RNASE10

Summary

RNASE10 (ribonuclease A family member 10 (inactive), HGNC:19275) is a protein-coding gene on chromosome 14q11.2, encoding Inactive ribonuclease-like protein 10 (Q5GAN6). Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility.

Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including defense response to Gram-positive bacterium; positive regulation of flagellated sperm motility; and regulation of fertilization. Predicted to act upstream of or within epithelial cell morphogenesis; seminiferous tubule development; and single fertilization. Predicted to be located in extracellular region.

Source: NCBI Gene 338879 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 37 total
• MANE Select transcript: NM_001386206

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19275
Approved symbol	RNASE10
Name	ribonuclease A family member 10 (inactive)
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Aliases	RNASE9, RAH1
Ensembl gene	ENSG00000182545
Ensembl biotype	protein_coding
OMIM	621046
Entrez	338879

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000328444, ENST00000430083

RefSeq mRNA: 2 — MANE Select: NM_001386206 NM_001012975, NM_001386206

CCDS: CCDS32035

Canonical transcript exons

ENST00000430083 — 2 exons

Exon	Start	End
ENSE00001712160	20510467	20513884
ENSE00001738786	20505537	20506019

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 80.35.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.35	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.30	gold quality
bone marrow cell	CL:0002092	68.64	silver quality
hindlimb stylopod muscle	UBERON:0004252	67.78	gold quality
lower esophagus mucosa	UBERON:0035834	66.09	gold quality
apex of heart	UBERON:0002098	64.20	gold quality
stromal cell of endometrium	CL:0002255	60.78	gold quality
right uterine tube	UBERON:0001302	60.69	gold quality
sural nerve	UBERON:0015488	59.10	silver quality
ganglionic eminence	UBERON:0004023	59.06	gold quality
left adrenal gland	UBERON:0001234	58.70	gold quality
granulocyte	CL:0000094	58.31	gold quality
left adrenal gland cortex	UBERON:0035825	58.17	gold quality
right adrenal gland	UBERON:0001233	57.67	gold quality
adrenal gland	UBERON:0002369	56.40	gold quality
right adrenal gland cortex	UBERON:0035827	56.38	gold quality
tonsil	UBERON:0002372	56.17	silver quality
bone marrow	UBERON:0002371	54.70	gold quality
duodenum	UBERON:0002114	54.34	gold quality
left uterine tube	UBERON:0001303	53.81	gold quality
urinary bladder	UBERON:0001255	53.61	gold quality
mucosa of transverse colon	UBERON:0004991	53.36	gold quality
gastrocnemius	UBERON:0001388	53.00	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	52.65	gold quality
esophagus mucosa	UBERON:0002469	52.43	gold quality
uterine cervix	UBERON:0000002	52.21	gold quality
right coronary artery	UBERON:0001625	52.20	gold quality
endocervix	UBERON:0000458	52.07	gold quality
muscle of leg	UBERON:0001383	52.01	gold quality
left ovary	UBERON:0002119	51.77	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-36552	yes	62.58
E-ANND-3	no	0.97

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rnase10	ENSMUSG00000021872
rattus_norvegicus	Rnase10	ENSRNOG00000010261

Paralogs (12): RNASE1 (ENSG00000129538), RNASE7 (ENSG00000165799), RNASE2 (ENSG00000169385), RNASE3 (ENSG00000169397), RNASE6 (ENSG00000169413), RNASE8 (ENSG00000173431), RNASE11 (ENSG00000173464), RNASE9 (ENSG00000188655), RNASE13 (ENSG00000206150), ANG (ENSG00000214274), RNASE12 (ENSG00000258436), RNASE4 (ENSG00000258818)

Protein

Protein identifiers

Inactive ribonuclease-like protein 10 — Q5GAN6 (reviewed: Q5GAN6)

All UniProt accessions (2): Q5GAN6, W0UTC4

UniProt curated annotations — full annotation on UniProt →

Function. Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity.

Subcellular location. Secreted.

Post-translational modifications. The N-terminus is blocked. Glycosylated.

