RNU5A-1

Summary

RNU5A-1 (RNA, U5A small nuclear 1, HGNC:10211) is a small nuclear RNA gene on chromosome 15q22.31.

Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U5 snRNP.

Source: NCBI Gene 26831 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10211
Approved symbol	RNU5A-1
Name	RNA, U5A small nuclear 1
Location	15q22.31
Locus type	RNA, small nuclear
Status	Approved
Aliases	U5A, U5B1
Ensembl gene	ENSG00000199568
Ensembl biotype	snRNA
OMIM	180691
Entrez	26831
RNAcentral	URS000075BAAE — snRNA, 117 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000362698

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362698 — 1 exons

Exon	Start	End
ENSE00001807565	65296051	65296167

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 99.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.0583 / max 2528.3986, expressed in 1342 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147221	10.0583	1342

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.93	gold quality
sural nerve	UBERON:0015488	99.81	gold quality
granulocyte	CL:0000094	99.10	gold quality
calcaneal tendon	UBERON:0003701	95.02	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.78	gold quality
bone marrow	UBERON:0002371	91.37	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	91.21	gold quality
kidney	UBERON:0002113	87.56	gold quality
leukocyte	CL:0000738	86.90	gold quality
monocyte	CL:0000576	86.46	gold quality
adult mammalian kidney	UBERON:0000082	83.28	gold quality
cortex of kidney	UBERON:0001225	83.13	gold quality
liver	UBERON:0002107	82.82	gold quality
endometrium	UBERON:0001295	79.90	gold quality
blood	UBERON:0000178	79.51	gold quality
stomach	UBERON:0000945	79.12	gold quality
ectocervix	UBERON:0012249	78.52	gold quality
muscle of leg	UBERON:0001383	76.96	gold quality
right testis	UBERON:0004534	76.74	gold quality
islet of Langerhans	UBERON:0000006	76.64	gold quality
skeletal muscle tissue	UBERON:0001134	76.64	gold quality
adrenal gland	UBERON:0002369	76.05	gold quality
testis	UBERON:0000473	75.02	gold quality
lung	UBERON:0002048	74.76	gold quality
lower esophagus mucosa	UBERON:0035834	74.57	gold quality
left testis	UBERON:0004533	74.56	gold quality
body of pancreas	UBERON:0001150	74.50	gold quality
duodenum	UBERON:0002114	74.39	gold quality
placenta	UBERON:0001987	74.19	gold quality
rectum	UBERON:0001052	73.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.93

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.