RHOF

Summary

RHOF (ras homolog family member F, filopodia associated, HGNC:15703) is a protein-coding gene on chromosome 12q24.31, encoding Rho-related GTP-binding protein RhoF (Q9HBH0). Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. It is a selective cancer dependency (DepMap: 14.2% of cell lines).

Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in actin filament organization. Located in extracellular exosome.

Source: NCBI Gene 54509 — RefSeq curated summary.

At a glance

• GWAS associations: 15
• Clinical variants (ClinVar): 39 total
• Cancer dependency (DepMap): dependent in 14.2% of screened cell lines
• MANE Select transcript: NM_019034

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15703
Approved symbol	RHOF
Name	ras homolog family member F, filopodia associated
Location	12q24.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20247, RIF
Ensembl gene	ENSG00000139725
Ensembl biotype	protein_coding
OMIM	618867
Entrez	54509

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000267205, ENST00000535560, ENST00000537171, ENST00000537265, ENST00000541657, ENST00000545544, ENST00000546227

RefSeq mRNA: 1 — MANE Select: NM_019034 NM_019034

CCDS: CCDS9222

Canonical transcript exons

ENST00000267205 — 5 exons

Exon	Start	End
ENSE00001320034	121777754	121779662
ENSE00003705133	121793152	121793239
ENSE00003708134	121781083	121781192
ENSE00003708483	121780872	121781006
ENSE00003842855	121793496	121793688

Expression profiles

Bgee: expression breadth ubiquitous, 229 present calls, max score 94.96.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 38.7424 / max 995.1086, expressed in 1682 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133758	22.9672	1312
133759	12.5225	1473
133761	1.3954	659
133763	1.1487	549
133760	0.4756	111
133757	0.1248	52
133752	0.1082	36

Top tissues by expression

269 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	94.96	gold quality
lower esophagus mucosa	UBERON:0035834	91.77	gold quality
blood	UBERON:0000178	91.43	gold quality
mucosa of transverse colon	UBERON:0004991	90.84	gold quality
apex of heart	UBERON:0002098	89.62	gold quality
lymph node	UBERON:0000029	89.05	gold quality
cartilage tissue	UBERON:0002418	88.22	gold quality
duodenum	UBERON:0002114	87.83	gold quality
jejunal mucosa	UBERON:0000399	87.25	gold quality
spleen	UBERON:0002106	86.28	gold quality
leukocyte	CL:0000738	86.09	gold quality
epithelium of nasopharynx	UBERON:0001951	85.57	gold quality
bone marrow cell	CL:0002092	85.49	gold quality
vermiform appendix	UBERON:0001154	85.38	gold quality
monocyte	CL:0000576	85.29	gold quality
mononuclear cell	CL:0000842	85.28	gold quality
colonic mucosa	UBERON:0000317	85.28	gold quality
upper lobe of left lung	UBERON:0008952	84.84	gold quality
bone marrow	UBERON:0002371	84.66	gold quality
upper lobe of lung	UBERON:0008948	84.49	gold quality
metanephros cortex	UBERON:0010533	84.44	gold quality
amniotic fluid	UBERON:0000173	84.39	gold quality
ileal mucosa	UBERON:0000331	84.27	silver quality
heart left ventricle	UBERON:0002084	84.22	gold quality
cardiac ventricle	UBERON:0002082	84.03	gold quality
adrenal tissue	UBERON:0018303	83.74	gold quality
caecum	UBERON:0001153	83.35	gold quality
small intestine	UBERON:0002108	83.30	gold quality
small intestine Peyer’s patch	UBERON:0003454	83.10	gold quality
mucosa of sigmoid colon	UBERON:0004993	83.04	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-GEOD-86618	yes	459.60
E-MTAB-8142	yes	25.44
E-MTAB-7249	yes	10.98
E-ANND-3	yes	4.84
E-CURD-120	no	7.06

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

93 targeting RHOF, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-6079	99.84	68.54	1170
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-498-5P	99.76	69.64	1807
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-10393-3P	99.72	66.56	961
HSA-MIR-6801-5P	99.72	66.50	981
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-30B-3P	99.70	65.76	2325

