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RHOD

gene
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Also known as RhoHP1Rho

Summary

RHOD (ras homolog family member D, HGNC:670) is a protein-coding gene on chromosome 11q13.2, encoding Rho-related GTP-binding protein RhoD (O00212). Involved in endosome dynamics.

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 29984 — RefSeq curated summary.

At a glance

  • GWAS associations: 4
  • Clinical variants (ClinVar): 29 total
  • MANE Select transcript: NM_014578

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:670
Approved symbolRHOD
Nameras homolog family member D
Location11q13.2
Locus typegene with protein product
StatusApproved
AliasesRhoHP1, Rho
Ensembl geneENSG00000173156
Ensembl biotypeprotein_coding
OMIM605781
Entrez29984

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 9 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000308831, ENST00000532559, ENST00000533360, ENST00000858135, ENST00000858136, ENST00000858137, ENST00000858138, ENST00000858139, ENST00000941015, ENST00000941016

RefSeq mRNA: 2 — MANE Select: NM_014578 NM_001300886, NM_014578

CCDS: CCDS73330, CCDS8155

Canonical transcript exons

ENST00000308831 — 5 exons

ExonStartEnd
ENSE000011870126707042567070559
ENSE000012192726707143567072017
ENSE000021529836705684767057034
ENSE000037141546706673867066847
ENSE000037248456706589667065983

Expression profiles

Bgee: expression breadth ubiquitous, 225 present calls, max score 99.14.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.3928 / max 428.5863, expressed in 1283 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
11539218.06731217
1153915.69241121
1153933.6331702

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
lower esophagus mucosaUBERON:003583499.14gold quality
esophagus mucosaUBERON:000246996.75gold quality
endometrium epitheliumUBERON:000481196.73gold quality
pancreatic ductal cellCL:000207995.89silver quality
right lobe of liverUBERON:000111494.76gold quality
tongue squamous epitheliumUBERON:000691994.46gold quality
apex of heartUBERON:000209894.18gold quality
ileal mucosaUBERON:000033193.56silver quality
skin of legUBERON:000151192.89gold quality
skin of abdomenUBERON:000141692.53gold quality
gingivaUBERON:000182892.00gold quality
gingival epitheliumUBERON:000194991.88gold quality
heart left ventricleUBERON:000208491.75gold quality
upper leg skinUBERON:000426291.75gold quality
cardiac ventricleUBERON:000208291.21gold quality
amniotic fluidUBERON:000017390.99gold quality
buccal mucosa cellCL:000233690.94gold quality
oral cavityUBERON:000016790.91gold quality
periodontal ligamentUBERON:000826690.62gold quality
zone of skinUBERON:000001490.53gold quality
right coronary arteryUBERON:000162590.52gold quality
right atrium auricular regionUBERON:000663190.46gold quality
esophagusUBERON:000104390.41gold quality
hindlimb stylopod muscleUBERON:000425290.40gold quality
squamous epitheliumUBERON:000691490.16gold quality
epithelium of esophagusUBERON:000197690.11gold quality
tibialis anteriorUBERON:000138589.98silver quality
ascending aortaUBERON:000149689.83gold quality
thoracic aortaUBERON:000151589.68gold quality
esophagus squamous epitheliumUBERON:000692089.31gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes6.58

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

6 targeting RHOD, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-582-5P99.4770.792635
HSA-MIR-57899.4668.361787
HSA-MIR-367-5P98.8467.18902
HSA-MIR-93598.8269.361072
HSA-MIR-66597.6065.641781
HSA-MIR-426496.3564.761480

Literature-anchored findings (GeneRIF, showing 28)

