RMEL3

Summary

RMEL3 (enriched in melanoma 3, HGNC:53975) is a long non-coding RNA gene on chromosome 5q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53975
Approved symbol	RMEL3
Name	enriched in melanoma 3
Location	5q11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250961
Ensembl biotype	lncRNA
Entrez	102724122
RNAcentral	URS00026A273F — lncRNA, 2839 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000506106, ENST00000664944, ENST00000771489, ENST00000771490, ENST00000771491, ENST00000771492, ENST00000771493, ENST00000771494, ENST00000771495, ENST00000771496, ENST00000771497, ENST00000771498, ENST00000771499, ENST00000771500, ENST00000771501, ENST00000771502

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000506106 — 4 exons

Exon	Start	End
ENSE00002020964	57532936	57533424
ENSE00002045516	57494075	57494225
ENSE00002055986	57395060	57395178
ENSE00002069967	57496780	57496917

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 95.58.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.58	gold quality
colonic epithelium	UBERON:0000397	67.45	silver quality
stromal cell of endometrium	CL:0002255	62.77	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.50	gold quality
tonsil	UBERON:0002372	59.04	silver quality
skeletal muscle tissue	UBERON:0001134	58.46	silver quality
sural nerve	UBERON:0015488	58.13	silver quality
cortex of kidney	UBERON:0001225	56.54	gold quality
left ovary	UBERON:0002119	55.84	gold quality
ovary	UBERON:0000992	54.89	gold quality
thoracic mammary gland	UBERON:0005200	54.23	gold quality
liver	UBERON:0002107	53.82	silver quality
rectum	UBERON:0001052	53.80	gold quality
duodenum	UBERON:0002114	53.34	gold quality
placenta	UBERON:0001987	53.25	gold quality
urinary bladder	UBERON:0001255	52.24	gold quality
gall bladder	UBERON:0002110	51.93	gold quality
muscle tissue	UBERON:0002385	51.64	silver quality
monocyte	CL:0000576	51.54	silver quality
prefrontal cortex	UBERON:0000451	51.53	gold quality
metanephros cortex	UBERON:0010533	51.43	gold quality
right ovary	UBERON:0002118	51.34	gold quality
endometrium	UBERON:0001295	51.23	gold quality
kidney	UBERON:0002113	51.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	51.11	gold quality
adipose tissue	UBERON:0001013	50.34	gold quality
left coronary artery	UBERON:0001626	50.24	gold quality
blood	UBERON:0000178	49.36	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	49.35	gold quality
descending thoracic aorta	UBERON:0002345	48.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• RMEL3 overexpression, in immortalized fibroblasts and melanoma cells, increased proliferation and survival under serum starvation, clonogenic ability, and xenografted melanoma tumor growth. (PMID:30457212)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.