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 14.2% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• The protein encoded by this gene causes the formation of long, actin-rich filopodia. In combination with RAC1 and CDC42 it causes additional actin rearrangments, suggesting that this protein is intimately involved in regulation of the cytoskeleton. (PMID:11084341)
• deletion of genes RHOF in early-stage mycosis fungoides. (PMID:18663754)
• Rif GTPase is an alternative trigger of stress-fiber formation in epithelial cells. (PMID:20233848)
• The authors show that enteropathogenic Escherichia coli translocates EspH, which inactivates mammalian RhoGEFs and triggers cytotoxicity. (PMID:22251971)
• In the present review, our aim is to summarize the current information about the Rif effectors and how Rif remodels actin cytoskeleton in many aspects. [Review] (PMID:22260703)
• Rif has two separate roles in FARP1 regulation-in controlling its association with plexinA4, and in releasing active RhoA from a plexinA4/FARP1 complex. (PMID:25668492)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	rhof	ENSDARG00000054389
mus_musculus	Rhof	ENSMUSG00000029449
rattus_norvegicus	Rhof	ENSRNOG00000042607

Paralogs (22): RHOBTB2 (ENSG00000008853), RHOA (ENSG00000067560), CDC42 (ENSG00000070831), RHOBTB1 (ENSG00000072422), RHOV (ENSG00000104140), RND2 (ENSG00000108830), RND3 (ENSG00000115963), RHOU (ENSG00000116574), RHOQ (ENSG00000119729), RHOJ (ENSG00000126785), RHOT1 (ENSG00000126858), RAC2 (ENSG00000128340), RAC1 (ENSG00000136238), RHOT2 (ENSG00000140983), RHOB (ENSG00000143878), RHOC (ENSG00000155366), RHOBTB3 (ENSG00000164292), RHOH (ENSG00000168421), RAC3 (ENSG00000169750), RND1 (ENSG00000172602), RHOD (ENSG00000173156), RHOG (ENSG00000177105)

Protein

Protein identifiers

Rho-related GTP-binding protein RhoF — Q9HBH0 (reviewed: Q9HBH0)

Alternative names: Rho family GTPase Rif, Rho in filopodia

All UniProt accessions (5): Q9HBH0, F5GXB1, V9GY67, V9GYB3, V9GYQ1

UniProt curated annotations — full annotation on UniProt →

Function. Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.

Subcellular location. Cell membrane. Cytoplasm. Cytoskeleton.

Similarity. Belongs to the small GTPase superfamily. Rho family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9HBH0-1	1	yes
Q9HBH0-2	2

RefSeq proteins (1): NP_061907* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001806	Small_GTPase	Family
IPR003578	Small_GTPase_Rho	Family
IPR005225	Small_GTP-bd	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily

Pfam: PF00071

UniProt features (13 total): binding site 3, splice variant 2, sequence conflict 2, modified residue 2, chain 1, propeptide 1, short sequence motif 1, lipid moiety-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HBH0-F1	92.25	0.83

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (3): 26–33; 73–77; 131–134

Post-translational modifications (3): 1, 208, 208

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation
R-HSA-9035034	RHOF GTPase cycle

MSigDB gene sets: 232 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_UP, REACTOME_INNATE_IMMUNE_SYSTEM, GOCC_SECRETORY_GRANULE, GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, RODRIGUES_NTN1_TARGETS_DN, GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS, AMIT_EGF_RESPONSE_480_MCF10A, RICKMAN_METASTASIS_DN, KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP, WOO_LIVER_CANCER_RECURRENCE_UP, GOBP_ACTIN_FILAMENT_ORGANIZATION, GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOBP_REGULATION_OF_CYTOSKELETON_ORGANIZATION, GOCC_SECRETORY_VESICLE, AACATTC_MIR4093P

GO Biological Process (6): actin filament organization (GO:0007015), signal transduction (GO:0007165), small GTPase-mediated signal transduction (GO:0007264), cell migration (GO:0016477), regulation of actin cytoskeleton organization (GO:0032956), regulation of small GTPase mediated signal transduction (GO:0051056)

