RMND5A

Summary

RMND5A (required for meiotic nuclear division 5 homolog A, HGNC:25850) is a protein-coding gene on chromosome 2p11.2, encoding E3 ubiquitin-protein transferase RMND5A (Q9H871). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. It is a selective cancer dependency (DepMap: 31.7% of cell lines).

Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Located in cytoplasm and nucleoplasm. Part of ubiquitin ligase complex.

Source: NCBI Gene 64795 — RefSeq curated summary.

At a glance

• GWAS associations: 14
• Clinical variants (ClinVar): 34 total
• Cancer dependency (DepMap): dependent in 31.7% of screened cell lines
• MANE Select transcript: NM_022780

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25850
Approved symbol	RMND5A
Name	required for meiotic nuclear division 5 homolog A
Location	2p11.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ13910, RMD5, GID2, GID2A, p44CTLH
Ensembl gene	ENSG00000153561
Ensembl biotype	protein_coding
OMIM	618964
Entrez	64795

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000283632, ENST00000466417, ENST00000471113, ENST00000472843, ENST00000882508, ENST00000932494

RefSeq mRNA: 1 — MANE Select: NM_022780 NM_022780

CCDS: CCDS1991

Canonical transcript exons

ENST00000283632 — 9 exons

Exon	Start	End
ENSE00001011438	86753458	86753558
ENSE00001011440	86765027	86765193
ENSE00001221631	86773348	86778041
ENSE00001653794	86720291	86720809
ENSE00002531730	86740927	86741069
ENSE00003501155	86770023	86770125
ENSE00003515844	86751896	86752030
ENSE00003553243	86771558	86771712
ENSE00003607935	86765859	86766024

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.7331 / max 162.8225, expressed in 1729 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21304	9.3549	1724
202268	0.3538	155
21306	0.0131	2
21307	0.0082	4
21305	0.0030	2

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.38	gold quality
oocyte	CL:0000023	98.35	gold quality
buccal mucosa cell	CL:0002336	97.78	gold quality
esophagus squamous epithelium	UBERON:0006920	96.88	gold quality
epithelium of esophagus	UBERON:0001976	96.33	gold quality
amniotic fluid	UBERON:0000173	95.82	gold quality
paraflocculus	UBERON:0005351	95.68	gold quality
lower esophagus mucosa	UBERON:0035834	95.37	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	95.35	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	95.30	gold quality
gluteal muscle	UBERON:0002000	95.29	gold quality
biceps brachii	UBERON:0001507	95.12	gold quality
left ventricle myocardium	UBERON:0006566	95.01	gold quality
skeletal muscle tissue	UBERON:0001134	94.96	gold quality
deltoid	UBERON:0001476	94.69	gold quality
tibialis anterior	UBERON:0001385	94.56	gold quality
cerebellum	UBERON:0002037	94.33	gold quality
cerebellar cortex	UBERON:0002129	93.99	gold quality
quadriceps femoris	UBERON:0001377	93.92	gold quality
cerebellar hemisphere	UBERON:0002245	93.91	gold quality
vastus lateralis	UBERON:0001379	93.89	gold quality
muscle tissue	UBERON:0002385	93.88	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.59	gold quality
muscle organ	UBERON:0001630	93.53	gold quality
skeletal muscle organ	UBERON:0014892	93.53	gold quality
triceps brachii	UBERON:0001509	93.37	gold quality
muscle of leg	UBERON:0001383	93.18	gold quality
gastrocnemius	UBERON:0001388	93.14	gold quality
heart right ventricle	UBERON:0002080	93.13	gold quality
corpus callosum	UBERON:0002336	92.87	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.72
E-MTAB-6058	no	506.33

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

313 targeting RMND5A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-181A-5P	99.99	72.96	2995

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 31.7% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 5)

• RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells. (PMID:17467196)
• Duplications of this region involving RMND5A, whose product contains a C-terminal to lis homology (LisH) domain, have not previously been associated with a defined phenotype but may present insight into encephalocele formation. (PMID:22681319)
• The study identifies a miR-138-RMND5A-Exportin-5 as a previously unknown miRNA processing regulatory pathway in HeLa cells. (PMID:24057215)
• GID2 Interacts With CDKN3 and Regulates Pancreatic Cancer Growth and Apoptosis. (PMID:36828188)
• Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. (PMID:38759627)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rmnd5a	ENSMUSG00000002222
rattus_norvegicus	Rmnd5a	ENSRNOG00000065409
drosophila_melanogaster	Sou	FBGN0034573
caenorhabditis_elegans		WBGENE00020301

