RHPN1-AS1

Summary

RHPN1-AS1 (RHPN1 antisense RNA 1, HGNC:28457) is a long non-coding RNA gene on chromosome 8q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28457
Approved symbol	RHPN1-AS1
Name	RHPN1 antisense RNA 1
Location	8q24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC3113
Ensembl gene	ENSG00000254389
Ensembl biotype	lncRNA
Entrez	78998
RNAcentral	URS000075C57E — lncRNA, 2030 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000518049

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000518049 — 1 exons

Exon	Start	End
ENSE00004280255	143366422	143368637

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 81.80.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3763 / max 28.5061, expressed in 598 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95466	0.8821	438
95467	0.4942	263

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.80	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.67	gold quality
pancreatic ductal cell	CL:0002079	74.42	silver quality
ileal mucosa	UBERON:0000331	69.08	silver quality
buccal mucosa cell	CL:0002336	67.84	gold quality
ventricular zone	UBERON:0003053	66.11	gold quality
tibialis anterior	UBERON:0001385	65.85	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	62.64	gold quality
ganglionic eminence	UBERON:0004023	62.08	gold quality
secondary oocyte	CL:0000655	62.07	gold quality
right uterine tube	UBERON:0001302	60.12	gold quality
sperm	CL:0000019	60.10	gold quality
cortical plate	UBERON:0005343	59.66	silver quality
oviduct epithelium	UBERON:0004804	59.63	silver quality
male germ cell	CL:0000015	59.48	gold quality
choroid plexus epithelium	UBERON:0003911	59.06	gold quality
islet of Langerhans	UBERON:0000006	58.63	gold quality
bronchial epithelial cell	CL:0002328	58.24	silver quality
right lobe of thyroid gland	UBERON:0001119	57.86	gold quality
deltoid	UBERON:0001476	57.05	gold quality
left lobe of thyroid gland	UBERON:0001120	57.02	gold quality
fallopian tube	UBERON:0003889	57.02	gold quality
thyroid gland	UBERON:0002046	56.65	gold quality
embryo	UBERON:0000922	56.39	gold quality
muscle of leg	UBERON:0001383	56.19	gold quality
upper leg skin	UBERON:0004262	56.17	silver quality
prefrontal cortex	UBERON:0000451	56.12	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.04	gold quality
gastrocnemius	UBERON:0001388	55.71	gold quality
oocyte	CL:0000023	55.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• RHPN1-AS1 could be an oncoRNA in uveal melanoma (UM), which may serve as a candidate prognostic biomarker and target for new therapies in malignant UM. (PMID:28124977)
• RHPN1-AS1 is a molecular sponge of miR-4261, and direct transcriptional target of c-Myc. (PMID:31089812)
• Investigation showed that miR-299-3p was targeted and inversely regulated by RHPN1-AS1. In addition, miR-299-3p targeted the 3’ untranslated region of fibroblast growth factor 2 (FGF2) to suppress its expression. (PMID:31525429)
• RHPN1-AS1 Drives the Progression of Hepatocellular Carcinoma via Regulating miR-596/IGF2BP2 Axis. (PMID:31692433)
• lncRNA RHPN1-AS1 promotes the progression of endometrial cancer through the activation of ERK/MAPK pathway. (PMID:33169491)
• lncRNA RHPN1-AS1 Serves as a Sponge for miR-3133 Modulating the Cell Proliferation of Retinoblastoma through JAK2. (PMID:33426053)
• RHPN1AS1 promotes ovarian carcinogenesis by sponging miR4855p and releasing TPX2 mRNA. (PMID:33907841)
• LncRNA RHPN1-AS1 promotes the progression of nasopharyngeal carcinoma by targeting CELF2 expression. (PMID:34358519)
• RHPN1AS1 promotes ovarian carcinogenesis by sponging miR68845p thus releasing TOP2A mRNA. (PMID:34414458)
• Rhophilin rho GTPase binding protein 1-antisense RNA 1 (RHPN1-AS1) promotes ovarian carcinogenesis by sponging microRNA-485-5p and releasing DNA topoisomerase II alpha (TOP2A). (PMID:34787052)
• LncRNA RHPN1-AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR-7-5p/EGFR/PI3K/AKT/mTOR signaling pathway. (PMID:36125241)
• METTL3-mediated m6A modification of lnc RNA RHPN1-AS1 enhances cisplatin resistance in ovarian cancer by activating PI3K/AKT pathway. (PMID:36336887)
• Roles, biological functions, and clinical significances of RHPN1-AS1 in cancer. (PMID:37285733)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.