RNF185-AS1

Summary

RNF185-AS1 (RNF185 antisense RNA 1, HGNC:41161) is a long non-coding RNA gene on chromosome 22q12.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41161
Approved symbol	RNF185-AS1
Name	RNF185 antisense RNA 1
Location	22q12.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254835
Ensembl biotype	lncRNA
Entrez	100852405
RNAcentral	URS00003F4805 — lncRNA, 353 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000526089

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000526089 — 1 exons

Exon	Start	End
ENSE00002183863	31205264	31205616

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 87.43.

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.43	gold quality
colonic epithelium	UBERON:0000397	84.60	gold quality
islet of Langerhans	UBERON:0000006	82.39	gold quality
sural nerve	UBERON:0015488	81.21	gold quality
ganglionic eminence	UBERON:0004023	80.21	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.61	gold quality
bone marrow cell	CL:0002092	78.32	gold quality
cortical plate	UBERON:0005343	77.79	gold quality
hindlimb stylopod muscle	UBERON:0004252	77.15	gold quality
ventricular zone	UBERON:0003053	76.99	gold quality
rectum	UBERON:0001052	76.11	gold quality
prefrontal cortex	UBERON:0000451	76.07	gold quality
smooth muscle tissue	UBERON:0001135	75.87	gold quality
stromal cell of endometrium	CL:0002255	74.99	gold quality
popliteal artery	UBERON:0002250	74.49	gold quality
tibial artery	UBERON:0007610	74.39	gold quality
muscle of leg	UBERON:0001383	74.17	gold quality
gastrocnemius	UBERON:0001388	73.76	gold quality
pancreas	UBERON:0001264	73.67	gold quality
aorta	UBERON:0000947	72.77	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.47	gold quality
right lobe of thyroid gland	UBERON:0001119	72.16	gold quality
right coronary artery	UBERON:0001625	72.14	gold quality
descending thoracic aorta	UBERON:0002345	72.07	gold quality
left coronary artery	UBERON:0001626	71.62	gold quality
endocervix	UBERON:0000458	71.48	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.47	gold quality
left uterine tube	UBERON:0001303	71.19	gold quality
lower esophagus	UBERON:0013473	71.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• RNF185-AS1 promotes hepatocellular carcinoma progression through targeting miR-221-5p/integrin beta5 axis. (PMID:33358902)
• RNF185 antisense RNA 1 (RNF185-AS1) promotes proliferation, migration, and invasion in papillary thyroid carcinoma. (PMID:35324519)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.