Paralogs (2): MAEA (ENSG00000090316), RMND5B (ENSG00000145916)

Protein

Protein identifiers

E3 ubiquitin-protein transferase RMND5A — Q9H871 (reviewed: Q9H871)

Alternative names: P44CTLH, Protein RMD5 homolog A

All UniProt accessions (1): Q9H871

UniProt curated annotations — full annotation on UniProt →

Function. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.

Subunit / interactions. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles.

Subcellular location. Nucleus. Nucleoplasm. Cytoplasm.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H871-1	1	yes
Q9H871-2	2

RefSeq proteins (1): NP_073617* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006594	LisH	Conserved_site
IPR006595	CTLH_C	Domain
IPR013144	CRA_dom	Domain
IPR024964	CTLH/CRA	Domain
IPR027370	Znf-RING_euk	Domain
IPR037680	RMD5A_dRING	Domain
IPR044063	ZF_RING_GID	Domain
IPR045098	Fyv10_fam	Family

Pfam: PF10607, PF13445

UniProt features (26 total): helix 10, strand 6, domain 2, splice variant 2, sequence conflict 2, chain 1, turn 1, zinc finger region 1, modified residue 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8PJN	ELECTRON MICROSCOPY	3.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H871-F1	89.97	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 1

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-9861718	Regulation of pyruvate metabolism
R-HSA-1428517	Aerobic respiration and respiratory electron transport
R-HSA-1430728	Metabolism
R-HSA-70268	Pyruvate metabolism

MSigDB gene sets: 290 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP, FREAC2_01, GCM_ZNF198, MORF_RRM1, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, BROWNE_HCMV_INFECTION_16HR_UP, CACCAGC_MIR138, PUJANA_CHEK2_PCC_NETWORK, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_PROTEIN_POLYUBIQUITINATION, TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA, AACTTT_UNKNOWN, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP

GO Biological Process (2): protein polyubiquitination (GO:0000209), proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

GO Molecular Function (6): ubiquitin-protein transferase activity (GO:0004842), zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (6): ubiquitin ligase complex (GO:0000151), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), GID complex (GO:0034657)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Pyruvate metabolism	1
Metabolism	1
Aerobic respiration and respiratory electron transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
protein ubiquitination	1
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
ubiquitin-like protein transferase activity	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
catalytic activity	1
cation binding	1
intracellular protein-containing complex	1
transferase complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
ubiquitin ligase complex	1

Protein interactions and networks

STRING

886 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RMND5A	GID8	Q9NWU2	993
RMND5A	RANBP9	Q96S59	960
RMND5A	ARMC8	Q8IUR7	948
RMND5A	WDR26	Q9H7D7	947
RMND5A	MKLN1	Q9UL63	945
RMND5A	GID4	Q8IVV7	942
RMND5A	PAFAH1B1	P43034	764
RMND5A	RANBP10	Q6VN20	731
RMND5A	YPEL5	P62699	608
RMND5A	UBE2H	P37286	607
RMND5A	MAEA	Q7L5Y9	582
RMND5A	SWSAP1	Q6NVH7	556
RMND5A	ZNHIT3	Q15649	546
RMND5A	ZMYND19	Q96E35	509
RMND5A	SCFD1	Q8WVM8	464

IntAct

155 interactions, top by confidence:

