RNF10

Summary

RNF10 (ring finger protein 10, HGNC:10055) is a protein-coding gene on chromosome 12q24.31, encoding E3 ubiquitin-protein ligase RNF10 (Q8N5U6). E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling.

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known.

Source: NCBI Gene 9921 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 124 total
• Druggable target: yes
• MANE Select transcript: NM_014868

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10055
Approved symbol	RNF10
Name	ring finger protein 10
Location	12q24.31
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0262, RIE2
Ensembl gene	ENSG00000022840
Ensembl biotype	protein_coding
OMIM	615998
Entrez	9921

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 9 protein_coding, 6 retained_intron, 6 protein_coding_CDS_not_defined, 4 nonsense_mediated_decay

ENST00000325954, ENST00000366112, ENST00000413266, ENST00000535395, ENST00000535417, ENST00000535470, ENST00000536869, ENST00000537376, ENST00000537740, ENST00000537997, ENST00000538254, ENST00000538796, ENST00000539486, ENST00000540046, ENST00000542207, ENST00000542438, ENST00000542701, ENST00000543578, ENST00000543675, ENST00000543757, ENST00000544124, ENST00000544805, ENST00000545419, ENST00000546262, ENST00000551139

RefSeq mRNA: 2 — MANE Select: NM_014868 NM_001330474, NM_014868

CCDS: CCDS81746, CCDS9201

Canonical transcript exons

ENST00000325954 — 17 exons

Exon	Start	End
ENSE00001111618	120563347	120563623
ENSE00001128109	120557546	120557682
ENSE00001300954	120534356	120534968
ENSE00002337700	120576590	120577588
ENSE00003468945	120560726	120560886
ENSE00003485301	120565072	120565189
ENSE00003488989	120554718	120554808
ENSE00003506784	120566825	120566980
ENSE00003594401	120557282	120557466
ENSE00003601576	120575631	120575688
ENSE00003612200	120562945	120563070
ENSE00003618976	120552499	120552698
ENSE00003643213	120563810	120563943
ENSE00003658274	120565428	120565529
ENSE00003660228	120546405	120546601
ENSE00003661539	120571191	120571291
ENSE00003680623	120575792	120575950

Expression profiles

Bgee: expression breadth ubiquitous, 290 present calls, max score 99.16.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 185.7230 / max 4252.6792, expressed in 1826 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128354	174.8516	1825
128355	9.2242	1781
128356	1.6472	863

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	99.16	gold quality
right testis	UBERON:0004534	99.11	gold quality
lower esophagus mucosa	UBERON:0035834	99.07	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.99	gold quality
gastrocnemius	UBERON:0001388	98.92	gold quality
sural nerve	UBERON:0015488	98.92	gold quality
cortical plate	UBERON:0005343	98.84	gold quality
stromal cell of endometrium	CL:0002255	98.83	gold quality
adenohypophysis	UBERON:0002196	98.83	gold quality
tibial nerve	UBERON:0001323	98.80	gold quality
colonic epithelium	UBERON:0000397	98.79	gold quality
ventricular zone	UBERON:0003053	98.79	gold quality
muscle of leg	UBERON:0001383	98.76	gold quality
blood	UBERON:0000178	98.73	gold quality
lower esophagus	UBERON:0013473	98.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	98.73	gold quality
metanephros cortex	UBERON:0010533	98.71	gold quality
ganglionic eminence	UBERON:0004023	98.69	gold quality
right atrium auricular region	UBERON:0006631	98.67	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.67	gold quality
right lung	UBERON:0002167	98.63	gold quality
apex of heart	UBERON:0002098	98.61	gold quality
left adrenal gland	UBERON:0001234	98.57	gold quality
right adrenal gland	UBERON:0001233	98.55	gold quality
cerebellar hemisphere	UBERON:0002245	98.55	gold quality
right adrenal gland cortex	UBERON:0035827	98.55	gold quality
right lobe of thyroid gland	UBERON:0001119	98.54	gold quality
body of pancreas	UBERON:0001150	98.54	gold quality
muscle layer of sigmoid colon	UBERON:0035805	98.54	gold quality
skin of leg	UBERON:0001511	98.53	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9221	yes	14.06
E-MTAB-10137	no	267.33
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MEOX2

