RGL3

Summary

RGL3 (ral guanine nucleotide dissociation stimulator like 3, HGNC:30282) is a protein-coding gene on chromosome 19p13.2, encoding Ral guanine nucleotide dissociation stimulator-like 3 (Q3MIN7). Guanine nucleotide exchange factor (GEF) for Ral-A.

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in cytosol. Predicted to be active in plasma membrane.

Source: NCBI Gene 57139 — RefSeq curated summary.

At a glance

• GWAS associations: 22
• Clinical variants (ClinVar): 184 total
• MANE Select transcript: NM_001035223

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30282
Approved symbol	RGL3
Name	ral guanine nucleotide dissociation stimulator like 3
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ32585
Ensembl gene	ENSG00000205517
Ensembl biotype	protein_coding
OMIM	616743
Entrez	57139

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 15 protein_coding, 7 retained_intron, 3 protein_coding_CDS_not_defined, 3 nonsense_mediated_decay

ENST00000380456, ENST00000393423, ENST00000453604, ENST00000561570, ENST00000561687, ENST00000562663, ENST00000563436, ENST00000563726, ENST00000565895, ENST00000566153, ENST00000566919, ENST00000567080, ENST00000567431, ENST00000568420, ENST00000568628, ENST00000569439, ENST00000589032, ENST00000853010, ENST00000853011, ENST00000853012, ENST00000853013, ENST00000920282, ENST00000920283, ENST00000920284, ENST00000920285, ENST00000920286, ENST00000971805, ENST00000971806

RefSeq mRNA: 2 — MANE Select: NM_001035223 NM_001035223, NM_001161616

CCDS: CCDS32910, CCDS54221

Canonical transcript exons

ENST00000380456 — 19 exons

Exon	Start	End
ENSE00002597346	11394060	11394520
ENSE00003477844	11402650	11402706
ENSE00003489220	11402455	11402541
ENSE00003492020	11419246	11419314
ENSE00003495336	11406419	11406634
ENSE00003495481	11402011	11402132
ENSE00003503247	11399855	11399951
ENSE00003505544	11416836	11417059
ENSE00003507757	11406722	11406864
ENSE00003543241	11400202	11400297
ENSE00003555034	11416614	11416667
ENSE00003575126	11397244	11397358
ENSE00003610631	11405323	11405426
ENSE00003636755	11418671	11418784
ENSE00003638243	11402215	11402247
ENSE00003650541	11405147	11405231
ENSE00003674622	11397445	11397597
ENSE00003677413	11400040	11400108
ENSE00003790508	11415937	11416148

Expression profiles

Bgee: expression breadth ubiquitous, 178 present calls, max score 99.28.

FANTOM5 (CAGE): breadth broad, TPM avg 3.5413 / max 194.9024, expressed in 735 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179230	2.4465	641
179228	0.3217	156
179229	0.2708	150
179232	0.2531	145
179231	0.1531	73
179233	0.0961	36

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	99.28	gold quality
left lobe of thyroid gland	UBERON:0001120	99.17	gold quality
metanephros cortex	UBERON:0010533	98.44	gold quality
thyroid gland	UBERON:0002046	98.17	gold quality
body of pancreas	UBERON:0001150	96.70	gold quality
right uterine tube	UBERON:0001302	95.96	gold quality
endocervix	UBERON:0000458	94.43	gold quality
left adrenal gland cortex	UBERON:0035825	94.38	gold quality
adenohypophysis	UBERON:0002196	94.18	gold quality
right coronary artery	UBERON:0001625	94.01	gold quality
right adrenal gland	UBERON:0001233	93.85	gold quality
right adrenal gland cortex	UBERON:0035827	93.66	gold quality
right lung	UBERON:0002167	93.61	gold quality
left adrenal gland	UBERON:0001234	93.54	gold quality
apex of heart	UBERON:0002098	93.34	gold quality
right lobe of liver	UBERON:0001114	93.30	gold quality
adult mammalian kidney	UBERON:0000082	92.70	gold quality
pituitary gland	UBERON:0000007	92.41	gold quality
right atrium auricular region	UBERON:0006631	92.15	gold quality
adrenal cortex	UBERON:0001235	91.99	gold quality
pancreatic ductal cell	CL:0002079	91.82	silver quality
body of stomach	UBERON:0001161	91.74	gold quality
left coronary artery	UBERON:0001626	91.59	gold quality
ascending aorta	UBERON:0001496	91.57	gold quality
upper lobe of left lung	UBERON:0008952	91.57	gold quality
thoracic aorta	UBERON:0001515	91.42	gold quality
descending thoracic aorta	UBERON:0002345	91.32	gold quality
adrenal gland	UBERON:0002369	90.91	gold quality
aorta	UBERON:0000947	90.70	gold quality
omental fat pad	UBERON:0010414	90.60	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-111727	yes	33.16
E-ANND-3	yes	6.55

