RNF19B

Summary

RNF19B (ring finger protein 19B, HGNC:26886) is a protein-coding gene on chromosome 1p35.1, encoding E3 ubiquitin-protein ligase RNF19B (Q6ZMZ0). E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1.

This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region.

Source: NCBI Gene 127544 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 112 total
• MANE Select transcript: NM_001300826

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26886
Approved symbol	RNF19B
Name	ring finger protein 19B
Location	1p35.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ90005, NKLAM
Ensembl gene	ENSG00000116514
Ensembl biotype	protein_coding
OMIM	610872
Entrez	127544

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 protein_coding

ENST00000235150, ENST00000356990, ENST00000373456, ENST00000921592, ENST00000921593, ENST00000921594, ENST00000959790, ENST00000959791, ENST00000959792, ENST00000959793, ENST00000959794, ENST00000959795, ENST00000959796, ENST00000959797, ENST00000959798

RefSeq mRNA: 3 — MANE Select: NM_001300826 NM_001127361, NM_001300826, NM_153341

CCDS: CCDS372, CCDS44107, CCDS72754

Canonical transcript exons

ENST00000235150 — 9 exons

Exon	Start	End
ENSE00000764275	32938397	32938528
ENSE00000764276	32942252	32942459
ENSE00000764277	32944019	32944159
ENSE00000764278	32945514	32945628
ENSE00000764279	32946402	32946564
ENSE00000764281	32949569	32949774
ENSE00000826573	32948222	32948363
ENSE00001762997	32936449	32937259
ENSE00003907808	32964051	32964809

Expression profiles

Bgee: expression breadth ubiquitous, 271 present calls, max score 95.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.4821 / max 1123.8292, expressed in 1814 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
11578	21.3245	1771
11580	3.6985	1373
11579	2.3883	1368
11581	1.0708	526

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	95.89	gold quality
right testis	UBERON:0004534	95.77	gold quality
testis	UBERON:0000473	94.00	gold quality
type B pancreatic cell	CL:0000169	93.26	gold quality
monocyte	CL:0000576	93.06	gold quality
mononuclear cell	CL:0000842	93.04	gold quality
leukocyte	CL:0000738	92.95	gold quality
ileal mucosa	UBERON:0000331	92.34	gold quality
islet of Langerhans	UBERON:0000006	92.12	gold quality
blood	UBERON:0000178	91.63	gold quality
cortical plate	UBERON:0005343	90.51	gold quality
granulocyte	CL:0000094	90.41	gold quality
rectum	UBERON:0001052	89.66	gold quality
olfactory bulb	UBERON:0002264	89.55	gold quality
nasal cavity epithelium	UBERON:0005384	89.23	gold quality
esophagus mucosa	UBERON:0002469	88.94	gold quality
mucosa of transverse colon	UBERON:0004991	88.80	gold quality
cartilage tissue	UBERON:0002418	88.19	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.85	gold quality
duodenum	UBERON:0002114	87.79	gold quality
lower esophagus mucosa	UBERON:0035834	87.75	gold quality
transverse colon	UBERON:0001157	87.20	gold quality
vermiform appendix	UBERON:0001154	86.74	gold quality
male germ cell	CL:0000015	86.57	gold quality
smooth muscle tissue	UBERON:0001135	86.57	gold quality
gall bladder	UBERON:0002110	86.54	gold quality
skin of abdomen	UBERON:0001416	86.22	gold quality
jejunal mucosa	UBERON:0000399	86.19	gold quality
popliteal artery	UBERON:0002250	86.14	gold quality
tibial artery	UBERON:0007610	86.13	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.64
E-GEOD-110499	no	197.34

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): EZH2

miRNA regulators (miRDB)

34 targeting RNF19B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-329-3P	99.91	66.56	1234
HSA-MIR-362-3P	99.91	66.38	1267
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-636	99.80	69.58	1500
HSA-MIR-4679	99.76	69.19	1229
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-1179	99.71	68.70	1040
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-4677-3P	99.49	67.91	1246
HSA-MIR-183-3P	99.41	69.41	1598
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-4711-3P	98.97	66.87	1020
HSA-MIR-648	98.64	66.13	553
HSA-MIR-6830-3P	98.62	68.07	1760
HSA-MIR-603	98.58	68.28	1603

Literature-anchored findings (GeneRIF, showing 1)

• NKLAM is a positive regulator of STAT1-mediated transcriptional activity and is an important component of the innate immune response. (PMID:27570112)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	rnf19b	ENSDARG00000060926
mus_musculus	Rnf19b	ENSMUSG00000028793
rattus_norvegicus	Rnf19b	ENSRNOG00000000123
caenorhabditis_elegans		WBGENE00015926
caenorhabditis_elegans		WBGENE00021721

