RN7SL2

Summary

RN7SL2 (RNA component of signal recognition particle 7SL2, HGNC:23134) is a non-coding RNA gene on chromosome 14q21.3.

The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides (e.g., SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL2, that is partially homologous to Alu DNA (Ullu and Weiner, 1984 [PubMed 6084597]).

Source: NCBI Gene 378706 — RefSeq curated summary.

At a glance

• Gene type: non-coding (misc_RNA) — no protein product.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23134
Approved symbol	RN7SL2
Name	RNA component of signal recognition particle 7SL2
Location	14q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	7SL1c, 7L30.1, RNSRP2
Ensembl gene	ENSG00000274012
Ensembl biotype	misc_RNA
OMIM	612179
Entrez	378706
RNAcentral	URS00003ACFC1 — ncRNA, 299 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 misc_RNA

ENST00000490232

RefSeq mRNA: 0

Canonical transcript exons

ENST00000490232 — 1 exons

Exon	Start	End
ENSE00002691386	49862550	49862849

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 100.00.

Highest expression (Bgee): bone marrow cell, colonic epithelium, corpus callosum, adrenal tissue, calcaneal tendon.

Top tissues by expression

showing 100 of 134 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	100.00	gold quality
colonic epithelium	UBERON:0000397	100.00	gold quality
corpus callosum	UBERON:0002336	100.00	gold quality
adrenal tissue	UBERON:0018303	100.00	gold quality
calcaneal tendon	UBERON:0003701	99.99	gold quality
sural nerve	UBERON:0015488	99.99	gold quality
primary visual cortex	UBERON:0002436	99.95	gold quality
superior frontal gyrus	UBERON:0002661	99.95	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.91	gold quality
monocyte	CL:0000576	99.89	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.76	gold quality
leukocyte	CL:0000738	99.72	gold quality
cerebellar cortex	UBERON:0002129	99.58	gold quality
cerebellar hemisphere	UBERON:0002245	99.57	gold quality
cerebellum	UBERON:0002037	99.56	gold quality
blood	UBERON:0000178	99.54	gold quality
putamen	UBERON:0001874	99.52	gold quality
skeletal muscle tissue	UBERON:0001134	99.51	gold quality
pituitary gland	UBERON:0000007	99.49	gold quality
adenohypophysis	UBERON:0002196	99.48	gold quality
bone marrow	UBERON:0002371	99.42	gold quality
right frontal lobe	UBERON:0002810	99.35	gold quality
caudate nucleus	UBERON:0001873	99.33	gold quality
cortex of kidney	UBERON:0001225	99.31	gold quality
body of pancreas	UBERON:0001150	99.28	gold quality
nucleus accumbens	UBERON:0001882	99.25	gold quality
kidney	UBERON:0002113	99.25	gold quality
Ammon’s horn	UBERON:0001954	99.24	gold quality
brain	UBERON:0000955	99.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	99.09	gold quality
temporal lobe	UBERON:0001871	99.05	gold quality
amygdala	UBERON:0001876	99.04	gold quality
pancreas	UBERON:0001264	99.03	gold quality
adult mammalian kidney	UBERON:0000082	99.00	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	99.00	gold quality
cerebral cortex	UBERON:0000956	98.97	gold quality
hypothalamus	UBERON:0001898	98.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	98.95	gold quality
