RNU5F-1

Summary

RNU5F-1 (RNA, U5F small nuclear 1, HGNC:10216) is a small nuclear RNA gene on chromosome 1p34.1.

Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U5 snRNP.

Source: NCBI Gene 26828 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10216
Approved symbol	RNU5F-1
Name	RNA, U5F small nuclear 1
Location	1p34.1
Locus type	RNA, small nuclear
Status	Approved
Ensembl gene	ENSG00000199377
Ensembl biotype	snRNA
OMIM	620363
Entrez	26828
RNAcentral	URS0000759ECB — snRNA, 116 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000362507

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362507 — 1 exons

Exon	Start	End
ENSE00001437270	44721785	44721902

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 95.91.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 385.0972 / max 55843.6961, expressed in 1758 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12086	385.0972	1758

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	95.91	gold quality
calcaneal tendon	UBERON:0003701	89.27	gold quality
bone marrow	UBERON:0002371	88.24	gold quality
right uterine tube	UBERON:0001302	87.29	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.13	gold quality
monocyte	CL:0000576	86.80	gold quality
leukocyte	CL:0000738	86.22	gold quality
sural nerve	UBERON:0015488	85.54	gold quality
liver	UBERON:0002107	82.05	gold quality
right lung	UBERON:0002167	81.75	gold quality
granulocyte	CL:0000094	81.12	gold quality
right lobe of liver	UBERON:0001114	80.95	gold quality
right adrenal gland cortex	UBERON:0035827	78.33	gold quality
left ovary	UBERON:0002119	78.15	gold quality
prefrontal cortex	UBERON:0000451	77.62	gold quality
blood	UBERON:0000178	77.43	gold quality
ovary	UBERON:0000992	77.23	gold quality
caudate nucleus	UBERON:0001873	75.68	gold quality
myometrium	UBERON:0001296	75.48	gold quality
right ovary	UBERON:0002118	75.26	gold quality
adrenal gland	UBERON:0002369	75.03	gold quality
right adrenal gland	UBERON:0001233	74.94	gold quality
lymph node	UBERON:0000029	74.78	gold quality
endocervix	UBERON:0000458	74.58	gold quality
lung	UBERON:0002048	74.51	gold quality
fallopian tube	UBERON:0003889	74.44	gold quality
stomach	UBERON:0000945	74.43	gold quality
islet of Langerhans	UBERON:0000006	74.22	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.17	gold quality
vermiform appendix	UBERON:0001154	74.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.44

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.