RNF150

Summary

RNF150 (ring finger protein 150, HGNC:23138) is a protein-coding gene on chromosome 4q31.21, encoding RING finger protein 150 (Q9ULK6).

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm.

Source: NCBI Gene 57484 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 69 total
• MANE Select transcript: NM_020724

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23138
Approved symbol	RNF150
Name	ring finger protein 150
Location	4q31.21
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1214
Ensembl gene	ENSG00000170153
Ensembl biotype	protein_coding
Entrez	57484

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000306799, ENST00000420921, ENST00000506101, ENST00000507500, ENST00000515057, ENST00000515673

RefSeq mRNA: 1 — MANE Select: NM_020724 NM_020724

CCDS: CCDS34065

Canonical transcript exons

ENST00000515673 — 7 exons

Exon	Start	End
ENSE00001139115	140925977	140926073
ENSE00002036557	140859807	140868379
ENSE00003574389	140949301	140949372
ENSE00003633546	140967623	140967873
ENSE00003671119	140947654	140947736
ENSE00003788357	140911144	140911354
ENSE00003847744	141132325	141133469

Expression profiles

Bgee: expression breadth ubiquitous, 244 present calls, max score 96.73.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.8420 / max 216.6548, expressed in 1071 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
54151	4.2821	919
54149	0.9684	432
54146	0.8690	408
54148	0.5771	276
54152	0.2941	126
54145	0.2582	129
54150	0.2540	138
54155	0.2145	56
54147	0.0897	44
54154	0.0180	4

Top tissues by expression

260 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ventricle myocardium	UBERON:0006566	96.73	gold quality
buccal mucosa cell	CL:0002336	96.41	gold quality
oviduct epithelium	UBERON:0004804	94.82	gold quality
parotid gland	UBERON:0001831	94.38	gold quality
pigmented layer of retina	UBERON:0001782	93.09	gold quality
retina	UBERON:0000966	93.06	gold quality
heart right ventricle	UBERON:0002080	92.02	gold quality
cardiac muscle of right atrium	UBERON:0003379	91.61	gold quality
myocardium	UBERON:0002349	91.23	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	90.72	gold quality
corpus epididymis	UBERON:0004359	90.05	gold quality
cauda epididymis	UBERON:0004360	90.00	gold quality
deltoid	UBERON:0001476	89.80	gold quality
vastus lateralis	UBERON:0001379	89.29	gold quality
quadriceps femoris	UBERON:0001377	89.24	gold quality
adrenal tissue	UBERON:0018303	88.96	gold quality
caput epididymis	UBERON:0004358	88.23	gold quality
seminal vesicle	UBERON:0000998	87.57	gold quality
entorhinal cortex	UBERON:0002728	87.05	gold quality
biceps brachii	UBERON:0001507	87.01	gold quality
fallopian tube	UBERON:0003889	86.74	gold quality
tibialis anterior	UBERON:0001385	86.50	silver quality
hindlimb stylopod muscle	UBERON:0004252	86.08	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	86.05	gold quality
skeletal muscle tissue	UBERON:0001134	85.51	gold quality
muscle tissue	UBERON:0002385	85.51	gold quality
endometrium	UBERON:0001295	85.49	gold quality
cardiac ventricle	UBERON:0002082	85.20	gold quality
Brodmann (1909) area 23	UBERON:0013554	85.17	gold quality
heart left ventricle	UBERON:0002084	84.99	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	40.08
E-ANND-3	yes	6.69
E-CURD-10	no	128.43

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

129 targeting RNF150, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-9718	99.94	68.91	918
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-137-3P	99.87	74.74	2401

Literature-anchored findings (GeneRIF, showing 1)

• rs10007052 in the RNF150 gene is significantly associated with the risk of COPD in Chinese populations of Hainan province. (PMID:25609945)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	rnf150a	ENSDARG00000024827
mus_musculus	Rnf150	ENSMUSG00000047747
rattus_norvegicus	Rnf150	ENSRNOG00000003479
drosophila_melanogaster	gol	FBGN0004919
caenorhabditis_elegans		WBGENE00019185

