RNU2-2

Summary

RNU2-2 (RNA, U2 small nuclear 2, HGNC:10152) is a small nuclear RNA gene on chromosome 11q12.3.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10152
Approved symbol	RNU2-2
Name	RNA, U2 small nuclear 2
Location	11q12.3
Locus type	RNA, small nuclear
Status	Approved
Aliases	U2
Ensembl gene	ENSG00000222328
Ensembl biotype	snRNA
OMIM	621238
Entrez	26855
RNAcentral	URS00006D1C46 — snRNA, 191 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000410396

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410396 — 1 exons

Exon	Start	End
ENSE00001808017	62841619	62841809

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 99.99.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3080 / max 65.2490, expressed in 443 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
120246	1.1189	359
120248	0.4913	236
120247	0.1890	65

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.99	gold quality
corpus callosum	UBERON:0002336	99.92	gold quality
sural nerve	UBERON:0015488	99.91	gold quality
calcaneal tendon	UBERON:0003701	99.86	gold quality
colonic epithelium	UBERON:0000397	99.67	gold quality
bone marrow cell	CL:0002092	98.61	gold quality
bone marrow	UBERON:0002371	94.09	gold quality
superior frontal gyrus	UBERON:0002661	92.80	gold quality
tonsil	UBERON:0002372	90.10	gold quality
primary visual cortex	UBERON:0002436	89.39	gold quality
skeletal muscle tissue	UBERON:0001134	89.13	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.30	gold quality
granulocyte	CL:0000094	86.96	gold quality
blood	UBERON:0000178	86.44	gold quality
cortex of kidney	UBERON:0001225	86.38	gold quality
monocyte	CL:0000576	83.80	gold quality
muscle tissue	UBERON:0002385	83.61	gold quality
subcutaneous adipose tissue	UBERON:0002190	82.10	gold quality
thoracic mammary gland	UBERON:0005200	81.39	gold quality
kidney	UBERON:0002113	80.93	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.50	gold quality
liver	UBERON:0002107	78.50	gold quality
adipose tissue	UBERON:0001013	77.84	gold quality
islet of Langerhans	UBERON:0000006	77.50	gold quality
prefrontal cortex	UBERON:0000451	76.07	gold quality
skin of abdomen	UBERON:0001416	75.99	gold quality
urinary bladder	UBERON:0001255	75.98	gold quality
endometrium	UBERON:0001295	75.51	gold quality
lung	UBERON:0002048	75.44	gold quality
uterine cervix	UBERON:0000002	75.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

23 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm25813	ENSMUSG00000064682
mus_musculus	Gm22973	ENSMUSG00000065232
mus_musculus	Gm24950	ENSMUSG00000118718
mus_musculus	Gm25939	ENSMUSG00000118790
mus_musculus	Rnu2-10	ENSMUSG00000118837
mus_musculus	Gm25360	ENSMUSG00000118839
mus_musculus	Gm23472	ENSMUSG00000119668
mus_musculus	Gm23849	ENSMUSG00000119776
mus_musculus	Gm23444	ENSMUSG00000119838
mus_musculus	Gm24497	ENSMUSG00000119873
mus_musculus	Gm23971	ENSMUSG00000119892
rattus_norvegicus	LOC120094493	ENSRNOG00000057627
rattus_norvegicus	LOC120103289	ENSRNOG00000061141
rattus_norvegicus	U2	ENSRNOG00000071517
rattus_norvegicus	U2	ENSRNOG00000072226
rattus_norvegicus	U2	ENSRNOG00000073678
rattus_norvegicus	U2	ENSRNOG00000074032
rattus_norvegicus	U2	ENSRNOG00000077099
rattus_norvegicus	U2	ENSRNOG00000077556
rattus_norvegicus	U2	ENSRNOG00000078921
rattus_norvegicus	U2	ENSRNOG00000081686
rattus_norvegicus	U2	ENSRNOG00000082969
rattus_norvegicus	U2	ENSRNOG00000087575

Paralogs (90): RNU2-3P (ENSG00000222076), RNU2-65P (ENSG00000222094), RNU2-9P (ENSG00000222126), RNU2-17P (ENSG00000222222), RNU2-54P (ENSG00000222231), RNU2-43P (ENSG00000222238), RNU2-33P (ENSG00000222276), RNU2-36P (ENSG00000222293), RNU2-21P (ENSG00000222300), RNU2-29P (ENSG00000222355), RNU2-20P (ENSG00000222357), RNU2-28P (ENSG00000222389), RNU2-59P (ENSG00000222414), RNU2-50P (ENSG00000222426), RNU2-26P (ENSG00000222440), RNU2-5P (ENSG00000222465), RNU2-23P (ENSG00000222477), RNU2-39P (ENSG00000222536), RNU2-47P (ENSG00000222581), RNU2-66P (ENSG00000222582), RNU2-49P (ENSG00000222598), RNU2-52P (ENSG00000222612), RNU2-15P (ENSG00000222624), RNU2-48P (ENSG00000222626), RNU2-37P (ENSG00000222627), RNU2-42P (ENSG00000222629), RNU2-51P (ENSG00000222640), RNU2-16P (ENSG00000222644), RNU2-70P (ENSG00000222650), RNU2-8P (ENSG00000222659), RNU2-63P (ENSG00000222724), RNU2-7P (ENSG00000222726), RNU2-40P (ENSG00000222765), RNU2-38P (ENSG00000222788), RNU2-62P (ENSG00000222800), RNU2-68P (ENSG00000222810), RNU2-41P (ENSG00000222923), RNU2-25P (ENSG00000222973), RNU2-14P (ENSG00000222985), RNU2-61P (ENSG00000223001)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.