Paralogs (9): ANKIB1 (ENSG00000001629), RNF14 (ENSG00000013561), RNF19A (ENSG00000034677), RNF144B (ENSG00000137393), RNF217 (ENSG00000146373), RNF144A (ENSG00000151692), ARIH1 (ENSG00000166233), ARIH2 (ENSG00000177479), PRKN (ENSG00000185345)

Protein

Protein identifiers

E3 ubiquitin-protein ligase RNF19B — Q6ZMZ0 (reviewed: Q6ZMZ0)

Alternative names: IBR domain-containing protein 3, Natural killer lytic-associated molecule, RING finger protein 19B

All UniProt accessions (1): Q6ZMZ0

UniProt curated annotations — full annotation on UniProt →

Function. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death.

Subunit / interactions. Interacts with UBE2L3, UBE2L6 and UCKL1.

Subcellular location. Cytoplasmic granule membrane. Endoplasmic reticulum membrane.

Tissue specificity. Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells. Present in natural killer cells (at protein level). Ubiquitously expressed with high expression in testis.

Domain organisation. The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1. Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.

Induction. In natural killer cells, by IFNB1/IFN-beta and IL2/interleukin-2 (at protein level). Up-regulated by endoplasmic reticulum (ER) stress triggered by thapsigargin or tunicamycin.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the RBR family. RNF19 subfamily.

Isoforms (4)

UniProt ID	Names	Canonical?
Q6ZMZ0-1	1	yes
Q6ZMZ0-2	2
Q6ZMZ0-3	3
Q6ZMZ0-4	4

RefSeq proteins (3): NP_001120833, NP_001287755, NP_699172 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR002867	IBR_dom	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR031127	E3_UB_ligase_RBR	Family
IPR044066	TRIAD_supradom	Domain

Pfam: PF01485, PF22191

UniProt features (40 total): binding site 20, compositionally biased region 4, splice variant 4, region of interest 4, zinc finger region 3, transmembrane region 2, chain 1, active site 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZMZ0-F1	59.07	0.20

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 302

Ligand- & substrate-binding residues (20): 119; 122; 142; 145; 206; 211; 228; 233; 238; 241; 246; 251 …

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-9958825	Activation of STAT3 by cadherin engagement
R-HSA-1280218	Adaptive Immune System
R-HSA-168256	Immune System
R-HSA-983169	Class I MHC mediated antigen processing & presentation

MSigDB gene sets: 397 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, GSE45365_NK_CELL_VS_BCELL_UP, MYOGENIN_Q6, PAX4_01, TGCGCANK_UNKNOWN, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, GCANCTGNY_MYOD_Q6, ASTON_MAJOR_DEPRESSIVE_DISORDER_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_LEUKOCYTE_MEDIATED_CYTOTOXICITY, BROWNE_HCMV_INFECTION_16HR_UP, TGACCTY_ERR1_Q2

GO Biological Process (6): adaptive immune response (GO:0002250), ubiquitin-dependent protein catabolic process (GO:0006511), natural killer cell mediated cytotoxicity (GO:0042267), protein autoubiquitination (GO:0051865), immune system process (GO:0002376), protein ubiquitination (GO:0016567)

GO Molecular Function (8): zinc ion binding (GO:0008270), ubiquitin conjugating enzyme binding (GO:0031624), ubiquitin binding (GO:0043130), ubiquitin protein ligase activity (GO:0061630), ubiquitin-protein transferase activity (GO:0004842), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (7): ubiquitin ligase complex (GO:0000151), cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), cytosol (GO:0005829), cytolytic granule (GO:0044194), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Class I MHC mediated antigen processing & presentation	1
Adherens junctions interactions	1
Immune System	1
Adaptive Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
protein ubiquitination	2
cytoplasm	2
immune response	1
modification-dependent protein catabolic process	1
leukocyte mediated cytotoxicity	1
natural killer cell mediated immunity	1
biological_process	1
protein modification by small protein conjugation	1
transition metal ion binding	1
ubiquitin-like protein conjugating enzyme binding	1
ubiquitin-like protein binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
ubiquitin-like protein transferase activity	1
binding	1
catalytic activity	1
cation binding	1
intracellular protein-containing complex	1
transferase complex	1
intracellular anatomical structure	1
endomembrane system	1
intracellular membrane-bounded organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
lysosome	1

