RIC8B

Summary

RIC8B (RIC8 guanine nucleotide exchange factor B, HGNC:25555) is a protein-coding gene on chromosome 12q23.3, encoding Chaperone Ric-8B (Q9NVN3). Chaperone that specifically binds and folds nascent G(s) G-alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane.

Enables G-protein alpha-subunit binding activity. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in centrosome; cytosol; and plasma membrane.

Source: NCBI Gene 55188 — RefSeq curated summary.

At a glance

• GWAS associations: 25
• Clinical variants (ClinVar): 43 total
• MANE Select transcript: NM_001330145

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25555
Approved symbol	RIC8B
Name	RIC8 guanine nucleotide exchange factor B
Location	12q23.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10620, hSyn, RIC8
Ensembl gene	ENSG00000111785
Ensembl biotype	protein_coding
OMIM	609147
Entrez	55188

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 6 protein_coding, 4 nonsense_mediated_decay, 2 retained_intron

ENST00000355478, ENST00000392837, ENST00000392839, ENST00000462949, ENST00000470628, ENST00000470960, ENST00000546449, ENST00000548914, ENST00000549643, ENST00000550215, ENST00000551756, ENST00000552619

RefSeq mRNA: 10 — MANE Select: NM_001330145 NM_001330145, NM_001330146, NM_001330147, NM_001351361, NM_001351362, NM_001351363, NM_001351364, NM_001351366, NM_001351367, NM_018157

CCDS: CCDS81733, CCDS81734, CCDS86331, CCDS9109

Canonical transcript exons

ENST00000392837 — 10 exons

Exon	Start	End
ENSE00001688673	106885904	106889316
ENSE00003507867	106774682	106774829
ENSE00003525714	106783997	106784044
ENSE00003532843	106814696	106815304
ENSE00003535310	106842589	106842817
ENSE00003553505	106825726	106825820
ENSE00003609511	106851450	106851594
ENSE00003610462	106843852	106843947
ENSE00003628202	106870823	106870942
ENSE00003637066	106860268	106860412

Expression profiles

Bgee: expression breadth ubiquitous, 270 present calls, max score 89.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.0734 / max 121.5649, expressed in 1436 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
127838	2.1808	1024
127837	1.5100	811
127839	0.3826	150

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	89.48	gold quality
caudate nucleus	UBERON:0001873	89.47	gold quality
putamen	UBERON:0001874	88.96	gold quality
ganglionic eminence	UBERON:0004023	87.64	gold quality
ventricular zone	UBERON:0003053	87.33	gold quality
nucleus accumbens	UBERON:0001882	86.85	gold quality
cortical plate	UBERON:0005343	86.76	gold quality
adrenal tissue	UBERON:0018303	86.27	gold quality
islet of Langerhans	UBERON:0000006	86.14	gold quality
pancreatic ductal cell	CL:0002079	85.96	silver quality
right lobe of thyroid gland	UBERON:0001119	85.70	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	85.11	gold quality
left lobe of thyroid gland	UBERON:0001120	84.72	gold quality
cerebellar cortex	UBERON:0002129	84.68	gold quality
cerebellar hemisphere	UBERON:0002245	84.66	gold quality
gall bladder	UBERON:0002110	84.59	gold quality
calcaneal tendon	UBERON:0003701	84.47	gold quality
thyroid gland	UBERON:0002046	84.24	gold quality
embryo	UBERON:0000922	84.12	gold quality
cerebellum	UBERON:0002037	84.09	gold quality
sural nerve	UBERON:0015488	84.03	gold quality
popliteal artery	UBERON:0002250	83.53	gold quality
tibial artery	UBERON:0007610	83.52	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.36	gold quality
pancreas	UBERON:0001264	83.29	gold quality
heart left ventricle	UBERON:0002084	83.29	gold quality
tibial nerve	UBERON:0001323	83.28	gold quality
cardiac ventricle	UBERON:0002082	83.24	gold quality
cerebellar vermis	UBERON:0004720	83.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.34

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CEBPB, SMARCA1

miRNA regulators (miRDB)

