RN7SL3

Summary

RN7SL3 (RNA component of signal recognition particle 7SL3, HGNC:23135) is a non-coding RNA gene on chromosome 14q21.3.

The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides (e.g., SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL3, that is partially homologous to Alu DNA (Ullu and Weiner, 1984 [PubMed 6084597]).

Source: NCBI Gene 378707 — RefSeq curated summary.

At a glance

• Gene type: non-coding (misc_RNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23135
Approved symbol	RN7SL3
Name	RNA component of signal recognition particle 7SL3
Location	14q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	7L30.2, RNSRP3
Ensembl gene	ENSG00000278771
Ensembl biotype	misc_RNA
OMIM	612180
Entrez	378707
RNAcentral	URS0000A8D543 — ncRNA, 299 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 misc_RNA

ENST00000610674

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610674 — 1 exons

Exon	Start	End
ENSE00003736104	49853616	49853914

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 99.95.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	99.95	gold quality
colonic epithelium	UBERON:0000397	99.90	gold quality
adrenal tissue	UBERON:0018303	99.71	gold quality
bone marrow cell	CL:0002092	99.65	gold quality
urinary bladder	UBERON:0001255	99.59	gold quality
tonsil	UBERON:0002372	99.53	gold quality
sural nerve	UBERON:0015488	99.18	gold quality
calcaneal tendon	UBERON:0003701	93.46	gold quality
bone marrow	UBERON:0002371	90.63	gold quality
superior frontal gyrus	UBERON:0002661	90.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.98	gold quality
skeletal muscle tissue	UBERON:0001134	87.73	gold quality
primary visual cortex	UBERON:0002436	87.31	gold quality
muscle tissue	UBERON:0002385	84.63	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.06	gold quality
liver	UBERON:0002107	78.82	gold quality
uterine cervix	UBERON:0000002	78.10	gold quality
Ammon’s horn	UBERON:0001954	74.92	gold quality
ventricular zone	UBERON:0003053	74.64	gold quality
monocyte	CL:0000576	74.25	gold quality
leukocyte	CL:0000738	73.82	gold quality
prefrontal cortex	UBERON:0000451	73.06	gold quality
kidney	UBERON:0002113	72.85	gold quality
substantia nigra	UBERON:0002038	72.65	gold quality
blood	UBERON:0000178	71.61	gold quality
cortical plate	UBERON:0005343	71.42	gold quality
lung	UBERON:0002048	70.39	gold quality
hypothalamus	UBERON:0001898	70.16	gold quality
frontal cortex	UBERON:0001870	69.73	gold quality
putamen	UBERON:0001874	69.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.73

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• RN7SL3 is a functional gene with two novelregiulatory sequences: a TATA box and intrnal A and B box-like motifs. (PMID:15667936)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Metazoa_SRP	ENSRNOG00000060497

Paralogs (847): Metazoa_SRP (ENSG00000196274), Metazoa_SRP (ENSG00000197334), Metazoa_SRP (ENSG00000203286), Metazoa_SRP (ENSG00000203411), Metazoa_SRP (ENSG00000203436), Metazoa_SRP (ENSG00000203573), Metazoa_SRP (ENSG00000213167), Metazoa_SRP (ENSG00000214305), Metazoa_SRP (ENSG00000237261), Metazoa_SRP (ENSG00000237611), RN7SL499P (ENSG00000239202), RN7SL563P (ENSG00000239211), RN7SL442P (ENSG00000239221), RN7SL546P (ENSG00000239224), RN7SL578P (ENSG00000239228), RN7SL589P (ENSG00000239247), RN7SL757P (ENSG00000239249), RN7SL271P (ENSG00000239250), RN7SL184P (ENSG00000239279), RN7SL11P (ENSG00000239316), RN7SL854P (ENSG00000239319), RN7SL658P (ENSG00000239333), RN7SL309P (ENSG00000239356), RN7SL477P (ENSG00000239367), RN7SL87P (ENSG00000239390), RN7SL414P (ENSG00000239396), RN7SL342P (ENSG00000239398), RN7SL535P (ENSG00000239419), RN7SL752P (ENSG00000239437), RN7SL691P (ENSG00000239464), RN7SL552P (ENSG00000239466), RN7SL569P (ENSG00000239468), RN7SL584P (ENSG00000239471), RN7SL221P (ENSG00000239472), RN7SL333P (ENSG00000239494), RN7SL583P (ENSG00000239504), RN7SL399P (ENSG00000239542), RN7SL822P (ENSG00000239545), RN7SL843P (ENSG00000239547), RN7SL12P (ENSG00000239553)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.