RNF38

Summary

RNF38 (ring finger protein 38, HGNC:18052) is a protein-coding gene on chromosome 9p13.2, encoding E3 ubiquitin-protein ligase RNF38 (Q9H0F5). Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies.

This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 152006 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 82 total
• MANE Select transcript: NM_022781

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18052
Approved symbol	RNF38
Name	ring finger protein 38
Location	9p13.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000137075
Ensembl biotype	protein_coding
OMIM	612488
Entrez	152006

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000259605, ENST00000350199, ENST00000353739, ENST00000357058, ENST00000377877, ENST00000377885, ENST00000484621, ENST00000488058, ENST00000491349, ENST00000611646

RefSeq mRNA: 5 — MANE Select: NM_022781 NM_022781, NM_194328, NM_194329, NM_194330, NM_194332

CCDS: CCDS6603, CCDS6604

Canonical transcript exons

ENST00000259605 — 12 exons

Exon	Start	End
ENSE00000699921	36351115	36351199
ENSE00000700013	36353170	36353331
ENSE00000700080	36356303	36356473
ENSE00000833096	36352742	36352848
ENSE00001288183	36344832	36344953
ENSE00001694763	36342325	36342424
ENSE00001906081	36400097	36400269
ENSE00003529472	36369719	36369932
ENSE00003597181	36390467	36390616
ENSE00003612670	36357775	36357942
ENSE00003671576	36375934	36376127
ENSE00003843153	36336400	36339814

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 99.85.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 20.9550 / max 315.9184, expressed in 1803 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100695	12.8710	1787
100691	2.3013	1157
100692	1.8095	864
100693	0.8037	439
100689	0.7151	249
100690	0.7018	418
100686	0.3717	182
100684	0.3467	165
100688	0.2883	99
100685	0.2765	135

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	99.85	gold quality
secondary oocyte	CL:0000655	99.68	gold quality
oocyte	CL:0000023	98.63	gold quality
male germ cell	CL:0000015	97.99	gold quality
left testis	UBERON:0004533	96.53	gold quality
right testis	UBERON:0004534	96.42	gold quality
cortical plate	UBERON:0005343	95.80	gold quality
ganglionic eminence	UBERON:0004023	95.59	gold quality
testis	UBERON:0000473	95.48	gold quality
cauda epididymis	UBERON:0004360	94.68	gold quality
metanephric glomerulus	UBERON:0004736	94.63	gold quality
germinal epithelium of ovary	UBERON:0001304	94.59	gold quality
choroid plexus epithelium	UBERON:0003911	94.51	gold quality
adult organism	UBERON:0007023	94.44	gold quality
renal glomerulus	UBERON:0000074	94.42	gold quality
Brodmann (1909) area 23	UBERON:0013554	94.10	gold quality
corpus epididymis	UBERON:0004359	94.03	gold quality
parietal pleura	UBERON:0002400	93.44	gold quality
endothelial cell	CL:0000115	93.34	gold quality
embryo	UBERON:0000922	93.30	gold quality
middle temporal gyrus	UBERON:0002771	93.27	gold quality
trabecular bone tissue	UBERON:0002483	93.06	gold quality
esophagus squamous epithelium	UBERON:0006920	93.01	gold quality
visceral pleura	UBERON:0002401	92.95	gold quality
superficial temporal artery	UBERON:0001614	92.80	gold quality
pleura	UBERON:0000977	92.72	gold quality
caput epididymis	UBERON:0004358	92.67	gold quality
seminal vesicle	UBERON:0000998	92.22	gold quality
blood vessel layer	UBERON:0004797	92.16	gold quality
palpebral conjunctiva	UBERON:0001812	91.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.99

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

357 targeting RNF38, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-363-3P	99.98	74.72	1821

Literature-anchored findings (GeneRIF, showing 10)

