RNF112

Summary

RNF112 (ring finger protein 112, HGNC:12968) is a protein-coding gene on chromosome 17p11.2, encoding RING finger protein 112 (Q9ULX5). E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development.

This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17.

Source: NCBI Gene 7732 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 76 total
• MANE Select transcript: NM_007148

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12968
Approved symbol	RNF112
Name	ring finger protein 112
Location	17p11.2
Locus type	gene with protein product
Status	Approved
Aliases	BFP
Ensembl gene	ENSG00000128482
Ensembl biotype	protein_coding
OMIM	601237
Entrez	7732

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 4 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000461366, ENST00000574149, ENST00000574782, ENST00000575165, ENST00000580109, ENST00000908743, ENST00000908744

RefSeq mRNA: 1 — MANE Select: NM_007148 NM_007148

CCDS: CCDS58529

Canonical transcript exons

ENST00000461366 — 14 exons

Exon	Start	End
ENSE00001673294	19415286	19415339
ENSE00001707377	19415518	19415592
ENSE00001831819	19411232	19411462
ENSE00001861552	19415038	19415207
ENSE00001947999	19415705	19417276
ENSE00001957989	19412938	19413144
ENSE00002337627	19414586	19414660
ENSE00002338221	19413577	19413681
ENSE00002339271	19414449	19414505
ENSE00002411226	19413280	19413411
ENSE00002420866	19414095	19414145
ENSE00002422186	19414770	19414887
ENSE00003562119	19411630	19411670
ENSE00003658263	19412498	19412783

Expression profiles

Bgee: expression breadth ubiquitous, 198 present calls, max score 98.02.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0612 / max 178.0678, expressed in 280 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
159841	1.2519	220
159840	0.5006	132
159838	0.2281	85
159839	0.0806	43

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	98.02	gold quality
cerebellar cortex	UBERON:0002129	97.99	gold quality
cerebellar hemisphere	UBERON:0002245	97.99	gold quality
cerebellum	UBERON:0002037	97.69	gold quality
cerebellar vermis	UBERON:0004720	96.95	gold quality
ganglionic eminence	UBERON:0004023	92.86	gold quality
right frontal lobe	UBERON:0002810	92.35	gold quality
cortical plate	UBERON:0005343	92.13	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.02	gold quality
nucleus accumbens	UBERON:0001882	90.77	gold quality
prefrontal cortex	UBERON:0000451	90.46	gold quality
frontal cortex	UBERON:0001870	90.02	gold quality
putamen	UBERON:0001874	89.70	gold quality
neocortex	UBERON:0001950	89.69	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	89.39	gold quality
caudate nucleus	UBERON:0001873	89.12	gold quality
anterior cingulate cortex	UBERON:0009835	89.08	gold quality
cerebral cortex	UBERON:0000956	88.73	gold quality
ventricular zone	UBERON:0003053	88.61	gold quality
brain	UBERON:0000955	88.00	gold quality
Ammon’s horn	UBERON:0001954	87.76	gold quality
hypothalamus	UBERON:0001898	87.46	gold quality
primary visual cortex	UBERON:0002436	87.18	gold quality
forebrain	UBERON:0001890	87.14	gold quality
amygdala	UBERON:0001876	87.09	gold quality
occipital lobe	UBERON:0002021	87.00	gold quality
parietal lobe	UBERON:0001872	86.49	gold quality
superior frontal gyrus	UBERON:0002661	86.28	gold quality
tendon of biceps brachii	UBERON:0008188	86.16	gold quality
postcentral gyrus	UBERON:0002581	86.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.92

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

3 targets.

Target	Regulation
CDK5
CDKN1B
IL12A

Upstream regulators (CollecTRI, top): RAI1

miRNA regulators (miRDB)

38 targeting RNF112, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-6081	99.48	66.07	1446
HSA-MIR-4696	99.48	67.48	1040
HSA-MIR-6853-3P	99.36	70.79	1558
HSA-MIR-6837-5P	99.25	65.47	1632
HSA-MIR-4685-5P	99.25	65.99	1563
HSA-MIR-361-3P	99.19	66.45	1381
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-376A-3P	99.06	69.17	1128
HSA-MIR-376B-3P	99.06	69.17	1128
HSA-MIR-10A-5P	98.89	69.85	712
HSA-MIR-10B-5P	98.89	69.86	711
HSA-MIR-330-5P	98.73	67.63	1788
HSA-MIR-7155-5P	98.65	66.14	1290
HSA-MIR-5008-5P	98.42	65.87	1019
HSA-MIR-4436B-3P	98.25	65.26	1494
HSA-MIR-326	98.25	66.44	1565
HSA-MIR-6735-5P	98.24	65.36	1488
HSA-MIR-7843-5P	98.12	65.26	1421
HSA-MIR-4438	97.96	63.70	947
HSA-MIR-7113-5P	97.88	67.33	1735
HSA-MIR-4632-5P	97.82	65.38	1470
HSA-MIR-6879-5P	97.77	65.52	1521