146 targeting RIC8B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515

Literature-anchored findings (GeneRIF, showing 4)

• We identified a protein member of the synembryn family as one of the interacting proteins in human brain. Gqalpha also interacts with synembryn. Synembryn translocates to the plasma membrane in response to carbachol and isoproterenol. (PMID:12652642)
• Ric-8B plays a critical and specific role in the control of G alpha(s) protein levels by modulating G alpha(s) ubiquitination and positively regulates G(s) signaling (PMID:20133939)
• these data show the existence of functional CREB and C/EBP binding sites in the human RIC8B gene promoter, a particular distribution of these sites and demonstrate a relevant role of CREB in stimulating transcriptional activity of this gene. (PMID:26729411)
• overexpression of ARMS blocked NGF-mediated secretion, without affecting basal secretion, a decrease in ARMS resulted in potentiation. Similar effects were observed with synembryn-B, a protein that interacts directly with ARMS. Downstream of ARMS and synembryn-B are Galphaq and Trio proteins, which modulate the activity of Rac1 in response to NGF (PMID:26966186)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ric8b	ENSDARG00000005972
mus_musculus	Ric8b	ENSMUSG00000035620
rattus_norvegicus	Ric8b	ENSRNOG00000007323
drosophila_melanogaster	ric8a	FBGN0028292
caenorhabditis_elegans		WBGENE00004367

Paralogs (1): RIC8A (ENSG00000177963)

Protein

Protein identifiers

Chaperone Ric-8B — Q9NVN3 (reviewed: Q9NVN3)

Alternative names: Brain synembryn, Synembryn-B

All UniProt accessions (7): Q9NVN3, B7WPL0, F8VR30, F8VSN5, F8VY51, H0YHS3, J3QRA4

UniProt curated annotations — full annotation on UniProt →

Function. Chaperone that specifically binds and folds nascent G(s) G-alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane. Also acts as a guanine nucleotide exchange factor (GEF) for G(s) proteins by stimulating exchange of bound GDP for free GTP. Acts as an important component for odorant signal transduction by mediating GNAL (G(olf)-alpha) folding, thereby promoting-dependent cAMP accumulation in olfactory sensory neurons.

Subunit / interactions. Interacts with GDP-bound G alpha proteins, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

Subcellular location. Cytoplasm. Cell cortex.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the synembryn family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9NVN3-5	5	yes
Q9NVN3-1	1
Q9NVN3-3	3
Q9NVN3-4	4

RefSeq proteins (10): NP_001317074, NP_001317075, NP_001317076, NP_001338290, NP_001338291, NP_001338292, NP_001338293, NP_001338295, NP_001338296, NP_060627 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008376	Chaperone_Ric-8_A/B	Domain
IPR011989	ARM-like	Homologous_superfamily
IPR016024	ARM-type_fold	Homologous_superfamily
IPR019318	Gua_nucleotide_exch_fac_Ric8	Family

Pfam: PF10165

UniProt features (11 total): splice variant 5, modified residue 2, chain 1, region of interest 1, sequence conflict 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NVN3-F1	86.41	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 468, 473

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 137 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, AGTCTTA_MIR499, GOBP_PROTEIN_MATURATION, GOBP_PROTEIN_FOLDING, BENPORATH_NOS_TARGETS, GOBP_SENSORY_PERCEPTION, ACTTTAT_MIR1425P, CCAGGGG_MIR331, ACEVEDO_LIVER_CANCER_UP, PARENT_MTOR_SIGNALING_UP, BENPORATH_OCT4_TARGETS, AACATTC_MIR4093P, GOMF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY, CHEN_HOXA5_TARGETS_9HR_UP, GOMF_G_PROTEIN_ALPHA_SUBUNIT_BINDING

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), regulation of G protein-coupled receptor signaling pathway (GO:0008277), protein folding (GO:0006457)

GO Molecular Function (3): G-protein alpha-subunit binding (GO:0001965), guanyl-nucleotide exchange factor activity (GO:0005085), protein folding chaperone (GO:0044183)

