RNVU1-17

Summary

RNVU1-17 (RNA, variant U1 small nuclear 17, HGNC:48322) is a small nuclear RNA gene on chromosome 1q21.2.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 101954269 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48322
Approved symbol	RNVU1-17
Name	RNA, variant U1 small nuclear 17
Location	1q21.2
Locus type	RNA, small nuclear
Status	Approved
Aliases	vU1.17, RNU1-127
Ensembl gene	ENSG00000207349
Ensembl biotype	snRNA
Entrez	101954269
RNAcentral	URS0000669D0F — snRNA, 164 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000384619

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384619 — 1 exons

Exon	Start	End
ENSE00001806847	143699456	143699619

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 95.98.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1110 / max 10.6134, expressed in 49 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14111	0.1110	49

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	95.98	gold quality
lung	UBERON:0002048	86.73	gold quality
liver	UBERON:0002107	84.98	gold quality
kidney	UBERON:0002113	82.02	gold quality
sural nerve	UBERON:0015488	77.86	gold quality
monocyte	CL:0000576	76.40	gold quality
stomach	UBERON:0000945	73.50	gold quality
heart	UBERON:0000948	72.32	gold quality
blood	UBERON:0000178	72.01	gold quality
colon	UBERON:0001155	70.95	gold quality
bone marrow	UBERON:0002371	68.60	gold quality
corpus callosum	UBERON:0002336	67.40	gold quality
left coronary artery	UBERON:0001626	66.74	gold quality
left uterine tube	UBERON:0001303	65.96	gold quality
smooth muscle tissue	UBERON:0001135	64.59	gold quality
tibial nerve	UBERON:0001323	64.34	gold quality
body of pancreas	UBERON:0001150	64.10	gold quality
muscle of leg	UBERON:0001383	63.88	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.55	gold quality
adrenal tissue	UBERON:0018303	63.40	gold quality
fallopian tube	UBERON:0003889	63.25	gold quality
Ammon’s horn	UBERON:0001954	63.13	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.13	gold quality
left lobe of thyroid gland	UBERON:0001120	63.11	gold quality
multicellular organism	UBERON:0000468	62.89	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.63	gold quality
tibial artery	UBERON:0007610	62.39	gold quality
gastrocnemius	UBERON:0001388	62.11	gold quality
skin of abdomen	UBERON:0001416	62.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm26444	ENSMUSG00000118751
mus_musculus	Gm25679	ENSMUSG00000118864
mus_musculus	Gm22317	ENSMUSG00000119206
mus_musculus	Gm24305	ENSMUSG00000119670
rattus_norvegicus	U1	ENSRNOG00000073744
rattus_norvegicus	U1	ENSRNOG00000076089
rattus_norvegicus	U1	ENSRNOG00000079204
rattus_norvegicus	U1	ENSRNOG00000081590
rattus_norvegicus	U1	ENSRNOG00000083039
rattus_norvegicus	U1	ENSRNOG00000086374
rattus_norvegicus	U1	ENSRNOG00000088534

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.