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting RGL3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6505-5P	99.73	69.25	1595
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-548V	99.29	69.47	1157
HSA-MIR-6744-3P	99.22	64.41	972
HSA-MIR-4757-5P	99.12	64.51	981
HSA-MIR-4758-3P	99.12	63.96	869
HSA-MIR-4711-3P	98.97	66.87	1020
HSA-MIR-4656	98.79	66.22	1306
HSA-MIR-330-5P	98.73	67.63	1788
HSA-MIR-323A-5P	98.59	65.13	651
HSA-MIR-6764-3P	98.44	67.64	1153
HSA-MIR-6824-3P	98.44	67.62	1154
HSA-MIR-581	98.39	67.42	835
HSA-MIR-326	98.25	66.44	1565
HSA-MIR-6773-3P	98.17	65.51	1213
HSA-MIR-615-5P	98.10	63.76	591
HSA-MIR-637	97.91	64.05	1517
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-3620-5P	97.42	63.95	792
HSA-MIR-1587	96.95	64.03	932
HSA-MIR-5702	96.68	68.21	958

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rgl3	ENSMUSG00000040146
rattus_norvegicus	Ralgdsl3	ENSRNOG00000013027

Paralogs (24): RASGRF1 (ENSG00000058335), RASGRP2 (ENSG00000068831), RAPGEF3 (ENSG00000079337), RAPGEF4 (ENSG00000091428), SOS2 (ENSG00000100485), RAPGEF1 (ENSG00000107263), RAPGEFL1 (ENSG00000108352), RAPGEF2 (ENSG00000109756), RASGRF2 (ENSG00000113319), SOS1 (ENSG00000115904), RALGPS2 (ENSG00000116191), RAPGEF5 (ENSG00000136237), RALGPS1 (ENSG00000136828), RASGEF1B (ENSG00000138670), RGL1 (ENSG00000143344), RASGEF1C (ENSG00000146090), RASGRP3 (ENSG00000152689), RAPGEF6 (ENSG00000158987), RGL4 (ENSG00000159496), RALGDS (ENSG00000160271), RASGRP4 (ENSG00000171777), RASGRP1 (ENSG00000172575), RASGEF1A (ENSG00000198915), RGL2 (ENSG00000237441)

Protein

Protein identifiers

Ral guanine nucleotide dissociation stimulator-like 3 — Q3MIN7 (reviewed: Q3MIN7)

All UniProt accessions (6): H3BN42, H3BQS8, H3BRW0, K7EIS7, K7EMV7, Q3MIN7

UniProt curated annotations — full annotation on UniProt →

Function. Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1.

Subunit / interactions. Interacts with GTP-bound forms of RIT1, HRAS and MRAS.

Domain organisation. The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.

Isoforms (2)

UniProt ID	Names	Canonical?
Q3MIN7-1	1	yes
Q3MIN7-2	2

RefSeq proteins (2): NP_001030300, NP_001155088 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000159	RA_dom	Domain
IPR000651	Ras-like_Gua-exchang_fac_N	Domain
IPR001895	RASGEF_cat_dom	Domain
IPR008937	Ras-like_GEF	Family
IPR019804	Ras_G-nucl-exch_fac_CS	Conserved_site
IPR023578	Ras_GEF_dom_sf	Homologous_superfamily
IPR029071	Ubiquitin-like_domsf	Homologous_superfamily
IPR030750	RGL3_RA	Domain
IPR036964	RASGEF_cat_dom_sf	Homologous_superfamily

Pfam: PF00617, PF00618, PF00788

UniProt features (26 total): modified residue 8, compositionally biased region 5, region of interest 5, domain 3, sequence variant 3, chain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q3MIN7-F1	73.21	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 52, 508, 512, 555, 569, 573, 591, 601