  • These results suggest a critical role for the CS amplitude and the balance between Rac and Rho in mechanochemical regulation of lung EC barrier. (PMID:16651639)
  • Methylophiopogonanone B appears to induce Rho activation, resulting in actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation. (PMID:17029007)
  • Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4 (PMID:17056591)
  • The data suggest that Rho-kinase dependent cell contractility contributes to global and local matrix remodeling, whereas Rho dependent activation of mDia and/or other downstream effectors regulates the structure and number of cell processes. (PMID:17342762)
  • Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain (PMID:17916560)
  • the the increased expression of p120 isoform 1 during tumor progression contributes to the invasive phenotype of cadherin-deficient carcinomas and that the N-terminal domain of p120 is a valid therapeutic target (PMID:18407999)
  • strongly activated in HTLV-1 infected T cell lines derived from HAM/TSP patients. (PMID:18552504)
  • DLC1 negatively regulates Rho/ROCK/MLC2 (PMID:18648664)
  • A previously unknown function of Brk in regulating both RhoA and Ras by phosphorylating p190 and a crucial role of this Brk-elicited signaling pathway in promoting breast malignancy. (PMID:18829532)
  • Rho mediates various phenotypes of malignant transformation by Ras and Src through its effectors, ROCK and mDia [review] (PMID:19160018)
  • Data suggest that mammalian cells have two potential steps that require active Rho for the stabilization of midzone microtubules during mitosis and cytokinesis. (PMID:19576212)
  • The expression of RhoA/Rho kinase mRNA and protein and function in the RA were significantly stronger than in the IMA, suggesting that RhoA/Rho kinase pathway may be one mechanism by which RA is more susceptible to spasm than IMA. (PMID:19682162)
  • estrogen receptor-alpha transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway (PMID:19826002)
  • Overexpression of RhoD is associated with multiple myeloma. (PMID:20528248)
  • Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments. (PMID:20630939)
  • A GTPase-deficient mutant of RhoD, RhoDG26V, causes hyperplasia and perturbed differentiation of the epidermis. (PMID:22665057)
  • Fetal RHD detection in early pregnancy using a single-exon assay in a routine clinical setting is feasible and accurate after its implementation in an unselected pregnant population. (PMID:22776962)
  • Data show that RhoD binds the actin nucleation-promoting factor WHAMM (WASp homologue associated with actin Golgi membranes and microtubules), as well as the related filamin A-binding protein FILIP1. (PMID:23087206)
  • Data from differentiating cultured erythroid precursor cells suggest that RhAG (Rh-associated glycoprotein) knockdown abolishes Rh blood group expression (RhoD; ICAM4 [intercellular adhesion molecule 4]; CD47 Rh-related antigen) in erythroid cells. (PMID:23417980)
  • RhoD interacts with ZIPK in a GTP-dependent manner and modulates stress fiber and focal adhesion reorganization. (PMID:23454120)
  • Activated p42/44-MAP kinase, Rho GTPase. (PMID:24706358)
  • It regulates relaxation of vascular smooth muscle. (PMID:24717605)
  • A novel signaling pathway involving RhoD and its binding partner WHAMM, regulate Golgi dynamics. (PMID:25746724)
  • RhoD silencing leads to increased actin filament-containing structures and disruption of cell migration and proliferation. (PMID:28196728)
  • RhoD recruits Pak6 to the plasma membrane to antagonize RhoC signaling during cell contraction and blebbing (PMID:28486133)
  • The GTPase deficient atypical Rho GTPases, which have a stalled GTPase activity, RhoD has an elevated intrinsic GDP/GTP exchange activity, rendering the protein constitutively active. (PMID:29776664)
  • The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis. (PMID:33872315)
  • Rho GTPase gene expression and breast cancer risk: a Mendelian randomization analysis. (PMID:35087170)

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusRhodENSMUSG00000041845
rattus_norvegicusRhodENSRNOG00000019220

Paralogs (22): RHOBTB2 (ENSG00000008853), RHOA (ENSG00000067560), CDC42 (ENSG00000070831), RHOBTB1 (ENSG00000072422), RHOV (ENSG00000104140), RND2 (ENSG00000108830), RND3 (ENSG00000115963), RHOU (ENSG00000116574), RHOQ (ENSG00000119729), RHOJ (ENSG00000126785), RHOT1 (ENSG00000126858), RAC2 (ENSG00000128340), RAC1 (ENSG00000136238), RHOF (ENSG00000139725), RHOT2 (ENSG00000140983), RHOB (ENSG00000143878), RHOC (ENSG00000155366), RHOBTB3 (ENSG00000164292), RHOH (ENSG00000168421), RAC3 (ENSG00000169750), RND1 (ENSG00000172602), RHOG (ENSG00000177105)

Protein

Protein identifiers

Rho-related GTP-binding protein RhoD — O00212 (reviewed: O00212)

Alternative names: Rho-related protein HP1

All UniProt accessions (2): O00212, E9PIG5

UniProt curated annotations — full annotation on UniProt →

Function. Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.

Subunit / interactions. Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.

Subcellular location. Cell membrane. Early endosome.

Tissue specificity. Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.

Similarity. Belongs to the small GTPase superfamily. Rho family.

