RNASE11

Summary

RNASE11 (ribonuclease A family member 11 (inactive), HGNC:19269) is a protein-coding gene on chromosome 14q11.2, encoding Putative inactive ribonuclease 11 (Q8TAA1).

Predicted to enable endonuclease activity and nucleic acid binding activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region.

Source: NCBI Gene 122651 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 30 total
• MANE Select transcript: NM_001394190

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19269
Approved symbol	RNASE11
Name	ribonuclease A family member 11 (inactive)
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Aliases	RAJ1
Ensembl gene	ENSG00000173464
Ensembl biotype	protein_coding
Entrez	122651

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 protein_coding

ENST00000398008, ENST00000398009, ENST00000413502, ENST00000432835, ENST00000443456, ENST00000553849, ENST00000554842, ENST00000555841, ENST00000557105, ENST00000557503, ENST00000912520

RefSeq mRNA: 9 — MANE Select: NM_001394190 NM_001394189, NM_001394190, NM_001394191, NM_001394192, NM_001394193, NM_001394194, NM_001394195, NM_001394196, NM_145250

CCDS: CCDS9553

Canonical transcript exons

ENST00000557105 — 3 exons

Exon	Start	End
ENSE00002433376	20582892	20584496
ENSE00002509964	20587860	20588001
ENSE00003705889	20587563	20587625

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 93.10.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1353 / max 133.5404, expressed in 6 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142041	0.0589	3
142043	0.0561	5
142040	0.0077	1
142042	0.0074	1
207137	0.0052	1

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	93.10	gold quality
testis	UBERON:0000473	92.74	gold quality
right testis	UBERON:0004534	92.64	gold quality
placenta	UBERON:0001987	41.89	gold quality
bone marrow cell	CL:0002092	38.81	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ectocervix	UBERON:0012249	36.88	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
metanephros cortex	UBERON:0010533	33.92	silver quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	33.10	gold quality
adrenal tissue	UBERON:0018303	32.87	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
uterine cervix	UBERON:0000002	31.68	silver quality
right uterine tube	UBERON:0001302	31.57	gold quality
monocyte	CL:0000576	31.16	silver quality
right lung	UBERON:0002167	31.09	silver quality
muscle tissue	UBERON:0002385	31.06	gold quality
cortex of kidney	UBERON:0001225	30.97	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
leukocyte	CL:0000738	30.84	silver quality
left adrenal gland cortex	UBERON:0035825	30.02	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
urinary bladder	UBERON:0001255	29.45	silver quality
left adrenal gland	UBERON:0001234	29.41	silver quality
adrenal gland	UBERON:0002369	29.08	silver quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
tonsil	UBERON:0002372	28.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

51 targeting RNASE11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-520F-3P	99.82	71.32	1216
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-139-5P	99.80	69.50	1399
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-7856-5P	99.75	69.99	2901
HSA-MIR-3913-3P	99.74	66.53	938
HSA-MIR-4428	99.73	66.41	1733
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-377-3P	99.37	70.18	1905

Cross-species orthologs

0 orthologs

Paralogs (12): RNASE1 (ENSG00000129538), RNASE7 (ENSG00000165799), RNASE2 (ENSG00000169385), RNASE3 (ENSG00000169397), RNASE6 (ENSG00000169413), RNASE8 (ENSG00000173431), RNASE10 (ENSG00000182545), RNASE9 (ENSG00000188655), RNASE13 (ENSG00000206150), ANG (ENSG00000214274), RNASE12 (ENSG00000258436), RNASE4 (ENSG00000258818)

Protein

Protein identifiers

Putative inactive ribonuclease 11 — Q8TAA1 (reviewed: Q8TAA1)

All UniProt accessions (6): Q8TAA1, C9JHH6, C9JYR4, G3V3W8, G3V5L6, Q5GAN5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

Similarity. Belongs to the pancreatic ribonuclease family.

RefSeq proteins (9): NP_001381118, NP_001381119, NP_001381120, NP_001381121, NP_001381122, NP_001381123, NP_001381124, NP_001381125, NP_660293 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001427	RNaseA	Family
IPR023412	RNaseA_domain	Domain
IPR036816	RNaseA-like_dom_sf	Homologous_superfamily

Pfam: PF00074

UniProt features (11 total): glycosylation site 3, sequence variant 2, disulfide bond 2, signal peptide 1, chain 1, active site 1, binding site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TAA1-F1	55.38	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 82 (proton acceptor)

Ligand- & substrate-binding residues (1): 115–119

Disulfide bonds (2): 98–158, 114–169

Glycosylation sites (3): 61, 89, 111

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 53 (showing top): GOMF_RNA_NUCLEASE_ACTIVITY, GOMF_NUCLEASE_ACTIVITY, GOBP_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM, GOBP_DEFENSE_RESPONSE_TO_BACTERIUM, KONDO_PROSTATE_CANCER_HCP_WITH_H3K27ME3, RNCTGNYNRNCTGNY_UNKNOWN, GOBP_RESPONSE_TO_BACTERIUM, GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA, BRF1_TARGET_GENES, DYRK1A_TARGET_GENES, FOXN3_TARGET_GENES, GUCY1B1_TARGET_GENES, KAT2A_TARGET_GENES, RUVBL1_TARGET_GENES, RYBP_TARGET_GENES

GO Biological Process (1): defense response to Gram-positive bacterium (GO:0050830)

GO Molecular Function (2): nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
defense response to bacterium	1
cellular anatomical structure	1