GO Cellular Component (5): cytoplasm (GO:0005737), centrosome (GO:0005813), cytosol (GO:0005829), plasma membrane (GO:0005886), cell cortex (GO:0005938)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoplasm	2
cell periphery	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
regulation of signal transduction	1
cellular process	1
protein maturation	1
protein binding	1
GTP binding	1
GDP binding	1
GTPase regulator activity	1
molecular_function	1
protein folding	1
intracellular anatomical structure	1
centriole	1
microtubule organizing center	1
membrane	1

Protein interactions and networks

STRING

968 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RIC8B	SYN1	P17600	872
RIC8B	SYN3	O14994	840
RIC8B	SYN2	Q92777	818
RIC8B	RABIF	P47224	784
RIC8B	TMTC1	Q8IUR5	784
RIC8B	GNAL	P38405	781
RIC8B	GNAQ	P50148	711
RIC8B	SLC32A1	Q9H598	696
RIC8B	SLC17A6	Q9P2U8	696
RIC8B	GNAI3	P08754	694
RIC8B	SUCLG1	P53597	679
RIC8B	RTP1	P59025	665
RIC8B	PVALB	P20472	623
RIC8B	CAMK2A	Q9UQM7	622
RIC8B	FOS	P01100	621

IntAct

33 interactions, top by confidence:

A	B	Type	Score
TFDP3	E2F3	psi-mi:“MI:0914”(association)	0.530
TIGD5	P4HA2	psi-mi:“MI:0914”(association)	0.530
NAP1L1	FNTB	psi-mi:“MI:0914”(association)	0.530
UBE2O	RPL23	psi-mi:“MI:0914”(association)	0.530
NAP1L1	H2AC11	psi-mi:“MI:0914”(association)	0.530
GNAS	CPT2	psi-mi:“MI:0914”(association)	0.530
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
JAK3	PIK3R2	psi-mi:“MI:0914”(association)	0.350
PPP4R1L	IFT56	psi-mi:“MI:0914”(association)	0.350
LINC01587	UBA6	psi-mi:“MI:0914”(association)	0.350
OVOL2	TNPO2	psi-mi:“MI:0914”(association)	0.350
OCIAD1	BTAF1	psi-mi:“MI:0914”(association)	0.350
ZHX1-C8orf76	FANCG	psi-mi:“MI:0914”(association)	0.350
BORCS8	TP73	psi-mi:“MI:0914”(association)	0.350
AARSD1	MAP3K7	psi-mi:“MI:0914”(association)	0.350
CPNE9	RAD21	psi-mi:“MI:0914”(association)	0.350
GNAI2	GNG7	psi-mi:“MI:0914”(association)	0.350
RIC8B	GNAS	psi-mi:“MI:0914”(association)	0.350
MAGED2	PTPN6	psi-mi:“MI:0914”(association)	0.350
CEP41	ATP12A	psi-mi:“MI:0914”(association)	0.350
ABHD8	RIC8B	psi-mi:“MI:0914”(association)	0.350
KLHL34	IFT56	psi-mi:“MI:0914”(association)	0.350
SULT1C4	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
UPP1	A2ML1	psi-mi:“MI:0914”(association)	0.350
NUBP2	TK2	psi-mi:“MI:0914”(association)	0.350
PPM1M	GAK	psi-mi:“MI:0914”(association)	0.350
VWA2	RECQL4	psi-mi:“MI:0914”(association)	0.350
MAGED2	AMY1A	psi-mi:“MI:0914”(association)	0.350
PHETA2	INPP5B	psi-mi:“MI:0914”(association)	0.350
MAGED2	PJA2	psi-mi:“MI:0914”(association)	0.350

BioGRID (61): RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), GNAS (Reconstituted Complex), GNAQ (Reconstituted Complex), RIC8B (Two-hybrid), RIC8B (Two-hybrid)

