RNU6ATAC

Summary

RNU6ATAC (RNA, U6atac small nuclear, HGNC:34017) is a small nuclear RNA gene on chromosome 9q34.2.

Predicted to enable U4atac snRNA binding activity and pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition and spliceosomal tri-snRNP complex assembly. Predicted to be part of U6atac snRNP.

Source: NCBI Gene 100151684 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34017
Approved symbol	RNU6ATAC
Name	RNA, U6atac small nuclear
Location	9q34.2
Locus type	RNA, small nuclear
Status	Approved
Aliases	RNU6ATAC1
Ensembl gene	ENSG00000221676
Ensembl biotype	snRNA
OMIM	601429
Entrez	100151684
RNAcentral	URS0000443498 — ncRNA, 125 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000408749

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408749 — 1 exons

Exon	Start	End
ENSE00001807603	134164439	134164564

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 99.58.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5130 / max 293.6205, expressed in 112 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
103050	0.5130	112

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.58	gold quality
sural nerve	UBERON:0015488	99.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	86.97	gold quality
calcaneal tendon	UBERON:0003701	83.77	gold quality
liver	UBERON:0002107	82.93	gold quality
blood	UBERON:0000178	81.67	gold quality
kidney	UBERON:0002113	79.40	gold quality
stomach	UBERON:0000945	77.31	gold quality
islet of Langerhans	UBERON:0000006	77.23	gold quality
monocyte	CL:0000576	76.96	gold quality
skeletal muscle tissue	UBERON:0001134	76.16	gold quality
lung	UBERON:0002048	74.60	gold quality
lymph node	UBERON:0000029	74.42	gold quality
anterior cingulate cortex	UBERON:0009835	74.39	gold quality
placenta	UBERON:0001987	73.95	gold quality
bone marrow	UBERON:0002371	73.87	gold quality
descending thoracic aorta	UBERON:0002345	73.29	gold quality
lower esophagus mucosa	UBERON:0035834	73.28	gold quality
muscle of leg	UBERON:0001383	73.25	gold quality
adult mammalian kidney	UBERON:0000082	73.03	gold quality
right coronary artery	UBERON:0001625	72.91	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.91	gold quality
cerebral cortex	UBERON:0000956	72.87	gold quality
Ammon’s horn	UBERON:0001954	72.48	gold quality
right lobe of liver	UBERON:0001114	72.28	gold quality
heart	UBERON:0000948	72.24	gold quality
gastrocnemius	UBERON:0001388	71.87	gold quality
amygdala	UBERON:0001876	71.87	gold quality
frontal cortex	UBERON:0001870	71.85	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Study shows a detailed structure-function analysis and requirement of a substructure of U6atac 3’ stem-loop in U12-dependent in vivo splicing. Also, the distal 3’ stem-loop of U6atac recognizes the C-terminal RNA recognition motif of p65, a U12 snRNA binding protein. (PMID:27510544)

Cross-species orthologs

0 orthologs

Paralogs (10): RNU6ATAC19P (ENSG00000221023), RNU6ATAC7P (ENSG00000221038), RNU6ATAC6P (ENSG00000221059), RNU6ATAC27P (ENSG00000221216), RNU6ATAC8P (ENSG00000221387), RNU6ATAC41P (ENSG00000221527), RNU6ATAC21P (ENSG00000221583), RNU6ATAC39P (ENSG00000252118), RNU6ATAC22P (ENSG00000252603), (ENSG00000276642)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.