UBERON:0004534	93.70	gold quality
left testis	UBERON:0004533	93.57	gold quality
epithelium of mammary gland	UBERON:0003244	93.48	gold quality
superior surface of tongue	UBERON:0007371	93.48	gold quality
mammary duct	UBERON:0001765	93.40	gold quality
upper leg skin	UBERON:0004262	93.38	gold quality
penis	UBERON:0000989	93.36	gold quality
upper arm skin	UBERON:0004263	93.35	gold quality
trachea	UBERON:0003126	93.04	gold quality
Brodmann (1909) area 23	UBERON:0013554	92.93	gold quality
mammalian vulva	UBERON:0000997	92.89	gold quality
layer of synovial tissue	UBERON:0007616	92.70	gold quality
blood	UBERON:0000178	92.66	gold quality
cardia of stomach	UBERON:0001162	92.64	gold quality
pharyngeal mucosa	UBERON:0000355	92.61	gold quality
germinal epithelium of ovary	UBERON:0001304	92.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.55

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NRF1

miRNA regulators (miRDB)

181 targeting RETREG3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-6778-3P	99.96	67.29	2693

Literature-anchored findings (GeneRIF, showing 2)

• We verified that NRF-1 positively regulates FAM134C and ENOX1, and negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. (PMID:23939472)
• RTN4B interacting protein FAM134C promotes ER membrane curvature and has a functional role in autophagy. (PMID:33826365)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Retreg3	ENSMUSG00000017802
rattus_norvegicus	Retreg3	ENSRNOG00000020056

Protein

Protein identifiers

Reticulophagy regulator 3 — Q86VR2 (reviewed: Q86VR2)

All UniProt accessions (9): Q86VR2, K7EJ34, K7EJ42, K7ELM8, K7EMF4, K7ENF4, K7ENZ6, K7EPD0, K7EQI9

UniProt curated annotations — full annotation on UniProt →

Function. Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress. When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins. Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes. Required for collagen quality control in a LIR motif-dependent manner. Mediates NRF1-enhanced neurite outgrowth.

Subunit / interactions. Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Interacts with CANX. Interacts with RTN4 isoform B.

Subcellular location. Endoplasmic reticulum membrane.

Domain organisation. The LIR motif interacts with ATG8 family proteins.

Induction. Induced by amino acid starvation but not by endoplasmic reticulum stress.

Similarity. Belongs to the RETREG family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q86VR2-1	1	yes
Q86VR2-2	2

RefSeq proteins (1): NP_835227* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR043384	RETREG1/3	Family
IPR055258	RETR3_RHD	Domain
IPR057282	RETREG1-3-like_RHD	Domain

Pfam: PF24456

UniProt features (38 total): modified residue 16, topological domain 5, compositionally biased region 4, transmembrane region 4, region of interest 3, mutagenesis site 2, initiator methionine 1, chain 1, short sequence motif 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86VR2-F1	61.61	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (16): 2, 10, 26, 258, 260, 283, 285, 288, 293, 303, 307, 310, 313, 320, 360, 440

Mutagenesis-validated functional residues (2):

Position	Phenotype
445–450	reduced formation of autophagosomes.
447–450	abolishes interaction with atg8 family proteins, induction of er fragmentation and er degradation.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 195 (showing top): AAGCAAT_MIR137, TGCGCANK_UNKNOWN, GOBP_VACUOLE_ORGANIZATION, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GOBP_NEUROGENESIS, GOBP_MACROAUTOPHAGY, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, MARTINEZ_RB1_TARGETS_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP, GOBP_ORGANELLE_ASSEMBLY, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, DOUGLAS_BMI1_TARGETS_DN, GOBP_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT, GOBP_CELL_PROJECTION_ORGANIZATION, GOBP_ENDOPLASMIC_RETICULUM_ORGANIZATION

GO Biological Process (7): positive regulation of neuron projection development (GO:0010976), collagen catabolic process (GO:0030574), reticulophagy (GO:0061709), endoplasmic reticulum tubular network organization (GO:0071786), autophagy (GO:0006914), endoplasmic reticulum organization (GO:0007029), substrate localization to autophagosome (GO:0061753)

GO Molecular Function (2): endoplasmic reticulum-autophagosome adaptor activity (GO:0140506), protein binding (GO:0005515)

