RNVU1-22

Summary

RNVU1-22 (RNA, variant U1 small nuclear 22, HGNC:48462) is a small nuclear RNA gene on chromosome 1q21.2.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 106481627 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48462
Approved symbol	RNVU1-22
Name	RNA, variant U1 small nuclear 22
Location	1q21.2
Locus type	RNA, small nuclear
Status	Approved
Ensembl gene	ENSG00000199879
Ensembl biotype	snRNA
Entrez	106481627
RNAcentral	URS000065A7DE — snRNA, 157 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000363009

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000363009 — 1 exons

Exon	Start	End
ENSE00001437772	148263476	148263632

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 82.19.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.7038 / max 215.3217, expressed in 1058 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
4994	10.7038	1058

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	82.19	gold quality
monocyte	CL:0000576	78.17	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.50	gold quality
bone marrow	UBERON:0002371	75.40	gold quality
calcaneal tendon	UBERON:0003701	72.82	gold quality
lung	UBERON:0002048	72.64	gold quality
stomach	UBERON:0000945	72.43	gold quality
right uterine tube	UBERON:0001302	72.35	gold quality
islet of Langerhans	UBERON:0000006	72.13	gold quality
liver	UBERON:0002107	71.97	gold quality
urinary bladder	UBERON:0001255	71.37	gold quality
lymph node	UBERON:0000029	71.20	gold quality
granulocyte	CL:0000094	70.60	gold quality
blood	UBERON:0000178	70.20	gold quality
placenta	UBERON:0001987	70.00	gold quality
adrenal gland	UBERON:0002369	69.45	gold quality
tonsil	UBERON:0002372	69.29	gold quality
muscle of leg	UBERON:0001383	69.17	gold quality
ectocervix	UBERON:0012249	68.93	gold quality
vermiform appendix	UBERON:0001154	68.32	gold quality
kidney	UBERON:0002113	68.27	gold quality
skin of abdomen	UBERON:0001416	67.61	gold quality
right lobe of liver	UBERON:0001114	67.52	gold quality
heart	UBERON:0000948	66.81	gold quality
gastrocnemius	UBERON:0001388	66.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.44	gold quality
zone of skin	UBERON:0000014	66.24	gold quality
skin of leg	UBERON:0001511	65.22	gold quality
fallopian tube	UBERON:0003889	64.93	gold quality
tibial artery	UBERON:0007610	64.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.14

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio	U1	ENSDARG00000084068

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155), RNU1-132P (ENSG00000201170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.