RNU6-8

Summary

RNU6-8 (RNA, U6 small nuclear 8, HGNC:34285) is a small nuclear RNA gene on chromosome 14q12.

Predicted to enable U4 snRNA binding activity. Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U6 snRNP.

Source: NCBI Gene 101954278 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34285
Approved symbol	RNU6-8
Name	RNA, U6 small nuclear 8
Location	14q12
Locus type	RNA, small nuclear
Status	Approved
Aliases	U6-8
Ensembl gene	ENSG00000202337
Ensembl biotype	snRNA
Entrez	101954278
RNAcentral	URS000021BDC3 — snRNA, 107 nt, 120 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000365467

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000365467 — 1 exons

Exon	Start	End
ENSE00001807457	32203163	32203269

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 93.59.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	93.59	gold quality
adrenal tissue	UBERON:0018303	92.81	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	91.37	gold quality
granulocyte	CL:0000094	90.10	gold quality
calcaneal tendon	UBERON:0003701	87.44	gold quality
prefrontal cortex	UBERON:0000451	87.18	gold quality
sural nerve	UBERON:0015488	86.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	86.08	gold quality
lower esophagus	UBERON:0013473	85.98	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	85.49	gold quality
popliteal artery	UBERON:0002250	84.92	gold quality
tibial artery	UBERON:0007610	84.92	gold quality
myometrium	UBERON:0001296	84.23	gold quality
endocervix	UBERON:0000458	83.69	gold quality
hypothalamus	UBERON:0001898	83.53	gold quality
left uterine tube	UBERON:0001303	83.52	gold quality
right coronary artery	UBERON:0001625	82.64	gold quality
left coronary artery	UBERON:0001626	82.60	gold quality
body of uterus	UBERON:0009853	82.52	gold quality
urinary bladder	UBERON:0001255	82.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	82.10	gold quality
ascending aorta	UBERON:0001496	81.83	gold quality
ectocervix	UBERON:0012249	81.71	gold quality
amygdala	UBERON:0001876	81.68	gold quality
thoracic aorta	UBERON:0001515	81.65	gold quality
tibial nerve	UBERON:0001323	81.61	gold quality
nucleus accumbens	UBERON:0001882	81.52	gold quality
right hemisphere of cerebellum	UBERON:0014890	81.34	gold quality
anterior cingulate cortex	UBERON:0009835	80.39	gold quality
cerebellar hemisphere	UBERON:0002245	80.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.07

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm23296	ENSMUSG00000119013
mus_musculus	Gm24859	ENSMUSG00000119273
rattus_norvegicus	U6	ENSRNOG00000086017
rattus_norvegicus	U6	ENSRNOG00000090553

Paralogs (1313): RNU6-1123P (ENSG00000199217), RNU6-500P (ENSG00000199219), RNU6-50P (ENSG00000199226), RNU6-834P (ENSG00000199237), RNU6-896P (ENSG00000199246), RNU6-28P (ENSG00000199248), RNU6-664P (ENSG00000199251), RNU6-874P (ENSG00000199260), RNU6-349P (ENSG00000199272), RNU6-661P (ENSG00000199279), RNU6-1094P (ENSG00000199286), RNU6-502P (ENSG00000199289), RNU6-1312P (ENSG00000199295), RNU6-208P (ENSG00000199301), RNU6-858P (ENSG00000199306), RNU6-222P (ENSG00000199308), RNU6-1298P (ENSG00000199326), RNU6-230P (ENSG00000199327), RNU6-204P (ENSG00000199335), RNU6-766P (ENSG00000199348), RNU6-1115P (ENSG00000199360), RNU6-1084P (ENSG00000199368), RNU6-79P (ENSG00000199381), RNU6-369P (ENSG00000199385), RNU6-600P (ENSG00000199394), RNU6-543P (ENSG00000199446), RNU6-845P (ENSG00000199448), RNU6-1216P (ENSG00000199460), RNU6-556P (ENSG00000199468), RNU6-633P (ENSG00000199482), RNU6-1313P (ENSG00000199492), RNU6-247P (ENSG00000199506), RNU6-212P (ENSG00000199512), RNU6-235P (ENSG00000199514), RNU6-386P (ENSG00000199520), RNU6-462P (ENSG00000199529), RNU6-315P (ENSG00000199536), RNU6-545P (ENSG00000199551), RNU6-37P (ENSG00000199562), RNU6-228P (ENSG00000199570)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.