RNF216-IT1

Summary

RNF216-IT1 (RNF216 intronic transcript 1, HGNC:41463) is a long non-coding RNA gene on chromosome 7p22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41463
Approved symbol	RNF216-IT1
Name	RNF216 intronic transcript 1
Location	7p22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237738
Ensembl biotype	lncRNA
Entrez	100874342
RNAcentral	URS0000042637 — lncRNA, 337 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000443837

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000443837 — 3 exons

Exon	Start	End
ENSE00001594981	5662432	5662565
ENSE00001746416	5666610	5666704
ENSE00001748971	5680354	5680461

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 75.79.

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	75.79	gold quality
bone marrow	UBERON:0002371	71.74	gold quality
skeletal muscle tissue	UBERON:0001134	70.08	gold quality
colonic epithelium	UBERON:0000397	69.22	silver quality
lower esophagus muscularis layer	UBERON:0035833	65.71	gold quality
lower esophagus	UBERON:0013473	65.70	gold quality
primary visual cortex	UBERON:0002436	64.45	gold quality
blood	UBERON:0000178	64.15	gold quality
monocyte	CL:0000576	63.48	gold quality
popliteal artery	UBERON:0002250	63.24	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.17	gold quality
tibial artery	UBERON:0007610	63.14	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.34	gold quality
lymph node	UBERON:0000029	62.07	gold quality
prefrontal cortex	UBERON:0000451	60.61	gold quality
adrenal tissue	UBERON:0018303	60.33	gold quality
esophagus	UBERON:0001043	60.10	gold quality
mucosa of stomach	UBERON:0001199	59.93	gold quality
gall bladder	UBERON:0002110	59.51	gold quality
colon	UBERON:0001155	59.48	gold quality
heart left ventricle	UBERON:0002084	59.44	gold quality
left coronary artery	UBERON:0001626	59.39	gold quality
urinary bladder	UBERON:0001255	59.25	gold quality
islet of Langerhans	UBERON:0000006	59.15	gold quality
heart	UBERON:0000948	59.11	gold quality
tonsil	UBERON:0002372	58.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	58.73	gold quality
right atrium auricular region	UBERON:0006631	58.59	gold quality
ascending aorta	UBERON:0001496	58.51	gold quality
thoracic aorta	UBERON:0001515	58.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.92

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.