Literature-anchored findings (GeneRIF, showing 3)

• Plzf was identified as a specific interacting protein of Znf179; the region containing the first two zinc fingers is critical for its interaction with Znf179. Cellular localization of Znf179 changed from cytoplasm to nucleus when Plzf was co-expressed. (PMID:24359566)
• Znf179 can reprogram glioblastoma multiforme cells into a more-differentiated phenotype and prevent the progression of gliomas to a more-malignant state through p53-mediated cell-cycle signaling pathways. (PMID:28684796)
• RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer. (PMID:37288663)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rnf112	ENSMUSG00000010086
rattus_norvegicus	Rnf112	ENSRNOG00000002364
drosophila_melanogaster	atl	FBGN0039213

Paralogs (10): GBP3 (ENSG00000117226), GBP1 (ENSG00000117228), ATL2 (ENSG00000119787), GBP5 (ENSG00000154451), GBP2 (ENSG00000162645), GBP4 (ENSG00000162654), GBP6 (ENSG00000183347), ATL3 (ENSG00000184743), ATL1 (ENSG00000198513), GBP7 (ENSG00000213512)

Protein

Protein identifiers

RING finger protein 112 — Q9ULX5 (reviewed: Q9ULX5)

Alternative names: Brain finger protein, Zinc finger protein 179

All UniProt accessions (2): Q9ULX5, J3QRB8

UniProt curated annotations — full annotation on UniProt →

Function. E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density.

Subunit / interactions. Self-associates. Interacts with SP1 in an oxidative stress-regulated manner. Interacts with SIGMAR1 in an oxidative stress-regulated manner. Interacts with ZBTB16 (via C2H2-type zinc finger domains 1 and 2).

Subcellular location. Membrane. Cytoplasm. Nucleus. Nuclear body. Nucleoplasm. Endosome. Cytoplasmic vesicle. Secretory vesicle. Synaptic vesicle. Postsynaptic density. Perikaryon. Cell projection. Neuron projection.

Tissue specificity. Predominantly expressed in brain. Decreased expression in glioma brain tumors as compared to normal brains (at protein level).

Post-translational modifications. Auto-ubiquitinated.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9ULX5-1	1	yes
Q9ULX5-2	2

RefSeq proteins (1): NP_009079* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR015894	Guanylate-bd_N	Domain
IPR018957	Znf_C3HC4_RING-type	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR030386	G_GB1_RHD3_dom	Domain

Pfam: PF00097, PF02263

UniProt features (8 total): transmembrane region 2, chain 1, domain 1, zinc finger region 1, region of interest 1, binding site 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULX5-F1	70.04	0.35

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 318–319

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 112 (showing top): SASAI_TARGETS_OF_CXCR6_AND_PTCH1_UP, SP3_Q3, GOBP_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION, GOBP_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION, GOBP_NEUROGENESIS, GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT, GOBP_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT, BEIER_GLIOMA_STEM_CELL_DN, GOBP_REGULATION_OF_NEURON_DIFFERENTIATION, GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION, GATA6_01, GOBP_REGULATION_OF_CELL_CYCLE, GOBP_PROTEIN_AUTOUBIQUITINATION, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

GO Biological Process (12): endoplasmic reticulum organization (GO:0007029), neuron differentiation (GO:0030182), response to hydroperoxide (GO:0033194), positive regulation of neuron differentiation (GO:0045666), positive regulation of glial cell differentiation (GO:0045687), protein homooligomerization (GO:0051260), regulation of cell cycle (GO:0051726), protein autoubiquitination (GO:0051865), G1 to G0 transition involved in cell differentiation (GO:0070315), embryonic brain development (GO:1990403), nervous system development (GO:0007399), protein ubiquitination (GO:0016567)

GO Molecular Function (8): GTPase activity (GO:0003924), GTP binding (GO:0005525), zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), nucleotide binding (GO:0000166), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (14): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), endosome (GO:0005768), synaptic vesicle (GO:0008021), postsynaptic density (GO:0014069), membrane (GO:0016020), nuclear body (GO:0016604), neuron projection (GO:0043005), perikaryon (GO:0043204), cell body (GO:0044297), cytoplasmic vesicle (GO:0031410), cell projection (GO:0042995), synapse (GO:0045202)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	6
cell differentiation	2
organelle organization	1
endomembrane system organization	1
generation of neurons	1
response to oxidative stress	1
response to oxygen-containing compound	1
neuron differentiation	1
positive regulation of cell differentiation	1
regulation of neuron differentiation	1
glial cell differentiation	1
positive regulation of gliogenesis	1
regulation of glial cell differentiation	1
protein complex oligomerization	1
cell cycle	1
regulation of cellular process	1
protein ubiquitination	1
G1 to G0 transition	1
embryonic organ development	1
system development	1
protein modification by small protein conjugation	1
ribonucleoside triphosphate phosphatase activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
catalytic activity	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
endomembrane system	1
cytoplasmic vesicle	1
exocytic vesicle	1
presynapse	1
asymmetric synapse	1