Similarity. Belongs to the pancreatic ribonuclease family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5GAN6-1	1	yes
Q5GAN6-2	2

RefSeq proteins (2): NP_001012993, NP_001373135* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001427	RNaseA	Family
IPR023412	RNaseA_domain	Domain
IPR036816	RNaseA-like_dom_sf	Homologous_superfamily

Pfam: PF00074

UniProt features (5 total): signal peptide 1, chain 1, region of interest 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5GAN6-F1	65.05	0.32

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 69 (showing top): GOBP_SINGLE_FERTILIZATION, GOBP_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS, GOMF_RNA_NUCLEASE_ACTIVITY, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, GOMF_NUCLEASE_ACTIVITY, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION, GOBP_CELL_CELL_ADHESION, GOBP_CILIUM_MOVEMENT, GOBP_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT, GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY, GOBP_REGULATION_OF_REPRODUCTIVE_PROCESS, GOBP_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM, GOBP_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION, GOBP_REGULATION_OF_CILIUM_MOVEMENT

GO Biological Process (7): single fertilization (GO:0007338), positive regulation of cell-cell adhesion (GO:0022409), heterotypic cell-cell adhesion (GO:0034113), defense response to Gram-positive bacterium (GO:0050830), regulation of fertilization (GO:0080154), positive regulation of flagellated sperm motility (GO:1902093), cell adhesion (GO:0007155)

GO Molecular Function (2): nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
fertilization	2
cell-cell adhesion	2
binding	2
regulation of cell-cell adhesion	1
positive regulation of cell adhesion	1
defense response to bacterium	1
regulation of reproductive process	1
positive regulation of cilium movement	1
flagellated sperm motility	1
regulation of flagellated sperm motility	1
positive regulation of cilium-dependent cell motility	1
positive regulation of reproductive process	1
cellular process	1
cellular anatomical structure	1

Protein interactions and networks

STRING

226 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RNASE10	PDILT	Q8N807	628
RNASE10	PRSS37	A4D1T9	615
RNASE10	PRSS55	Q6UWB4	530
RNASE10	CALR3	Q96L12	520
RNASE10	RNASE8	Q8TDE3	507
RNASE10	TEX101	Q9BY14	499
RNASE10	TPST2	O60704	494
RNASE10	PMIS2	A0A1W2PS18	479
RNASE10	LCN9	Q8WX39	478
RNASE10	CLGN	O14967	477
RNASE10	ADAM2	P78326	471
RNASE10	RNASE11	Q8TAA1	470
RNASE10	CST11	Q9H112	461
RNASE10	LCN8	Q6JVE9	449
RNASE10	TNFAIP6	P98066	412

IntAct

23 interactions, top by confidence:

A	B	Type	Score
SGTA	RNASE10	psi-mi:“MI:0915”(physical association)	0.560
RNASE10	CREB3L1	psi-mi:“MI:0915”(physical association)	0.560
BFSP2	RNASE10	psi-mi:“MI:0915”(physical association)	0.560
RNASE10	SGTB	psi-mi:“MI:0915”(physical association)	0.560
RNASE10	MRM1	psi-mi:“MI:0915”(physical association)	0.560
SGPL1	RNASE10	psi-mi:“MI:0915”(physical association)	0.560
RNASE10	TRMT1	psi-mi:“MI:0915”(physical association)	0.400
MOSPD3	TSN	psi-mi:“MI:0914”(association)	0.350
RNASE10	SGTA	psi-mi:“MI:0915”(physical association)	0.000
RNASE10	CREB3L1	psi-mi:“MI:0915”(physical association)	0.000
BFSP2	RNASE10	psi-mi:“MI:0915”(physical association)	0.000
RNASE10	SGTB	psi-mi:“MI:0915”(physical association)	0.000
RNASE10	MRM1	psi-mi:“MI:0915”(physical association)	0.000
RNASE10	SGPL1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (9): PGAM5 (Co-fractionation), RNASE10 (Two-hybrid), RNASE10 (Two-hybrid), RNASE10 (Two-hybrid), RNASE10 (Two-hybrid), SGTB (Two-hybrid), MRM1 (Two-hybrid), RNASE10 (Affinity Capture-MS), TRMT1 (Affinity Capture-MS)

ESM2 similar proteins: A8MXK1, O09163, O46633, O54713, O76096, O95684, P01148, P01268, P01269, P01270, P01344, P04089, P07352, P07456, P07490, P10286, P10764, P13562, P14745, P15696, P17647, P23695, P33717, P37042, P41694, P49921, P51459, P51462, P52212, P55247, Q05078, Q08279, Q27IM2, Q28588, Q29423, Q2YDD1, Q3SXP7, Q4R7M4, Q4R7V3, Q5GAN6

Diamond homologs: A1YLB9, B3EWJ0, O18937, O35290, O35291, O35292, O46525, O46526, O46527, O46528, O46529, O46530, O46531, O46532, O46533, O46534, O55004, P00657, P00680, P00682, P00685, P03950, P08904, P10153, P12724, P15466, P15467, P15468, P16414, P24717, P34096, P47778, P47779, P47780, P47781, P47782, P47783, P47784, P47785, P47786

