RN7SK

Summary

RN7SK (RNA component of 7SK nuclear ribonucleoprotein, HGNC:10037) is a small nuclear RNA gene on chromosome 6p12.2.

Predicted to be involved in negative regulation of transcription elongation by RNA polymerase II. Part of 7SK snRNP.

Source: NCBI Gene 125050 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10037
Approved symbol	RN7SK
Name	RNA component of 7SK nuclear ribonucleoprotein
Location	6p12.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	7SK
Ensembl gene	ENSG00000283293
Ensembl biotype	snRNA
OMIM	606515
Entrez	125050
RNAcentral	URS0000734D8F — lncRNA, 332 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000636484

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636484 — 1 exons

Exon	Start	End
ENSE00003794401	52995621	52995948

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 100.00.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4179 / max 42.7723, expressed in 192 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
204025	0.4179	192

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	100.00	gold quality
bone marrow cell	CL:0002092	99.99	gold quality
colonic epithelium	UBERON:0000397	99.99	gold quality
tonsil	UBERON:0002372	99.99	gold quality
adrenal tissue	UBERON:0018303	99.99	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.71	gold quality
primary visual cortex	UBERON:0002436	98.83	gold quality
blood	UBERON:0000178	96.47	gold quality
ventricular zone	UBERON:0003053	96.39	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.67	gold quality
cortex of kidney	UBERON:0001225	95.56	gold quality
caudate nucleus	UBERON:0001873	95.52	gold quality
monocyte	CL:0000576	94.95	gold quality
bone marrow	UBERON:0002371	94.88	gold quality
skeletal muscle tissue	UBERON:0001134	94.84	gold quality
cerebellar cortex	UBERON:0002129	94.45	gold quality
kidney	UBERON:0002113	94.44	gold quality
metanephros cortex	UBERON:0010533	94.43	gold quality
cerebellum	UBERON:0002037	94.40	gold quality
cerebellar hemisphere	UBERON:0002245	94.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.34	gold quality
leukocyte	CL:0000738	93.92	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	93.87	gold quality
urinary bladder	UBERON:0001255	93.79	gold quality
liver	UBERON:0002107	93.37	gold quality
putamen	UBERON:0001874	93.21	gold quality
endocervix	UBERON:0000458	93.20	gold quality
sural nerve	UBERON:0015488	93.19	gold quality
ganglionic eminence	UBERON:0004023	93.05	gold quality
nucleus accumbens	UBERON:0001882	92.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): POU2F2

Literature-anchored findings (GeneRIF, showing 28)

• major portion of nuclear P-TEFb is sequestered and inactivated by the coordinated actions of the 7SK snRNA (PMID:14627702)
• analysis of positive transcription elongation factor - HEXIM1 - 7SK RNA complex (PMID:15994294)
• the interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct its binding to P-TEFb and subcellular localization that culminates in the inhibition of transcription (PMID:16362050)
• Because the DNA substrate-binding site in APOBEC3C differs from the region for 7SK binding, 7SK does not act as a substrate competitor in inhibiting APOBEC3C. (PMID:17381310)
• PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. (PMID:18483222)
• T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes. (PMID:20201073)
• HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. (PMID:20471949)
• The configuration of the stem loop 4 of 7SK suggests that the loop is poised to make ternary contacts with P-TEFb and HEXIM or Tat. (PMID:20816986)
• Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. (PMID:20976203)
• HMGA1 transcription activity can dependent and independent of 7SK snRNA. (PMID:21282977)
• The 7SK snRNP complex acts as a reservoir where active transcription elongation factor P-TEFb can be withdrawn by Tat to stimulate HIV-1 transcription. (PMID:21360054)
• 7SK RNA thus establishes gene-dependent plasticity between HMGA1 chromatin remodeling and transcription initiation and P-TEFb transcription elongation. (PMID:21957495)
• Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein. (PMID:22952229)
• the release of P-TEFb from the 7SK snRNP led to increased synthesis of HEXIM1 but not HEXIM2 (PMID:24515107)
• a region in HEXIM1 C-terminal to its previously mapped RNA-binding motif was also required for interactions between HEXIM1 and 7SK. (PMID:24917669)
• results suggest that LARP7 uses both its N- and C-terminal domains to stabilize 7SK in a closed structure, which forms by joining conserved sequences at the 5’-end with the foot of the 3’ hairpin and has thus functional implications (PMID:25753663)
• KAP1 controls 7SK snRNP delivery to promoter-proximal regions to facilitate “on-site” P-TEFb activation and Pol II elongation. (PMID:26725010)
• 7SK physically interacts with the BAF chromatin-remodeling complex, recruits BAF to enhancers and inhibits enhancer transcription by modulating chromatin structure. (PMID:26878240)
• 7SK expression is significantly down-regulated in cancer.7SK transcriptional level decreased in stem cells in comparison with differentiated cell types. (PMID:27752877)
• The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, also functions as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes. (PMID:28254838)
• The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA genes. (PMID:28820318)
• These findings identify a novel role for HIV-1 TAR in the absence of Tat, involving the interference with host cellular immune responses by targeting 7SK RNA-mediated gene expression and P-TEFb inactivation. (PMID:29037489)
• Our results demonstrated the transient knockdown of Rn7SK in mesenchymal stem cells leads to delayed senescence, while its overexpressions shows opposite effects. (PMID:30637716)
• Analysis of RNA binding properties of human Ku protein reveals its interactions with 7SK snRNA and protein components of 7SK snRNP complex. (PMID:32105815)
• [7SK truncation at 128-179 nt suppresses embryonic stem cell proliferation in vitro by downregulating CDC6]. (PMID:34549701)
• RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin. (PMID:34620876)
• A positive feedback circuit between RN7SK snRNA and m[6]A readers is essential for tumorigenesis. (PMID:36566349)
• 7SK small nuclear RNA (Rn7SK) induces apoptosis through intrinsic and extrinsic pathways in human embryonic kidney cell line. (PMID:38193993)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.