RefSeq proteins (2): NP_001287815, NP_055393* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR001806Small_GTPaseFamily
IPR003578Small_GTPase_RhoFamily
IPR005225Small_GTP-bdDomain
IPR027417P-loop_NTPaseHomologous_superfamily

Pfam: PF00071

UniProt features (28 total): helix 9, strand 7, binding site 3, turn 2, chain 1, propeptide 1, short sequence motif 1, modified residue 1, lipid moiety-binding region 1, sequence variant 1, mutagenesis site 1

Structure

Experimental structures (PDB)

2 structures.

PDBMethodResolution (Å)
2J1LX-RAY DIFFRACTION2.5
7KDCX-RAY DIFFRACTION3.1

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-O00212-F189.340.81

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (3): 24–31; 71–75; 129–132

Post-translational modifications (2): 207, 207

Mutagenesis-validated functional residues (1):

PositionPhenotype
207abolishes endosomal localization.

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

IDPathway
R-HSA-5663220RHO GTPases Activate Formins
R-HSA-9013405RHOD GTPase cycle

MSigDB gene sets: 447 (showing top): GSE45365_NK_CELL_VS_BCELL_UP, GOBP_ACTIN_FILAMENT_BUNDLE_ORGANIZATION, MYOGENIN_Q6, GOBP_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS, BROWNE_HCMV_INFECTION_8HR_UP, LFA1_Q6, ENK_UV_RESPONSE_KERATINOCYTE_UP, GOBP_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS, GOBP_FOCAL_ADHESION_ASSEMBLY, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, AAGCCAT_MIR135A_MIR135B, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_PROTEIN_TARGETING, GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION

GO Biological Process (16): protein targeting (GO:0006605), Rho protein signal transduction (GO:0007266), fibroblast growth factor receptor signaling pathway (GO:0008543), lamellipodium assembly (GO:0030032), actin filament polymerization (GO:0030041), positive regulation of cell migration (GO:0030335), regulation of actin cytoskeleton organization (GO:0032956), positive regulation of cell adhesion (GO:0045785), focal adhesion assembly (GO:0048041), actin filament bundle assembly (GO:0051017), regulation of small GTPase mediated signal transduction (GO:0051056), regulation of focal adhesion assembly (GO:0051893), actin filament organization (GO:0007015), small GTPase-mediated signal transduction (GO:0007264), cell projection assembly (GO:0030031), response to fibroblast growth factor (GO:0071774)

GO Molecular Function (6): GTPase activity (GO:0003924), guanyl-nucleotide exchange factor activity (GO:0005085), GTP binding (GO:0005525), protein kinase binding (GO:0019901), nucleotide binding (GO:0000166), protein binding (GO:0005515)

GO Cellular Component (9): Golgi membrane (GO:0000139), mitochondrial outer membrane (GO:0005741), early endosome (GO:0005769), cytosol (GO:0005829), plasma membrane (GO:0005886), endosome membrane (GO:0010008), cell projection (GO:0042995), endosome (GO:0005768), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

CategoryPathways
RHO GTPase Effectors1
RHO GTPase cycle1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure3
small GTPase-mediated signal transduction2
actin cytoskeleton organization2
cellular component assembly2
bounding membrane of organelle2
endosome2
establishment of protein localization1
cell surface receptor protein tyrosine kinase signaling pathway1
cellular response to fibroblast growth factor stimulus1
lamellipodium organization1
plasma membrane bounded cell projection assembly1
actin polymerization or depolymerization1
protein polymerization1
cell migration1
regulation of cell migration1
positive regulation of cell motility1
regulation of actin filament-based process1
regulation of cytoskeleton organization1
cell adhesion1
regulation of cell adhesion1
positive regulation of cellular process1
cell-substrate junction assembly1
cell-matrix adhesion1
actin filament bundle organization1
regulation of intracellular signal transduction1
regulation of cell-matrix adhesion1
focal adhesion assembly1
regulation of cell-substrate junction assembly1
supramolecular fiber organization1
intracellular signaling cassette1
cell projection organization1
response to growth factor1
ribonucleoside triphosphate phosphatase activity1
GTP binding1
GDP binding1
GTPase regulator activity1
guanyl ribonucleotide binding1
purine ribonucleoside triphosphate binding1
kinase binding1
nucleoside phosphate binding1