GO Molecular Function (5): GTPase activity (GO:0003924), guanyl-nucleotide exchange factor activity (GO:0005085), GTP binding (GO:0005525), protein kinase binding (GO:0019901), nucleotide binding (GO:0000166)

GO Cellular Component (7): cytosol (GO:0005829), cytoskeleton (GO:0005856), plasma membrane (GO:0005886), secretory granule membrane (GO:0030667), extracellular exosome (GO:0070062), cytoplasm (GO:0005737), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Innate Immune System	1
RHO GTPase cycle	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
actin cytoskeleton organization	2
supramolecular fiber organization	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
intracellular signaling cassette	1
cell motility	1
regulation of actin filament-based process	1
regulation of cytoskeleton organization	1
small GTPase-mediated signal transduction	1
regulation of intracellular signal transduction	1
ribonucleoside triphosphate phosphatase activity	1
GTP binding	1
GDP binding	1
GTPase regulator activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
kinase binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
cytoplasm	1
intracellular membraneless organelle	1
membrane	1
cell periphery	1
secretory granule	1
cytoplasmic vesicle membrane	1
bounding membrane of organelle	1
extracellular vesicle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

3156 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RHOF	DOCK10	Q96BY6	596
RHOF	TMEM120B	A0PK00	563
RHOF	DIAPH3	Q9NSV4	478
RHOF	RHOBTB3	O94955	475
RHOF	SOWAHA	Q2M3V2	452
RHOF	SYDE2	Q5VT97	445
RHOF	GTPBP4	Q9BZE4	426
RHOF	ARRDC2	Q8TBH0	418
RHOF	RASL11B	Q9BPW5	410
RHOF	NIBAN2	Q96TA1	410
RHOF	ARHGDIA	P52565	405
RHOF	CNKSR1	Q969H4	402
RHOF	ARHGDIG	Q99819	391
RHOF	DOCK5	Q9H7D0	390
RHOF	RHOB	P01121	385

IntAct

39 interactions, top by confidence:

A	B	Type	Score
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
RAP1GDS1	DIRAS1	psi-mi:“MI:0914”(association)	0.640
DIAPH1	RHOF	psi-mi:“MI:0407”(direct interaction)	0.440
Tor1aip1	PEX10	psi-mi:“MI:0914”(association)	0.350
Cep78	ING5	psi-mi:“MI:0914”(association)	0.350
GAR1	TAF1	psi-mi:“MI:0914”(association)	0.350
Mta2	MTA3	psi-mi:“MI:0914”(association)	0.350
RALA	AKR7A2	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
MAD2L2		psi-mi:“MI:0914”(association)	0.350
	HLA-C	psi-mi:“MI:0914”(association)	0.350
TTC9C	PLD2	psi-mi:“MI:0914”(association)	0.350
LY86	PLXNB2	psi-mi:“MI:0914”(association)	0.350
RHOF	GSTT1	psi-mi:“MI:0914”(association)	0.350
KLRD1	TMEM131L	psi-mi:“MI:0914”(association)	0.350
UPK2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
LYZL2	POTEF	psi-mi:“MI:0914”(association)	0.350
ADAM7	RIOK3	psi-mi:“MI:0914”(association)	0.350
HLA-B	RAB29	psi-mi:“MI:0914”(association)	0.350
RHOF	STIP1	psi-mi:“MI:0914”(association)	0.350
TTC9C	LIPA	psi-mi:“MI:0914”(association)	0.350
AFG2A	ESYT2	psi-mi:“MI:0914”(association)	0.350
POLD3	ESYT2	psi-mi:“MI:0914”(association)	0.350
AFG2B	MMP24OS	psi-mi:“MI:0914”(association)	0.350
C1QTNF9B	DNASE2	psi-mi:“MI:0914”(association)	0.350
DNAJA2	ENC1	psi-mi:“MI:0914”(association)	0.350
LY86	MAP2K7	psi-mi:“MI:0914”(association)	0.350
LYPD1	ADAM10	psi-mi:“MI:0914”(association)	0.350
MIS18A	CCDC85C	psi-mi:“MI:0914”(association)	0.350
NPTN	RIMOC1	psi-mi:“MI:0914”(association)	0.350