Paralogs (9): RNF13 (ENSG00000082996), RNF215 (ENSG00000099999), ZNRF4 (ENSG00000105428), RNF167 (ENSG00000108523), RNF130 (ENSG00000113269), RNF128 (ENSG00000133135), RNF149 (ENSG00000163162), RNF133 (ENSG00000188050), RNF148 (ENSG00000235631)

Protein

Protein identifiers

RING finger protein 150 — Q9ULK6 (reviewed: Q9ULK6)

All UniProt accessions (2): Q9ULK6, D6RIE5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9ULK6-1	1	yes
Q9ULK6-2	2
Q9ULK6-3	3
Q9ULK6-4	4

RefSeq proteins (1): NP_065775* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR003137	PA_domain	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR046450	PA_dom_sf	Homologous_superfamily

Pfam: PF02225, PF13639

UniProt features (16 total): splice variant 5, glycosylation site 4, topological domain 2, signal peptide 1, chain 1, transmembrane region 1, domain 1, zinc finger region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULK6-F1	76.22	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (4): 186, 45, 125, 153

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 101 (showing top): GOBP_MACROMOLECULE_CATABOLIC_PROCESS, CHANDRAN_METASTASIS_DN, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, RICKMAN_HEAD_AND_NECK_CANCER_A, LINDVALL_IMMORTALIZED_BY_TERT_UP, GOBP_PROTEIN_CATABOLIC_PROCESS, CTGAGCC_MIR24, GOBP_PROTEOLYSIS, GOMF_ACYLTRANSFERASE_ACTIVITY, GOMF_AMINOACYLTRANSFERASE_ACTIVITY, GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY, CHENG_IMPRINTED_BY_ESTRADIOL, LEE_BMP2_TARGETS_UP, DURAND_STROMA_S_UP, GSE13522_WT_VS_IFNG_KO_SKIN_UP

GO Biological Process (1): ubiquitin-dependent protein catabolic process (GO:0006511)

GO Molecular Function (4): zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
protein ubiquitination	1
modification-dependent protein catabolic process	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
cation binding	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

876 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RNF150	RNF183	Q96D59	566
RNF150	TIGD4	Q8IY51	530
RNF150	TMEM131L	A2VDJ0	517
RNF150	RMND5B	Q96G75	514
RNF150	RNF175	Q8N4F7	512
RNF150	SMIM14	Q96QK8	497
RNF150	CCDC106	Q9BWC9	483
RNF150	SNX15	Q9NRS6	479
RNF150	COMMD8	Q9NX08	479
RNF150	RNF182	Q8N6D2	467
RNF150	OCIAD2	Q56VL3	462
RNF150	TMEM63C	Q9P1W3	457
RNF150	ARFIP1	P53367	456
RNF150	RNF186	Q9NXI6	454
RNF150	VWA5A	O00534	451

IntAct

13 interactions, top by confidence:

A	B	Type	Score
RNF150	CNN1	psi-mi:“MI:0915”(physical association)	0.400
UBE2D1	RNF150	psi-mi:“MI:0915”(physical association)	0.370
RNF150	UBE2D2	psi-mi:“MI:0915”(physical association)	0.370
RNF150	UBE2D3	psi-mi:“MI:0915”(physical association)	0.370
RNF150	UBE2D4	psi-mi:“MI:0915”(physical association)	0.370
UBE2E1	RNF150	psi-mi:“MI:0915”(physical association)	0.370
RNF150	UBE2E3	psi-mi:“MI:0915”(physical association)	0.370
RNF150	UBE2L6	psi-mi:“MI:0915”(physical association)	0.370
RNF150	UBE2U	psi-mi:“MI:0915”(physical association)	0.370
RNF150	UBE2W	psi-mi:“MI:0915”(physical association)	0.370
RNF150	UBE2Z	psi-mi:“MI:0915”(physical association)	0.370
HCN1	POTEF	psi-mi:“MI:0914”(association)	0.350