GO Cellular Component (5): endoplasmic reticulum membrane (GO:0005789), protein-containing complex (GO:0032991), endoplasmic reticulum tubular network (GO:0071782), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
catabolic process	2
endoplasmic reticulum subcompartment	2
regulation of neuron projection development	1
neuron projection development	1
positive regulation of cell projection organization	1
collagen metabolic process	1
macroautophagy	1
endoplasmic reticulum organization	1
transmembrane transport	1
process utilizing autophagic mechanism	1
organelle organization	1
endomembrane system organization	1
autophagosome assembly	1
establishment of localization in cell	1
autophagosome-membrane adaptor activity	1
endoplasmic reticulum-organelle membrane tether activity	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
cellular_component	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1430 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RETREG3	GABARAP	O95166	793
RETREG3	TEX264	Q9Y6I9	548
RETREG3	CCPG1	Q9ULG6	537
RETREG3	MANSC1	Q9H8J5	522
RETREG3	TMEM171	Q8WVE6	502
RETREG3	RTN3	O95197	495
RETREG3	SEC62	Q99442	493
RETREG3	LNPK	Q9C0E8	450
RETREG3	RTN4	Q9NQC3	413
RETREG3	ENOX1	Q8TC92	405
RETREG3	CACFD1	Q9UGQ2	404
RETREG3	MRFAP1L1	Q96HT8	402
RETREG3	PACC1	Q9H813	399
RETREG3	ENTREP1	Q15884	386
RETREG3	ATL3	Q6DD88	380

IntAct

488 interactions, top by confidence:

A	B	Type	Score
RETREG3	GABARAPL1	psi-mi:“MI:0915”(physical association)	0.830
GABARAPL1	RETREG3	psi-mi:“MI:0915”(physical association)	0.830
ABHD16A	RETREG3	psi-mi:“MI:0915”(physical association)	0.780
ARL6IP1	RETREG3	psi-mi:“MI:0915”(physical association)	0.780
RETREG3	MAP1LC3A	psi-mi:“MI:0915”(physical association)	0.780
RETREG3	ABHD16A	psi-mi:“MI:0915”(physical association)	0.780
RETREG3	ARL6IP1	psi-mi:“MI:0915”(physical association)	0.780
MAP1LC3A	RETREG3	psi-mi:“MI:0915”(physical association)	0.780
RETREG3	STAP1	psi-mi:“MI:0915”(physical association)	0.720
ATP5PB	SLC19A2	psi-mi:“MI:0914”(association)	0.640
CCDC167	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
LRCH4	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
MOB2	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
TMEM65	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
CMTM3	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
YIPF1	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
CMTM5	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
HMOX2	RETREG3	psi-mi:“MI:0915”(physical association)	0.560
ANKRD46	RETREG3	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (341): FAM134C (Two-hybrid), FAM134C (Two-hybrid), FAM134C (Two-hybrid), FAM134C (Two-hybrid), FAM134C (Two-hybrid), FAM134C (Affinity Capture-RNA), FAM134C (Affinity Capture-RNA), FAM134C (Affinity Capture-MS), FAM134C (Affinity Capture-MS), FAM134C (Affinity Capture-MS), FAM134C (Affinity Capture-MS), FAM134C (Affinity Capture-MS), FAM134C (Affinity Capture-MS), JPH1 (Affinity Capture-MS), ATP12A (Affinity Capture-MS)

ESM2 similar proteins: A1L3T7, A2A699, A7YWL5, O70622, O75298, O94983, Q0P4Z1, Q16799, Q1L899, Q1LU99, Q2T9L4, Q3T1H8, Q3TES0, Q3UJB9, Q3ZAV8, Q4FZU8, Q4VAC9, Q5E9U3, Q5IS59, Q5RBI7, Q5XIS1, Q64548, Q66H43, Q68FE6, Q6NS82, Q6P2E9, Q6PDH0, Q6WN19, Q6ZQ29, Q6ZS17, Q76LL6, Q76N89, Q80Y50, Q86UU1, Q86VR2, Q8BG26, Q8CD60, Q8K0T0, Q8K330, Q8TE77

Diamond homologs: Q0P4Z1, Q3MHU5, Q5E9K8, Q5FVM3, Q6NS82, Q86VR2, Q8NC44, Q8VE91, Q9CQV4, Q9H6L5

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
NRF1	“up-regulates quantity by expression”	RETREG3	“transcriptional regulation”
NRF1	up-regulates	RETREG3
RETREG3	up-regulates	Neurite_outgrowth

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 125 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
vesicle fusion	5	30.7×	1e-04
endoplasmic reticulum organization	5	21.5×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

78 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	67
Likely benign	1
Benign	2

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3338057	NM_001070.5(TUBG1):c.664A>C (p.Asn222His)	Likely pathogenic

SpliceAI

2050 predictions. Top by Δscore:

Variant	Effect	Δscore
17:42582266:TAGGT:T	acceptor_gain	1.0000
17:42582270:TC:T	acceptor_loss	1.0000
17:42582271:C:CC	acceptor_gain	1.0000
17:42582668:CCTCA:C	donor_loss	1.0000
17:42582669:CTCAC:C	donor_loss	1.0000
17:42582670:TCACC:T	donor_loss	1.0000
17:42582671:CA:C	donor_loss	1.0000
17:42582673:C:CG	donor_loss	1.0000
17:42582685:T:TA	donor_gain	1.0000
17:42582803:CCAG:C	acceptor_gain	1.0000
17:42582804:CAG:C	acceptor_gain	1.0000
17:42582804:CAGC:C	acceptor_gain	1.0000
17:42582807:C:CC	acceptor_gain	1.0000
17:42582808:T:C	acceptor_gain	1.0000
17:42582808:T:TC	acceptor_gain	1.0000
17:42582821:A:T	acceptor_gain	1.0000
17:42583493:GATAC:G	donor_loss	1.0000
17:42583494:ATACC:A	donor_loss	1.0000
17:42583495:TACCT:T	donor_loss	1.0000
17:42583496:A:AT	donor_loss	1.0000
17:42583497:C:CG	donor_loss	1.0000
17:42583499:TGAGG:T	donor_gain	1.0000
17:42583576:GCGTA:G	acceptor_gain	1.0000
17:42583577:CGTA:C	acceptor_gain	1.0000
17:42583577:CGTAC:C	acceptor_gain	1.0000
17:42583578:GTA:G	acceptor_gain	1.0000
17:42583579:TA:T	acceptor_gain	1.0000
17:42583580:ACTG:A	acceptor_loss	1.0000
17:42583581:C:CC	acceptor_gain	1.0000
17:42583581:C:G	acceptor_loss	1.0000

AlphaMissense

3029 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:42586783:T:A	K162N	0.997
17:42586783:T:G	K162N	0.997
17:42586135:G:C	F169L	0.996
17:42586135:G:T	F169L	0.996
17:42586137:A:G	F169L	0.996
17:42581873:A:C	F447L	0.995
17:42581873:A:T	F447L	0.995
17:42581875:A:G	F447L	0.995
17:42581874:A:C	F447C	0.994
17:42586123:G:C	S173R	0.993
17:42586123:G:T	S173R	0.993
17:42586125:T:G	S173R	0.993
17:42582717:G:C	F300L	0.990
17:42582717:G:T	F300L	0.990
17:42582719:A:G	F300L	0.990
17:42586784:T:A	K162I	0.989
17:42592086:A:G	W106R	0.989
17:42592086:A:T	W106R	0.989
17:42583507:G:C	F267L	0.988
17:42583507:G:T	F267L	0.988
17:42583509:A:G	F267L	0.988
17:42586122:A:G	C174R	0.988
17:42609141:A:G	W62R	0.988
17:42609141:A:T	W62R	0.988
17:42586134:A:G	C170R	0.987
17:42586136:A:G	F169S	0.986
17:42592098:A:G	C102R	0.986
17:42582236:A:C	F326L	0.983
17:42582236:A:T	F326L	0.983
17:42582238:A:G	F326L	0.983

dbSNP variants (sampled 300 via entrez): RS1000082779 (17:42605009 G>A,C), RS1000205705 (17:42589285 A>C,G), RS1000266418 (17:42604683 C>T), RS1000371644 (17:42599687 G>T), RS1000543364 (17:42604368 T>C), RS1000627953 (17:42579617 C>A), RS1000637859 (17:42605711 G>A,C), RS1000691492 (17:42597696 TCTC>T), RS1000847302 (17:42591270 T>C), RS1000999074 (17:42604588 G>A), RS1000999620 (17:42584134 T>A), RS1001113921 (17:42583876 C>T), RS1001232470 (17:42579943 A>G), RS1001240843 (17:42607020 TA>T), RS1001246946 (17:42579036 G>A)

Disease associations

OMIM: gene MIM:616498 | disease phenotypes: MIM:615412

GenCC curated gene-disease

Mondo (1): complex cortical dysplasia with other brain malformations 4 (MONDO:0014171)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009325_53	Parkinson’s disease or first degree relation to individual with Parkinson’s disease	1.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	3
Arsenic	affects methylation, decreases expression, increases abundance	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
testosterone enanthate	affects expression	1
bisphenol A	increases expression	1
trichostatin A	affects expression	1
sodium arsenite	decreases expression, increases abundance	1
perfluorooctanoic acid	decreases expression	1
ochratoxin A	decreases expression	1
potassium chromate(VI)	increases expression	1
coumarin	decreases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
bisphenol S	increases expression	1
bisphenol AF	increases expression	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, decreases expression	1
Cadmium	increases abundance, increases expression	1
Caffeine	affects phosphorylation	1
Estradiol	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	increases expression	1
Vanadates	decreases expression	1

Cellosaurus cell lines

15 cell lines: 15 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D1IA	H9 AAVS1-TRE3G-NGN2 RETREG3-/-	Embryonic stem cell	Female
CVCL_D1IB	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/-	Embryonic stem cell	Female
CVCL_D1IC	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/-	Embryonic stem cell	Female
CVCL_D1ID	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/-	Embryonic stem cell	Female
CVCL_D1IE	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/- CCPG1-/-	Embryonic stem cell	Female
CVCL_D1IP	H9 AAVS1-TRE3G-NGN2 RETREG3-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IQ	H9 AAVS1-TRE3G-NGN2 RETREG3-/- Keima-REEP5	Embryonic stem cell	Female
CVCL_D1IR	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IS	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- Keima-REEP5	Embryonic stem cell	Female
CVCL_D1IT	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- Keima-RAMP4	Embryonic stem cell	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.