Literature-anchored findings (GeneRIF, showing 6)

• MEOX2 and Meox2 binding to RNF10 protein was characterized. (PMID:16335786)
• RNF10 is a trans-acting protein regulating MAG expression and is required for myelin formation. (PMID:18941509)
• CYB5A, which has a role in stearyl-CoA-desaturase activity, and RNF10, with an unknown role in weight regulating pathways, associated with adiposity and nominally increased the risk for T2D in American Indians. (PMID:24151200)
• Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation. (PMID:33249776)
• The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation. (PMID:34348161)
• CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer. (PMID:36054164)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	rnf10	ENSDARG00000079687
mus_musculus	Rnf10	ENSMUSG00000041740
rattus_norvegicus	Rnf10	ENSRNOG00000001172
drosophila_melanogaster	CG12099	FBGN0035232

Protein

Protein identifiers

E3 ubiquitin-protein ligase RNF10 — Q8N5U6 (reviewed: Q8N5U6)

Alternative names: RING finger protein 10

All UniProt accessions (13): A0A024RBP0, A0A0G2JKT9, Q8N5U6, F5H3A4, F5H510, F5H5P6, F5H5Z1, H0YF69, H0YFN9, H0YFQ9, H0YG28, H0YGL7, H0YGX5

UniProt curated annotations — full annotation on UniProt →

Function. E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC) or elongation. The ribosome quality control is activated in response to ribosome subunit imbalance, amino acid starvation or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR). RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3: monoubiquitinated RPS2/us5 and RPS3/us3 are then recognized by RIOK3 kinase, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit. The action of RNF10 in iRQC is counteracted by USP10.

Subunit / interactions. Interacts with MEOX2.

Subcellular location. Cytoplasm. Nucleus.

Induction. Regulated at the translational level in response to amino acid starvation. In the absence of stress, ribosomes re-initiate translation at an inhibitory open reading frame (uORF) upstream of the RNF10 transcript, which precludes RNF10 translation. In response to stress, ribosomes bypass the inhibitory uORF and re-initiate translation at the RNF10 coding sequence.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the RNF10 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N5U6-1	1	yes
Q8N5U6-2	2

RefSeq proteins (2): NP_001317403, NP_055683* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR018957	Znf_C3HC4_RING-type	Domain
IPR039739	MAG2/RNF10	Family

Pfam: PF00097

UniProt features (23 total): compositionally biased region 7, region of interest 5, modified residue 3, mutagenesis site 3, sequence variant 2, chain 1, zinc finger region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N5U6-F1	65.67	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 5, 110, 128

Mutagenesis-validated functional residues (3):

Position	Phenotype
225–228	abolished e3 ubiquitin-protein ligase activity and ability to monoubiquitinate rps2/us5 and rps3/us3.
225	abolished e3 ubiquitin-protein ligase activity and ability to monoubiquitinate rps2/us5 and rps3/us3.
228	abolished e3 ubiquitin-protein ligase activity and ability to monoubiquitinate rps2/us5 and rps3/us3.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 197 (showing top): GOBP_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT, PAX4_01, GOBP_NEGATIVE_REGULATION_OF_GLIOGENESIS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_NEUROGENESIS, GOBP_REGULATION_OF_MYELINATION, GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT, CHANDRAN_METASTASIS_DN, GOBP_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT, GOBP_CELL_CELL_SIGNALING, BROWNE_HCMV_INFECTION_48HR_DN, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS, GOBP_REGULATION_OF_GLIAL_CELL_PROLIFERATION, GOBP_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION, GOBP_ENSHEATHMENT_OF_NEURONS

GO Biological Process (9): protein monoubiquitination (GO:0006513), negative regulation of Schwann cell proliferation (GO:0010626), positive regulation of myelination (GO:0031643), positive regulation of DNA-templated transcription (GO:0045893), positive regulation of transcription by RNA polymerase II (GO:0045944), protein autoubiquitination (GO:0051865), postsynapse to nucleus signaling pathway (GO:0099527), ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116), protein ubiquitination (GO:0016567)

