RNU5E-1

Summary

RNU5E-1 (RNA, U5E small nuclear 1, HGNC:10215) is a small nuclear RNA gene on chromosome 1p36.22.

Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U5 snRNP.

Source: NCBI Gene 26829 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10215
Approved symbol	RNU5E-1
Name	RNA, U5E small nuclear 1
Location	1p36.22
Locus type	RNA, small nuclear
Status	Approved
Aliases	U5E
Ensembl gene	ENSG00000199347
Ensembl biotype	snRNA
OMIM	620362
Entrez	26829
RNAcentral	URS000075DD00 — snRNA, 119 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000362477

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362477 — 1 exons

Exon	Start	End
ENSE00001437240	11908152	11908272

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 98.11.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4431 / max 29.3620, expressed in 202 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201353	0.4431	202

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.11	gold quality
adrenal tissue	UBERON:0018303	94.64	gold quality
liver	UBERON:0002107	91.57	gold quality
kidney	UBERON:0002113	88.57	gold quality
stomach	UBERON:0000945	85.76	gold quality
lung	UBERON:0002048	83.61	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.58	gold quality
adult mammalian kidney	UBERON:0000082	82.41	gold quality
bone marrow	UBERON:0002371	81.05	gold quality
prefrontal cortex	UBERON:0000451	80.63	gold quality
lymph node	UBERON:0000029	75.85	gold quality
monocyte	CL:0000576	75.78	gold quality
blood	UBERON:0000178	73.97	gold quality
heart	UBERON:0000948	71.59	gold quality
granulocyte	CL:0000094	71.35	gold quality
gastrocnemius	UBERON:0001388	70.85	gold quality
muscle of leg	UBERON:0001383	70.78	gold quality
islet of Langerhans	UBERON:0000006	70.45	gold quality
minor salivary gland	UBERON:0001830	69.68	gold quality
endometrium	UBERON:0001295	69.55	gold quality
intestine	UBERON:0000160	69.12	gold quality
right lobe of liver	UBERON:0001114	68.70	gold quality
body of pancreas	UBERON:0001150	67.93	gold quality
body of stomach	UBERON:0001161	66.77	gold quality
ectocervix	UBERON:0012249	66.58	gold quality
left adrenal gland cortex	UBERON:0035825	66.15	gold quality
tibial artery	UBERON:0007610	65.89	gold quality
left adrenal gland	UBERON:0001234	65.84	gold quality
left ovary	UBERON:0002119	65.40	gold quality
right ovary	UBERON:0002118	65.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.