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-5673001	RAF/MAP kinase cascade

MSigDB gene sets: 57 (showing top): MODULE_169, GOMF_GTPASE_BINDING, GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION, GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, NUYTTEN_EZH2_TARGETS_DN, GOMF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY, chr19p13, GOMF_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY, GOMF_ENZYME_REGULATOR_ACTIVITY, MODULE_456, LEE_BMP2_TARGETS_UP, RATTENBACHER_BOUND_BY_CELF1, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_MAPK_FAMILY_SIGNALING_CASCADES, ESC_J1_UP_LATE.V1_UP

GO Biological Process (3): Ras protein signal transduction (GO:0007265), signal transduction (GO:0007165), small GTPase-mediated signal transduction (GO:0007264)

GO Molecular Function (3): guanyl-nucleotide exchange factor activity (GO:0005085), small GTPase binding (GO:0031267), protein binding (GO:0005515)

GO Cellular Component (2): cytosol (GO:0005829), plasma membrane (GO:0005886)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
MAPK1/MAPK3 signaling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
small GTPase-mediated signal transduction	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
intracellular signaling cassette	1
GTP binding	1
GDP binding	1
GTPase regulator activity	1
GTPase binding	1
binding	1
cytoplasm	1
cellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

458 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RGL3	RALA	P11233	615
RGL3	RALB	P11234	605
RGL3	ARAF	P07557	533
RGL3	KRAS	P01116	519
RGL3	RAF1	P04049	519
RGL3	RALGAPB	Q86X10	515
RGL3	BRAF	P15056	514
RGL3	RGL2	O15211	487
RGL3	RIT1	Q92963	476
RGL3	RRAS	P10301	462
RGL3	FIGNL2	A6NMB9	445
RGL3	RGL1	Q9NZL6	436
RGL3	MAP2K1	Q02750	429
RGL3	RALGAPA1	Q6GYQ0	412
RGL3	RRAS2	P17082	393

IntAct

61 interactions, top by confidence:

A	B	Type	Score
HRAS	RAF1	psi-mi:“MI:0914”(association)	0.980
RFXANK	RFXAP	psi-mi:“MI:0914”(association)	0.780
HRAS	RGL2	psi-mi:“MI:0914”(association)	0.660
RGL3	RRAS2	psi-mi:“MI:0915”(physical association)	0.560
RGL3	RIT2	psi-mi:“MI:0915”(physical association)	0.560
RGL3	KLHL12	psi-mi:“MI:0915”(physical association)	0.560
RGL3	FAM200A	psi-mi:“MI:0915”(physical association)	0.560
RGL3	RIT1	psi-mi:“MI:0915”(physical association)	0.560
RRAS2	RGL3	psi-mi:“MI:0915”(physical association)	0.560
NRAS	RGL3	psi-mi:“MI:0915”(physical association)	0.560
HSPB8	VWA8	psi-mi:“MI:0914”(association)	0.530
ZNRD2	MYO9A	psi-mi:“MI:0914”(association)	0.530
RGL3	CHCHD3	psi-mi:“MI:0915”(physical association)	0.400
B4GALT2	LENG9	psi-mi:“MI:0914”(association)	0.350
NPAS1	CIBAR1	psi-mi:“MI:0914”(association)	0.350
INF2	PIPSL	psi-mi:“MI:0914”(association)	0.350
PLEKHG7	MROH6	psi-mi:“MI:0914”(association)	0.350
EEF1AKMT3	SMCHD1	psi-mi:“MI:0914”(association)	0.350
HES6	RGPD3	psi-mi:“MI:0914”(association)	0.350
UBXN6	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
CLASRP	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
D2HGDH	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
PLBD1	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
PSG11	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
C9orf163	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
SULT1C4	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
CRYBB3	ARHGAP32	psi-mi:“MI:0914”(association)	0.350

BioGRID (49): RGL3 (Two-hybrid), RGL3 (Two-hybrid), RGL3 (Two-hybrid), RGL3 (Two-hybrid), NRAS (Two-hybrid), FAM200A (Two-hybrid), CHCHD3 (Proximity Label-MS), RGL3 (Affinity Capture-MS), RGL3 (Affinity Capture-MS), RGL3 (Affinity Capture-MS), RGL3 (Affinity Capture-MS), RGL3 (Affinity Capture-MS), RGL3 (Affinity Capture-MS), RGL3 (Affinity Capture-MS), RGL3 (Affinity Capture-MS)

ESM2 similar proteins: A3R064, A7MBB8, B2RYG7, D3ZZN9, E1BDF2, O60496, O70469, O94989, O95153, P97465, P97680, P98077, Q13671, Q14B98, Q1RMU7, Q3MIN7, Q3UR97, Q3UYI5, Q494U1, Q4QQV2, Q58EX7, Q5EA84, Q5FWH6, Q6ICB4, Q6PGG2, Q6ZW31, Q7L591, Q7TNF8, Q8BH49, Q8BWA8, Q8IW93, Q8IYJ3, Q8N878, Q8NAG6, Q8NFA2, Q91WA6, Q921Q7, Q92502, Q969H4, Q969T3

Diamond homologs: A2AR50, A2CEA7, B0M0P8, B0UXH6, F1M386, F1MSG6, F1PBJ0, O14827, P27671, P28818, P70392, Q03385, Q03386, Q07889, Q07890, Q12967, Q13905, Q13972, Q3MIN7, Q3UYI5, Q4R7W3, Q54FF3, Q54PQ4, Q54TK8, Q552M5, Q55GH9, Q5JS13, Q5ZJK0, Q60695, Q86G47, Q86X27, Q8CHG7, Q8IS14, Q8IS15, Q8IS16, Q8IS18, Q8IS20, Q8IS21, Q8SSQ0, Q8SSW7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 73 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
Ras protein signal transduction	7	21.8×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

184 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	141
Likely benign	11
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3547 predictions. Top by Δscore:

Variant	Effect	Δscore
19:11400035:CTCA:C	donor_loss	1.0000
19:11400036:TCACC:T	donor_loss	1.0000
19:11400037:CA:C	donor_loss	1.0000
19:11400038:A:T	donor_loss	1.0000
19:11400039:C:A	donor_loss	1.0000
19:11400105:CTTC:C	acceptor_gain	1.0000
19:11400108:CCTAA:C	acceptor_loss	1.0000
19:11400109:C:CA	acceptor_loss	1.0000
19:11400109:C:CC	acceptor_gain	1.0000
19:11400110:T:A	acceptor_loss	1.0000
19:11400200:A:AC	donor_gain	1.0000
19:11400201:C:CA	donor_gain	1.0000
19:11400201:CG:C	donor_gain	1.0000
19:11400201:CGCA:C	donor_gain	1.0000
19:11400204:A:AC	donor_gain	1.0000
19:11400205:C:CC	donor_gain	1.0000
19:11400307:CAATA:C	acceptor_gain	1.0000
19:11400308:A:T	acceptor_gain	1.0000
19:11400309:A:AC	acceptor_gain	1.0000
19:11400311:A:AC	acceptor_gain	1.0000
19:11400311:A:C	acceptor_gain	1.0000
19:11400322:G:GC	acceptor_gain	1.0000
19:11402645:CTCA:C	donor_gain	1.0000
19:11402646:TCA:T	donor_loss	1.0000
19:11402647:CACTG:C	donor_loss	1.0000
19:11402648:A:AC	donor_gain	1.0000
19:11402648:ACT:A	donor_loss	1.0000
19:11402649:C:CA	donor_gain	1.0000
19:11402649:CT:C	donor_gain	1.0000
19:11402649:CTG:C	donor_gain	1.0000