BioGRID (21): RNF150 (Affinity Capture-RNA), CNN1 (Affinity Capture-MS), RNF150 (Reconstituted Complex), RNF150 (Affinity Capture-RNA), RNF150 (Two-hybrid), CNN1 (Affinity Capture-MS), MAP3K5 (Affinity Capture-Western), RNF150 (Affinity Capture-Western), RNF150 (Cross-Linking-MS (XL-MS)), RNF150 (Cross-Linking-MS (XL-MS)), RNF150 (Two-hybrid), RNF150 (Two-hybrid), RNF150 (Two-hybrid), RNF150 (Two-hybrid), RNF150 (Two-hybrid)

ESM2 similar proteins: B6ZK76, C5IAW9, F4HZZ4, F4HZZ5, G3X9R7, O08721, O08747, O43567, O54965, O95185, P00545, P05622, P07333, Q00495, Q05030, Q0VD51, Q14B02, Q29RU0, Q2TA44, Q3TT99, Q3U2C5, Q566M8, Q5DTZ6, Q5RCV8, Q5RF74, Q5XIL0, Q66HG0, Q6AY01, Q6NRX0, Q6NXM3, Q6W3E5, Q6Y290, Q6ZN44, Q761X5, Q7T2Z5, Q86XS8, Q8AWW4, Q8K1S4, Q8N7C7, Q8NC42

Diamond homologs: A0A3L6DPG1, A5WWA0, A6HD62, D3ZSP7, F1QB30, G3X9R7, O13797, O16259, O35814, O54981, O88196, P31948, P53041, P53042, P53804, Q06003, Q0JL44, Q14B02, Q29RU0, Q2TA44, Q388N2, Q3U2C5, Q3ZBZ8, Q496Y0, Q4R8N7, Q54DA8, Q566M8, Q5DTZ6, Q5QLR5, Q5R8D8, Q5RF74, Q5SPX3, Q5XEP2, Q5Z880, Q5ZHY5, Q60676, Q60864, Q6AY01, Q6DGE9, Q6NPT7

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	RNF150	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 13 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	6	184.2×	5e-12
Antigen processing: Ubiquitination & Proteasome degradation	10	31.0×	5e-13

GO biological processes:

GO term	Partners	Fold	FDR
protein K48-linked ubiquitination	6	77.8×	2e-09
protein polyubiquitination	7	62.1×	3e-10
ubiquitin-dependent protein catabolic process	7	40.0×	2e-09
protein ubiquitination	5	15.9×	7e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

69 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2940 predictions. Top by Δscore:

Variant	Effect	Δscore
4:140911135:AGAAC:A	donor_loss	1.0000
4:140911136:GAACT:G	donor_loss	1.0000
4:140911137:AACTC:A	donor_loss	1.0000
4:140911138:ACT:A	donor_loss	1.0000
4:140911139:CT:C	donor_loss	1.0000
4:140911140:TCACT:T	donor_loss	1.0000
4:140911141:CA:C	donor_loss	1.0000
4:140911142:A:AC	donor_gain	1.0000
4:140911142:AC:A	donor_loss	1.0000
4:140911143:C:A	donor_loss	1.0000
4:140911143:C:CC	donor_gain	1.0000
4:140911143:CTG:C	donor_gain	1.0000
4:140911143:CTGTT:C	donor_gain	1.0000
4:140911170:T:TA	donor_gain	1.0000
4:140911198:C:CT	donor_gain	1.0000
4:140911199:C:CT	donor_gain	1.0000
4:140911350:TTGGG:T	acceptor_gain	1.0000
4:140911351:TGGG:T	acceptor_gain	1.0000
4:140911352:GGG:G	acceptor_gain	1.0000
4:140911355:C:CC	acceptor_gain	1.0000
4:140947647:GACT:G	donor_loss	1.0000
4:140947648:ACT:A	donor_loss	1.0000
4:140947649:CTC:C	donor_loss	1.0000
4:140947650:TCA:T	donor_loss	1.0000
4:140947651:CACCG:C	donor_loss	1.0000
4:140947652:A:AC	donor_gain	1.0000
4:140947653:C:CC	donor_gain	1.0000
4:140947653:C:CG	donor_loss	1.0000
4:140947653:CCGG:C	donor_gain	1.0000
4:140947734:TTC:T	acceptor_gain	1.0000

