RNVU1-1

Summary

RNVU1-1 (RNA, variant U1 small nuclear 1, HGNC:10133) is a small nuclear RNA gene on chromosome 1q21.1.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 101954273 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10133
Approved symbol	RNVU1-1
Name	RNA, variant U1 small nuclear 1
Location	1q21.1
Locus type	RNA, small nuclear
Status	Approved
Aliases	vU1.1, U1P14, U1.4, vU1.10, RNU1-53
Ensembl gene	ENSG00000207340
Ensembl biotype	snRNA
Entrez	101954273
RNAcentral	URS0000162127 — snRNA, 164 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000384610

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384610 — 1 exons

Exon	Start	End
ENSE00001808155	148362370	148362533

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 97.76.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9096 / max 83.6374, expressed in 350 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201695	0.9096	350

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.76	gold quality
sural nerve	UBERON:0015488	95.28	gold quality
corpus callosum	UBERON:0002336	89.37	gold quality
ganglionic eminence	UBERON:0004023	85.14	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.80	gold quality
cortical plate	UBERON:0005343	82.84	gold quality
superior frontal gyrus	UBERON:0002661	81.05	gold quality
calcaneal tendon	UBERON:0003701	79.76	gold quality
prefrontal cortex	UBERON:0000451	79.71	gold quality
liver	UBERON:0002107	77.31	gold quality
ectocervix	UBERON:0012249	76.98	gold quality
primary visual cortex	UBERON:0002436	76.26	gold quality
adult mammalian kidney	UBERON:0000082	76.21	gold quality
monocyte	CL:0000576	76.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	75.60	gold quality
islet of Langerhans	UBERON:0000006	75.51	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.32	gold quality
cerebellum	UBERON:0002037	75.24	gold quality
cerebellar cortex	UBERON:0002129	75.23	gold quality
cerebellar hemisphere	UBERON:0002245	74.99	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.02	gold quality
kidney	UBERON:0002113	73.56	gold quality
vagina	UBERON:0000996	73.46	gold quality
granulocyte	CL:0000094	73.44	gold quality
mucosa of stomach	UBERON:0001199	72.85	gold quality
esophagus mucosa	UBERON:0002469	72.69	gold quality
frontal cortex	UBERON:0001870	72.53	gold quality
pancreas	UBERON:0001264	72.05	gold quality
endocervix	UBERON:0000458	71.55	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	71.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.85

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	U1	ENSRNOG00000083273

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.