mucosa of transverse colon	UBERON:0004991	98.93	gold quality
frontal cortex	UBERON:0001870	98.91	gold quality
anterior cingulate cortex	UBERON:0009835	98.91	gold quality
ventricular zone	UBERON:0003053	98.61	gold quality
ganglionic eminence	UBERON:0004023	98.58	gold quality
prefrontal cortex	UBERON:0000451	98.57	gold quality
cortical plate	UBERON:0005343	98.53	gold quality
myometrium	UBERON:0001296	98.52	gold quality
islet of Langerhans	UBERON:0000006	98.46	gold quality
spleen	UBERON:0002106	98.46	gold quality
right uterine tube	UBERON:0001302	98.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.45	gold quality
substantia nigra	UBERON:0002038	98.44	gold quality
left adrenal gland cortex	UBERON:0035825	98.43	gold quality
adrenal gland	UBERON:0002369	98.42	gold quality
left adrenal gland	UBERON:0001234	98.39	gold quality
liver	UBERON:0002107	98.36	gold quality
stomach	UBERON:0000945	98.34	gold quality
left ovary	UBERON:0002119	98.34	gold quality
descending thoracic aorta	UBERON:0002345	98.33	gold quality
metanephros cortex	UBERON:0010533	98.33	gold quality
saliva-secreting gland	UBERON:0001044	98.29	gold quality
ovary	UBERON:0000992	98.26	gold quality
prostate gland	UBERON:0002367	98.26	gold quality
minor salivary gland	UBERON:0001830	98.23	gold quality
small intestine Peyer’s patch	UBERON:0003454	98.17	gold quality
body of uterus	UBERON:0009853	98.16	gold quality
right adrenal gland cortex	UBERON:0035827	98.13	gold quality
stromal cell of endometrium	CL:0002255	98.09	gold quality
body of stomach	UBERON:0001161	98.06	gold quality
right lung	UBERON:0002167	98.06	gold quality
lower esophagus muscularis layer	UBERON:0035833	98.00	gold quality
lower esophagus	UBERON:0013473	97.98	gold quality
uterine cervix	UBERON:0000002	97.95	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.93	gold quality
tonsil	UBERON:0002372	97.91	gold quality
right testis	UBERON:0004534	97.90	gold quality
right adrenal gland	UBERON:0001233	97.83	gold quality
right ovary	UBERON:0002118	97.76	gold quality
small intestine	UBERON:0002108	97.75	gold quality
multicellular organism	UBERON:0000468	97.72	gold quality
intestine	UBERON:0000160	97.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	97.69	gold quality
thoracic aorta	UBERON:0001515	97.67	gold quality
ascending aorta	UBERON:0001496	97.66	gold quality
colon	UBERON:0001155	97.64	gold quality
endocervix	UBERON:0000458	97.62	gold quality
fundus of stomach	UBERON:0001160	97.52	gold quality
muscle tissue	UBERON:0002385	97.51	gold quality
left testis	UBERON:0004533	97.44	gold quality
left lobe of thyroid gland	UBERON:0001120	97.41	gold quality
left coronary artery	UBERON:0001626	97.38	gold quality
esophagus	UBERON:0001043	97.30	gold quality
transverse colon	UBERON:0001157	97.30	gold quality
lung	UBERON:0002048	97.27	gold quality
ectocervix	UBERON:0012249	97.22	gold quality
thyroid gland	UBERON:0002046	97.17	gold quality
right lobe of liver	UBERON:0001114	97.13	gold quality
popliteal artery	UBERON:0002250	97.13	gold quality
tibial artery	UBERON:0007610	97.12	gold quality
heart	UBERON:0000948	97.08	gold quality
right lobe of thyroid gland	UBERON:0001119	97.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.58