• Cloning and characterization of the RNF38 gene (PMID:12074600)
• These results suggest RNF38 is an E3 ubiquitin ligase that may play a role in regulating p53. (PMID:23973461)
• Data show that E3 ubiquitin-protein ligase RNF38 (RNF38) interacts with the nonreceptor tyrosine phosphatase SH2-containing protein tyrosine phosphatase 1 (SHP-1) and induces the polyubiquitination of SHP-1, which leads to destabilization of SHP-1. (PMID:30112836)
• identified RNF38 as a novel E3 ligase that modifies RUNX1 function without inducing its degradation (PMID:30309654)
• AHNAK interference restored the hepatocellular carcinoma (HCC) cell invasion and metastasis deprived by RNF38 downregulation. Clinically, elevated RNF38 and transforming growth factor beta receptor 1 (TGFBR1) expression was related to short overall survival (OS) and high cumulative recurrence rates in HCC patients. (PMID:30836988)
• Long non-coding RNA SNHG5 promotes human hepatocellular carcinoma progression by regulating miR-363-3p/RNF38 axis. (PMID:32329834)
• Inhibiting microRNA-301b suppresses cell growth and targets RNF38 in cervical carcinoma. (PMID:32643846)
• RNF38 inhibits osteosarcoma cell proliferation by binding to CRY1. (PMID:34460347)
• RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma. (PMID:35568845)
• Hsa_circ_0097009 regulates proliferation, apoptosis, migration and invasion of hepatocellular carcinoma cells via miR-568/RNF38 axis. (PMID:36598315)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	rnf38	ENSDARG00000062055
mus_musculus	Rnf38	ENSMUSG00000035696
rattus_norvegicus	Rnf38	ENSRNOG00000013956

Paralogs (3): RNF6 (ENSG00000127870), RLIM (ENSG00000131263), RNF44 (ENSG00000146083)

Protein

Protein identifiers

E3 ubiquitin-protein ligase RNF38 — Q9H0F5 (reviewed: Q9H0F5)

Alternative names: RING finger protein 38, RING-type E3 ubiquitin transferase RNF38

All UniProt accessions (1): Q9H0F5

UniProt curated annotations — full annotation on UniProt →

Function. Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.

Subcellular location. Nucleus.

Tissue specificity. Widely expressed with highest levels in testis.

Pathway. Protein modification; protein ubiquitination.

Isoforms (5)

UniProt ID	Names	Canonical?
Q9H0F5-1	1	yes
Q9H0F5-2	2
Q9H0F5-3	3
Q9H0F5-4	4
Q9H0F5-5	5

RefSeq proteins (5): NP_073618, NP_919309, NP_919310, NP_919311, NP_919313 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily

Pfam: PF13639

UniProt features (25 total): splice variant 5, strand 5, turn 3, sequence conflict 2, helix 2, short sequence motif 2, compositionally biased region 2, chain 1, zinc finger region 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

6 structures.

PDB	Method	Resolution (Å)
9Q88	X-RAY DIFFRACTION	1.2
4V3L	X-RAY DIFFRACTION	1.53
4V3K	X-RAY DIFFRACTION	2.04
7OJX	X-RAY DIFFRACTION	2.4
9Q8Y	X-RAY DIFFRACTION	2.63
1X4J	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H0F5-F1	52.69	0.14

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 300 (showing top): MYAATNNNNNNNGGC_UNKNOWN, GGTGTGT_MIR329, TGCGCANK_UNKNOWN, CMYB_01, TATTATA_MIR374, AREB6_01, GGGTGGRR_PAX4_03, LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN, CATTTCA_MIR203, MCAATNNNNNGCG_UNKNOWN, chr9p13, TGTGTGA_MIR377, ACATTCC_MIR1_MIR206, TGACATY_UNKNOWN, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

GO Biological Process (2): male gonad development (GO:0008584), protein ubiquitination (GO:0016567)

GO Molecular Function (5): zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), sperm flagellum (GO:0036126)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
gonad development	1
development of primary male sexual characteristics	1
protein modification by small protein conjugation	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
catalytic activity	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
9+2 motile cilium	1

Protein interactions and networks

STRING

902 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RNF38	GNE	Q9Y223	952
RNF38	UBE2D2	P51669	899
RNF38	NANS	Q9NR45	575
RNF38	UAP1	Q16222	569
RNF38	TMEM169	Q96HH4	497
RNF38	UBB	P02248	496
RNF38	BIRC7	Q96CA5	438
RNF38	SHB	Q15464	434
RNF38	TRIM31	Q9BZY9	434
RNF38	BSN	Q9UPA5	433
RNF38	RBBP6	Q7Z6E9	425
RNF38	RNF4	P78317	422
RNF38	FAM174A	Q8TBP5	422
RNF38	OPCML	Q14982	403
RNF38	NREP	Q16612	400

IntAct

54 interactions, top by confidence:

A	B	Type	Score
RNF38	RNF208	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	RNF38	psi-mi:“MI:0915”(physical association)	0.560
OXER1	RNF38	psi-mi:“MI:0915”(physical association)	0.560
LASP1	RNF38	psi-mi:“MI:0915”(physical association)	0.560
KRTAP8-1	RNF38	psi-mi:“MI:0915”(physical association)	0.560
KRTAP6-2	RNF38	psi-mi:“MI:0915”(physical association)	0.560
KPRP	RNF38	psi-mi:“MI:0915”(physical association)	0.560
KRTAP11-1	RNF38	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	RNF38	psi-mi:“MI:0915”(physical association)	0.560
KRTAP21-2	RNF38	psi-mi:“MI:0915”(physical association)	0.560
KRTAP7-1	RNF38	psi-mi:“MI:0915”(physical association)	0.560
KRTAP19-5	RNF38	psi-mi:“MI:0915”(physical association)	0.560
RNF38		psi-mi:“MI:0915”(physical association)	0.490
NEDD4	RNF38	psi-mi:“MI:0407”(direct interaction)	0.440
YAP1	RNF38	psi-mi:“MI:0407”(direct interaction)	0.440
KPNA4	RNF38	psi-mi:“MI:0407”(direct interaction)	0.440
RNF38	bipA	psi-mi:“MI:0915”(physical association)	0.370
RNF38	iglC2	psi-mi:“MI:0915”(physical association)	0.370
UBE2D1	RNF38	psi-mi:“MI:0915”(physical association)	0.370
RNF38	UBE2D2	psi-mi:“MI:0915”(physical association)	0.370
UBE2D3	RNF38	psi-mi:“MI:0915”(physical association)	0.370
RNF38	UBE2H	psi-mi:“MI:0915”(physical association)	0.370
RNF38	UBE2D4	psi-mi:“MI:0915”(physical association)	0.370
DZIP3	RNF38	psi-mi:“MI:0915”(physical association)	0.370
RNF114	RNF38	psi-mi:“MI:0915”(physical association)	0.370
RNF38	DTX3	psi-mi:“MI:0915”(physical association)	0.370
ZDHHC17	RNF38	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (125): RNF38 (Two-hybrid), RNF38 (Biochemical Activity), RNF38 (Reconstituted Complex), UBE2D2 (Reconstituted Complex), UBC (Biochemical Activity), RNF38 (Affinity Capture-RNA), RNF38 (Reconstituted Complex), RNF38 (Affinity Capture-Western), PTPN6 (Affinity Capture-Western), RNF38 (Affinity Capture-MS), AHNAK (Affinity Capture-MS), TRIM21 (Affinity Capture-MS), DCD (Affinity Capture-MS), SPIDR (Affinity Capture-MS), CD109 (Affinity Capture-MS)

ESM2 similar proteins: A2AFE9, A2X0Q6, A3A2Z8, A5PJK7, B1ATL7, C7IW64, O65685, O94602, P03413, P11821, P38128, P80074, Q01196, Q03347, Q08775, Q0V9R0, Q10108, Q13761, Q2HRB6, Q5R476, Q5UQP5, Q63046, Q66J97, Q6AWY2, Q6F2E2, Q6NRV8, Q6PF39, Q6ZNA4, Q7L0R7, Q84JP1, Q8CFA7, Q8LFU0, Q8VY64, Q90ZT7, Q93ZH2, Q945M9, Q99ML9, Q9D1Z2, Q9E6P2, Q9FGD6

Diamond homologs: A5WWA0, E9QAU8, O22197, O43567, O49500, O54965, O64763, O80927, P0CH02, P0CH30, P0DPR2, Q06003, Q07G42, Q08CG8, Q08D68, Q0V9R0, Q0VD51, Q0WPW5, Q3T0W3, Q3U2C5, Q3UHJ8, Q4KLR8, Q4V7B8, Q566M8, Q5DTZ6, Q5M974, Q5NCP0, Q5R476, Q5RCV8, Q5SSZ7, Q5XIL0, Q641J8, Q66HG0, Q66J97, Q67YI6, Q68DV7, Q69U49, Q6AVN2, Q6AXU4, Q6GPV5

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	RNF38	ubiquitination
RNF38	“down-regulates activity”	TP53	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 27 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	6	18.6×	2e-05
Antigen processing: Ubiquitination & Proteasome degradation	8	16.5×	7e-07

GO biological processes:

GO term	Partners	Fold	FDR
protein K48-linked ubiquitination	5	44.4×	3e-06
protein polyubiquitination	6	36.5×	6e-07
ubiquitin-dependent protein catabolic process	7	27.4×	4e-07
protein ubiquitination	6	13.1×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

82 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1953 predictions. Top by Δscore:

Variant	Effect	Δscore
9:36339810:TTTGC:T	acceptor_gain	1.0000
9:36339811:TTGC:T	acceptor_gain	1.0000
9:36339812:TGC:T	acceptor_gain	1.0000
9:36339812:TGCC:T	acceptor_loss	1.0000
9:36339813:GC:G	acceptor_gain	1.0000
9:36339814:CC:C	acceptor_gain	1.0000
9:36339815:C:CA	acceptor_loss	1.0000
9:36339815:C:CC	acceptor_gain	1.0000
9:36339816:T:G	acceptor_loss	1.0000
9:36339818:C:CT	acceptor_gain	1.0000
9:36344826:A:AC	donor_gain	1.0000
9:36344826:ACTT:A	donor_loss	1.0000
9:36344827:C:CC	donor_gain	1.0000
9:36344828:TTACA:T	donor_loss	1.0000
9:36344829:TACAA:T	donor_loss	1.0000
9:36344830:A:AC	donor_gain	1.0000
9:36344830:AC:A	donor_loss	1.0000
9:36344831:C:CA	donor_gain	1.0000
9:36344831:CA:C	donor_gain	1.0000
9:36344831:CAA:C	donor_gain	1.0000
9:36344831:CAAA:C	donor_gain	1.0000
9:36344831:CAAAG:C	donor_gain	1.0000
9:36344954:C:CC	acceptor_gain	1.0000
9:36344954:CT:C	acceptor_loss	1.0000
9:36344961:G:T	acceptor_gain	1.0000
9:36351110:CTAA:C	donor_loss	1.0000
9:36351111:TAA:T	donor_loss	1.0000
9:36351112:AAC:A	donor_loss	1.0000
9:36351114:C:CT	donor_loss	1.0000
9:36352740:A:AC	donor_gain	1.0000

AlphaMissense

3328 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:36339789:C:G	R504P	1.000
9:36339791:G:C	C503W	1.000
9:36339792:C:A	C503F	1.000
9:36339792:C:G	C503S	1.000
9:36339792:C:T	C503Y	1.000
9:36339793:A:G	C503R	1.000
9:36339793:A:T	C503S	1.000
9:36339795:A:C	I502S	1.000
9:36339795:A:T	I502N	1.000
9:36339798:G:C	P501R	1.000
9:36339798:G:T	P501Q	1.000
9:36339799:G:A	P501S	1.000
9:36339799:G:T	P501T	1.000
9:36339800:G:C	C500W	1.000
9:36339801:C:A	C500F	1.000
9:36339801:C:G	C500S	1.000
9:36339801:C:T	C500Y	1.000
9:36339802:A:C	C500G	1.000
9:36339802:A:G	C500R	1.000
9:36339802:A:T	C500S	1.000
9:36342329:A:G	L494P	1.000
9:36342329:A:T	L494H	1.000
9:36342331:C:A	W493C	1.000
9:36342331:C:G	W493C	1.000
9:36342332:C:G	W493S	1.000
9:36342333:A:G	W493R	1.000
9:36342333:A:T	W493R	1.000
9:36342341:A:T	V490D	1.000
9:36342343:A:C	C489W	1.000
9:36342344:C:A	C489F	1.000

dbSNP variants (sampled 300 via entrez): RS1000017056 (9:36419275 T>G), RS1000056828 (9:36484128 T>G), RS1000073931 (9:36460464 C>G), RS1000076679 (9:36471873 G>A), RS1000081663 (9:36481939 G>A), RS1000085255 (9:36466127 T>C), RS1000092040 (9:36415427 TTTTG>T), RS1000116341 (9:36357543 T>C), RS1000143052 (9:36415646 T>C), RS1000152024 (9:36389728 T>C), RS1000165998 (9:36367213 G>C,T), RS1000184878 (9:36484998 C>G), RS1000189934 (9:36406921 A>G), RS1000223180 (9:36373234 T>C), RS1000227469 (9:36454827 A>C,G)

Disease associations

OMIM: gene MIM:612488 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002815_5	Bipolar disorder (inflammation and infection response interaction)	6.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007050	HSV1 seropositivity

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	decreases methylation, increases expression	2
Valproic Acid	affects expression, decreases expression	2
Cyclosporine	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
bisphenol A	increases expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
monomethylarsonous acid	increases expression	1
erastin	affects cotreatment, increases expression	1
abrine	decreases expression	1
bisphenol S	increases expression	1
(+)-JQ1 compound	increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	increases expression	1
Atrazine	decreases expression	1
Cadmium	decreases expression, increases abundance	1
Doxorubicin	decreases expression	1
Doxycycline	increases expression, affects cotreatment	1
Endosulfan	increases expression	1
Formaldehyde	decreases expression	1
Lead	affects splicing	1
Testosterone	increases expression	1
Thiram	increases expression	1
Urethane	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Isotretinoin	increases expression	1
Antirheumatic Agents	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.