RFPL3S

Summary

RFPL3S (RFPL3 antisense, HGNC:9981) is a long non-coding RNA gene on chromosome 22q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9981
Approved symbol	RFPL3S
Name	RFPL3 antisense
Location	22q12.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RFPL3-AS, NCRNA00005
Ensembl gene	ENSG00000205853
Ensembl biotype	lncRNA
OMIM	605971
Entrez	10737
RNAcentral	URS000075E5D6 — lncRNA, 1237 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000382084, ENST00000382086, ENST00000400234, ENST00000461833, ENST00000577714, ENST00000655996, ENST00000657380, ENST00000657810, ENST00000658273, ENST00000659039, ENST00000745225, ENST00000745226

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000382084 — 4 exons

Exon	Start	End
ENSE00001490871	32367690	32367714
ENSE00001490873	32368497	32368567
ENSE00003878188	32359886	32360839
ENSE00004084962	32370899	32371043

Expression profiles

Bgee: expression breadth ubiquitous, 177 present calls, max score 98.36.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0946 / max 75.3312, expressed in 4 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193743	0.0765	3
193744	0.0180	4

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	98.36	gold quality
male germ cell	CL:0000015	95.80	gold quality
left testis	UBERON:0004533	95.31	gold quality
right testis	UBERON:0004534	95.10	gold quality
testis	UBERON:0000473	92.20	gold quality
adult organism	UBERON:0007023	87.61	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.34	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.65	gold quality
secondary oocyte	CL:0000655	77.77	gold quality
cerebellar hemisphere	UBERON:0002245	76.58	gold quality
cerebellar cortex	UBERON:0002129	76.30	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.82	gold quality
cerebellum	UBERON:0002037	73.03	gold quality
cortical plate	UBERON:0005343	70.87	gold quality
ventricular zone	UBERON:0003053	70.10	gold quality
colonic epithelium	UBERON:0000397	70.04	gold quality
adenohypophysis	UBERON:0002196	70.04	gold quality
ganglionic eminence	UBERON:0004023	68.96	gold quality
oocyte	CL:0000023	68.64	gold quality
spleen	UBERON:0002106	68.19	gold quality
lower esophagus mucosa	UBERON:0035834	68.16	gold quality
stromal cell of endometrium	CL:0002255	68.06	gold quality
right frontal lobe	UBERON:0002810	67.50	gold quality
pituitary gland	UBERON:0000007	67.45	gold quality
mucosa of transverse colon	UBERON:0004991	67.25	gold quality
granulocyte	CL:0000094	67.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.72	gold quality
right ovary	UBERON:0002118	66.67	gold quality
nucleus accumbens	UBERON:0001882	66.33	gold quality
left ovary	UBERON:0002119	66.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long Non-Coding RNA RFPL3S Functions as a Biomarker of Prognostic and Immunotherapeutic Prediction in Testicular Germ Cell Tumor. (PMID:35669771)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.