Protein interactions and networks

STRING

1992 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RNF112	STX2	P32856	666
RNF112	STX1A	Q16623	595
RNF112	ST8SIA2	Q92186	583
RNF112	PHGDH	O43175	570
RNF112	LLGL1	Q15334	568
RNF112	PPP1R12C	Q9BZL4	505
RNF112	RHBDD3	Q9Y3P4	448
RNF112	ARF1	P10947	436
RNF112	CREM	Q03060	429
RNF112	CD226	Q15762	428
RNF112	PMCH	P20382	419
RNF112	TOMM20	Q15388	419
RNF112	EPN2	O95208	415
RNF112	SEC61B	P38390	400
RNF112	H2BC21	Q16778	398

IntAct

109 interactions, top by confidence:

A	B	Type	Score
RNF112	A2M	psi-mi:“MI:0915”(physical association)	0.560
RNF112	APP	psi-mi:“MI:0915”(physical association)	0.560
RNF112	DBH	psi-mi:“MI:0915”(physical association)	0.560
RNF112	DCTN1	psi-mi:“MI:0915”(physical association)	0.560
RNF112		psi-mi:“MI:0915”(physical association)	0.560
RNF112	ELAVL4	psi-mi:“MI:0915”(physical association)	0.560
RNF112	GRN	psi-mi:“MI:0915”(physical association)	0.560
RNF112	MECP2	psi-mi:“MI:0915”(physical association)	0.560
RNF112	NDUFV2	psi-mi:“MI:0915”(physical association)	0.560
RNF112	PRKN	psi-mi:“MI:0915”(physical association)	0.560
RNF112	PHYH	psi-mi:“MI:0915”(physical association)	0.560
RNF112	PMP22	psi-mi:“MI:0915”(physical association)	0.560
RNF112	PRPH	psi-mi:“MI:0915”(physical association)	0.560
RNF112	PSEN1	psi-mi:“MI:0915”(physical association)	0.560
RNF112	UCHL1	psi-mi:“MI:0915”(physical association)	0.560
RNF112	OPTN	psi-mi:“MI:0915”(physical association)	0.560
RNF112	PARK7	psi-mi:“MI:0915”(physical association)	0.560
RNF112	RNF11	psi-mi:“MI:0915”(physical association)	0.560
PEX26	RNF112	psi-mi:“MI:0915”(physical association)	0.560
SOD1	RNF112	psi-mi:“MI:0915”(physical association)	0.560
APP	RNF112	psi-mi:“MI:0915”(physical association)	0.560
SNCA	RNF112	psi-mi:“MI:0915”(physical association)	0.560
HTT	RNF112	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (778): RNF112 (Affinity Capture-MS), RNF112 (Affinity Capture-MS), RNF112 (Affinity Capture-Western), FOXM1 (Affinity Capture-Western), RNF112 (Affinity Capture-Western), RNF112 (Reconstituted Complex), PRRC2A (Affinity Capture-MS), RNF112 (Affinity Capture-MS), TCOF1 (Affinity Capture-MS), NAT10 (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), DDX41 (Affinity Capture-MS), CHD3 (Affinity Capture-MS), GTPBP4 (Affinity Capture-MS), GNL3 (Affinity Capture-MS)

ESM2 similar proteins: A0A061IR73, A0A1B0GUU1, A6H687, A8MYJ7, B1WC39, D3ZVB0, E1BD59, G3MY25, G3MZC5, O75064, P07199, P27790, P29597, P48988, P52333, P52824, Q08DF2, Q0VCE3, Q13608, Q1JPD6, Q2VPB7, Q3TAP4, Q3U1Y4, Q3ZBE0, Q499M4, Q53EQ6, Q5JZY3, Q62137, Q63272, Q6B0B8, Q6DI92, Q6ZPS2, Q6ZS72, Q7TM95, Q80VI1, Q86UT6, Q8BYG9, Q8N9M5, Q8R5G7, Q8TE96

Diamond homologs: A0A3B3IT33, A0JN74, A4QPC6, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, A6NLU0, B1H278, B6VQ60, C9J1S8, D4ABM4, F6ZQ54, F8VTS6, I1YAP6, O00478, O00481, O15344, O70583, O75677, O75678, O75679, O76064, P0CI25, P0CI26, P18892, P19474, P82458, P86448, P86449, Q02398, Q03605, Q13410, Q14258, Q1L5Z9, Q1XHT8, Q2HJ46, Q2T9Z0, Q3TL54