ESM2 similar proteins: A0A571BF63, A0JMA8, A1A535, A1A5P5, A4D1P6, A8XSV3, B0BF33, D3ZY60, E7F187, Q05B30, Q09263, Q14156, Q14738, Q14D04, Q19317, Q28653, Q2HJE1, Q2KI89, Q4R6I5, Q5JWR5, Q5PQS3, Q5R629, Q5SPP5, Q5U245, Q5XUN4, Q5ZLL7, Q61QK6, Q620W3, Q62240, Q641A2, Q68F70, Q6IV68, Q6ZQ18, Q7TMQ7, Q7Z3E5, Q80XE1, Q80Y84, Q80ZG0, Q8BG67, Q8BL99

Diamond homologs: Q29IC2, Q3TIR3, Q45TX8, Q4R720, Q5E9J8, Q5R8F5, Q5ZL77, Q61A92, Q642H7, Q6DRJ9, Q6P4W7, Q80XE1, Q80ZG0, Q80ZG1, Q9NPQ8, Q9NVN3, Q9W358, Q9GSX9

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
GNAL	“up-regulates activity”	RIC8B	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	31
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1914 predictions. Top by Δscore:

Variant	Effect	Δscore
12:106774826:CAAGG:C	donor_loss	1.0000
12:106774827:AAG:A	donor_loss	1.0000
12:106774828:AGG:A	donor_loss	1.0000
12:106783996:GCATA:G	acceptor_gain	1.0000
12:106805254:G:GG	donor_gain	1.0000
12:106814690:TTTCA:T	acceptor_loss	1.0000
12:106814692:TCAG:T	acceptor_loss	1.0000
12:106814693:CAG:C	acceptor_loss	1.0000
12:106814694:A:AG	acceptor_gain	1.0000
12:106814694:AGAA:A	acceptor_loss	1.0000
12:106814695:G:GG	acceptor_gain	1.0000
12:106814695:G:GT	acceptor_loss	1.0000
12:106814695:GA:G	acceptor_gain	1.0000
12:106814695:GAA:G	acceptor_gain	1.0000
12:106814695:GAAA:G	acceptor_gain	1.0000
12:106842587:A:AG	acceptor_gain	1.0000
12:106842588:G:GA	acceptor_gain	1.0000
12:106842588:GC:G	acceptor_gain	1.0000
12:106842588:GCAAT:G	acceptor_gain	1.0000
12:106842714:C:G	donor_gain	1.0000
12:106843850:AG:A	acceptor_gain	1.0000
12:106843851:GG:G	acceptor_gain	1.0000
12:106844192:G:GT	donor_gain	1.0000
12:106844192:G:T	donor_gain	1.0000
12:106851444:CATCA:C	acceptor_loss	1.0000
12:106851446:TCAGG:T	acceptor_loss	1.0000
12:106851447:CAGGT:C	acceptor_loss	1.0000
12:106851448:AGG:A	acceptor_loss	1.0000
12:106851590:GAGAG:G	donor_gain	1.0000
12:106851592:GAG:G	donor_gain	1.0000

AlphaMissense

3690 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:106815068:T:C	F169L	1.000
12:106815070:C:A	F169L	1.000
12:106815070:C:G	F169L	1.000
12:106815266:T:C	F235L	1.000
12:106815268:C:A	F235L	1.000
12:106815268:C:G	F235L	1.000
12:106851451:T:A	V388D	1.000
12:106851483:C:T	P399S	1.000
12:106851484:C:A	P399H	1.000
12:106851492:G:C	G402R	1.000
12:106851514:T:C	L409P	1.000
12:106851517:T:A	V410E	1.000
12:106851523:T:C	L412P	1.000
12:106851571:T:C	L428P	1.000
12:106851573:T:C	F429L	1.000
12:106851574:T:C	F429S	1.000
12:106851575:T:A	F429L	1.000
12:106851575:T:G	F429L	1.000
12:106851580:T:A	L431H	1.000
12:106851580:T:C	L431P	1.000
12:106851583:G:A	C432Y	1.000
12:106851584:C:G	C432W	1.000
12:106851586:A:T	K433I	1.000
12:106860277:T:C	L439P	1.000
12:106860291:G:C	G444R	1.000
12:106860291:G:T	G444C	1.000
12:106860292:G:A	G444D	1.000
12:106860292:G:T	G444V	1.000
12:106860297:G:A	G446R	1.000
12:106860297:G:C	G446R	1.000