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

37 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	31
Likely benign	3
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

829 predictions. Top by Δscore:

Variant	Effect	Δscore
14:20558526:C:A	donor_gain	1.0000
14:20558538:A:AC	donor_gain	1.0000
14:20558539:C:CC	donor_gain	1.0000
14:20557084:C:CC	acceptor_gain	0.9900
14:20557573:T:TA	donor_gain	0.9900
14:20557579:A:C	donor_gain	0.9900
14:20558524:ATC:A	donor_gain	0.9900
14:20558537:CA:C	donor_gain	0.9900
14:20558551:T:TA	donor_gain	0.9900
14:20557082:CA:C	acceptor_gain	0.9800
14:20557578:AAC:A	donor_gain	0.9800
14:20558521:C:CA	donor_gain	0.9800
14:20558525:T:TA	donor_gain	0.9800
14:20558534:T:A	donor_gain	0.9800
14:20558554:T:TA	donor_gain	0.9800
14:20558508:C:CA	donor_gain	0.9600
14:20558547:AGTGT:A	donor_gain	0.9600
14:20560870:TTACC:T	donor_loss	0.9600
14:20560871:TACC:T	donor_loss	0.9600
14:20560872:AC:A	donor_loss	0.9600
14:20560873:CC:C	donor_loss	0.9600
14:20560903:A:AC	donor_gain	0.9600
14:20560904:C:CC	donor_gain	0.9600
14:20557081:ACA:A	acceptor_gain	0.9500
14:20557082:CAC:C	acceptor_gain	0.9500
14:20560336:C:CC	donor_gain	0.9500
14:20557084:CTAAA:C	acceptor_loss	0.9400
14:20557085:T:G	acceptor_loss	0.9400
14:20558517:T:A	donor_gain	0.9400
14:20557093:A:C	acceptor_loss	0.9300

AlphaMissense

1622 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:20510976:A:C	S169R	0.995
14:20510978:C:A	S169R	0.995
14:20510978:C:G	S169R	0.995
14:20511003:T:A	C178S	0.994
14:20511004:G:C	C178S	0.994
14:20510889:T:C	F140L	0.993
14:20510891:C:A	F140L	0.993
14:20510891:C:G	F140L	0.993
14:20510890:T:G	F140C	0.991
14:20511039:T:A	C190S	0.991
14:20511040:G:C	C190S	0.991
14:20510826:T:A	C119S	0.989
14:20510827:G:C	C119S	0.989
14:20511004:G:A	C178Y	0.986
14:20510967:T:A	C166S	0.985
14:20510968:G:C	C166S	0.985
14:20511046:A:G	Y192C	0.985
14:20510925:T:A	C152S	0.983
14:20510926:G:C	C152S	0.983
14:20511003:T:C	C178R	0.982
14:20511005:C:G	C178W	0.982
14:20510871:T:A	C134S	0.980
14:20510872:G:C	C134S	0.980
14:20510890:T:C	F140S	0.980
14:20510967:T:C	C166R	0.979
14:20511004:G:T	C178F	0.978
14:20510970:C:G	H167D	0.976
14:20511040:G:T	C190F	0.976
14:20511040:G:A	C190Y	0.975
14:20511084:T:A	C205S	0.975

dbSNP variants (sampled 300 via entrez): RS1000129149 (14:20508262 A>G), RS1000652076 (14:20509210 G>A), RS1000732823 (14:20509419 T>C), RS1000743352 (14:20502305 G>A), RS1001737462 (14:20514348 AT>A,ATT), RS1001980295 (14:20503857 A>T), RS1002576538 (14:20504858 C>A,G,T), RS1002683043 (14:20512302 G>C,T), RS1002828711 (14:20504722 A>C), RS1003205283 (14:20504636 C>A,G,T), RS1003658851 (14:20513192 G>C), RS1003690189 (14:20513304 G>A), RS1003694697 (14:20503681 G>T), RS1003800771 (14:20507674 A>T), RS1003988499 (14:20507901 C>G)

Disease associations

OMIM: gene MIM:621046 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002441_9	Immune response to measles-mumps-rubella vaccine	7.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004645	response to vaccine

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
CGP 52608	affects binding, increases reaction	1
Grape Seed Proanthocyanidins	decreases expression, affects cotreatment	1
Benzo(a)pyrene	affects methylation	1
Catechin	affects cotreatment, decreases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.