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	RNF112	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 23 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
adult locomotory behavior	6	78.5×	6e-08
negative regulation of neuron apoptotic process	7	33.7×	3e-07
negative regulation of gene expression	6	18.0×	7e-05
positive regulation of apoptotic process	5	12.3×	1e-03
positive regulation of gene expression	5	8.4×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1823 predictions. Top by Δscore:

Variant	Effect	Δscore
17:19411487:G:GT	donor_gain	1.0000
17:19411487:G:T	donor_gain	1.0000
17:19411492:A:T	donor_gain	1.0000
17:19411628:A:G	acceptor_gain	1.0000
17:19411667:GTTG:G	donor_gain	1.0000
17:19411668:TTG:T	donor_gain	1.0000
17:19411671:G:GA	donor_loss	1.0000
17:19411671:G:GG	donor_gain	1.0000
17:19411672:T:G	donor_loss	1.0000
17:19412493:CACA:C	acceptor_loss	1.0000
17:19412495:CAGGT:C	acceptor_loss	1.0000
17:19412930:T:TA	acceptor_gain	1.0000
17:19413099:G:GT	donor_gain	1.0000
17:19413275:TGCAG:T	acceptor_loss	1.0000
17:19413277:CA:C	acceptor_loss	1.0000
17:19413278:A:AG	acceptor_gain	1.0000
17:19413278:A:AT	acceptor_loss	1.0000
17:19413278:AG:A	acceptor_gain	1.0000
17:19413279:G:GC	acceptor_gain	1.0000
17:19413279:GG:G	acceptor_gain	1.0000
17:19413279:GGA:G	acceptor_gain	1.0000
17:19413279:GGAGT:G	acceptor_gain	1.0000
17:19413405:G:T	donor_gain	1.0000
17:19413409:AAG:A	donor_loss	1.0000
17:19413411:GGT:G	donor_loss	1.0000
17:19413412:G:GC	donor_loss	1.0000
17:19413413:T:A	donor_loss	1.0000
17:19414086:T:A	acceptor_gain	1.0000
17:19414092:CAG:C	acceptor_loss	1.0000
17:19414093:A:AG	acceptor_gain	1.0000

AlphaMissense

4092 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:19413062:T:A	V169D	0.996
17:19413587:T:C	F244S	0.996
17:19415943:G:A	G555E	0.996
17:19415979:G:A	G567D	0.996
17:19416006:C:A	A576D	0.996
17:19413670:A:C	S272R	0.995
17:19413672:C:A	S272R	0.995
17:19413672:C:G	S272R	0.995
17:19415906:T:C	F543L	0.995
17:19415908:C:A	F543L	0.995
17:19415908:C:G	F543L	0.995
17:19415985:G:A	G569D	0.995
17:19416027:C:A	A583D	0.995
17:19416039:C:A	A587D	0.995
17:19415181:G:T	G424W	0.994
17:19415182:G:A	G424E	0.994
17:19415894:T:G	Y539D	0.994
17:19415922:C:A	A548D	0.994
17:19415957:G:C	G560R	0.994
17:19415967:G:A	G563E	0.994
17:19415982:C:A	A568D	0.994
17:19415997:C:A	A573D	0.994
17:19415942:G:A	G555R	0.993
17:19415942:G:C	G555R	0.993
17:19416030:C:A	A584D	0.993
17:19416044:G:A	G589R	0.993
17:19416044:G:C	G589R	0.993
17:19416045:G:A	G589E	0.993
17:19416066:T:A	V596D	0.993
17:19412640:T:C	C80R	0.992

dbSNP variants (sampled 300 via entrez): RS1000072294 (17:19416876 T>C), RS1000143734 (17:19415473 G>C,T), RS1000529770 (17:19416614 A>G,T), RS1000612547 (17:19413253 T>C), RS1001299652 (17:19413686 TG>T,TGG), RS1001411805 (17:19411286 G>A,T), RS1002231180 (17:19417404 G>C), RS1002606519 (17:19416991 C>T), RS1002858033 (17:19416764 T>G), RS1003418593 (17:19414337 A>C,G), RS1003441007 (17:19411200 G>A), RS1003878636 (17:19414005 G>A), RS1003939733 (17:19415863 G>A,T), RS1003970753 (17:19416272 C>A,T), RS1004651370 (17:19416405 G>A)

Disease associations

OMIM: gene MIM:601237 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Silicon Dioxide	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
sulforaphane	increases expression	1
beta-methylcholine	affects expression	1
tebuconazole	increases expression	1
(+)-JQ1 compound	decreases expression	1
Temozolomide	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Citrulline	decreases expression	1
Dexamethasone	decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Polychlorinated Biphenyls	affects expression	1
Testosterone	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	increases methylation	1
1-Methyl-4-phenylpyridinium	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.