A	B	Type	Score
RMND5A	GID8	psi-mi:“MI:0915”(physical association)	0.880
ARMC8	HTRA2	psi-mi:“MI:0914”(association)	0.750
GID8	MAEA	psi-mi:“MI:0914”(association)	0.730
GID8	PGRMC2	psi-mi:“MI:0914”(association)	0.640
CCDC120	AIP	psi-mi:“MI:0914”(association)	0.640
CRIPTO	AIP	psi-mi:“MI:0914”(association)	0.640
NDUFS6	NDUFS8	psi-mi:“MI:0914”(association)	0.640
RANBP10	MAEA	psi-mi:“MI:0914”(association)	0.640
RANBP9	YPEL5	psi-mi:“MI:0914”(association)	0.640
PRG2	YPEL5	psi-mi:“MI:0914”(association)	0.640
CAMKV	AP3B1	psi-mi:“MI:0914”(association)	0.640
GID8	HTRA2	psi-mi:“MI:0914”(association)	0.610
RMND5A	MEOX2	psi-mi:“MI:0915”(physical association)	0.560
MEOX2	RMND5A	psi-mi:“MI:0915”(physical association)	0.560
RMND5A	NDUFV1	psi-mi:“MI:0915”(physical association)	0.560
RMND5A	WFS1	psi-mi:“MI:0915”(physical association)	0.560
ATXN1	RMND5A	psi-mi:“MI:0915”(physical association)	0.560
TARDBP	RMND5A	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (283): RMND5A (Two-hybrid), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RMND5A (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP9 (Affinity Capture-MS), WDR26 (Affinity Capture-MS)

ESM2 similar proteins: A0MT11, A1Z3X3, A2VD00, A4GWN3, A4II09, A4QNE0, A4VCH4, B5KFI0, O35841, P48553, P49754, Q09161, Q0P5I8, Q15386, Q3TLI0, Q3UYV9, Q56A27, Q5E9L7, Q5KU39, Q5R644, Q5XI83, Q5ZJZ6, Q5ZKG8, Q5ZMW3, Q640V2, Q6GLK9, Q6GLP4, Q6N069, Q6NRL4, Q6TGY8, Q6WKZ8, Q7L5D6, Q7ZY79, Q80U95, Q80UM3, Q80YQ8, Q8BWQ6, Q8IWV8, Q8VZM1, Q91W86

Diamond homologs: O59668, Q640V2, Q6GLP4, Q80YQ8, Q9H871, Q9T075, Q91YQ7, Q96G75, Q11072

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	RMND5A	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 130 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Regulation of pyruvate metabolism	8	53.1×	3e-10
Aerobic respiration and respiratory electron transport	7	7.2×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	20
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1380 predictions. Top by Δscore:

Variant	Effect	Δscore
2:86740922:TATA:T	acceptor_loss	1.0000
2:86740924:TA:T	acceptor_loss	1.0000
2:86740925:A:AG	acceptor_gain	1.0000
2:86740925:A:T	acceptor_loss	1.0000
2:86740926:G:GA	acceptor_gain	1.0000
2:86741067:AAGG:A	donor_loss	1.0000
2:86741068:AGGT:A	donor_loss	1.0000
2:86741070:G:GC	donor_loss	1.0000
2:86741070:G:GG	donor_gain	1.0000
2:86741071:T:A	donor_loss	1.0000
2:86751891:CCCAG:C	acceptor_loss	1.0000
2:86751894:A:AG	acceptor_gain	1.0000
2:86751895:G:GG	acceptor_gain	1.0000
2:86751895:GA:G	acceptor_gain	1.0000
2:86751895:GAA:G	acceptor_gain	1.0000
2:86751895:GAAT:G	acceptor_gain	1.0000
2:86751895:GAATT:G	acceptor_gain	1.0000
2:86752027:TCAG:T	donor_loss	1.0000
2:86752028:CAG:C	donor_loss	1.0000
2:86752031:GT:G	donor_loss	1.0000
2:86752032:T:G	donor_loss	1.0000
2:86753454:CCA:C	acceptor_loss	1.0000
2:86753456:A:AG	acceptor_gain	1.0000
2:86753457:G:GG	acceptor_gain	1.0000
2:86753457:GGA:G	acceptor_gain	1.0000
2:86753457:GGAAT:G	acceptor_gain	1.0000
2:86753556:GGA:G	donor_gain	1.0000
2:86753557:GA:G	donor_gain	1.0000
2:86753557:GAG:G	donor_gain	1.0000
2:86753559:G:GG	donor_gain	1.0000