AlphaMissense

2895 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:140926007:C:A	K319N	1.000
4:140926007:C:G	K319N	1.000
4:140926010:G:C	C318W	1.000
4:140926011:C:A	C318F	1.000
4:140926011:C:G	C318S	1.000
4:140926011:C:T	C318Y	1.000
4:140926012:A:G	C318R	1.000
4:140926012:A:T	C318S	1.000
4:140926017:G:T	P316H	1.000
4:140926018:G:A	P316S	1.000
4:140926019:A:C	C315W	1.000
4:140926020:C:A	C315F	1.000
4:140926020:C:G	C315S	1.000
4:140926020:C:T	C315Y	1.000
4:140926021:A:C	C315G	1.000
4:140926021:A:G	C315R	1.000
4:140926021:A:T	C315S	1.000
4:140926038:A:G	L309P	1.000
4:140926038:A:T	L309H	1.000
4:140926040:C:A	W308C	1.000
4:140926040:C:G	W308C	1.000
4:140926042:A:G	W308R	1.000
4:140926042:A:T	W308R	1.000
4:140926050:A:T	V305D	1.000
4:140926052:A:C	C304W	1.000
4:140926053:C:A	C304F	1.000
4:140926053:C:G	C304S	1.000
4:140926053:C:T	C304Y	1.000
4:140926054:A:C	C304G	1.000
4:140926054:A:G	C304R	1.000

dbSNP variants (sampled 300 via entrez): RS1000008230 (4:141105190 T>C), RS10000204 (4:141036812 T>A), RS1000035102 (4:141188058 T>C), RS1000042494 (4:140986384 G>GT), RS1000051005 (4:140875609 C>T), RS1000051199 (4:141111024 T>C), RS1000052049 (4:141024302 G>A), RS1000056847 (4:141047161 C>A), RS1000063212 (4:141028597 G>C), RS1000064220 (4:141098763 A>G), RS1000065070 (4:140916687 G>A,C), RS1000077940 (4:141194922 G>A), RS1000080063 (4:141145594 C>A), RS1000081765 (4:141110539 C>T), RS1000093097 (4:141130451 C>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST001737_18	Chronic obstructive pulmonary disease-related biomarkers	1.000000e-07
GCST004607_226	Plateletcrit	3.000000e-14
GCST008017_4	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome	3.000000e-06
GCST008477_25	Emphysema annual change measurement in smokers (adjusted lung density)	9.000000e-06
GCST010002_16	Refractive error	2.000000e-08
GCST010725_4	Malaria	4.000000e-10
GCST010725_84	Malaria	7.000000e-11
GCST010725_89	Malaria	7.000000e-11
GCST90002400_442	Plateletcrit	2.000000e-24
GCST90002402_748	Platelet count	3.000000e-14
GCST90020026_295	Hip index	2.000000e-09
GCST90020026_296	Hip index	5.000000e-09

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007985	platelet crit
EFO:0007626	emphysema imaging measurement
EFO:0004309	platelet count
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression	4
bisphenol A	decreases expression, increases methylation	2
entinostat	affects cotreatment, decreases expression, increases expression	2
belinostat	increases expression, affects cotreatment	2
Panobinostat	increases expression, affects cotreatment	2
Estradiol	affects cotreatment, increases expression	2
Nickel	decreases expression	2
Silicon Dioxide	decreases expression, increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
methylmercuric chloride	increases expression	1
malachite green	affects response to substance	1
propionaldehyde	increases expression	1
trichostatin A	increases expression	1
arsenite	increases methylation	1
sulforaphane	decreases expression	1
sodium arsenite	decreases expression, increases abundance, affects cotreatment	1
manganese chloride	increases abundance, affects cotreatment, decreases expression	1
tri-o-cresyl phosphate	increases expression	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
licochalcone B	decreases expression	1
Temozolomide	increases expression	1
Leflunomide	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	increases abundance, affects cotreatment, decreases expression	1
Benzo(a)pyrene	increases methylation	1
Carbamazepine	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.