RGMB-AS1

Summary

RGMB-AS1 (RGMB antisense RNA 1, HGNC:48666) is a long non-coding RNA gene on chromosome 5q15.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48666
Approved symbol	RGMB-AS1
Name	RGMB antisense RNA 1
Location	5q15
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246763
Ensembl biotype	lncRNA
Entrez	503569
RNAcentral	URS000075F05F — lncRNA, 2053 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000498871, ENST00000501938, ENST00000505362, ENST00000505677, ENST00000515003, ENST00000652853, ENST00000657458, ENST00000668195, ENST00000812107, ENST00000812108, ENST00000812109, ENST00000812110, ENST00000812111, ENST00000812112, ENST00000812113, ENST00000812114, ENST00000812115

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000498871 — 3 exons

Exon	Start	End
ENSE00001975610	98772622	98772798
ENSE00003856309	98772967	98773139
ENSE00004210797	98769618	98771184

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 97.51.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.0760 / max 119.5375, expressed in 1121 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
62725	1.8593	1079
62726	0.0748	20
62722	0.0533	4
62721	0.0382	13
62724	0.0363	4
62720	0.0065	3
62727	0.0048	4
62723	0.0028	1

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	97.51	gold quality
right testis	UBERON:0004534	97.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.79	gold quality
testis	UBERON:0000473	93.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.96	gold quality
sural nerve	UBERON:0015488	90.94	gold quality
rectum	UBERON:0001052	89.35	gold quality
body of stomach	UBERON:0001161	86.12	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.28	gold quality
lower esophagus	UBERON:0013473	84.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.60	gold quality
stomach	UBERON:0000945	83.54	gold quality
mucosa of stomach	UBERON:0001199	82.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	82.08	gold quality
right uterine tube	UBERON:0001302	81.55	gold quality
gastrocnemius	UBERON:0001388	80.89	gold quality
tibial nerve	UBERON:0001323	80.65	gold quality
transverse colon	UBERON:0001157	80.31	gold quality
small intestine Peyer’s patch	UBERON:0003454	80.27	gold quality
stromal cell of endometrium	CL:0002255	79.89	gold quality
muscle of leg	UBERON:0001383	79.24	gold quality
colonic epithelium	UBERON:0000397	78.84	gold quality
mucosa of transverse colon	UBERON:0004991	78.63	gold quality
body of pancreas	UBERON:0001150	78.01	gold quality
small intestine	UBERON:0002108	77.33	gold quality
prostate gland	UBERON:0002367	77.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	77.25	gold quality
minor salivary gland	UBERON:0001830	75.29	gold quality
esophagus	UBERON:0001043	75.11	gold quality
fundus of stomach	UBERON:0001160	74.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• lncRNA RGMB-AS1 serves an anti-oncogenic role in hepatocellular carcinoma. (PMID:29288973)
• E2F1 promotes the transcription of lncRNA RGMB-AS1 in papillary thyroid carcinoma (PTC). (PMID:29687852)
• lncRNA RGMB-AS1 could exert as an oncogenic factor through modulating miR-22/NLRP3 pathway. (PMID:31351424)
• RGMB-AS1/miR-22-3p/NFIB axis contributes to the progression of gastric cancer. (PMID:32064882)
• LncRNA RGMB-AS1 facilitates pancreatic cancer cell proliferation and migration but inhibits cell apoptosis via miR-574-3p/PIM3 axis. (PMID:34468207)
• LncRNA RGMB-AS1 up-regulates ANKRD1 Through Competitively Sponging miR-3614-5p to Promote OSA Cell Proliferation and Invasion. (PMID:34583851)
• Long non-coding RNA RGMB-AS1 represses nasopharyngeal carcinoma progression via binding to forkhead box A1. (PMID:35184697)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.