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (847): Metazoa_SRP (ENSG00000196274), Metazoa_SRP (ENSG00000197334), Metazoa_SRP (ENSG00000203286), Metazoa_SRP (ENSG00000203411), Metazoa_SRP (ENSG00000203436), Metazoa_SRP (ENSG00000203573), Metazoa_SRP (ENSG00000213167), Metazoa_SRP (ENSG00000214305), Metazoa_SRP (ENSG00000237261), Metazoa_SRP (ENSG00000237611), RN7SL499P (ENSG00000239202), RN7SL563P (ENSG00000239211), RN7SL442P (ENSG00000239221), RN7SL546P (ENSG00000239224), RN7SL578P (ENSG00000239228), RN7SL589P (ENSG00000239247), RN7SL757P (ENSG00000239249), RN7SL271P (ENSG00000239250), RN7SL184P (ENSG00000239279), RN7SL11P (ENSG00000239316), RN7SL854P (ENSG00000239319), RN7SL658P (ENSG00000239333), RN7SL309P (ENSG00000239356), RN7SL477P (ENSG00000239367), RN7SL87P (ENSG00000239390), RN7SL414P (ENSG00000239396), RN7SL342P (ENSG00000239398), RN7SL535P (ENSG00000239419), RN7SL752P (ENSG00000239437), RN7SL691P (ENSG00000239464), RN7SL552P (ENSG00000239466), RN7SL569P (ENSG00000239468), RN7SL584P (ENSG00000239471), RN7SL221P (ENSG00000239472), RN7SL333P (ENSG00000239494), RN7SL583P (ENSG00000239504), RN7SL399P (ENSG00000239542), RN7SL822P (ENSG00000239545), RN7SL843P (ENSG00000239547), RN7SL12P (ENSG00000239553), RN7SL841P (ENSG00000239555), RN7SL479P (ENSG00000239560), RN7SL388P (ENSG00000239577), RN7SL325P (ENSG00000239579), RN7SL675P (ENSG00000239580), RN7SL79P (ENSG00000239595), RN7SL573P (ENSG00000239607), RN7SL241P (ENSG00000239625), RN7SL62P (ENSG00000239640), RN7SL193P (ENSG00000239679), RN7SL668P (ENSG00000239690), RN7SL507P (ENSG00000239702), RN7SL568P (ENSG00000239703), RN7SL782P (ENSG00000239708), RN7SL692P (ENSG00000239710), RN7SL688P (ENSG00000239726), RN7SL825P (ENSG00000239731), RN7SL672P (ENSG00000239742), RN7SL63P (ENSG00000239744), RN7SL790P (ENSG00000239745)

+787 more (showing top 60).

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
RN7SL3	scRNA	378707
ARF6	protein-coding	382
NEMF	protein-coding	9147
MIR6076	ncRNA	102464828
KLHDC1	protein-coding	122773
KLHDC2	protein-coding	23588
POLE2	protein-coding	5427

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 37 curated MSigDB gene sets — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

GOBP_PROTEIN_TARGETING, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_PROTEIN_TARGETING_TO_MEMBRANE, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOBP_LOCALIZATION_WITHIN_MEMBRANE, GOCC_RIBONUCLEOPROTEIN_COMPLEX, GOBP_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE, GOCC_SIGNAL_RECOGNITION_PARTICLE, E2F2_TARGET_GENES, ELF2_TARGET_GENES, FEV_TARGET_GENES, FOXD2_TARGET_GENES, FOXE1_TARGET_GENES, GUCY1B1_TARGET_GENES, HOXC6_TARGET_GENES, ID1_TARGET_GENES, TEAD2_TARGET_GENES, TERT_TARGET_GENES, ZNF282_TARGET_GENES, ZNF768_TARGET_GENES, ZSCAN31_TARGET_GENES, GOBP_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE_SIGNAL_SEQUENCE_RECOGNITION, PGM3_TARGET_GENES, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION, BDP1_TARGET_GENES, ZSCAN5DP_TARGET_GENES, MZF1_TARGET_GENES, ZFP36L1_TARGET_GENES, ZNF394_TARGET_GENES, INSM2_TARGET_GENES, DNMT3A_TARGET_GENES, HOEK_MONOCYTE_2011_2012_TIV_ADULT_3DY_UP, HOEK_NK_CELL_2011_2012_TIV_1D_VS_0DY_ADULT_1D_DN, GOBP_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE, GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION, chr14q21

Non-coding RNA function

Functional annotation for the RNA itself (RNAcentral / Rfam), independent of any protein product.