dbSNP variants (sampled 300 via entrez): RS1000023082 (12:106782702 C>G), RS1000030292 (12:106844869 A>G), RS1000061514 (12:106844460 A>G), RS1000087574 (12:106837459 A>G,T), RS1000088644 (12:106776719 G>C,T), RS1000116359 (12:106887012 A>G,T), RS1000125371 (12:106819828 C>T), RS1000128340 (12:106792480 C>A,T), RS1000129649 (12:106865386 A>G), RS1000183083 (12:106821388 C>T), RS1000189853 (12:106793126 T>C), RS1000195322 (12:106831199 A>T), RS1000214623 (12:106838107 A>G), RS1000251518 (12:106819512 G>A), RS1000270456 (12:106830757 C>T)

Disease associations

OMIM: gene MIM:609147 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

25 associations (top):

Study	Trait	p-value
GCST002228_5	Social autistic-like traits	4.000000e-06
GCST003123_28	Severe influenza A (H1N1) infection	3.000000e-09
GCST003542_94	Night sleep phenotypes	5.000000e-06
GCST004237_23	Triglyceride levels	2.000000e-07
GCST005537_90	Chronic inflammatory diseases (ankylosing spondylitis, Crohn’s disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy)	2.000000e-08
GCST008839_66	Height	8.000000e-12
GCST009152_6	Triglyceride levels	2.000000e-14
GCST009723_49	Vertical cup-disc ratio (adjusted for vertical disc diameter)	9.000000e-12
GCST009724_99	Vertical cup-disc ratio (multi-trait analysis)	8.000000e-15
GCST010050_7	Adiponectin levels	1.000000e-07
GCST010173_99	Triglyceride levels	3.000000e-10
GCST010244_277	Triglyceride levels	5.000000e-16
GCST010320_115	PR interval	1.000000e-15
GCST010321_77	PR interval	5.000000e-17
GCST010703_94	Brain morphology (MOSTest)	6.000000e-52
GCST011353_15	Serum alkaline phosphatase levels	1.000000e-08
GCST012227_554	Hip circumference adjusted for BMI	5.000000e-08
GCST012227_555	Hip circumference adjusted for BMI	3.000000e-10
GCST012227_556	Hip circumference adjusted for BMI	2.000000e-10
GCST90000025_994	Appendicular lean mass	8.000000e-11
GCST90011900_72	Serum alkaline phosphatase levels	6.000000e-18
GCST90020025_100	Waist-to-hip ratio adjusted for BMI	4.000000e-08
GCST90020025_98	Waist-to-hip ratio adjusted for BMI	1.000000e-09
GCST90020027_1678	Waist-hip index	1.000000e-09
GCST90020028_947	Hip circumference adjusted for BMI	3.000000e-09

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0005426	autism spectrum disorder symptom
EFO:1001488	influenza A (H1N1)
EFO:0004530	triglyceride measurement
EFO:0006939	cup-to-disc ratio measurement
EFO:0004502	adiponectin measurement
EFO:0004462	PR interval
EFO:0004346	neuroimaging measurement
EFO:0004533	alkaline phosphatase measurement
EFO:0008039	BMI-adjusted hip circumference
EFO:0004980	appendicular lean mass
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, decreases methylation	3
FR900359	increases phosphorylation	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	increases methylation	1
titanium dioxide	increases methylation	1
trichostatin A	increases expression	1
sodium arsenite	affects cotreatment, decreases expression, increases abundance	1
butyraldehyde	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
benzo(e)pyrene	decreases methylation	1
methacrylaldehyde	increases oxidation, increases abundance, affects cotreatment	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Leflunomide	decreases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	increases abundance, increases oxidation, affects cotreatment	1
Arsenic	increases abundance, affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Folic Acid	decreases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Methapyrilene	decreases methylation	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.