BioGRID (686): RHOF (Affinity Capture-RNA), RHOF (Affinity Capture-RNA), RHOF (Affinity Capture-RNA), ANKFY1 (Affinity Capture-Western), RHOF (Two-hybrid), RHOF (Affinity Capture-MS), RHOF (Affinity Capture-MS), RHOF (Affinity Capture-MS), RHOF (Affinity Capture-MS), RHOF (Affinity Capture-MS), RHOF (Affinity Capture-MS), NAA25 (Affinity Capture-MS), RAP1GDS1 (Affinity Capture-MS), CCT6B (Affinity Capture-MS), RHOF (Affinity Capture-RNA)

ESM2 similar proteins: A8NU18, D3Z8L7, G4N1S3, O08989, O14807, O42785, O93856, O95716, P01114, P08647, P0CQ42, P0CQ43, P10301, P10833, P22126, P28775, P35276, P46629, P51146, P51156, P56371, P59190, P61017, P61018, P62070, P62071, P70425, P70426, P97538, Q01387, Q05058, Q12526, Q1RMR4, Q29RR0, Q3SZA1, Q4X241, Q53B90, Q5BJQ5, Q63942, Q86YS6

Diamond homologs: A0A286QZ36, C4YDI6, O00212, O42825, O76321, O77683, O88931, O96390, P01122, P06780, P08134, P0CY33, P15153, P17081, P19073, P22122, P24406, P34144, P34145, P34146, P34148, P34149, P34150, P40792, P40793, P48148, P48554, P52198, P60763, P60764, P60766, P60952, P60953, P61585, P61586, P61587, P61588, P61589, P62745, P62746

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

39 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	31
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

942 predictions. Top by Δscore:

Variant	Effect	Δscore
12:121779658:AGGCC:A	acceptor_gain	1.0000
12:121779659:GGCC:G	acceptor_gain	1.0000
12:121779660:GCC:G	acceptor_gain	1.0000
12:121779661:CC:C	acceptor_gain	1.0000
12:121779661:CCC:C	acceptor_gain	1.0000
12:121779662:CC:C	acceptor_gain	1.0000
12:121779663:C:CC	acceptor_gain	1.0000
12:121779663:C:T	acceptor_gain	1.0000
12:121779667:G:C	acceptor_gain	1.0000
12:121779667:G:GC	acceptor_gain	1.0000
12:121780867:CCCA:C	donor_loss	1.0000
12:121780868:CCAC:C	donor_loss	1.0000
12:121780869:CA:C	donor_loss	1.0000
12:121780870:A:C	donor_loss	1.0000
12:121780871:C:CT	donor_loss	1.0000
12:121780874:G:A	donor_gain	1.0000
12:121780976:C:CT	acceptor_gain	1.0000
12:121780976:C:T	acceptor_gain	1.0000
12:121781002:AACCA:A	acceptor_gain	1.0000
12:121781003:ACCA:A	acceptor_gain	1.0000
12:121781004:CCA:C	acceptor_gain	1.0000
12:121781004:CCAC:C	acceptor_gain	1.0000
12:121781005:CA:C	acceptor_gain	1.0000
12:121781005:CACTG:C	acceptor_gain	1.0000
12:121781007:C:CC	acceptor_gain	1.0000
12:121781008:T:G	acceptor_loss	1.0000
12:121781077:CCTCA:C	donor_loss	1.0000
12:121781078:CTCA:C	donor_loss	1.0000
12:121781079:TCACC:T	donor_loss	1.0000
12:121781080:CAC:C	donor_loss	1.0000