GO Molecular Function (7): transcription cis-regulatory region binding (GO:0000976), zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), DNA binding (GO:0003677), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (5): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosolic ribosome (GO:0022626), glutamatergic synapse (GO:0098978), extrinsic component of postsynaptic density membrane (GO:0099147)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein ubiquitination	2
regulation of Schwann cell proliferation	1
Schwann cell proliferation	1
negative regulation of glial cell proliferation	1
regulation of myelination	1
positive regulation of nervous system process	1
myelination	1
positive regulation of cellular process	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
positive regulation of RNA biosynthetic process	1
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
postsynaptic signal transduction	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
protein modification by small protein conjugation	1
transcription regulatory region nucleic acid binding	1
sequence-specific double-stranded DNA binding	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
nucleic acid binding	1
binding	1
catalytic activity	1
cation binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
cytosol	1
ribosome	1
synapse	1
postsynaptic density membrane	1
extrinsic component of postsynaptic specialization membrane	1

Protein interactions and networks

STRING

1273 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RNF10	AKIRIN2	Q53H80	555
RNF10	GRIN2A	Q12879	496
RNF10	GRIFIN	A4D1Z8	480
RNF10	AP4E1	Q9UPM8	444
RNF10	COQ5	Q5HYK3	434
RNF10	DRAXIN	Q8NBI3	427
RNF10	COPS5	Q92905	420
RNF10	DPH6	Q7L8W6	415
RNF10	BICDL1	Q6ZP65	408
RNF10	CNPY2	Q9Y2B0	399
RNF10	ABHD17A	Q96GS6	375
RNF10	A0A2R8Y4M4	A0A2R8Y4M4	366
RNF10	ACTR10	Q9NZ32	351
RNF10	RNFT1	Q5M7Z0	345
RNF10	RNF208	Q9H0X6	335

IntAct

119 interactions, top by confidence:

A	B	Type	Score
NCOA4	FTL	psi-mi:“MI:0914”(association)	0.790
PSMD2	PSMD11	psi-mi:“MI:0914”(association)	0.730
RNF10	UBE2D1	psi-mi:“MI:0915”(physical association)	0.620
UBE2D2	RNF10	psi-mi:“MI:0915”(physical association)	0.620
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
RNF10	CASP6	psi-mi:“MI:0915”(physical association)	0.560
RNF10	DMWD	psi-mi:“MI:0915”(physical association)	0.560
RNF10	HIP1	psi-mi:“MI:0915”(physical association)	0.560
RNF10	HSPB1	psi-mi:“MI:0915”(physical association)	0.560
RNF10	LAMP2	psi-mi:“MI:0915”(physical association)	0.560
PRKN	RNF10	psi-mi:“MI:0915”(physical association)	0.560
RAN	RNF10	psi-mi:“MI:0915”(physical association)	0.560
RNF10	WFS1	psi-mi:“MI:0915”(physical association)	0.560
RNF10	CLSTN1	psi-mi:“MI:0915”(physical association)	0.560
RNF10	KIF1B	psi-mi:“MI:0915”(physical association)	0.560
RNF10	RNF11	psi-mi:“MI:0915”(physical association)	0.560
PRPF40A	RNF10	psi-mi:“MI:0915”(physical association)	0.560
RNF10	COQ8A	psi-mi:“MI:0915”(physical association)	0.560
RNF10	SPRED1	psi-mi:“MI:0915”(physical association)	0.560
SNCA	RNF10	psi-mi:“MI:0915”(physical association)	0.560
TARDBP	RNF10	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (461): RNF10 (Affinity Capture-RNA), RNF10 (Affinity Capture-RNA), RNF10 (Affinity Capture-RNA), RNF10 (Affinity Capture-RNA), RNF10 (Affinity Capture-MS), RNF10 (Affinity Capture-MS), RNF10 (Affinity Capture-MS), RNF10 (Affinity Capture-MS), RNF10 (Affinity Capture-MS), RNF10 (Affinity Capture-MS), RNF10 (Affinity Capture-MS), RNF10 (Reconstituted Complex), RNF10 (Affinity Capture-RNA), RNF10 (Affinity Capture-MS), RNF10 (Affinity Capture-RNA)