AlphaMissense

2589 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:86741023:A:T	K80I	1.000
2:86741024:A:C	K80N	1.000
2:86741024:A:T	K80N	1.000
2:86741031:C:G	H83D	1.000
2:86741041:T:A	V86D	1.000
2:86741053:G:A	G90E	1.000
2:86741055:A:G	K91E	1.000
2:86741057:A:C	K91N	1.000
2:86741057:A:T	K91N	1.000
2:86753552:C:A	A172D	1.000
2:86765028:T:A	W175R	1.000
2:86765028:T:C	W175R	1.000
2:86765030:G:C	W175C	1.000
2:86765030:G:T	W175C	1.000
2:86765031:G:C	A176P	1.000
2:86765086:T:C	L194P	1.000
2:86765095:T:C	L197P	1.000
2:86765155:C:A	A217D	1.000
2:86765967:T:C	F266S	1.000
2:86765978:G:C	A270P	1.000
2:86770033:G:C	G289R	1.000
2:86770034:G:A	G289D	1.000
2:86770121:T:C	L318S	1.000
2:86771600:T:C	F334L	1.000
2:86771601:T:C	F334S	1.000
2:86771602:T:A	F334L	1.000
2:86771602:T:G	F334L	1.000
2:86771604:C:A	A335D	1.000
2:86771606:T:A	C336S	1.000
2:86771606:T:C	C336R	1.000

dbSNP variants (sampled 300 via entrez): RS1000106432 (2:86719805 G>A,C), RS1000193952 (2:86772484 CAAAAA>C,CA,CAAAA,CAAAAAA), RS1000222729 (2:86765430 A>G), RS1000290826 (2:86745864 A>T), RS1000294570 (2:86764844 T>C), RS1000434612 (2:86772097 G>A,C), RS1000524793 (2:86759280 T>A), RS1000689517 (2:86760170 G>C), RS1000779085 (2:86772317 T>C), RS1000866255 (2:86760420 G>T), RS1000946323 (2:86754708 G>A), RS1000975687 (2:86754446 A>T), RS1001001520 (2:86747482 A>G), RS1001087980 (2:86767381 G>A), RS1001131549 (2:86760403 G>A)

Disease associations

OMIM: gene MIM:618964 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

14 associations (top):

Study	Trait	p-value
GCST004602_89	Mean corpuscular volume	9.000000e-15
GCST004611_14	High light scatter reticulocyte count	9.000000e-15
GCST004612_170	High light scatter reticulocyte percentage of red cells	5.000000e-15
GCST004619_56	Reticulocyte fraction of red cells	3.000000e-12
GCST004622_152	Reticulocyte count	3.000000e-11
GCST004628_147	Immature fraction of reticulocytes	1.000000e-09
GCST004630_29	Mean corpuscular hemoglobin	4.000000e-10
GCST90002385_134	High light scatter reticulocyte count	6.000000e-28
GCST90002386_250	High light scatter reticulocyte percentage of red cells	1.000000e-29
GCST90002387_260	Immature fraction of reticulocytes	2.000000e-14
GCST90002390_365	Mean corpuscular hemoglobin	2.000000e-21
GCST90002392_207	Mean corpuscular volume	9.000000e-25
GCST90002405_130	Reticulocyte count	2.000000e-25
GCST90002406_23	Reticulocyte fraction of red cells	7.000000e-29

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0004527	mean corpuscular hemoglobin

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	increases expression, increases methylation	3
Cadmium Chloride	increases abundance, increases expression	2
triphenyl phosphate	affects expression	1
terbufos	increases methylation	1
tetrahydropalmatine	increases expression	1
cobaltous chloride	increases expression	1
butyraldehyde	decreases expression	1
potassium chromate(VI)	affects cotreatment, increases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
pentanal	decreases expression	1
tamibarotene	decreases expression	1
K 7174	increases expression	1
abrine	increases expression	1
jinfukang	decreases expression	1
PCI 5002	affects cotreatment, increases expression	1
Acetaminophen	increases expression	1
Air Pollutants, Occupational	affects expression	1
Amphotericin B	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	increases abundance, increases expression	1
Fonofos	increases methylation	1
Estradiol	affects cotreatment, decreases expression	1
Hydrogen Peroxide	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Parathion	increases methylation	1
Plant Oils	increases expression	1
Silver	increases expression	1
Theophylline	affects cotreatment, increases expression	1
Tretinoin	decreases expression	1
Urethane	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2JF	HAP1 RMND5A (-) 1	Cancer cell line	Male
CVCL_E2JG	HAP1 RMND5A (-) 2	Cancer cell line	Male
CVCL_E2JH	HAP1 RMND5A (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.