Protein interactions and networks

STRING

805 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RNF19B	UCKL1	Q9NWZ5	938
RNF19B	UBE2L6	O14933	605
RNF19B	UCK2	Q9BZX2	577
RNF19B	GZMB	P10144	492
RNF19B	IFNB1	P01574	422
RNF19B	RNF217	Q8TC41	418
RNF19B	N4BP1	O75113	417
RNF19B	TTC13	Q8NBP0	397
RNF19B	UBR7	Q8N806	375
RNF19B	PLA2G6	O60733	375
RNF19B	RNF216	Q9NWF9	375
RNF19B	RNFT1	Q5M7Z0	360
RNF19B	USP18	Q9UMW8	355
RNF19B	RNF144A	P50876	348
RNF19B	ASB11	Q8WXH4	340

IntAct

103 interactions, top by confidence:

A	B	Type	Score
RNF19B	AP1M1	psi-mi:“MI:0915”(physical association)	0.740
UCKL1	RNF19B	psi-mi:“MI:0915”(physical association)	0.600
RNF19B	UCKL1	psi-mi:“MI:0915”(physical association)	0.600
UCKL1	RNF19B	psi-mi:“MI:0403”(colocalization)	0.600
CDIPT	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
TSPAN2	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
RAP1GDS1	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
RNF19B	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
RNF19B	GIMAP5	psi-mi:“MI:0915”(physical association)	0.560
MEST	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
TNF	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
RNF19B	TMEM208	psi-mi:“MI:0915”(physical association)	0.560
RNF19B	SACM1L	psi-mi:“MI:0915”(physical association)	0.560
MFSD5	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
GOSR2	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
RNF19B	CLEC1A	psi-mi:“MI:0915”(physical association)	0.560
MS4A1	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
ICMT	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
RNF19B	SEC22A	psi-mi:“MI:0915”(physical association)	0.560
RNF19B	SELENOK	psi-mi:“MI:0915”(physical association)	0.560
TAP1	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
DHODH	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
RNF19B	SLC30A3	psi-mi:“MI:0915”(physical association)	0.560
	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
SEC23A	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
FDPS	RNF19B	psi-mi:“MI:0915”(physical association)	0.560
TMEM120B	RNF19B	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (125): RNF19B (Affinity Capture-MS), RNF19B (Affinity Capture-MS), RNF19B (Affinity Capture-MS), KIAA0753 (Affinity Capture-MS), VPS13C (Affinity Capture-MS), UBB (Affinity Capture-MS), USP4 (Affinity Capture-MS), DDX49 (Affinity Capture-MS), USP15 (Affinity Capture-MS), USP46 (Affinity Capture-MS), FAM91A1 (Affinity Capture-MS), MPP5 (Affinity Capture-MS), CPNE7 (Affinity Capture-MS), WDR20 (Affinity Capture-MS), CDC27 (Affinity Capture-MS)

ESM2 similar proteins: A2A7Q9, F1LXF1, O08873, O14795, O35274, O46606, P11274, P12755, P22681, P22682, P49797, P50636, Q08B84, Q0VGY8, Q1L8L6, Q2VJ60, Q3UR85, Q3YEC7, Q4KUS2, Q60698, Q62768, Q69ZT9, Q6PAJ1, Q6R891, Q6T4P5, Q6ZMZ0, Q6ZWB6, Q7TMB0, Q7TPB0, Q80U28, Q86YJ5, Q8HXH0, Q8NEL9, Q8TEK3, Q8WXG6, Q8WXH2, Q92622, Q92625, Q96SB3, Q9CXG9

Diamond homologs: A2A7Q9, O01965, P50636, Q08B84, Q1L8L6, Q2VJ60, Q54CX4, Q6ZMZ0, Q9NV58, Q9P3U4, Q9SKC3, A2VEA3, A5PK27, B1H1E4, F4KGU4, O76924, O95376, P0C8K8, P36113, Q1L8G6, Q22431, Q32NS4, Q5RFV4, Q5UQ35, Q6NW85, Q6PFJ9, Q6T486, Q7Z419, Q84RQ8, Q84RR0, Q84RR2, Q8BKD6, Q8L829, Q94981, Q949V6, Q9LVW9, Q9LVX0, Q9SKC2, Q9SKC4, Q9Y4X5

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	RNF19B	ubiquitination
RNF19B	“down-regulates quantity by destabilization”	UCKL1	ubiquitination
UBE2L3	“up-regulates activity”	RNF19B	binding
UBE2E2	“up-regulates activity”	RNF19B	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	92
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1067 predictions. Top by Δscore:

Variant	Effect	Δscore
1:32937256:TTCT:T	acceptor_gain	1.0000
1:32937258:CT:C	acceptor_gain	1.0000
1:32937260:C:CC	acceptor_gain	1.0000
1:32938392:CATA:C	donor_loss	1.0000
1:32938393:ATACC:A	donor_loss	1.0000
1:32938394:TAC:T	donor_loss	1.0000
1:32938524:CTAAC:C	acceptor_gain	1.0000
1:32938527:ACC:A	acceptor_loss	1.0000
1:32938529:C:CA	acceptor_loss	1.0000
1:32938531:G:C	acceptor_gain	1.0000
1:32942460:C:CC	acceptor_gain	1.0000
1:32944006:T:TA	donor_gain	1.0000
1:32944013:TTTTA:T	donor_loss	1.0000
1:32944014:TTTAC:T	donor_loss	1.0000
1:32944015:TTACC:T	donor_loss	1.0000
1:32944016:TACCT:T	donor_loss	1.0000
1:32944017:ACCTG:A	donor_loss	1.0000
1:32944155:AATAC:A	acceptor_gain	1.0000
1:32944156:ATAC:A	acceptor_gain	1.0000
1:32944156:ATACC:A	acceptor_loss	1.0000
1:32944157:TAC:T	acceptor_gain	1.0000
1:32944157:TACCT:T	acceptor_loss	1.0000
1:32944158:AC:A	acceptor_gain	1.0000
1:32944158:ACCTG:A	acceptor_loss	1.0000
1:32944159:CC:C	acceptor_gain	1.0000
1:32944160:C:A	acceptor_loss	1.0000
1:32944160:C:CC	acceptor_gain	1.0000
1:32944161:T:G	acceptor_loss	1.0000
1:32945513:CCAA:C	donor_gain	1.0000
1:32945522:A:AC	donor_gain	1.0000

AlphaMissense

4791 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:32944103:A:G	C441R	1.000
1:32944105:A:G	L440P	1.000
1:32944105:A:T	L440H	1.000
1:32944114:G:C	P437R	1.000
1:32944114:G:T	P437H	1.000
1:32944120:A:T	V435D	1.000
1:32944123:C:T	G434E	1.000
1:32944124:C:G	G434R	1.000
1:32944124:C:T	G434R	1.000
1:32944127:A:G	Y433H	1.000
1:32944129:A:T	V432D	1.000
1:32944133:A:C	Y431D	1.000
1:32944133:A:G	Y431H	1.000
1:32944135:G:T	A430E	1.000
1:32944138:A:G	L429P	1.000
1:32944138:A:T	L429Q	1.000
1:32944141:A:C	M428R	1.000
1:32944141:A:T	M428K	1.000
1:32944144:A:T	I427N	1.000
1:32944147:G:C	P426R	1.000
1:32944147:G:T	P426H	1.000
1:32944153:C:T	G424D	1.000
1:32944154:C:G	G424R	1.000
1:32944159:C:T	G422D	1.000
1:32945514:C:G	G422R	1.000
1:32945516:A:T	V421D	1.000
1:32945518:A:C	S420R	1.000
1:32945518:A:T	S420R	1.000
1:32945520:T:G	S420R	1.000
1:32945522:A:T	V419D	1.000

dbSNP variants (sampled 300 via entrez): RS1000071009 (1:32963837 G>A), RS1000084351 (1:32957566 G>A), RS1000123025 (1:32963586 C>T), RS1000186427 (1:32963707 G>C), RS1000191161 (1:32932382 A>G), RS1000301037 (1:32960833 CAAA>C), RS1000341343 (1:32966066 C>A), RS1000354775 (1:32931611 G>A), RS1000452805 (1:32943822 A>C), RS1000456438 (1:32957756 C>T), RS1000707796 (1:32948444 T>C), RS1000806411 (1:32933488 C>T), RS1000858023 (1:32939954 T>C), RS1000862353 (1:32966436 A>G), RS1000889304 (1:32939513 C>T)

Disease associations

OMIM: gene MIM:610872 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009066_2	Mosaic loss of chromosome Y (Y chromosome dosage)	4.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007783	mosaic loss of chromosome Y measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

83 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	4
sodium arsenite	affects cotreatment, decreases expression, increases abundance, increases expression	3
Acetaminophen	increases expression	3
Cisplatin	decreases expression, increases expression	3
Nickel	increases expression	2
Valproic Acid	affects expression, increases methylation	2
Cyclosporine	increases expression	2
Particulate Matter	increases abundance, increases expression, affects cotreatment	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	increases expression	1
Glupearl 19S	decreases expression	1
alpha phellandrene	increases expression	1
triphenyl phosphate	affects expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
trichostatin A	affects expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, decreases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
cobaltous chloride	increases expression	1
butyraldehyde	increases expression	1
zinc chromate	increases expression, increases abundance	1
chloroquine diphosphate	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, affects response to substance, increases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
CGP 52608	affects binding, increases reaction	1
motexafin gadolinium	increases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1HA	Abcam A-549 RNF19B KO 2	Cancer cell line	Male
CVCL_B2PT	Abcam A-549 RNF19B KO 1	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.