RNU4-1

Summary

RNU4-1 (RNA, U4 small nuclear 1, HGNC:10192) is a small nuclear RNA gene on chromosome 12q24.31.

Predicted to enable U6 snRNA binding activity. Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4 snRNP and U4/U6 x U5 tri-snRNP complex.

Source: NCBI Gene 26835 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10192
Approved symbol	RNU4-1
Name	RNA, U4 small nuclear 1
Location	12q24.31
Locus type	RNA, small nuclear
Status	Approved
Aliases	U4BL, U4
Ensembl gene	ENSG00000200795
Ensembl biotype	snRNA
OMIM	620822
Entrez	26835
RNAcentral	URS00003F07BD — snRNA, 144 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000363925

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000363925 — 1 exons

Exon	Start	End
ENSE00001808090	120293093	120293237

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 99.90.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 96.6887 / max 3253.2496, expressed in 1536 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133624	96.6887	1536

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.90	gold quality
sural nerve	UBERON:0015488	99.36	gold quality
blood	UBERON:0000178	83.83	gold quality
corpus callosum	UBERON:0002336	82.75	gold quality
kidney	UBERON:0002113	81.72	gold quality
calcaneal tendon	UBERON:0003701	80.63	gold quality
monocyte	CL:0000576	80.07	gold quality
islet of Langerhans	UBERON:0000006	79.64	gold quality
liver	UBERON:0002107	79.24	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.01	gold quality
lung	UBERON:0002048	76.24	gold quality
adult mammalian kidney	UBERON:0000082	75.88	gold quality
stomach	UBERON:0000945	75.42	gold quality
right testis	UBERON:0004534	75.29	gold quality
body of pancreas	UBERON:0001150	74.63	gold quality
left testis	UBERON:0004533	74.38	gold quality
lymph node	UBERON:0000029	74.24	gold quality
testis	UBERON:0000473	74.23	gold quality
fundus of stomach	UBERON:0001160	74.10	gold quality
heart	UBERON:0000948	73.51	gold quality
bone marrow	UBERON:0002371	73.08	gold quality
muscle of leg	UBERON:0001383	72.73	gold quality
granulocyte	CL:0000094	72.52	gold quality
duodenum	UBERON:0002114	71.15	gold quality
gastrocnemius	UBERON:0001388	71.10	gold quality
adrenal gland	UBERON:0002369	71.01	gold quality
endometrium	UBERON:0001295	70.49	gold quality
myometrium	UBERON:0001296	70.04	gold quality
heart left ventricle	UBERON:0002084	70.03	gold quality
multicellular organism	UBERON:0000468	69.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• NMR structure of the 3’ stem-loop from U4 snRNA (PMID:12384583)
• mutant U4 snRNA designed to base pair with a mutant U6atac snRNA can activate U12-dependent splicing (PMID:14691257)
• Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus. (PMID:24796696)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.