Rfam family: Metazoan signal recognition particle RNA (RF00017)

Gene Ontology (Rfam-derived)

GO ID	Aspect	Term
GO:0005786	cellular component	signal recognition particle, endoplasmic reticulum targeting
GO:0006617	biological process	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition

ncRNA interactions

Experimentally supported non-coding-RNA interaction partners (NPInter).

showing 60 of 61 interaction partners:

Partner	Partner type	Level	Source
SF1	protein	RNA-Protein	Literature mining
WDR33	protein	RNA-Protein	High-throughput data
TARDBP	protein	RNA-Protein	High-throughput data
MOV10	protein	RNA-Protein	High-throughput data
HNRNPA1	protein	RNA-Protein	High-throughput data
CPSF7	protein	RNA-Protein	High-throughput data
CPSF6	protein	RNA-Protein	High-throughput data
C17ORF85	protein	RNA-Protein	High-throughput data combine LncPro prediction
CPSF5	protein	RNA-Protein	High-throughput data
FMR1	protein	RNA-Protein	High-throughput data
FXR1	protein	RNA-Protein	High-throughput data
CSTF2	protein	RNA-Protein	High-throughput data
LIN28A	protein	RNA-Protein	High-throughput data
YTHDF2	protein	RNA-Protein	High-throughput data
FUS	protein	RNA-Protein	High-throughput data
TARBP2	protein	RNA-Protein	High-throughput data
hnRNPA2B1	protein	RNA-Protein	High-throughput data
hsa-miR-22-3p	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-mir-28-3p	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-mir-320a	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-miR-320b	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-miR-320c	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-miR-320d	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-mir-34a-3p	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-mir-34c-5p	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-miR-4429	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-miR-449a	miRNA	RNA-RNA	TargetScan with Ago CLIP data
hsa-miR-449b-3p	miRNA	RNA-RNA	TargetScan with Ago CLIP data
RN7SL144P	ncRNA	RNA-RNA	RISE database
PEAK1	mRNA	RNA-RNA	RISE database
RN7SL752P	ncRNA	RNA-RNA	RISE database
RN7SL563P	ncRNA	RNA-RNA	RISE database
RN7SL124P	ncRNA	RNA-RNA	RISE database
RN7SL538P	ncRNA	RNA-RNA	RISE database
ZNF536	mRNA	RNA-RNA	RISE database
RN7SL296P	ncRNA	RNA-RNA	RISE database
RN7SL34P	ncRNA	RNA-RNA	RISE database
RN7SL173P	ncRNA	RNA-RNA	RISE database
RN7SL687P	ncRNA	RNA-RNA	RISE database
SLC5A10	mRNA	RNA-RNA	RISE database
RN7SL665P	ncRNA	RNA-RNA	RISE database
RN7SL675P	ncRNA	RNA-RNA	RISE database
RN7SL408P	ncRNA	RNA-RNA	RISE database
C8orf34-AS1	ncRNA	RNA-RNA	RISE database
XPO7	mRNA	RNA-RNA	RISE database
RN7SL116P	ncRNA	RNA-RNA	RISE database
RN7SL666P	ncRNA	RNA-RNA	RISE database
TRIM26	mRNA	RNA-RNA	RISE database
RN7SL396P	ncRNA	RNA-RNA	RISE database
CTC1	mRNA	RNA-RNA	RISE database
RN7SL493P	ncRNA	RNA-RNA	RISE database
RN7SL438P	ncRNA	RNA-RNA	RISE database
Metazoa_SRP	ncRNA	RNA-RNA	RISE database
OSBPL9P4	pseudogene	RNA-RNA	RISE database
RP11-832A4	mRNA	RNA-RNA	RISE database
RN7SL507P	ncRNA	RNA-RNA	RISE database
TMED9	mRNA	RNA-RNA	RISE database
RN7SL636P	ncRNA	RNA-RNA	RISE database
RN7SL397P	ncRNA	RNA-RNA	RISE database
RN7SL394P	ncRNA	RNA-RNA	RISE database

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No curated drug or pharmacology associations for this gene.