RN7SL2

Summary

RN7SL2 (RNA component of signal recognition particle 7SL2, HGNC:23134) is a non-coding RNA gene on chromosome 14q21.3.

The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides (e.g., SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL2, that is partially homologous to Alu DNA (Ullu and Weiner, 1984 [PubMed 6084597]).

Source: NCBI Gene 378706 — RefSeq curated summary.

At a glance

• Gene type: non-coding (misc_RNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23134
Approved symbol	RN7SL2
Name	RNA component of signal recognition particle 7SL2
Location	14q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	7SL1c, 7L30.1, RNSRP2
Ensembl gene	ENSG00000274012
Ensembl biotype	misc_RNA
OMIM	612179
Entrez	378706
RNAcentral	URS00003ACFC1 — ncRNA, 299 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 misc_RNA

ENST00000490232

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000490232 — 1 exons

Exon	Start	End
ENSE00002691386	49862550	49862849

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 100.00.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	100.00	gold quality
colonic epithelium	UBERON:0000397	100.00	gold quality
corpus callosum	UBERON:0002336	100.00	gold quality
adrenal tissue	UBERON:0018303	100.00	gold quality
calcaneal tendon	UBERON:0003701	99.99	gold quality
sural nerve	UBERON:0015488	99.99	gold quality
primary visual cortex	UBERON:0002436	99.95	gold quality
superior frontal gyrus	UBERON:0002661	99.95	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.91	gold quality
monocyte	CL:0000576	99.89	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.76	gold quality
leukocyte	CL:0000738	99.72	gold quality
cerebellar cortex	UBERON:0002129	99.58	gold quality
cerebellar hemisphere	UBERON:0002245	99.57	gold quality
cerebellum	UBERON:0002037	99.56	gold quality
blood	UBERON:0000178	99.54	gold quality
putamen	UBERON:0001874	99.52	gold quality
skeletal muscle tissue	UBERON:0001134	99.51	gold quality
pituitary gland	UBERON:0000007	99.49	gold quality
adenohypophysis	UBERON:0002196	99.48	gold quality
bone marrow	UBERON:0002371	99.42	gold quality
right frontal lobe	UBERON:0002810	99.35	gold quality
caudate nucleus	UBERON:0001873	99.33	gold quality
cortex of kidney	UBERON:0001225	99.31	gold quality
body of pancreas	UBERON:0001150	99.28	gold quality
nucleus accumbens	UBERON:0001882	99.25	gold quality
kidney	UBERON:0002113	99.25	gold quality
Ammon’s horn	UBERON:0001954	99.24	gold quality
brain	UBERON:0000955	99.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	99.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.58

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (847): Metazoa_SRP (ENSG00000196274), Metazoa_SRP (ENSG00000197334), Metazoa_SRP (ENSG00000203286), Metazoa_SRP (ENSG00000203411), Metazoa_SRP (ENSG00000203436), Metazoa_SRP (ENSG00000203573), Metazoa_SRP (ENSG00000213167), Metazoa_SRP (ENSG00000214305), Metazoa_SRP (ENSG00000237261), Metazoa_SRP (ENSG00000237611), RN7SL499P (ENSG00000239202), RN7SL563P (ENSG00000239211), RN7SL442P (ENSG00000239221), RN7SL546P (ENSG00000239224), RN7SL578P (ENSG00000239228), RN7SL589P (ENSG00000239247), RN7SL757P (ENSG00000239249), RN7SL271P (ENSG00000239250), RN7SL184P (ENSG00000239279), RN7SL11P (ENSG00000239316), RN7SL854P (ENSG00000239319), RN7SL658P (ENSG00000239333), RN7SL309P (ENSG00000239356), RN7SL477P (ENSG00000239367), RN7SL87P (ENSG00000239390), RN7SL414P (ENSG00000239396), RN7SL342P (ENSG00000239398), RN7SL535P (ENSG00000239419), RN7SL752P (ENSG00000239437), RN7SL691P (ENSG00000239464), RN7SL552P (ENSG00000239466), RN7SL569P (ENSG00000239468), RN7SL584P (ENSG00000239471), RN7SL221P (ENSG00000239472), RN7SL333P (ENSG00000239494), RN7SL583P (ENSG00000239504), RN7SL399P (ENSG00000239542), RN7SL822P (ENSG00000239545), RN7SL843P (ENSG00000239547), RN7SL12P (ENSG00000239553)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.