RNF152

Summary

RNF152 (ring finger protein 152, HGNC:26811) is a protein-coding gene on chromosome 18q21.33, encoding E3 ubiquitin-protein ligase RNF152 (Q8N8N0). E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB.

Enables small GTPase binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein ubiquitination. Located in lysosomal membrane.

Source: NCBI Gene 220441 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 43 total
• MANE Select transcript: NM_173557

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26811
Approved symbol	RNF152
Name	ring finger protein 152
Location	18q21.33
Locus type	gene with protein product
Status	Approved
Aliases	FLJ39176
Ensembl gene	ENSG00000176641
Ensembl biotype	protein_coding
OMIM	616512
Entrez	220441

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 26 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000312828, ENST00000588064, ENST00000588396, ENST00000591306, ENST00000619552, ENST00000873265, ENST00000873266, ENST00000873267, ENST00000873268, ENST00000873269, ENST00000873270, ENST00000873271, ENST00000873272, ENST00000873273, ENST00000873274, ENST00000873275, ENST00000873276, ENST00000873277, ENST00000873278, ENST00000873279, ENST00000873280, ENST00000969137, ENST00000969138, ENST00000969139, ENST00000969140, ENST00000969141, ENST00000969142, ENST00000969143, ENST00000969144

RefSeq mRNA: 1 — MANE Select: NM_173557 NM_173557

CCDS: CCDS11978

Canonical transcript exons

ENST00000312828 — 2 exons

Exon	Start	End
ENSE00001231424	61808067	61816598
ENSE00001332485	61892795	61893007

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 86.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.8977 / max 192.2446, expressed in 1271 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
172233	4.1391	1022
172234	2.6599	956
172235	0.8007	398
172231	0.1536	83
172232	0.1444	62

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	86.86	gold quality
adult mammalian kidney	UBERON:0000082	86.44	gold quality
popliteal artery	UBERON:0002250	86.04	gold quality
tibial artery	UBERON:0007610	86.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.81	gold quality
cerebellar cortex	UBERON:0002129	84.42	gold quality
cerebellar hemisphere	UBERON:0002245	84.29	gold quality
minor salivary gland	UBERON:0001830	83.95	gold quality
metanephros cortex	UBERON:0010533	83.35	gold quality
left coronary artery	UBERON:0001626	82.73	gold quality
colonic epithelium	UBERON:0000397	82.70	gold quality
skin of leg	UBERON:0001511	82.53	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.41	gold quality
endocervix	UBERON:0000458	82.38	gold quality
skin of abdomen	UBERON:0001416	82.09	gold quality
cerebellum	UBERON:0002037	82.01	gold quality
calcaneal tendon	UBERON:0003701	81.98	gold quality
cortex of kidney	UBERON:0001225	81.85	gold quality
aorta	UBERON:0000947	81.84	gold quality
right coronary artery	UBERON:0001625	81.74	gold quality
kidney	UBERON:0002113	81.46	gold quality
coronary artery	UBERON:0001621	80.65	gold quality
cortical plate	UBERON:0005343	80.46	gold quality
saliva-secreting gland	UBERON:0001044	80.09	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.43	gold quality
right lung	UBERON:0002167	79.30	gold quality
ectocervix	UBERON:0012249	79.27	gold quality
mouth mucosa	UBERON:0003729	78.36	gold quality
mucosa of transverse colon	UBERON:0004991	78.30	gold quality
lower esophagus mucosa	UBERON:0035834	78.22	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	24.96
E-ANND-3	yes	11.78
E-MTAB-6678	yes	11.48
E-CURD-114	yes	10.51
E-HCAD-35	yes	6.81

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

53 targeting RNF152, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-137-3P	99.87	74.74	2401
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-370-5P	99.78	66.81	706
HSA-MIR-1303	99.65	69.77	1662
HSA-MIR-9851-3P	99.63	69.68	1110
HSA-MIR-5003-5P	99.61	69.13	1624
HSA-MIR-18A-3P	99.56	65.68	1092
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-143-3P	99.49	69.05	1457
HSA-MIR-4770	99.49	69.09	1451
HSA-MIR-6740-3P	99.48	68.49	1392
HSA-MIR-582-5P	99.47	70.79	2635
HSA-MIR-3915	99.45	68.49	1905
HSA-MIR-135A-5P	99.36	71.85	1601
HSA-MIR-135B-5P	99.36	71.63	1613
HSA-MIR-584-3P	99.35	67.69	1082

Literature-anchored findings (GeneRIF, showing 4)

• RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities (PMID:21203937)
• A mechanism for regulation of mTORC1 signaling by RNF152-mediated K63-linked polyubiquitination of RagA. (PMID:25936802)
• The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function. (PMID:32486221)
• RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression. (PMID:37717980)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	rnf152	ENSDARG00000087782
mus_musculus	Rnf152	ENSMUSG00000047496
rattus_norvegicus	Rnf152	ENSRNOG00000014859

