RN7SL1

Summary

RN7SL1 (RNA component of signal recognition particle 7SL1, HGNC:10038) is a non-coding RNA gene on chromosome 14q21.3.

The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides (e.g., SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL1, that is partially homologous to Alu DNA (Ullu and Weiner, 1984 [PubMed 6084597]).

Source: NCBI Gene 6029 — RefSeq curated summary.

At a glance

• Gene type: non-coding (misc_RNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10038
Approved symbol	RN7SL1
Name	RNA component of signal recognition particle 7SL1
Location	14q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	7SL, 7L1a, RNSRP1
Ensembl gene	ENSG00000276168
Ensembl biotype	misc_RNA
OMIM	612177
Entrez	6029
RNAcentral	URS00000478B7 — ncRNA, 299 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 misc_RNA

ENST00000618786

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618786 — 1 exons

Exon	Start	End
ENSE00003741348	49586580	49586878

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 100.00.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	100.00	gold quality
colonic epithelium	UBERON:0000397	100.00	gold quality
corpus callosum	UBERON:0002336	100.00	gold quality
adrenal tissue	UBERON:0018303	100.00	gold quality
calcaneal tendon	UBERON:0003701	99.98	gold quality
primary visual cortex	UBERON:0002436	99.95	gold quality
superior frontal gyrus	UBERON:0002661	99.95	gold quality
sural nerve	UBERON:0015488	99.93	gold quality
monocyte	CL:0000576	99.83	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.78	gold quality
leukocyte	CL:0000738	99.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.25	gold quality
body of pancreas	UBERON:0001150	99.19	gold quality
blood	UBERON:0000178	99.10	gold quality
mucosa of transverse colon	UBERON:0004991	99.07	gold quality
putamen	UBERON:0001874	99.05	gold quality
right frontal lobe	UBERON:0002810	99.02	gold quality
pituitary gland	UBERON:0000007	98.92	gold quality
pancreas	UBERON:0001264	98.77	gold quality
adenohypophysis	UBERON:0002196	98.74	gold quality
bone marrow	UBERON:0002371	98.74	gold quality
adult mammalian kidney	UBERON:0000082	98.64	gold quality
cortex of kidney	UBERON:0001225	98.63	gold quality
caudate nucleus	UBERON:0001873	98.62	gold quality
liver	UBERON:0002107	98.55	gold quality
cerebellum	UBERON:0002037	98.51	gold quality
cerebellar cortex	UBERON:0002129	98.50	gold quality
left adrenal gland cortex	UBERON:0035825	98.47	gold quality
frontal cortex	UBERON:0001870	98.46	gold quality
cerebellar hemisphere	UBERON:0002245	98.45	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-10662	yes	1537.90
E-ANND-3	yes	17.16
E-MTAB-9543	no	14.67

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TBP

Literature-anchored findings (GeneRIF, showing 8)

• This study reports the crystal structure of Methanococcus jannaschii SRP19 bound to the S domain of human 7SL RNA at 2.9 A resolution. (PMID:12086622)
• crystal structure of a human SRP ternary complex consisting of SRP19, the M domain of SRP54 and the S domain of 7SL RNA (PMID:12244299)
• 7SL RNA that is encapsidated into diverse retroviruses is a key cofactor of the antiviral APOBEC3G. (PMID:17881443)
• Interaction with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging,l (PMID:18067920)
• In conclusion, this study suggests that 7SL RNA is a direct target of FOXP3 and may be involved in the formation of FOXP3/P53 feedback loop. (PMID:26718402)
• Study shows that triggering of stromal NOTCH-MYC by breast cancer cells results in a POL3-driven increase in RN7SL1, an endogenous RNA normally shielded by RNA binding proteins SRP9/14. This increase in RN7SL1 alters its stoichiometry with SRP9/14 and generates unshielded RN7SL1 in stromal exosomes. After exosome transfer to immune cells, unshielded RN7SL1 drives an inflammatory response. (PMID:28709002)
• Widespread association of ERalpha with RMRP and tRNA genes in MCF-7 cells and breast cancers. (PMID:35143945)
• Profiling of long non-coding RNAs in hippocampal-entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease. (PMID:38582873)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rn7s1	ENSMUSG00000118866
rattus_norvegicus	Metazoa_SRP	ENSRNOG00000085881

Paralogs (847): Metazoa_SRP (ENSG00000196274), Metazoa_SRP (ENSG00000197334), Metazoa_SRP (ENSG00000203286), Metazoa_SRP (ENSG00000203411), Metazoa_SRP (ENSG00000203436), Metazoa_SRP (ENSG00000203573), Metazoa_SRP (ENSG00000213167), Metazoa_SRP (ENSG00000214305), Metazoa_SRP (ENSG00000237261), Metazoa_SRP (ENSG00000237611), RN7SL499P (ENSG00000239202), RN7SL563P (ENSG00000239211), RN7SL442P (ENSG00000239221), RN7SL546P (ENSG00000239224), RN7SL578P (ENSG00000239228), RN7SL589P (ENSG00000239247), RN7SL757P (ENSG00000239249), RN7SL271P (ENSG00000239250), RN7SL184P (ENSG00000239279), RN7SL11P (ENSG00000239316), RN7SL854P (ENSG00000239319), RN7SL658P (ENSG00000239333), RN7SL309P (ENSG00000239356), RN7SL477P (ENSG00000239367), RN7SL87P (ENSG00000239390), RN7SL414P (ENSG00000239396), RN7SL342P (ENSG00000239398), RN7SL535P (ENSG00000239419), RN7SL752P (ENSG00000239437), RN7SL691P (ENSG00000239464), RN7SL552P (ENSG00000239466), RN7SL569P (ENSG00000239468), RN7SL584P (ENSG00000239471), RN7SL221P (ENSG00000239472), RN7SL333P (ENSG00000239494), RN7SL583P (ENSG00000239504), RN7SL399P (ENSG00000239542), RN7SL822P (ENSG00000239545), RN7SL843P (ENSG00000239547), RN7SL12P (ENSG00000239553)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.