Protein interactions and networks

STRING

2714 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
RHODPLXNB1O43157875
RHODDIAPH2O60879865
RHODDIAPH1O60610705
RHODWHAMMQ8TF30661
RHODSRCP12931593
RHODROCK1Q13464583
RHODPLXNA1Q9UIW2573
RHODANKFY1Q9P2R3567
RHODDAPK3O43293553
RHODPAK6Q9NQU5548
RHODTSTQ16762542
RHODRHOBTB3O94955506
RHODARHGDIGQ99819499
RHODMYOGP15173490
RHODRHPN1Q8TCX5471

IntAct

12 interactions, top by confidence:

ABTypeScore
RHODDAAM1psi-mi:“MI:0407”(direct interaction)0.690
RHODPLXNB2psi-mi:“MI:0914”(association)0.640
RHODDIAPH1psi-mi:“MI:0407”(direct interaction)0.590
PLXNB1RHODpsi-mi:“MI:0915”(physical association)0.400
RHODIHHpsi-mi:“MI:0915”(physical association)0.370
ADCK5RHODpsi-mi:“MI:0915”(physical association)0.370
RHODDAPK3psi-mi:“MI:0915”(physical association)0.370
ESR1ESYT2psi-mi:“MI:0914”(association)0.350

BioGRID (590): ANKFY1 (Affinity Capture-Western), ANKFY1 (Reconstituted Complex), RHOD (Two-hybrid), SPTB (Affinity Capture-MS), PLXNB2 (Affinity Capture-MS), DAAM1 (Affinity Capture-MS), TTC19 (Affinity Capture-MS), CETN3 (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), DIAPH1 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), C1orf198 (Affinity Capture-MS), C1orf198 (Affinity Capture-MS), SPTB (Affinity Capture-MS), DAAM1 (Affinity Capture-MS)

ESM2 similar proteins: D3Z8L7, E2RQ15, O00212, O13928, O77683, P06781, P10833, P35278, P46629, P51146, P51147, P51148, P52198, P57735, P61017, P61018, P61587, P61588, P97348, Q06AU6, Q0PD08, Q15669, Q1RMR4, Q23862, Q2HJ68, Q2HJG3, Q32NQ0, Q3SZA1, Q3ZC27, Q58DS9, Q58DW6, Q5R7L7, Q5R9F4, Q6SA80, Q86YS6, Q874R1, Q8BLR7, Q8BYP3, Q91ZR1, Q96AX2

Diamond homologs: A1L1L6, F4J0W4, O00212, O04369, O59781, O94844, P0CO78, P0CO79, P34144, P34150, P39722, P48554, P60763, P60764, Q17QI8, Q24814, Q298L5, Q2HJF8, Q2UM43, Q32LU1, Q35638, Q38912, Q38919, Q38937, Q39435, Q41253, Q41254, Q4I2W2, Q4PB75, Q4WN24, Q5B5L3, Q5E9M9, Q5ZM73, Q5ZM83, Q623S8, Q6C2J1, Q6CY37, Q6DIS1, Q6EP31, Q6FIR8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

29 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance20
Likely benign0
Benign1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1022 predictions. Top by Δscore:

VariantEffectΔscore
11:67057032:GAG:Gdonor_gain1.0000
11:67057032:GAGGT:Gdonor_loss1.0000
11:67057035:G:Cdonor_loss1.0000
11:67057035:G:GGdonor_gain1.0000
11:67057036:T:Adonor_loss1.0000
11:67065895:GA:Gacceptor_gain1.0000
11:67065980:GCAG:Gdonor_gain1.0000
11:67065981:CAG:Cdonor_loss1.0000
11:67065982:AG:Adonor_loss1.0000
11:67065983:GGTG:Gdonor_loss1.0000
11:67065984:G:Cdonor_loss1.0000
11:67065985:T:Adonor_loss1.0000
11:67066733:CCCA:Cacceptor_loss1.0000
11:67066735:CAGGG:Cacceptor_loss1.0000
11:67066736:A:ACacceptor_loss1.0000
11:67066736:A:AGacceptor_gain1.0000
11:67066737:G:GGacceptor_gain1.0000
11:67066846:GG:Gdonor_gain1.0000
11:67066846:GGGTA:Gdonor_loss1.0000
11:67066847:GG:Gdonor_gain1.0000
11:67070412:C:CAacceptor_gain1.0000
11:67070421:GCA:Gacceptor_loss1.0000
11:67070422:CAGTG:Cacceptor_loss1.0000
11:67070423:A:AGacceptor_gain1.0000
11:67070423:AGT:Aacceptor_gain1.0000
11:67070423:AGTG:Aacceptor_gain1.0000
11:67070424:G:GAacceptor_gain1.0000
11:67070424:GT:Gacceptor_gain1.0000
11:67070424:GTG:Gacceptor_gain1.0000
11:67070424:GTGG:Gacceptor_gain1.0000

