RNASEH2B-AS1

Summary

RNASEH2B-AS1 (RNASEH2B antisense RNA 1, HGNC:39967) is a long non-coding RNA gene on chromosome 13q14.3.

Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting.

Source: NCBI Gene 100874255 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39967
Approved symbol	RNASEH2B-AS1
Name	RNASEH2B antisense RNA 1
Location	13q14.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233672
Ensembl biotype	lncRNA
Entrez	100874255
RNAcentral	URS000038CC99 — lncRNA, 625 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000454605, ENST00000593369, ENST00000593750, ENST00000594244, ENST00000596992, ENST00000601286, ENST00000625818, ENST00000629989, ENST00000631080, ENST00000659913, ENST00000660528, ENST00000664199, ENST00000673853, ENST00000790597, ENST00000790598

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000454605 — 3 exons

Exon	Start	End
ENSE00001592006	50910483	50910764
ENSE00001688986	50889609	50889735
ENSE00001772889	50882048	50882645

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 80.10.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1722 / max 12.5491, expressed in 61 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137366	0.1722	61

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.10	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.01	gold quality
colonic epithelium	UBERON:0000397	74.65	gold quality
corpus callosum	UBERON:0002336	74.04	gold quality
calcaneal tendon	UBERON:0003701	74.03	gold quality
bone marrow cell	CL:0002092	71.27	silver quality
sural nerve	UBERON:0015488	71.24	gold quality
monocyte	CL:0000576	68.70	gold quality
ventricular zone	UBERON:0003053	68.66	gold quality
leukocyte	CL:0000738	68.12	gold quality
cerebellar cortex	UBERON:0002129	67.80	gold quality
cerebellar hemisphere	UBERON:0002245	67.72	gold quality
cortical plate	UBERON:0005343	67.71	gold quality
cerebellum	UBERON:0002037	67.67	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.98	gold quality
right lobe of thyroid gland	UBERON:0001119	66.54	gold quality
bone marrow	UBERON:0002371	65.26	gold quality
thyroid gland	UBERON:0002046	65.21	gold quality
left lobe of thyroid gland	UBERON:0001120	64.54	gold quality
tonsil	UBERON:0002372	64.48	gold quality
endometrium	UBERON:0001295	63.64	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	62.83	gold quality
superior frontal gyrus	UBERON:0002661	62.63	gold quality
ganglionic eminence	UBERON:0004023	62.58	gold quality
muscle tissue	UBERON:0002385	61.83	gold quality
smooth muscle tissue	UBERON:0001135	61.80	gold quality
fallopian tube	UBERON:0003889	61.32	gold quality
right uterine tube	UBERON:0001302	61.23	gold quality
spleen	UBERON:0002106	60.80	gold quality
substantia nigra	UBERON:0002038	60.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.24

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.