ESM2 similar proteins: A0A0G2L7I0, A0A0R4IWG9, A0JMK9, A5D979, B0BLU1, D3ZVU1, F6UH96, G3X912, O70445, O88700, P54132, P59110, Q03111, Q0VBD2, Q1LVK9, Q22557, Q24558, Q24595, Q28E45, Q5EAW4, Q5I2W8, Q5R1T0, Q5SPR8, Q5XI59, Q6A037, Q6DJS0, Q6INS5, Q6P2L6, Q6XV80, Q6ZPI0, Q71M44, Q7KW09, Q7L590, Q7T308, Q7ZVP1, Q7ZXG4, Q801E2, Q803U7, Q80Z32, Q8AXF4

Diamond homologs: A0A1L8FG46, A0A1L8FM16, A2XW69, A2ZAC2, B1AUE5, G2Q0E2, O35445, O54952, O60106, O64425, O74563, O77666, P38398, P40072, P48754, P62603, P87176, P93030, Q00940, Q08E13, Q09463, Q12899, Q14258, Q14527, Q1XHT8, Q32NQ8, Q336R3, Q3UIW5, Q4FE47, Q54S31, Q568Y3, Q5M807, Q5RFK9, Q5XI59, Q5ZIR9, Q6J6I8, Q6J6I9, Q6J6J0, Q6P9F5, Q6PC78

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	RNF10	ubiquitination
RNF10	“up-regulates activity”	MEOX2	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 90 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
TICAM1, RIP1-mediated IKK complex recruitment	5	45.5×	1e-05
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	8	44.6×	2e-09
IKK complex recruitment mediated by RIP1	5	37.6×	3e-05
HSF1 activation	5	28.8×	8e-05
PINK1-PRKN Mediated Mitophagy	5	27.0×	8e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	6	17.9×	8e-05
E3 ubiquitin ligases ubiquitinate target proteins	6	17.6×	8e-05
Maturation of DENV proteins	5	16.0×	4e-04

GO biological processes:

GO term	Partners	Fold	FDR
protein K11-linked ubiquitination	8	38.2×	1e-08
protein monoubiquitination	7	29.4×	5e-07
protein K48-linked ubiquitination	11	22.6×	1e-09
protein K63-linked ubiquitination	6	19.6×	7e-05
protein autoubiquitination	5	14.3×	2e-03
protein polyubiquitination	10	14.1×	4e-07
ubiquitin-dependent protein catabolic process	12	10.9×	2e-07
proteasome-mediated ubiquitin-dependent protein catabolic process	10	6.4×	4e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

124 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2916 predictions. Top by Δscore:

Variant	Effect	Δscore
12:120534964:GAGCG:G	donor_gain	1.0000
12:120534966:GCG:G	donor_gain	1.0000
12:120534968:GGTA:G	donor_loss	1.0000
12:120534969:G:A	donor_loss	1.0000
12:120534969:G:GG	donor_gain	1.0000
12:120534970:T:A	donor_loss	1.0000
12:120546396:T:A	acceptor_gain	1.0000
12:120546400:TTCA:T	acceptor_loss	1.0000
12:120546401:TCA:T	acceptor_loss	1.0000
12:120546402:CA:C	acceptor_loss	1.0000
12:120546403:A:AG	acceptor_gain	1.0000
12:120546403:AGAT:A	acceptor_gain	1.0000
12:120546403:AGATG:A	acceptor_gain	1.0000
12:120546404:G:GG	acceptor_gain	1.0000
12:120546404:GA:G	acceptor_gain	1.0000
12:120546404:GAT:G	acceptor_gain	1.0000
12:120546404:GATG:G	acceptor_gain	1.0000
12:120546404:GATGG:G	acceptor_gain	1.0000
12:120546586:TGG:T	donor_gain	1.0000
12:120546599:GAG:G	donor_gain	1.0000
12:120546600:AGG:A	donor_loss	1.0000
12:120546601:GGTA:G	donor_loss	1.0000
12:120546603:T:A	donor_loss	1.0000
12:120552620:G:GT	donor_gain	1.0000
12:120552699:G:GG	donor_gain	1.0000
12:120554714:CTA:C	acceptor_loss	1.0000
12:120554715:TA:T	acceptor_loss	1.0000
12:120554716:A:AG	acceptor_gain	1.0000
12:120554716:A:AT	acceptor_loss	1.0000
12:120554716:AGCT:A	acceptor_gain	1.0000