Paralogs (12): CD86 (ENSG00000114013), CD274 (ENSG00000120217), CD80 (ENSG00000121594), RFPL1 (ENSG00000128250), RFPL2 (ENSG00000128253), RFPL3 (ENSG00000128276), SPRYD4 (ENSG00000176422), RNF135 (ENSG00000181481), PDCD1LG2 (ENSG00000197646), RFPL4A (ENSG00000223638), RFPL4AL1 (ENSG00000229292), RFPL4B (ENSG00000251258)

Protein

Protein identifiers

E3 ubiquitin-protein ligase RNF152 — Q8N8N0 (reviewed: Q8N8N0)

Alternative names: RING finger protein 152, RING-type E3 ubiquitin transferase RNF152

All UniProt accessions (2): Q8N8N0, K7EMG3

UniProt curated annotations — full annotation on UniProt →

Function. E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes ‘Lys-63’-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates ‘Lys-48’-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.

Subunit / interactions. Interacts with RRAGA (inactive GDP-bound form); stimulated by amino acid starvation. Interacts with SEC16A.

Subcellular location. Lysosome membrane.

Tissue specificity. Widely expressed.

Post-translational modifications. Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the RNF152 family.

RefSeq proteins (1): NP_775828* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR033609	RING_RNF152	Domain
IPR045744	RNF152_C	Domain

Pfam: PF14634, PF19325

UniProt features (5 total): chain 1, transmembrane region 1, zinc finger region 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N8N0-F1	66.82	0.14

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-392499	Metabolism of proteins
R-HSA-597592	Post-translational protein modification
R-HSA-8852135	Protein ubiquitination

MSigDB gene sets: 115 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, TAATAAT_MIR126, MYOGENIN_Q6, GOCC_VACUOLAR_MEMBRANE, AAGCCAT_MIR135A_MIR135B, GOMF_GTPASE_BINDING, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, NKX61_01, BILD_HRAS_ONCOGENIC_SIGNATURE, CEBP_Q2, GGGCATT_MIR365, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, TGCTGAY_UNKNOWN, GOBP_NEGATIVE_REGULATION_OF_TOR_SIGNALING

GO Biological Process (18): protein monoubiquitination (GO:0006513), apoptotic process (GO:0006915), positive regulation of autophagy (GO:0010508), protein ubiquitination (GO:0016567), cellular response to amino acid starvation (GO:0034198), protein K63-linked ubiquitination (GO:0070534), protein K48-linked ubiquitination (GO:0070936), negative regulation of TORC1 signaling (GO:1904262), protein polyubiquitination (GO:0000209), cytoplasmic translation (GO:0002181), cellular response to starvation (GO:0009267), cellular response to nutrient levels (GO:0031669), TORC1 signaling (GO:0038202), negative regulation of translational initiation (GO:0045947), positive regulation of translational initiation (GO:0045948), protein localization to lysosome (GO:0061462), positive regulation of TORC1 signaling (GO:1904263), response to amino acid starvation (GO:1990928)

GO Molecular Function (7): ubiquitin-protein transferase activity (GO:0004842), zinc ion binding (GO:0008270), small GTPase binding (GO:0031267), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (4): lysosome (GO:0005764), lysosomal membrane (GO:0005765), organelle membrane (GO:0031090), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Protein ubiquitination	1
Metabolism of proteins	1
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein ubiquitination	2
protein polyubiquitination	2
TORC1 signaling	2
regulation of TORC1 signaling	2
response to starvation	2
translational initiation	2
regulation of translational initiation	2
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
autophagy	1
positive regulation of catabolic process	1
regulation of autophagy	1
protein modification by small protein conjugation	1
cellular response to starvation	1
response to amino acid starvation	1
negative regulation of TOR signaling	1
translation	1
cellular response to nutrient levels	1
cellular response to stress	1
response to nutrient levels	1
cellular response to stimulus	1
TOR signaling	1
negative regulation of translation	1
positive regulation of translation	1
protein localization to vacuole	1
positive regulation of TOR signaling	1
ubiquitin-like protein transferase activity	1
transition metal ion binding	1
GTPase binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
catalytic activity	1
cation binding	1
lytic vacuole	1
lysosome	1
lytic vacuole membrane	1
membrane	1
membrane-bounded organelle	1