Protein interactions and networks

STRING

150 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RNASE11	RNASE12	Q5GAN4	656
RNASE11	RNASE8	Q8TDE3	606
RNASE11	RNASE2	P10153	581
RNASE11	RNASE7	P80927	578
RNASE11	RNASE3	P12724	576
RNASE11	RNASE6	Q93091	507
RNASE11	RNASE13	Q5GAN3	507
RNASE11	RNASE10	Q5GAN6	470
RNASE11	C6orf118	Q5T5N4	446
RNASE11	HIBADH	P31937	363
RNASE11	ZNF343	Q6P1L6	359
RNASE11	ANG	P03950	321
RNASE11	TEX2	Q8IWB9	309
RNASE11	TBC1D16	Q8TBP0	309
RNASE11	GTF3C3	Q9Y5Q9	307

IntAct

4 interactions, top by confidence:

A	B	Type	Score
OTX2	RNASE11	psi-mi:“MI:0915”(physical association)	0.560
RNASE11	OTX2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (2): RNASE11 (Two-hybrid), APP (Reconstituted Complex)

ESM2 similar proteins: B1B212, B1B213, B3F0J0, C8AW45, F5HFB4, O08602, O08603, O08604, O54831, O62757, P08560, P08700, P11052, P15247, P15248, P20096, P20826, P21581, P21583, P28773, P46685, P51748, P52173, P79169, P79368, Q06220, Q06435, Q08125, Q09108, Q28132, Q29030, Q29118, Q3Y5G8, Q5WQV8, Q60481, Q6EAL8, Q6EBC2, Q7TSL0, Q865W5, Q865X3

Diamond homologs: Q5GAM9, Q8TAA1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

30 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

921 predictions. Top by Δscore:

Variant	Effect	Δscore
14:20584509:CAA:C	acceptor_gain	1.0000
14:20584511:A:AC	acceptor_gain	1.0000
14:20584511:A:C	acceptor_gain	1.0000
14:20584515:A:AC	acceptor_gain	1.0000
14:20584515:A:C	acceptor_gain	1.0000
14:20609667:T:TA	donor_gain	1.0000
14:20609668:C:A	donor_gain	1.0000
14:20584492:CTCTT:C	acceptor_gain	0.9900
14:20584494:CTT:C	acceptor_gain	0.9900
14:20584495:TT:T	acceptor_gain	0.9900
14:20584496:TC:T	acceptor_loss	0.9900
14:20584497:C:CA	acceptor_loss	0.9900
14:20584497:C:CC	acceptor_gain	0.9900
14:20584500:CAG:C	acceptor_gain	0.9900
14:20584501:A:T	acceptor_gain	0.9900
14:20584502:G:C	acceptor_gain	0.9900
14:20584502:G:GC	acceptor_gain	0.9900
14:20584510:A:T	acceptor_gain	0.9900
14:20590683:C:T	acceptor_gain	0.9800
14:20584493:TCTTC:T	acceptor_gain	0.9700
14:20594045:T:A	donor_gain	0.9700
14:20609538:TCTCA:T	donor_loss	0.9700
14:20609539:CTCA:C	donor_loss	0.9700
14:20609540:TCAC:T	donor_loss	0.9700
14:20609541:CACC:C	donor_loss	0.9700
14:20609542:A:C	donor_loss	0.9700
14:20609543:C:A	donor_loss	0.9700
14:20609664:A:AC	donor_gain	0.9700
14:20609665:C:CC	donor_gain	0.9700
14:20609719:T:TA	donor_gain	0.9700

AlphaMissense

1149 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:20584115:G:C	F120L	0.766
14:20584115:G:T	F120L	0.766
14:20584117:A:G	F120L	0.766
14:20584445:G:C	S10R	0.664
14:20584445:G:T	S10R	0.664
14:20584447:T:G	S10R	0.664
14:20584385:A:C	F30L	0.639
14:20584385:A:T	F30L	0.639
14:20584387:A:G	F30L	0.639
14:20584463:A:C	F4L	0.629
14:20584463:A:T	F4L	0.629
14:20584465:A:G	F4L	0.629
14:20584058:A:C	F139L	0.618
14:20584058:A:T	F139L	0.618
14:20584060:A:G	F139L	0.618

dbSNP variants (sampled 300 via entrez): RS1000174679 (14:20587001 C>A), RS1000432270 (14:20586220 T>C), RS1000484859 (14:20586550 T>G), RS1000579594 (14:20582539 G>A), RS1001147152 (14:20588065 A>G), RS1001572959 (14:20583526 C>T), RS1001924483 (14:20583215 A>G), RS1002120677 (14:20585532 A>G,T), RS1002178212 (14:20589812 G>A), RS1002528805 (14:20584492 C>A,G,T), RS1002957161 (14:20584802 A>G,T), RS1003548922 (14:20586162 T>A,C), RS1004131844 (14:20587033 G>C), RS1004955984 (14:20587582 A>G), RS1005119991 (14:20592212 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005721_6	Food allergy (parent-of-origin effect)	1.000000e-06
GCST005726_2	Milk allergy (parent-of-origin effect)	5.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0005939	parental genotype effect measurement
EFO:0007016	food allergy measurement
EFO:0007019	milk allergy measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation	1
CGP 52608	affects binding, increases reaction	1
Fulvestrant	affects cotreatment, decreases methylation	1
Benzo(a)pyrene	increases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.