AlphaMissense

5350 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:120552572:T:C	L143S	1.000
12:120554790:G:C	W209C	1.000
12:120554790:G:T	W209C	1.000
12:120557309:T:C	C225R	1.000
12:120557423:T:C	C263R	1.000
12:120552575:T:C	L144S	0.999
12:120552580:T:C	F146L	0.999
12:120552581:T:C	F146S	0.999
12:120552582:C:A	F146L	0.999
12:120552582:C:G	F146L	0.999
12:120552685:T:C	F181L	0.999
12:120552687:T:A	F181L	0.999
12:120552687:T:G	F181L	0.999
12:120552694:G:C	A184P	0.999
12:120554726:T:C	F188S	0.999
12:120554788:T:A	W209R	0.999
12:120554788:T:C	W209R	0.999
12:120557310:G:A	C225Y	0.999
12:120557311:C:G	C225W	0.999
12:120557316:T:A	I227K	0.999
12:120557318:T:C	C228R	0.999
12:120557320:C:G	C228W	0.999
12:120557354:T:C	C240R	0.999
12:120557358:G:A	G241E	0.999
12:120557360:C:G	H242D	0.999
12:120557362:C:A	H242Q	0.999
12:120557362:C:G	H242Q	0.999
12:120557369:T:C	C245R	0.999
12:120557370:G:A	C245Y	0.999
12:120557371:C:G	C245W	0.999

dbSNP variants (sampled 300 via entrez): RS1000027673 (12:120535007 C>T), RS1000171510 (12:120563320 C>G), RS1000206811 (12:120554160 C>T), RS1000426729 (12:120548559 G>A), RS1000494847 (12:120571088 G>A,T), RS1000544782 (12:120572346 A>G,T), RS1000594196 (12:120556321 T>G), RS1000615484 (12:120566634 T>C), RS1000648201 (12:120566354 T>C), RS1000770465 (12:120572839 G>A), RS1000779305 (12:120553469 C>G), RS1000842820 (12:120560371 C>T), RS1000849733 (12:120544151 C>G,T), RS1000880692 (12:120543776 G>C), RS1000911089 (12:120547752 T>G)

Disease associations

OMIM: gene MIM:615998 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST001688_8	Type 1 diabetes nephropathy	2.000000e-06
GCST003453_12	Chronotype	3.000000e-09
GCST004619_72	Reticulocyte fraction of red cells	7.000000e-69
GCST009310_35	Sensorimotor dexterity	2.000000e-06
GCST010796_2391	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-09
GCST010796_2392	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-09
GCST010796_2393	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-08
GCST90002404_145	Red cell distribution width	3.000000e-11

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0008354	cognitive function measurement
EFO:0004327	electrocardiography
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067323 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression	4
bisphenol A	affects expression, decreases methylation	2
cobaltous chloride	increases expression	2
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, increases expression	2
Arsenic	increases abundance, increases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases oxidation, increases abundance, affects cotreatment	1
uranyl acetate	affects expression	1
beta-lapachone	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
ciglitazone	affects binding, increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
abrine	increases expression	1
Acrolein	increases oxidation, increases abundance, affects cotreatment	1
Benzo(a)pyrene	affects methylation	1
Ozone	increases abundance, affects cotreatment, increases oxidation	1
Smoke	decreases expression	1
Dronabinol	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Uranium	affects expression	1
Urethane	increases expression	1
Particulate Matter	increases abundance, increases expression	1
Volatile Organic Compounds	affects cotreatment, increases oxidation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652272	Binding	Binding affinity to human RNF10 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3G3	Abcam HEK293T RNF10 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.