RFPL1S

Summary

RFPL1S (RFPL1 antisense RNA 1, HGNC:9978) is a long non-coding RNA gene on chromosome 22q12.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9978
Approved symbol	RFPL1S
Name	RFPL1 antisense RNA 1
Location	22q12.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	RFPL1-AS, NCRNA00006
Ensembl gene	ENSG00000225465
Ensembl biotype	lncRNA
OMIM	605972
Entrez	10740
RNAcentral	URS000075AF51 — lncRNA, 5125 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000248980, ENST00000419368, ENST00000461286, ENST00000657516, ENST00000658349, ENST00000661328, ENST00000669415, ENST00000752427, ENST00000752428, ENST00000752429, ENST00000752430, ENST00000752431

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000248980 — 3 exons

Exon	Start	End
ENSE00001797096	29438422	29439193
ENSE00003857461	29472306	29472449
ENSE00003874073	29478010	29478136

Expression profiles

Bgee: expression breadth ubiquitous, 194 present calls, max score 93.28.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5411 / max 57.4145, expressed in 99 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193527	0.4611	93
193526	0.0799	52

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
orbitofrontal cortex	UBERON:0004167	93.28	gold quality
CA1 field of hippocampus	UBERON:0003881	91.36	gold quality
superior frontal gyrus	UBERON:0002661	90.94	gold quality
cortical plate	UBERON:0005343	90.84	gold quality
postcentral gyrus	UBERON:0002581	90.71	gold quality
lateral nuclear group of thalamus	UBERON:0002736	89.99	gold quality
parietal lobe	UBERON:0001872	89.98	gold quality
prefrontal cortex	UBERON:0000451	89.92	gold quality
endothelial cell	CL:0000115	89.88	silver quality
entorhinal cortex	UBERON:0002728	89.74	gold quality
primary visual cortex	UBERON:0002436	89.57	gold quality
Brodmann (1909) area 46	UBERON:0006483	89.38	gold quality
Brodmann (1909) area 23	UBERON:0013554	89.05	gold quality
occipital lobe	UBERON:0002021	88.69	gold quality
frontal cortex	UBERON:0001870	87.81	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	87.34	gold quality
neocortex	UBERON:0001950	86.77	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.54	gold quality
middle temporal gyrus	UBERON:0002771	86.44	gold quality
cerebral cortex	UBERON:0000956	86.39	gold quality
telencephalon	UBERON:0001893	83.92	gold quality
right frontal lobe	UBERON:0002810	83.91	gold quality
temporal lobe	UBERON:0001871	83.78	gold quality
Ammon’s horn	UBERON:0001954	82.86	gold quality
cingulate cortex	UBERON:0003027	82.70	gold quality
anterior cingulate cortex	UBERON:0009835	82.41	gold quality
forebrain	UBERON:0001890	81.84	gold quality
pons	UBERON:0000988	81.77	gold quality
superior vestibular nucleus	UBERON:0007227	81.64	gold quality
nucleus accumbens	UBERON:0001882	81.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.85

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.