RNVU1-21

Summary

RNVU1-21 (RNA, variant U1 small nuclear 21, HGNC:48464) is a small nuclear RNA gene on chromosome 1q21.2.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 106480190 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48464
Approved symbol	RNVU1-21
Name	RNA, variant U1 small nuclear 21
Location	1q21.2
Locus type	RNA, small nuclear
Status	Approved
Ensembl gene	ENSG00000202408
Ensembl biotype	snRNA
Entrez	106480190
RNAcentral	URS00006D5E8B — snRNA, 156 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000365538

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000365538 — 1 exons

Exon	Start	End
ENSE00001440301	148334612	148334767

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 77.14.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.5577 / max 175.1403, expressed in 1085 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14246	6.5577	1085

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	77.14	gold quality
calcaneal tendon	UBERON:0003701	77.13	gold quality
right uterine tube	UBERON:0001302	75.54	gold quality
prefrontal cortex	UBERON:0000451	75.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.28	gold quality
liver	UBERON:0002107	73.39	gold quality
placenta	UBERON:0001987	71.84	gold quality
amygdala	UBERON:0001876	71.35	gold quality
granulocyte	CL:0000094	70.72	gold quality
caudate nucleus	UBERON:0001873	70.05	gold quality
muscle of leg	UBERON:0001383	69.90	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.88	gold quality
blood	UBERON:0000178	69.71	gold quality
bone marrow	UBERON:0002371	69.55	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.54	gold quality
islet of Langerhans	UBERON:0000006	69.30	gold quality
nucleus accumbens	UBERON:0001882	69.21	gold quality
frontal cortex	UBERON:0001870	69.03	gold quality
cerebral cortex	UBERON:0000956	68.81	gold quality
right frontal lobe	UBERON:0002810	68.70	gold quality
anterior cingulate cortex	UBERON:0009835	68.18	gold quality
putamen	UBERON:0001874	68.11	gold quality
Ammon’s horn	UBERON:0001954	67.83	gold quality
substantia nigra	UBERON:0002038	67.82	gold quality
brain	UBERON:0000955	67.80	gold quality
hypothalamus	UBERON:0001898	67.67	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.49	gold quality
adrenal tissue	UBERON:0018303	67.41	gold quality
vermiform appendix	UBERON:0001154	67.27	gold quality
gastrocnemius	UBERON:0001388	67.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.19

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio	U1	ENSDARG00000084068

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.