AlphaMissense

1363 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:121781006:A:G	W113R	0.999
12:121781006:A:T	W113R	0.999
12:121781104:G:C	S105R	0.999
12:121781104:G:T	S105R	0.999
12:121781106:T:G	S105R	0.999
12:121793160:T:A	D73V	0.999
12:121793160:T:C	D73G	0.999
12:121793160:T:G	D73A	0.999
12:121779613:G:A	S174F	0.998
12:121780947:C:A	K132N	0.998
12:121780947:C:G	K132N	0.998
12:121780954:C:T	G130D	0.998
12:121780983:G:C	F120L	0.998
12:121780983:G:T	F120L	0.998
12:121780985:A:G	F120L	0.998
12:121781128:G:C	C97W	0.998
12:121793161:C:G	D73H	0.998
12:121793219:G:C	F53L	0.998
12:121793219:G:T	F53L	0.998
12:121793221:A:G	F53L	0.998
12:121793502:G:C	F44L	0.998
12:121793502:G:T	F44L	0.998
12:121793504:A:G	F44L	0.998
12:121793536:G:A	T33I	0.998
12:121793538:C:A	K32N	0.998
12:121793538:C:G	K32N	0.998
12:121793539:T:A	K32M	0.998
12:121793540:T:G	K32Q	0.998
12:121793542:C:T	G31D	0.998
12:121793557:C:A	G26V	0.998

dbSNP variants (sampled 300 via entrez): RS1000148507 (12:121795445 G>A), RS1000233999 (12:121782059 C>T), RS1000284728 (12:121781892 T>C,G), RS1000363191 (12:121793293 T>C), RS1000372640 (12:121791770 G>C), RS1000566563 (12:121783365 A>C,G), RS1000585640 (12:121782693 C>T), RS1000618760 (12:121783073 T>A), RS1000727647 (12:121788782 G>A), RS1000794136 (12:121787589 T>C), RS1001384056 (12:121791730 G>C), RS1001401152 (12:121778428 G>A,C), RS1001679201 (12:121786521 C>A), RS1001717895 (12:121788243 T>C), RS1001748925 (12:121788006 T>G)

Disease associations

OMIM: gene MIM:618867 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

15 associations (top):

Study	Trait	p-value
GCST004599_196	Mean platelet volume	0.000000e+00
GCST004603_124	Platelet count	1.000000e-45
GCST004607_85	Plateletcrit	6.000000e-81
GCST004616_97	Platelet distribution width	1.000000e-184
GCST004619_216	Reticulocyte fraction of red cells	3.000000e-09
GCST008167_4	Mean platelet volume	8.000000e-11
GCST90002385_7	High light scatter reticulocyte count	3.000000e-10
GCST90002386_340	High light scatter reticulocyte percentage of red cells	4.000000e-13
GCST90002387_130	Immature fraction of reticulocytes	8.000000e-11
GCST90002395_145	Mean platelet volume	0.000000e+00
GCST90002400_735	Plateletcrit	9.000000e-196
GCST90002401_51	Platelet distribution width	2.000000e-212
GCST90002402_206	Platelet count	4.000000e-127
GCST90002405_246	Reticulocyte count	7.000000e-17
GCST90002406_351	Reticulocyte fraction of red cells	3.000000e-22

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004309	platelet count
EFO:0007985	platelet crit
EFO:0007984	platelet component distribution width
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	8
entinostat	affects cotreatment, increases expression	2
Air Pollutants	decreases expression, increases abundance	2
Smoke	decreases expression, increases abundance	2
Cyclosporine	increases expression	2
Cadmium Chloride	increases expression	2
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	increases expression, affects binding, increases activity	1
beta-lapachone	increases expression	1
sulforaphane	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
ochratoxin A	affects binding	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
beta-hydroxy simvastatin acid	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
NSC 689534	affects binding, increases expression	1
PCI 5002	increases expression, affects cotreatment	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic Trioxide	decreases response to substance	1
Troglitazone	increases expression	1
Adenosine Triphosphate	increases expression, decreases reaction	1
Benzene	increases expression	1
Copper	affects binding, increases expression	1
Estradiol	increases expression	1
Lipopolysaccharides	increases expression, affects response to substance	1
Methotrexate	increases expression	1
Methyl Methanesulfonate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.