AlphaMissense

4565 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:11406436:A:G	W327R	0.998
19:11406436:A:T	W327R	0.998
19:11406521:G:C	F298L	0.998
19:11406521:G:T	F298L	0.998
19:11406523:A:G	F298L	0.998
19:11405406:G:C	N339K	0.997
19:11405406:G:T	N339K	0.997
19:11405421:G:C	C334W	0.995
19:11405374:A:G	L350P	0.994
19:11402224:C:A	K451N	0.993
19:11402224:C:G	K451N	0.993
19:11405403:G:C	F340L	0.993
19:11405403:G:T	F340L	0.993
19:11405405:A:G	F340L	0.993
19:11406423:G:T	A331D	0.993
19:11406738:A:G	L255P	0.993
19:11405337:C:A	W362C	0.992
19:11405337:C:G	W362C	0.992
19:11405423:A:G	C334R	0.992
19:11405369:A:G	S352P	0.991
19:11405377:G:T	A349D	0.991
19:11406434:C:A	W327C	0.991
19:11406434:C:G	W327C	0.991
19:11406747:G:T	A252D	0.991
19:11405339:A:G	W362R	0.990
19:11405339:A:T	W362R	0.990
19:11406455:C:A	R320S	0.989
19:11406455:C:G	R320S	0.989
19:11400286:G:A	S499F	0.988
19:11402233:G:C	N448K	0.988

dbSNP variants (sampled 300 via entrez): RS1000279978 (19:11408890 G>A), RS1000471249 (19:11408584 C>A), RS1000538774 (19:11395367 G>A), RS1000614110 (19:11407725 C>T), RS1000804433 (19:11418553 C>T), RS1000877719 (19:11418159 C>A), RS1000913166 (19:11401605 T>C), RS1001027550 (19:11401007 G>A), RS1001077940 (19:11400747 G>A,C), RS1001169516 (19:11397492 G>A,T), RS1001303959 (19:11406650 G>A,C), RS1001378226 (19:11412763 G>A), RS1001535896 (19:11409992 G>A), RS1001615312 (19:11398281 C>G), RS1001677547 (19:11402946 A>G)

Disease associations

OMIM: gene MIM:616743 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

22 associations (top):

Study	Trait	p-value
GCST004279_38	Systolic blood pressure	7.000000e-09
GCST005194_32	Coronary artery disease	2.000000e-06
GCST006020_14	Diastolic blood pressure	3.000000e-32
GCST006021_16	Systolic blood pressure	9.000000e-27
GCST006022_14	Pulse pressure	6.000000e-07
GCST006023_10	Hypertension	3.000000e-15
GCST006227_15	Diastolic blood pressure	4.000000e-28
GCST006228_16	Systolic blood pressure	1.000000e-23
GCST006229_5	Hypertension	1.000000e-14
GCST006231_4	Mean arterial pressure	7.000000e-11
GCST007094_100	Diastolic blood pressure	4.000000e-22
GCST007096_156	Pulse pressure	3.000000e-08
GCST007099_210	Systolic blood pressure	2.000000e-21
GCST007267_153	Systolic blood pressure	4.000000e-36
GCST007927_50	Medication use (beta blocking agents)	5.000000e-12
GCST007928_53	Medication use (diuretics)	8.000000e-13
GCST007929_21	Medication use (calcium channel blockers)	1.000000e-15
GCST007930_91	Medication use (agents acting on the renin-angiotensin system)	1.000000e-24
GCST009685_26	Hypertension	8.000000e-16
GCST011141_19	Hypertension	2.000000e-08
GCST90002390_522	Mean corpuscular hemoglobin	1.000000e-11
GCST90002392_61	Mean corpuscular volume	1.000000e-09

EFO canonical traits (9, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure
EFO:0006336	diastolic blood pressure
EFO:0005763	pulse pressure measurement
EFO:0006340	mean arterial pressure
EFO:0009929	Beta blocking agent use measurement
EFO:0009928	Diuretic use measurement
EFO:0009930	Calcium channel blocker use measurement
EFO:0009931	Agents acting on the renin-angiotensin system use measurement
EFO:0004527	mean corpuscular hemoglobin

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation, affects methylation, decreases expression	3
entinostat	increases expression, affects cotreatment	2
Valproic Acid	affects cotreatment, increases expression	2
bufotalin	decreases expression	1
methylmercuric chloride	increases expression	1
pirinixic acid	increases activity, increases expression, affects binding	1
bisphenol A	decreases methylation	1
sodium arsenite	decreases expression	1
butyraldehyde	decreases expression	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	decreases methylation	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	increases methylation	1
Caffeine	affects phosphorylation	1
Cisplatin	increases expression, affects cotreatment	1
Estradiol	affects cotreatment, decreases expression	1
Methapyrilene	decreases methylation	1
Ozone	affects expression, increases abundance	1
Phenylmercuric Acetate	affects cotreatment, increases expression	1
Testosterone	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Triclosan	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.