RNA5-8SN1

Summary

RNA5-8SN1 (RNA, 5.8S ribosomal N1, HGNC:53517) is a ribosomal RNA gene on chromosome 21p11.2.

45S ribosomal DNA (rDNA) arrays, or clusters, are present on human chromosomes 13, 14, 15, 21 and 22, designated RNR1 through RNR5, respectively. Each cluster consists of multiple 45S rDNA repeat units, that vary in number among individuals and chromosomes, with total diploid copy number estimates ranging from 60 to >800 repeat units in a human genome. The 45S rDNA repeat unit encodes a 45S rRNA precursor, transcribed by RNA polymerase I, which is processed to form the 18S, 5.8S and 28S rRNAs. Gene and RefSeq, in collaboration with HGNC, currently describe one 45S rDNA cluster, and one set of 45S precursor and product rRNAs, for each of the five human chromosomes to which these loci are localized. This gene is a representative copy of the 5.8S ribosomal RNA on chromosome 21.

Source: NCBI Gene 106632260 — RefSeq curated summary.

At a glance

• Gene type: non-coding (rRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53517
Approved symbol	RNA5-8SN1
Name	RNA, 5.8S ribosomal N1
Location	21p11.2
Locus type	RNA, ribosomal
Status	Approved
Ensembl gene	ENSG00000278189
Ensembl biotype	rRNA
Entrez	106632260
RNAcentral	URS0000005270 — rRNA, 157 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 rRNA

ENST00000619471

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619471 — 1 exons

Exon	Start	End
ENSE00003732889	8439823	8439975

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 99.99.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.99	gold quality
mucosa of transverse colon	UBERON:0004991	99.58	gold quality
adrenal tissue	UBERON:0018303	99.41	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	99.30	gold quality
monocyte	CL:0000576	99.25	gold quality
duodenum	UBERON:0002114	98.96	gold quality
lower esophagus mucosa	UBERON:0035834	98.95	gold quality
vermiform appendix	UBERON:0001154	98.57	gold quality
transverse colon	UBERON:0001157	98.55	gold quality
saliva-secreting gland	UBERON:0001044	98.53	gold quality
right lobe of thyroid gland	UBERON:0001119	98.51	gold quality
minor salivary gland	UBERON:0001830	98.47	gold quality
small intestine	UBERON:0002108	98.46	gold quality
small intestine Peyer’s patch	UBERON:0003454	98.46	gold quality
tibial nerve	UBERON:0001323	98.35	gold quality
body of pancreas	UBERON:0001150	98.26	gold quality
spleen	UBERON:0002106	98.22	gold quality
right lobe of liver	UBERON:0001114	98.15	gold quality
rectum	UBERON:0001052	98.10	gold quality
right testis	UBERON:0004534	98.10	gold quality
left lobe of thyroid gland	UBERON:0001120	98.06	gold quality
right uterine tube	UBERON:0001302	98.05	gold quality
subcutaneous adipose tissue	UBERON:0002190	98.05	gold quality
pancreas	UBERON:0001264	98.04	gold quality
putamen	UBERON:0001874	97.95	gold quality
adenohypophysis	UBERON:0002196	97.91	gold quality
left testis	UBERON:0004533	97.86	gold quality
right ovary	UBERON:0002118	97.79	gold quality
prostate gland	UBERON:0002367	97.79	gold quality
leukocyte	CL:0000738	97.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	5_8S_rRNA	ENSRNOG00000078413
rattus_norvegicus	5_8S_rRNA	ENSRNOG00000082679
rattus_norvegicus	5_8S_rRNA	ENSRNOG00000083151

Paralogs (13): (ENSG00000273730), (ENSG00000274917), RNA5-8SN3 (ENSG00000275215), (ENSG00000275757), 5_8S_rRNA (ENSG00000275877), (ENSG00000276700), 5_8S_rRNA (ENSG00000276871), 5_8S_rRNA (ENSG00000277739), RNA5-8SN2 (ENSG00000278233), (ENSG00000278294), 5_8S_rRNA (ENSG00000283274), 5_8S_rRNA (ENSG00000283291), 5_8S_rRNA (ENSG00000283568)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.