RNU5B-1

Summary

RNU5B-1 (RNA, U5B small nuclear 1, HGNC:10212) is a small nuclear RNA gene on chromosome 15q22.

Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U5 snRNP.

Source: NCBI Gene 26832 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10212
Approved symbol	RNU5B-1
Name	RNA, U5B small nuclear 1
Location	15q22
Locus type	RNA, small nuclear
Status	Approved
Aliases	U5B1
Ensembl gene	ENSG00000200156
Ensembl biotype	snRNA
OMIM	621090
Entrez	26832
RNAcentral	URS000075B029 — snRNA, 117 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000363286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000363286 — 1 exons

Exon	Start	End
ENSE00001807093	65304677	65304793

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 99.92.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.92	gold quality
sural nerve	UBERON:0015488	99.78	gold quality
calcaneal tendon	UBERON:0003701	95.10	gold quality
bone marrow	UBERON:0002371	86.59	gold quality
granulocyte	CL:0000094	86.35	gold quality
corpus callosum	UBERON:0002336	85.20	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.90	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.71	gold quality
liver	UBERON:0002107	83.88	gold quality
adult mammalian kidney	UBERON:0000082	82.91	gold quality
kidney	UBERON:0002113	82.79	gold quality
monocyte	CL:0000576	82.16	gold quality
stomach	UBERON:0000945	80.73	gold quality
blood	UBERON:0000178	80.14	gold quality
vermiform appendix	UBERON:0001154	79.46	gold quality
endometrium	UBERON:0001295	78.50	gold quality
skeletal muscle tissue	UBERON:0001134	78.36	gold quality
muscle of leg	UBERON:0001383	76.62	gold quality
lung	UBERON:0002048	76.45	gold quality
islet of Langerhans	UBERON:0000006	74.46	gold quality
prefrontal cortex	UBERON:0000451	74.19	gold quality
gastrocnemius	UBERON:0001388	73.32	gold quality
heart	UBERON:0000948	73.24	gold quality
left coronary artery	UBERON:0001626	71.86	gold quality
lymph node	UBERON:0000029	71.01	gold quality
colon	UBERON:0001155	70.99	gold quality
intestine	UBERON:0000160	70.83	gold quality
right lobe of liver	UBERON:0001114	70.79	gold quality
body of pancreas	UBERON:0001150	70.70	gold quality
tibial artery	UBERON:0007610	70.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.76

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.