RNU11

Summary

RNU11 (RNA, U11 small nuclear, HGNC:10108) is a small nuclear RNA gene on chromosome 1p35.3.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to act upstream of or within RNA splicing. Predicted to be part of U11 snRNP.

Source: NCBI Gene 26824 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10108
Approved symbol	RNU11
Name	RNA, U11 small nuclear
Location	1p35.3
Locus type	RNA, small nuclear
Status	Approved
Aliases	U11, RNU11-1
Ensembl gene	ENSG00000274978
Ensembl biotype	snRNA
Entrez	26824
RNAcentral	URS000000A142 — snRNA, 135 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000387069

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000387069 — 1 exons

Exon	Start	End
ENSE00001502075	28648600	28648734

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 99.64.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.9692 / max 2554.4982, expressed in 1703 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
1820	26.9692	1703

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.64	gold quality
adrenal tissue	UBERON:0018303	99.62	gold quality
calcaneal tendon	UBERON:0003701	98.76	gold quality
granulocyte	CL:0000094	98.57	gold quality
skeletal muscle tissue	UBERON:0001134	95.94	gold quality
corpus callosum	UBERON:0002336	92.29	gold quality
bone marrow	UBERON:0002371	90.46	gold quality
kidney	UBERON:0002113	89.75	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.15	gold quality
muscle of leg	UBERON:0001383	86.25	gold quality
blood	UBERON:0000178	85.65	gold quality
adult mammalian kidney	UBERON:0000082	85.53	gold quality
gastrocnemius	UBERON:0001388	84.99	gold quality
prefrontal cortex	UBERON:0000451	84.01	gold quality
liver	UBERON:0002107	83.99	gold quality
monocyte	CL:0000576	83.79	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.04	gold quality
superior frontal gyrus	UBERON:0002661	82.43	gold quality
lung	UBERON:0002048	78.49	gold quality
stomach	UBERON:0000945	78.44	gold quality
placenta	UBERON:0001987	78.44	gold quality
subcutaneous adipose tissue	UBERON:0002190	77.13	gold quality
skin of abdomen	UBERON:0001416	76.70	gold quality
urinary bladder	UBERON:0001255	76.62	gold quality
heart	UBERON:0000948	76.41	gold quality
heart left ventricle	UBERON:0002084	76.17	gold quality
adipose tissue	UBERON:0001013	75.87	gold quality
islet of Langerhans	UBERON:0000006	75.75	gold quality
fundus of stomach	UBERON:0001160	75.73	gold quality
left uterine tube	UBERON:0001303	75.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.60

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• conclude that U11 functions not only in 5’ss recognition in constitutive splicing, but also as an activator of U2-dependent alternative splicing and as a regulator of the U12-dependent spliceosome. (PMID:20347424)
• Ribosomal protein eS1 is engaged in cellular events related to processing and functioning of U11 snRNA. (PMID:28666385)
• High serum level of U11snRNA correlate with autoimmune diseases in human subjects. U11snRNA contains sequences, particularly in the SM region, which fulfill a known criterion as a TLR7 agonist ligand, namely a U-rich sequence together with a G residue(s). (PMID:31694883)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.