Protein interactions and networks

STRING

706 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RNF152	RNF167	Q9H6Y7	573
RNF152	KLHL22	Q53GT1	572
RNF152	RRAGA	Q7L523	548
RNF152	A0A2R8Y4M4	A0A2R8Y4M4	506
RNF152	CASTOR1	Q8WTX7	464
RNF152	ZNRF1	Q8ND25	456
RNF152	ZNF507	Q8TCN5	455
RNF152	KICS2	Q96MD2	453
RNF152	ITFG2	Q969R8	452
RNF152	WDR24	Q96S15	445
RNF152	KLHL25	Q9H0H3	442
RNF152	SAMTOR	Q1RMZ1	440
RNF152	INTS5	Q6P9B9	437
RNF152	BNIP1	Q12981	435
RNF152	DNAJC11	Q9NVH1	434

IntAct

21 interactions, top by confidence:

A	B	Type	Score
KIR2DL3	RNF152	psi-mi:“MI:0915”(physical association)	0.560
TSPAN12	RNF152	psi-mi:“MI:0915”(physical association)	0.560
EBP	RNF152	psi-mi:“MI:0915”(physical association)	0.560
GJA8	RNF152	psi-mi:“MI:0915”(physical association)	0.560
RNF152	LITAF	psi-mi:“MI:0915”(physical association)	0.560
RNF152	C9orf40	psi-mi:“MI:0915”(physical association)	0.400
RNF152	UBE2E1	psi-mi:“MI:0915”(physical association)	0.370
RNF152	UBE2N	psi-mi:“MI:0915”(physical association)	0.370
RNF152	UBE2W	psi-mi:“MI:0915”(physical association)	0.370
RNF152	CROCC	psi-mi:“MI:0915”(physical association)	0.370
KIR2DL3	RNF152	psi-mi:“MI:0915”(physical association)	0.000
RNF152	EBP	psi-mi:“MI:0915”(physical association)	0.000
RNF152	GJA8	psi-mi:“MI:0915”(physical association)	0.000
RNF152	TSPAN12	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (44): RRAGA (Biochemical Activity), RRAGA (Affinity Capture-Western), RRAGA (Reconstituted Complex), RNF152 (Affinity Capture-Western), UBE2N (Reconstituted Complex), SEC16A (Affinity Capture-Western), RNF152 (PCA), RNF152 (Affinity Capture-Western), RHEB (Biochemical Activity), RHEB (Affinity Capture-Western), RHEB (Reconstituted Complex), RNF152 (Two-hybrid), RNF152 (Two-hybrid), RNF152 (Two-hybrid), KIR2DL3 (Two-hybrid)

ESM2 similar proteins: A6NCL7, A6NCQ9, A6QP29, A6QQV9, B1AVH7, B5DFA1, D2H0G5, D2H6Z0, D2H788, D3ZBM4, D4A723, E1C2W7, O95153, Q0QWG9, Q3SWY0, Q3T0Y9, Q3U0L2, Q3UV31, Q3V3A7, Q5RF77, Q60943, Q6INB3, Q6PGG2, Q7TNF8, Q7Z465, Q80TI1, Q810L3, Q8BG47, Q8BRJ3, Q8BXP5, Q8C0R7, Q8C432, Q8CEF8, Q8HYZ0, Q8N0U2, Q8N6D2, Q8N8N0, Q8NC24, Q8QZS5, Q8TED9

Diamond homologs: A0A7I2V3R4, D2H6Z0, D4A723, E1C2W7, Q03601, Q13049, Q3SWY0, Q58EC8, Q68EV7, Q6GND7, Q6NRD3, Q8BG47, Q8CH72, Q8N8N0, Q8QZS5, Q96D59, Q9D241, A4IF63, A5D7F8, A5D8S5, D2GXS7, D3ZQG6, E1BD59, F4I443, F6ZQ54, F7H9X2, O60858, O70277, O75382, P14373, Q14258, Q1XHU0, Q28E95, Q32L60, Q38HM4, Q495X7, Q496Y0, Q498M5, Q503I2, Q5M7V1

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	RNF152	ubiquitination
RNF152	“down-regulates activity”	RRAGA	polyubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1562 predictions. Top by Δscore:

Variant	Effect	Δscore
18:61893507:T:TA	donor_gain	1.0000
18:61893508:C:A	donor_gain	1.0000
18:61816594:CATTT:C	acceptor_gain	0.9900
18:61816596:TTT:T	acceptor_gain	0.9900
18:61816599:C:CC	acceptor_gain	0.9900
18:61825227:C:CT	acceptor_gain	0.9900
18:61839054:C:CT	acceptor_gain	0.9900
18:61872661:C:A	donor_gain	0.9900
18:61814833:T:A	donor_gain	0.9800
18:61816595:ATTTC:A	acceptor_loss	0.9800
18:61816597:TTCT:T	acceptor_loss	0.9800
18:61816598:TCTG:T	acceptor_loss	0.9800
18:61816599:C:A	acceptor_loss	0.9800
18:61816600:T:C	acceptor_loss	0.9800
18:61838965:T:A	donor_gain	0.9800
18:61839055:A:T	acceptor_gain	0.9800
18:61890527:C:CT	acceptor_gain	0.9800
18:61890528:A:C	acceptor_gain	0.9800
18:61838971:CA:C	donor_gain	0.9700
18:61892789:GGTTA:G	donor_loss	0.9700
18:61892790:GTTAC:G	donor_loss	0.9700
18:61892791:TTAC:T	donor_loss	0.9700
18:61892792:TA:T	donor_loss	0.9700
18:61892793:ACCT:A	donor_loss	0.9700
18:61892794:CCTG:C	donor_loss	0.9700
18:61893658:T:TA	donor_gain	0.9700
18:61814798:CCAAA:C	donor_gain	0.9600
18:61814861:TTAAA:T	donor_gain	0.9600
18:61814862:TAAAT:T	donor_gain	0.9600
18:61814863:A:AC	donor_gain	0.9600

AlphaMissense

1311 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:61816312:C:G	C51S	1.000
18:61816313:A:G	C51R	1.000
18:61816313:A:T	C51S	1.000
18:61816350:G:C	C38W	1.000
18:61816351:C:T	C38Y	1.000
18:61816352:A:G	C38R	1.000
18:61816359:A:C	C35W	1.000
18:61816360:C:T	C35Y	1.000
18:61816361:A:G	C35R	1.000
18:61816386:C:A	K26N	1.000
18:61816386:C:G	K26N	1.000
18:61816390:G:T	P25H	1.000
18:61816419:A:C	C15W	1.000
18:61816420:C:A	C15F	1.000
18:61816420:C:G	C15S	1.000
18:61816420:C:T	C15Y	1.000
18:61816421:A:G	C15R	1.000
18:61816421:A:T	C15S	1.000
18:61816430:A:G	C12R	1.000
18:61815873:G:C	F197L	0.999
18:61815873:G:T	F197L	0.999
18:61815875:A:G	F197L	0.999
18:61815904:A:G	L187P	0.999
18:61815916:A:G	L183P	0.999
18:61815919:A:G	L182P	0.999
18:61815919:A:T	L182H	0.999
18:61816258:A:G	L69P	0.999
18:61816302:G:C	C54W	0.999
18:61816303:C:A	C54F	0.999
18:61816303:C:G	C54S	0.999

dbSNP variants (sampled 300 via entrez): RS1000014159 (18:61856379 T>C), RS1000066455 (18:61856741 T>C), RS1000076826 (18:61859510 A>G), RS1000082760 (18:61850438 T>C), RS1000092058 (18:61818252 A>G), RS1000100540 (18:61809763 A>G), RS1000134195 (18:61852700 T>C), RS1000181177 (18:61849038 T>C), RS1000185603 (18:61853293 G>A), RS1000196066 (18:61884170 A>T), RS1000197234 (18:61810491 A>C), RS1000197724 (18:61843209 C>T), RS1000214302 (18:61832240 A>G), RS1000248188 (18:61893682 C>T), RS1000287689 (18:61823831 G>A,T)

Disease associations

OMIM: gene MIM:616512 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST003372_4	Glomerular filtration rate (creatinine)	3.000000e-06
GCST004292_49	Glomerular filtration rate (creatinine)	3.000000e-08
GCST007344_76	Estimated glomerular filtration rate	5.000000e-09
GCST007876_71	Estimated glomerular filtration rate	4.000000e-11

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
Benzo(a)pyrene	increases methylation, decreases expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Valproic Acid	decreases methylation, affects cotreatment, increases expression	2
Aflatoxin B1	decreases methylation	2
methyleugenol	decreases expression	1
bisphenol A	increases methylation	1
2-methyl-4-isothiazolin-3-one	increases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
arsenite	increases methylation	1
butyraldehyde	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
torcetrapib	increases expression	1
bisphenol S	decreases expression	1
theaflavin-3,3’-digallate	affects expression	1
Diethylhexyl Phthalate	increases expression	1
Dimethyl Sulfoxide	affects expression	1
Doxorubicin	decreases expression	1
Hydralazine	affects cotreatment, increases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Polychlorinated Biphenyls	affects expression	1
Smoke	decreases expression	1
Thiram	increases expression	1
Tretinoin	increases expression	1
Urethane	decreases expression	1
1-Methyl-4-phenylpyridinium	decreases expression	1
Cyclosporine	increases methylation	1
Cadmium Chloride	decreases expression	1
Palmitic Acid	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4BY	HEK293T TetOff-SNCA-A53T EGFP-RNF152-IRES-mScarlet-I	Transformed cell line	Female
CVCL_E4JW	HEK293T TetOff-SNCA-A53T EGFP-RNF152-IRES-mScarlet-I TMEM192-3xHA	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.