RNU6-2

Summary

RNU6-2 (RNA, U6 small nuclear 2, HGNC:34270) is a small nuclear RNA gene on chromosome 19p13.3.

Predicted to enable U4 snRNA binding activity. Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U6 snRNP.

Source: NCBI Gene 103625684 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34270
Approved symbol	RNU6-2
Name	RNA, U6 small nuclear 2
Location	19p13.3
Locus type	RNA, small nuclear
Status	Approved
Aliases	U6-2
Ensembl gene	ENSG00000207357
Ensembl biotype	snRNA
Entrez	103625684
RNAcentral	URS00001EC8D7 — snRNA, 107 nt, 212 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000384627

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384627 — 1 exons

Exon	Start	End
ENSE00003513160	1021522	1021628

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 99.60.

FANTOM5 (CAGE): breadth broad, TPM avg 2.4124 / max 468.2337, expressed in 667 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
172826	2.4124	667

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.60	gold quality
adrenal tissue	UBERON:0018303	95.53	gold quality
corpus callosum	UBERON:0002336	90.77	gold quality
granulocyte	CL:0000094	90.62	gold quality
calcaneal tendon	UBERON:0003701	88.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	88.25	gold quality
endometrium	UBERON:0001295	87.15	gold quality
skeletal muscle tissue	UBERON:0001134	86.57	gold quality
monocyte	CL:0000576	86.48	gold quality
blood	UBERON:0000178	86.32	gold quality
Ammon’s horn	UBERON:0001954	86.31	gold quality
anterior cingulate cortex	UBERON:0009835	86.20	gold quality
nucleus accumbens	UBERON:0001882	86.00	gold quality
leukocyte	CL:0000738	85.88	gold quality
right hemisphere of cerebellum	UBERON:0014890	85.62	gold quality
substantia nigra	UBERON:0002038	85.31	gold quality
hypothalamus	UBERON:0001898	85.19	gold quality
cerebral cortex	UBERON:0000956	84.99	gold quality
islet of Langerhans	UBERON:0000006	84.83	gold quality
frontal cortex	UBERON:0001870	84.30	gold quality
right frontal lobe	UBERON:0002810	84.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	84.00	gold quality
cerebellar hemisphere	UBERON:0002245	83.99	gold quality
brain	UBERON:0000955	83.70	gold quality
caudate nucleus	UBERON:0001873	83.67	gold quality
amygdala	UBERON:0001876	83.66	gold quality
bone marrow	UBERON:0002371	83.51	gold quality
putamen	UBERON:0001874	82.91	gold quality
prefrontal cortex	UBERON:0000451	82.82	gold quality
Brodmann (1909) area 9	UBERON:0013540	82.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.72

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm24205	ENSMUSG00000119461

Paralogs (1313): RNU6-1123P (ENSG00000199217), RNU6-500P (ENSG00000199219), RNU6-50P (ENSG00000199226), RNU6-834P (ENSG00000199237), RNU6-896P (ENSG00000199246), RNU6-28P (ENSG00000199248), RNU6-664P (ENSG00000199251), RNU6-874P (ENSG00000199260), RNU6-349P (ENSG00000199272), RNU6-661P (ENSG00000199279), RNU6-1094P (ENSG00000199286), RNU6-502P (ENSG00000199289), RNU6-1312P (ENSG00000199295), RNU6-208P (ENSG00000199301), RNU6-858P (ENSG00000199306), RNU6-222P (ENSG00000199308), RNU6-1298P (ENSG00000199326), RNU6-230P (ENSG00000199327), RNU6-204P (ENSG00000199335), RNU6-766P (ENSG00000199348), RNU6-1115P (ENSG00000199360), RNU6-1084P (ENSG00000199368), RNU6-79P (ENSG00000199381), RNU6-369P (ENSG00000199385), RNU6-600P (ENSG00000199394), RNU6-543P (ENSG00000199446), RNU6-845P (ENSG00000199448), RNU6-1216P (ENSG00000199460), RNU6-556P (ENSG00000199468), RNU6-633P (ENSG00000199482), RNU6-1313P (ENSG00000199492), RNU6-247P (ENSG00000199506), RNU6-212P (ENSG00000199512), RNU6-235P (ENSG00000199514), RNU6-386P (ENSG00000199520), RNU6-462P (ENSG00000199529), RNU6-315P (ENSG00000199536), RNU6-545P (ENSG00000199551), RNU6-37P (ENSG00000199562), RNU6-228P (ENSG00000199570)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.