AlphaMissense

1369 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
11:67070494:C:AR134S0.993
11:67070495:G:CR134P0.993
11:67066803:T:CF96L0.991
11:67066805:C:AF96L0.991
11:67066805:C:GF96L0.991
11:67057026:T:CF42L0.988
11:67057028:C:AF42L0.988
11:67057028:C:GF42L0.988
11:67065975:A:CD71A0.988
11:67056992:G:CK30N0.986
11:67056992:G:TK30N0.986
11:67065974:G:CD71H0.986
11:67070471:T:AV126D0.986
11:67056990:A:CK30Q0.984
11:67070425:T:AW111R0.984
11:67070425:T:CW111R0.984
11:67070484:G:CK130N0.984
11:67070484:G:TK130N0.984
11:67065975:A:TD71V0.983
11:67056991:A:CK30T0.982
11:67056991:A:TK30M0.982
11:67066824:A:CS103R0.982
11:67066826:C:AS103R0.982
11:67066826:C:GS103R0.982
11:67065914:T:CF51L0.981
11:67065916:T:AF51L0.981
11:67065916:T:GF51L0.981
11:67065976:C:AD71E0.980
11:67065976:C:GD71E0.980
11:67066802:C:GC95W0.979

dbSNP variants (sampled 300 via entrez): RS1000015276 (11:67058287 C>T), RS1000088422 (11:67058474 C>T), RS1000260392 (11:67062572 A>G), RS1000326106 (11:67063191 A>G), RS1000513718 (11:67071848 C>G), RS1000599425 (11:67065163 C>A), RS1000605759 (11:67064363 C>G), RS1000633499 (11:67064775 C>T), RS1000904414 (11:67057935 C>T), RS1000946749 (11:67071571 G>A), RS1001184509 (11:67070796 C>T), RS1001564285 (11:67071169 G>A), RS1001709159 (11:67057372 A>G), RS1001750892 (11:67070452 A>C), RS1001923103 (11:67057920 C>A,T)

Disease associations

OMIM: gene MIM:605781 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

StudyTraitp-value
GCST000817_49Height9.000000e-10
GCST002647_42Height6.000000e-15
GCST90020028_1916Hip circumference adjusted for BMI1.000000e-14
GCST90020029_342Waist circumference adjusted for body mass index4.000000e-10

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0008039BMI-adjusted hip circumference
EFO:0007789BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Benzo(a)pyrenedecreases methylation, increases expression, increases methylation2
Smokedecreases expression2
Aflatoxin B1increases expression2
Cadmium Chloridedecreases expression, increases abundance2
aristolochic acid Iincreases expression1
moringinaffects cotreatment, decreases expression1
sodium arseniteincreases expression1
3,4,3’,4’-tetrachlorobiphenylaffects expression1
S-(1,2-dichlorovinyl)cysteinedecreases expression1
epigallocatechin gallatedecreases expression1
perfluorooctane sulfonic acidincreases expression1
chloropicrindecreases expression1
dimethylarsinous acidincreases expression1
(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxidedecreases expression1
nutlin 3affects cotreatment, increases expression1
14-deoxy-11,12-didehydroandrographolidedecreases expression1
abrineincreases expression1
(+)-JQ1 compounddecreases expression1
Resveratrolaffects cotreatment, decreases expression1
Sunitinibincreases expression1
Arsenic Trioxidedecreases response to substance1
Ethanolaffects cotreatment, increases abundance, increases expression1
Atrazineincreases expression1
Cadmiumdecreases expression, increases abundance1
Camptothecinincreases expression1
Cannabidiolaffects cotreatment, decreases expression1
Carbamazepineaffects expression1
Cisplatinincreases expression1
Dactinomycinincreases expression, affects cotreatment1
Doxorubicinincreases expression1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_TI97HAP1 RHOD (-) 1Cancer cell lineMale
CVCL_TI98HAP1 RHOD (-) 2Cancer cell lineMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot